1XP9,1YY4


Conserved Protein Domain Family
NR_LBD_ER

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cd06949: NR_LBD_ER 
Click on image for an interactive view with Cn3D
Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
The ligand binding domain (LBD) of Estrogen receptor (ER): Estrogen receptor, a member of nuclear receptor superfamily, is activated by the hormone estrogen. Estrogen regulates many physiological processes including reproduction, bone integrity, cardiovascular health, and behavior. The main mechanism of action of the estrogen receptor is as a transcription factor by binding to the estrogen response element of target genes upon activation by estrogen and then recruiting coactivator proteins which are responsible for the transcription of target genes. Additionally some ERs may associate with other membrane proteins and can be rapidly activated by exposure of cells to estrogen. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, ER has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). The C-terminal LBD also contains AF-2 activation motif, the dimerization motif, and part of the nuclear localization region. Estrogen receptor has been linked to aging, cancer, obesity and other diseases.
Statistics
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PSSM-Id: 132747
View PSSM: cd06949
Aligned: 8 rows
Threshold Bit Score: 326.691
Threshold Setting Gi: 146742358
Created: 19-Nov-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1XP9_a; human estrogen receptor alpha binds to a Dihydrobenzoxathiin, molecule 18, contacts at 3.5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                   #    # #                             
1XP9_A         4 LTADQMVSALLDAEPPILYSEYdptr-------pfsEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECA 76
1YY4_A         1 LSPEQLVLTLLEAEPPHVLISRpsa--------pftEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESC 72
gi 170178459 303 NPTVPLISHLVNIEPNPILTGYnpqc-------tptEGYLMALVTDLANREIEGLVDWAARLPGYGMLPMDDQVNLIRTV 375
gi 82209527  280 LSPEELISRIMEAEPPEIYLMKdmkk-------pftEANVMMSLTNLADKELVHMISWAKKIPGFVELSLFDQVHLLECC 352
gi 119597    304 LTAEQMVSALLEAEPPIVYSEYdpnr-------pfnEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECA 376
gi 6015120   302 LTAEQLISALMEAEAPIVYSEHdstk-------plsEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECA 374
gi 146742358 226 QRLKALIDALDVKEGEHRGEENhptgqqagnwqeisNPELIESVSSLVDRELTGIICWGKKIPGYSKLSLNDQVLLMEST 305
gi 186659995 141 LSSEQFLTCLLNAEPPNMTCHHdvsr-------pftAERLMMLLTNLADRELVHMIGWAKKVPGFVQISLRDQVLLLESS 213
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #      #                                                                    
1XP9_A        77 WLEILMIGLVWRSMEHPG-KLLFAPNLLLDRNQGKc--------VEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIIL 147
1YY4_A        73 WMEVLMMGLMWRSIDHPG-KLIFAPDLVLDRDEGKc--------VEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMIL 143
gi 170178459 376 WLDLLMLGLVWRSMEHRGeWLVFAPDLLMDRSLCR---------LSGMEYICTPMLEFARQFADLQVPQEVYVCLKALTL 446
gi 82209527  353 WLEVLMLGLMWRSVNHPG-KLIFSPDLCLSRDESSc--------VQGLVEIFDMLLAATSRFRELKLQREEYVCLKAMIL 423
gi 119597    377 WLEILMIGLVWRSMEHPG-KLLFAPNLLLDRNQGKc--------VEGMVEIFDMLLATAARFRMMNLQGEEFVCLKSIIL 447
gi 6015120   375 WLEILMVGLIWRSVEHPG-KLSFAPNLLLDRNQGRc--------VEGLVEIFDMLVTTATRFRMMRLRGEEFICLKSIIL 445
gi 146742358 306 WLDLLILDLVWCSIRHKGeKLLLSGGVLVNRNTISnrrnnssgdDMEVLEMCDQILSIATKFYEFDLQRREYLCLKAITL 385
gi 186659995 214 WLEVLIMGLIWRSMSQPG-KLVFASNLILDRDDGEc--------VEGIFEIFDILLNIVQHFRELQVWMDEYVCLKAIIL 284
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                           #  #         
1XP9_A       148 LNSGVYtflsstlksLEEKDHIHRVLDKITDTLIHLMAKAgltlqQQHQRLAQLLLILSHIRHMSNKGMEHLysMKCKNV 227
1YY4_A       144 LNSSMYplvt-atqdADSSRKLAHLLNAVTDALVWVIAKSgissqQQSMRLANLLMLLSHVRHASNKGMEHLlnMKCKNV 222
gi 170178459 447 YTTAVSr--------LQDYRQVQRLQHEINEALAEACSSTf---gFSPGNIARLMMIVSQVRQLSSLGVDHLnrLRGAET 515
gi 82209527  424 LNSNMClgsseggedLQSRSKLLCLLDSVTDALVWAISKTglsfqQRSTRLAHLLMLLSHIRHVSNKGMDHLhcMKMKKM 503
gi 119597    448 LNSGVYtflsstlksLEERDYIHRVLDKITDTLIHLMAKSglslqQQHRRLAQLLLILSHIRHMSNKGMEHLynMKCKNV 527
gi 6015120   446 LNSGVYtflsstlesLEDTDLIHIILDKIIDTLVHFMAKSglslqQQQRRLAQLLLILSHIRHMSNKGMEHLysMKCKNV 525
gi 146742358 386 VHGSLKg--------LESDTQVRQLQDDLTDALMDVCSERh---aLGSRRPAKMLLLLSHLRQVSARASSHLgaVRNGLK 454
gi 186659995 285 LNASMMvat---sekDGSRAKVQQLVEATTDTLVKCIARRslatpEQFRRLSHLLTILSHIRHISNKGIQHMysMKCKNL 361
                        250
                 ....*....|....
Feature 1                      
1XP9_A       228 VPLYDLLLEMLDAH 241
1YY4_A       223 VPVYDLLLEMLNAH 236
gi 170178459 516 VSVEGLLREIVDEP 529
gi 82209527  504 VPLYDLLLEMLDAH 517
gi 119597    528 VPLYDLLLEMLDAH 541
gi 6015120   526 VPLYDLLLEMLDAH 539
gi 146742358 455 VPLYDILLDILTDQ 468
gi 186659995 362 VPFYDLLLEMLDAH 375

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