Conserved Protein Domain Family
NR_LBD_TR2_like

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cd06952: NR_LBD_TR2_like 
The ligand binding domain of the orphan nuclear receptors TR4 and TR2
The ligand binding domain of the TR4 and TR2 (human testicular receptor 4 and 2): TR4 and TR2 are orphan nuclear receptors. Several isoforms of TR4 and TR2 have been isolated in various tissues. TR2 is abundantly expressed in the androgen-sensitive prostate. TR4 transcripts are expressed in many tissues, including central nervous system, adrenal gland, spleen, thyroid gland, and prostate. The expression of TR2 is negatively regulated by androgen, retinoids, and radiation. The expression of both mouse TR2 and TR4 is up-regulated by neurocytokine ciliary neurotrophic factor (CNTF) in mouse. It has shown that human TR2 binds to a wide spectrum of natural hormone response elements (HREs) with distinct affinities suggesting that TR2 may cross-talk with other gene expression regulation systems. The genes responding to TR2 or TR4 include genes that are regulated by retinoic acid receptor, vitamin D receptor, peroxisome proliferator-activated receptor. TR4/2 binds to HREs as a dimer. Like other members of the nuclea r receptor (NR) superfamily of ligand-activated transcription factors, TR2-like receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132750
View PSSM: cd06952
Aligned: 12 rows
Threshold Bit Score: 331.99
Threshold Setting Gi: 110750942
Created: 19-Nov-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                ##   #                                 #   #  #         
gi 1351190   361 LLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQaLGQDCNTSLVRACWNELFTLGLAQCAqvmsl 440
gi 82228806  365 LLSDMHVPFKLMMPLPMPDFLNLNYICESASRLLFLSMHWARSIPAFQaLGSENGITLMKACWNELFALGLAQCShimnv 444
gi 45383862  334 LLSDAHVAFRLTMPSPMPEYLNVHYICETASRLLFLSMHWARSIPSFQaLGQDNSISLVKACWNELFTLGLAQCSqvmnv 413
gi 82198455  402 LLNDVHIAFRLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPSFLsLGQENSISLVKACWNELFSLGLAQCCqvmnv 481
gi 68566021  341 MLSDHHMQFKLTTPSPMPQFLNVHYICESASRLLFLSMHWARSLPAFQvLSADTHTSMVQKCWSELFTLGLAQCAqamal 420
gi 74893073  244 ILQEQHISFNLQIPGPVPPYLNIHYICESGSRLLFLSIHWTRNIPAFQyLTTETQITLLRGCWAELFTLGLAQCSqtlsl 323
gi 122049602 408 LMTDSNFVFELTTPTPLPEVFNVHYVCESASRLLFLSAQWARSIFAFQlLRTECHTSLLRDCWHELFMLGLAQCSrsmnl 487
gi 212511501 322 LLQDYHSTFNLQTPSPVPVHLNVHYVCESACRLLFLSIHWARSISAFQnLSHDLQVALVRRCWPELFALGLSQCSqilpl 401
gi 110750942 318 LISERHTLFELRAPSPAPAYLSIHYICESAARLLFLSVHWARGIPAFQaLPSEVQTTLVRSSWGQLFTLGLAQCAytlsl 397
gi 193688372 247 VMPSVNVNFPFQSPSPKYAYLNLHFICESASRLLFLSINWVQSLPVFQlLTFEVQLSLLKSSWSQLFILGLTQCAqalsl 326
gi 158296726 348 ALTEACVQFDIQVPTVLPSYLSVHYVCETGSRLLFATVHWMKKNHVFQmLGDGFQGELVRQVWPELFMIGLAQSSgqlsf 427
gi 24668099  370 LLTDVQCAFHVQPPTLVHSYLNIHYVCETGSRIIFLTIHTLRKVPVFEqLEAHTQVKLLRGVWPALMAIALAQCQgqlsv 449
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #                          #                                                
gi 1351190   441 sTILAAIVNHLQNSiqedklsgdrikqvmehIWKLQEFCNSMakLDIDGYEYAYLKAIVLFSPDHpgl----tsTSQIEK 516
gi 82228806  445 eTILTAIINHLQTSldeeklspervkqvmehIWRMQEFCNSMsrMSPDAYEYAYLKAVVLFSPDHsav----dgTLQIER 520
gi 45383862  414 aTILAAFVNHLHDSlqqdklptdrgklvmehIFKLQEFCNSMvkLCLDGYEYAYLKAIVLLSPDHpgl----enVVQIEK 489
gi 82198455  482 eTILAAFVNHLHNSmqhdklssdkvklvmdhIFKLQEFCNSMvkRCVDGYEYAYLKAIALFSPDHpgl----enVSHIEK 557
gi 68566021  421 sTILTAIVNHLQTSlqqdklsadrvkavmehIWKLQEFVTTTskLDVDQTEFAYLKTIVLFSPDHpgl----snVRQIEK 496
gi 74893073  324 sTILSALISHLHTLiaqdkmsatkvkqvsdhIVKLQDYANTMnrLNVDEHEYAYLKAITLFSADQpdi----llRKHVEK 399
gi 122049602 488 dRIIMTIIRHLKTSlqqgklttshvchvsehLNKLQDFVARLqkLEVDQHEYSYIKALALFSPDHvnq----lhRTQIQR 563
gi 212511501 402 rAMLAPIIAYLRTAvtqdtmaaqrliditdhIFKLHEYVTRMvsLQIDNHEYAYLKALVLFSWHLpglp--lalKRQIDR 479
gi 110750942 398 pSILTSIINHLQASiaqekitaskvksvtehICRLQDCVSSLhkLQVDSIEYAYLKALTLFSADNvla---gvwRKKVEV 474
gi 193688372 327 iPVLSSMITHLQNDeihnspnsskakelidyLNRIQDYITEMenIEVNDVEYAYLKLISLFNTDNps------eRQQLYK 400
gi 158296726 428 nTIMLALIQYMKSAilnkkhsadvinylkkyILLIQEFVNDLqkLNLTDHEYAYLRLLSIFNPDNvlqd--kekNQHLVK 505
gi 24668099  450 pTIIGQFIQSTRQLadidkieplkiskmanlTRTLHDFVQELqsLDVTDMEFGLLRLILLFNPTLlqqrkerslRGYVRR 529
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 1351190   517 FQEKAQMELQDYvqkty-----------------------------sedtyRLARILVRLPALRLMSsn-iTEELFFTGL 566
gi 82228806  521 FQEKAYMELQDYvskvy-----------------------------pedtyRLSKLLVRLPALRLMSaa-vTEELFFAGL 570
gi 45383862  490 FQEKAYMEFQDYvtkay-----------------------------pddtyRLSRLLLRLPALRLMSaa-iTEELFFAGL 539
gi 82198455  558 LQEKAYMEFQDYvtkty-----------------------------pedtyRLSRLLLRLPALRLLNaa-iTEELFFAGL 607
gi 68566021  497 FQEMAISELHDYeaqty-----------------------------psklnRFSKLLLRLPTLRLLSpa-iMEELFFAGL 546
gi 74893073  400 LQEKSFQALKTYvhnsf-----------------------------pddtdRFPRLLLRLPPLRGLEpl-vLEELFFAGL 449
gi 122049602 564 FQSRATTELREHemrty-----------------------------pedpdRMSLLLLSLPALRSLSss-iTEEIFFAGL 613
gi 212511501 480 LQEKALQELKSYvaknn-----------------------------seednRSSKLLLRLLPLRFLQpq-iMEELFFAGL 529
gi 110750942 475 LQEAAWTELQQRvg-----------------------------------snRLPRLLLRLAPLRSINpr-vLEDLFFAGL 518
gi 193688372 401 LQEKAVKELKQHlikec------------------------------ndehRIAILLLRLPTLRSLQpn-iIEEIFFSSL 449
gi 158296726 506 LQDLVLAEFRDYyrdrharlvsseseenlraneeddneddeeddyyerseqRLVKLLLKLPTLRALNskrdLEDLFFSNL 585
gi 24668099  530 VQLYALSSLRRQggig-------------------------------ggeeRFNVLVARLLPLSSLDae-aMEELFFANL 577
                        250
                 ....*....|....*.
Feature 1                        
gi 1351190   567 IGNVSIDSIIPYILKM 582
gi 82228806  571 IGNVQIDSIIPYILKM 586
gi 45383862  540 IGNVQIDSIIPYILRM 555
gi 82198455  608 IGNVQIDSIIPYILRM 623
gi 68566021  547 IGNVQIDSIIPYILRM 562
gi 74893073  450 IGQVQIDSVIPYILRM 465
gi 122049602 614 IGNVQIDSIIPYILKM 629
gi 212511501 530 IGNVQIDSVIPYILRM 545
gi 110750942 519 IGRVSVASVVPYILTM 534
gi 193688372 450 LGSFQIDAVIPQILKL 465
gi 158296726 586 IGQVQIDSVLTYVIQT 601
gi 24668099  578 VGQMQMDALIPFILMT 593

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