Conserved Protein Domain Family
NR_LBD_DHR4_like

?
cd06953: NR_LBD_DHR4_like 
The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
The ligand binding domain of Ecdysone-induced receptor DHR4: Ecdysone-induced orphan receptor DHR4 is a member of the nuclear receptor family. DHR4 is expressed during the early Drosophila larval development and is induced by ecdysone. DHR4 coordinates growth and maturation in Drosophila by mediating endocrine response to the attainment of proper body size during larval development. Mutations in DHR4 result in shorter larval development which translates into smaller and lighter flies. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, DHR4 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
?
PSSM-Id: 132751
View PSSM: cd06953
Aligned: 9 rows
Threshold Bit Score: 261.542
Threshold Setting Gi: 75038216
Created: 19-Nov-2008
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                         ##   #                                 #   #  # 
gi 118099468  351 QLVSAEDLEPLgtpmlied--gykvtqaeLFALLCRLADELLFRQIAWIKKLPFFcELSIKDYTCLLSSTWQELILLSSL 428
gi 148886998  211 QLLTAEDIEPLntpmlied--gykvtqseLFALLCRLADELLFRQITWVKKLPFFcDLSIKDYTCLLSTTWQELILLSSI 288
gi 68056708  1256 QTLIDCDAMEDiatlphfs--efledkseISEKLCNIGDSIVHKLVSWTKKLPFYlEIPVEIHTKLLTDKWHEILILTTA 1333
gi 12643728   256 QLLSAEDLEPLgtpmlied--gyavtqaeLFALLCRLADELLFRQIAWIKKLPFFcELSIKDYTCLLSSTWQELILLSSL 333
gi 82225956   222 QILADEDLTPLttpmlied--gysvtqseLLALLCGIADELLFRQIVWLKRLPFFtDLSIKDCTRLLGSSWHQLILLSSI 299
gi 122049714  350 QLVLAEDASFLvsigpdhgfndvtiskdqLFSILCKVADEMLYRQIVWIKKLPFFeTISIKDHTTLLSTTWAEIILLAAL 429
gi 75038216   454 VLKVAEKEGVNlkehrysdl-patmelddFRRLQCRLGEELVFHLVQWVKHLPFFtQLSAVEHTHLLKTKWLDLMLLCTI 532
gi 115702421  388 ALIVAEPIEPLtlpfevat--nqqvgyagLFELLCKLMDRMLHHQIQWTKRLPFQsKIPISDSTSLLTTCLIELLLLEVM 465
gi 75025546   222 ELVEMDCLDRLinlkglrinpsancdiapACKRLTRIGDEIVEQLVEWTKTLPFFdELPVEAHTHLLTQRWAELVLLSAG 301
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                         #               
gi 118099468  429 TVYsk----------------------------------------------------qIFGDLADVtskYSPSddelhrf 456
gi 148886998  289 TTYsk----------------------------------------------------qIFGDLTDVtskYSPSedelhrf 316
gi 68056708  1334 AYQalhgkrrgegggsrhgspastplstptgtplstpipspaqplhkddpefvsevnsHLSTLQTClttLMGQpiameql 1413
gi 12643728   334 TVYsk----------------------------------------------------qIFGELADVtakYSPSdeelhrf 361
gi 82225956   300 TVHsa----------------------------------------------------qILGELANVthhYTPSshtlqrf 327
gi 122049714  430 CVHed----------------------------------------------------qLFGDLADItskYLPDndelsrf 457
gi 75038216   533 SRAmhfkqplvnssvssgmsg-------------------kssggmdvglsfeqcthkNLLLLQECmnkTLDLrldmdvf 593
gi 115702421  466 RTQpl----------------------------------------------------eLFTKLGQIldtYIPSedelrkf 493
gi 75025546   302 YYAcsvftpdspdttem---------------------------idetdeisftnpqvNLRLLQNRlslVLGKeiplehv 354
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #                                                                        
gi 118099468  457 seegmevMERLIYLFRKFnqLKVSNEEYACMKAINFLNqdir---gltnASQLEQLNKRYWYVCQDFteyky-------- 525
gi 148886998  317 sedgmevMERLIYLFRKFsqLKVSNEEYVCMKAINFLNqdiq---gissASQVEQLNKRYWYVCQDFteyry-------- 385
gi 68056708  1414 kldvghmVDKMTQITIMFrrIKLKMEEYVCLKVYILLNk----------EVELESIQERYVQVLRSYlqnssp------- 1476
gi 12643728   362 sdegmevIERLIYLYHKFhqLKVSNEEYACMKAINFLNqdir---gltsASQLEQLNKRYWYICQDFteyky-------- 430
gi 82225956   328 gedamevMESLNFLFRKFhqLNISNEEYSCLKTITLLNqett---glcnTSMLKQLSERYWTLCRELterlh-------- 396
gi 122049714  458 tdyemeiLERVTYLYQKFshLKIDREEYVIMKVINFLNqdik---glqeVERVEEINKRYWYACQRYtelramernagrs 534
gi 75038216   594 rdemgevVEKVTKLAASFrtLGVTRNEYLLLKVILFLDqtg-----kpfSEQIRSVQEPYILALKDFmean--------- 659
gi 115702421  494 gqngleiIDVATNALARYraLKVSVQEHVCLKVICFLNpenp---nltkLPVIKDLSKQYYYVLHDHvqlnn-------- 562
gi 75025546   355 akeagplVTRFTTLLHSFsnLKVSPEAYVCIKAITLLHlsadstldrsiIDKVNTLQDHFVKTLQIHlhqpge------- 427
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
Feature 1                                                      
gi 118099468  526 -------phqpnRFPDLMMCLPEIRYIagkmvnvPLEQLPLLFKA 563
gi 148886998  386 -------phqpnRFPDLMMCLPEVRYIagklvnvPLEQLPLLFKA 423
gi 68056708  1477 -------qnpqaRLSELLSHIPEIQAAaslllesKMFYVPFVLNS 1514
gi 12643728   431 -------thqpnRFPDLMMCLPEIRYIagkmvnvPLEQLPLLFKV 468
gi 82225956   397 -------pqrpkRFSDIITCLTEIRHTsgkmmsiPLEQLPLLFKA 434
gi 122049714  535 dassnaaasgasRFRDLMLCLPEIRYVagkmlntDVTKLPLLFKA 579
gi 75038216   660 --------nqpgRFDDFLSQLPELHASsklllhsKLLYMPYLLNA 696
gi 115702421  563 -------niaaeRFRELLILIPQIRHLalkcnaiSFDNAPLLFKA 600
gi 75025546   428 -------daqttSLAQILDWLPDLRNAssvllhsKMFYVPFLLCK 465

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap