1R0O


Conserved Protein Domain Family
NR_DBD_EcR_like

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cd06959: NR_DBD_EcR_like 
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The DNA-binding domain of Ecdysone receptor (EcR) like nuclear receptor family is composed of two C4-type zinc fingers
The DNA-binding domain of Ecdysone receptor (EcR) like nuclear receptor family is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. EcR interacts with specific DNA sites upstream of the target gene and modulates the rate of transcriptional initiation. This family includes three types of nuclear receptors: Ecdysone receptor (EcR), Liver X receptor (LXR) and Farnesoid X receptor (FXR). The DNA binding activity is regulated by their corresponding ligands. The ligands for EcR are ecdysteroids; LXR is regulated by oxidized cholesterol derivatives or oxysterols; and bile acids control FXR's activities. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, EcR-like receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 143517
View PSSM: cd06959
Aligned: 8 rows
Threshold Bit Score: 114.465
Threshold Setting Gi: 38492975
Created: 21-Nov-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Structure:1R0O_B,Zn binding site of Ecdysone Receptor defined by 3.5 A contacts.
    View structure with Cn3D
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the co-ordination of a single zinc atom.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1          #  #             #  #               #     #         #  #                
1R0O_B          8 LCLVCGDRASGYHYNALTCEGCKGFFRRSVTKsAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVV 80
gi 148234789   88 VCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKnAQYSCKNNGKCQMDMYMRRKCQECRLRKCREAGMREQCVL 160
gi 219455050  646 DCVVCGDKGSGFHYGVYSCEGCKGFFRRTVTKgYVKACKSGSKCNMDMYTRRKCPECRLRSCRAAGMRSDCLL 718
gi 219453161   33 GCLVCGDKASGFHYGVYSCEGCKGFFRRSVTRgHVKACRWGNQCSMDLYTRRRCPECRLRSCKAAGMRPDCLL 105
gi 219453159   44 NCVVCGDKASGFHYGVYSCEGCKGFFRRSVNRgYVKACRWGNKCSMDLHSRRRCPDCRLRSCKAAGMRPDCLL 116
gi 219453159  622 NCLVCGEKASGFHYGVFSCESCKGFFRRSVHKgSVKVCKFGNRCCLNPSTKRSCADCRLRLCKAAGMRPDCLL 694
gi 219473546   60 ACVVCGDKASGFHYGALSCEGCKGFFRRSIQRnANYKCKYGGKCEIDTYMRRKCQECRLRKCKEAGMKSECLL 132
gi 45383880   127 LCVVCGDKASGYHYNALTCEGCKGFFRRSITKnAVYKCKNGGNCEMDMYMRRKCQECRLRKCKQMGMLAECLL 199

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