2VY9


Conserved Protein Domain Family
STAS_RsbR_RsbS_like

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cd07041: STAS_RsbR_RsbS_like 
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Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation
The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.
Statistics
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PSSM-Id: 132912
View PSSM: cd07041
Aligned: 154 rows
Threshold Bit Score: 65.1648
Threshold Setting Gi: 149921384
Created: 16-Oct-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VY9_A         4 RVPILKVd-dYWVVAIEETLHDQSVIQFKEELLHNITgvagkGLVIDISAL-EVVDsfVTRVLIEISRLAELLGLPFVLT 81
gi 37676241    6 SAISISKlqdVLIASVQVDLTESTLRDFSLDLLDAVKstrakGVMIELSGV-KTLDgeSMHRLLDVVKTVEVMGCRCLLV 84
gi 89098734  219 SSPLIPVidgITVLPLMGKFEENRSSQLIEKVLSGLLlhkpsTLIVDITGI-NSVDdyILELINNLTKTTTLMGVKPFIV 297
gi 205373156 138 STPILKLwdgILVFPIVGSLNEERSKKLVEVALNRIIkdraeHILLDLSSL-NTMDevSIHYLYQLVDTIRLVGSEAYLV 216
gi 89096278  139 SVPMITIwdcTLALPLIGGYDKERSDYVLGRLLEKCVkdkikYVLIDLSGL-YDFQeeTKFELQKLYDCLRLIGTECLLV 217
gi 89097743  136 SSPFIHIsdeLVLIPLFGELSEQLINQNKDRLLDMLHdsnvnRILIDFNGV-GSISrdGLIFFQQLLSQFSLLGAESVLI 214
gi 149180595 139 SVPIIKVwdrTIALPLIGHFDNDRAERMITAVLHECAsnkieYVLVDLSGI-YELDmnIKYHIQNLCDCLSLIGSQCVIA 217
gi 149180542 222 SSPIIPVlegVVVVPLLGKYDENRSEDLITKTLNNLPkhkadYLVIDLTGLhQYISqfTVELLSKLASAASLIGTETILV 301
gi 149180003 216 SSPIIPVmdsILVVPLIGRYDELRAEELLDRTLLNLPrykatHLIADLTSL-KGVNdyTLDFIDKFVKATSILGTKCILV 294
gi 89097120  218 STPIIPVlkgIVVVPLIGNFNDERLSNFIERSLLEFSrlkanYLLIDLTGV-KGLDsyTIEGIQKLILSIRLIGGECFIV 296
                         90       100       110
                 ....*....|....*....|....*....|.
2VY9_A        82 GIKpAVAITLTEXGLdl-rgXATALNLQKGL 111
gi 37676241   85 GLRpGVVIGLMDIGIdl-asTLCVADLEQGF 114
gi 89098734  298 GISpQISIQLTERNItl-ndQHCFATLKHAI 327
gi 205373156 217 GITpELTLSLINKGYkwktfMEAGQALLHII 247
gi 89096278  218 GMTaELARTAGDIHPsiqsfRSAHEGLKYLI 248
gi 89097743  215 GISpEQAKFIHNNFPgl--eAKYINSLHKAI 243
gi 149180595 218 GITpEFAKAAGELSGknlifSNAHAGLKYVI 248
gi 149180542 302 GISpKLAQEITGTDMql-srFSCFSTLKHGI 331
gi 149180003 295 GISsELSIQITQRGHri-dkVPCLSTLQKGV 324
gi 89097120  297 GISaDQAIQISHSNIlf-skVQTFSTLQHGV 326
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