1H4X,1AUZ,1TIL,1VC1


Conserved Protein Domain Family
STAS_anti-anti-sigma_factors

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cd07043: STAS_anti-anti-sigma_factors 
Click on image for an interactive view with Cn3D
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.
Statistics
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PSSM-Id: 132914
View PSSM: cd07043
Aligned: 472 rows
Threshold Bit Score: 43.2784
Threshold Setting Gi: 24214027
Created: 16-Oct-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
anti sigmaregulatory
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:anti sigma factor interaction site
Evidence:
  • Structure:1TIL; Geobacillus stearothermophilus SpoIIAA SpoIIAB complex, contacts determined at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         # ###     #                       # ### ###  ##                
1H4X_A         3 FQLEMVtreTVVIRLFGELDHHAVEQIRAKISTAIFqgavtTIIWNFERLsFMDXSGVGLVLGRMRELeavagRTILLNP 82
1TIL_F         8 IDLEVKq-dVLIVRLSGELDHHTAEELREQVTDVLEnrairHIVLNLGQLtFMDASGLGVILGRYKQIknvggQMVVCAV 86
gi 78777725    6 FKTIYSd-nKLSLKFKGELTLYNLMKYKKEIDKIAFsk-enAVVIDLLELsFLDSAGSIFLNNLQKELelkelKVDITCH 83
gi 83645900    3 VETKSStdgSVTISIRGQFDFGVVNQFRKAYEAHPQa---rSFCVDMRQTvRIDSSALGMLLNMRLYLggnraKIRIINC 79
gi 89092467    6 IFTEQQa-nSVTFSLPHSFTEANYDQLICAVEPFLQgy--eRFVIDLSHTdRIDTVVLGCFLVLKEKIqaskgEVVLLNP 82
gi 114321563   6 YTARNGk--ELVLEIQGRFDFGLHKPFRRAYRGRAGl---eTYRVDLRQAeSMDSSALGMLLLLREHAsgqgaRVVLRHC 80
gi 117923468  13 MIKTWNikgKIHIQLDEPLNAKNQVAFLKAVETHPQg---eQVSLHMDLVpYIDSSGLASLLQLRDHAhg-fhNVILCNP 88
gi 117923512   4 LHKEVQe-gVVILILEGRFDVSSIETFQEAYADQPPg---tIFKIHLDKVtYIDSAAFGLFHALKQHLgn-lgRVMLYNP 78
gi 117925384   3 IQQSIDa-eRVVLVLRGDLNHCAHQTFMRVIHSLSPd---tRCTIHLDMVaSIDSAGLGMLLVLFEQLgskpkTVLLCNP 78
gi 117926349   3 IHTSLNd-nELVISLVGSFSHAIFKEFKNAYLPLTPgp-sfRYCIDLSQVkSLDSSVLGMFLMLRAHAgeaeaDITLRNP 80
                         90       100
                 ....*....|....*....|.
Feature 1             #   ## #        
1H4X_A        83 SpTMRKVFQFSGLg--PWMMD 101
1TIL_F        87 SpAVKRLFDMSGLfkiIRVEA 107
gi 78777725   84 NrDVLDMLELIRVq-kITLKK 103
gi 83645900   80 SnEIRKIFEIAKFeksFIIES 100
gi 89092467   83 HgMTMQMLERANFsqlFQVEY 103
gi 114321563  81 QeEVDEILRTANFqklFEIER 101
gi 117923468  89 SeRVLHTLRVSNFhrlYTIQQ 109
gi 117923512  79 SdEVTHAIQVLGAhrsFEIMR 99
gi 117925384  79 CrQVAGALRNSNFyalFEIRD 99
gi 117926349  81 TnLVLRMLLAARFdtmFKIVT 101

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