1IJX,1IJY


Conserved Protein Domain Family
CRD_FZ

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cd07066: CRD_FZ 
Click on image for an interactive view with Cn3D
CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
CRD_FZ is an essential component of a number of cell surface receptors, which are involved in multiple signal transduction pathways, particularly in modulating the activity of the Wnt proteins, which play a fundamental role in the early development of metazoans. CRD is also found in secreted frizzled related proteins (SFRPs), which lack the transmembrane segment found in the frizzled protein. The CRD domain is also present in the alpha-1 chain of mouse type XVIII collagen, in carboxypeptidase Z, several receptor tyrosine kinases, and the mosaic transmembrane serine protease corin. The CRD domain is well conserved in metazoans - 10 frizzled proteins have been identified in mammals, 4 in Drosophila and 3 in Caenorhabditis elegans. CRD domains have also been identified in multiple tandem copies in a Dictyostelium discoideum protein. Very little is known about the mechanism by which CRD domains interact with their ligands. The domain contains 10 conserved cysteines.
Statistics
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PSSM-Id: 143549
View PSSM: cd07066
Aligned: 133 rows
Threshold Bit Score: 45.9607
Threshold Setting Gi: 66820580
Created: 30-Sep-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative Wnt
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       # ##         ###                                                  
1IJX_A          4 ACEPVRi------pLCKSl-------pWEMTKMPNhlhhs-------------tqanAILAMEQfe-----------glL 46
gi 66826381    51 TCSNYIgdsi-dqpLCNEklpn--yknIYTSKNITiqyi--------------nqkiVEKTFISlt------------fL 101
gi 66806175    34 ECLNYIgdpi-dqqLCNSklqn-ngdrIYTTTNSQids----------------qtnIKKSFEAit------------fL 83
gi 198413544   37 ECELINl------pRCGKl-------qSGFISLPNpfghwtqleivnssnykfleraSEVLMTQaesvhseeasnvtfeD 103
gi 66820865    36 KCLSFIgdsn-nqqLCNNklin-kqliYSTINKSNqiqs---------------lkmVEQSFKQlt------------fL 86
gi 66806187    34 QCMNYIgdsi-dqpLCKNklsnngefiYSTIGNSLnsqtl-------------sqqtIAKSFEAlt------------fI 87
gi 66825989    30 KCEILNpi-----sMCSNyl------gYKNIYLPYgytq--------------eiieANVTATLtnpmg------fsaiP 78
gi 66820580    31 KCEKYIgdgdsgkrICNGylan--pdsVYVHNKTQq--------------------eTLKDLRSlinll------elnnP 82
gi 66809559    35 KCEPYIgds--qitKCSTfl-----pnINSIYVSAns-------------------tQKDSMKTldnyfg----lllavG 84
gi 66809495    29 KCEQYIgds--vitPCNSiy------vSSTANQSTam------------------lsLNLYFSLlg------------gS 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
1IJX_A         47 GTHCSPd--LLFFLCAMYAPICTidfq--------hepiKPCKSVCErarqgCEPILIkyrhs----------------- 99
gi 66826381   102 QSKCFDlnfAEFGICDIYFPPCFqtpttitpiksvslpqRLCKSACErmvsnCSSLGAslncsdplkfpriatly----n 177
gi 66806175    84 QDQCKDllfAQFGICDIYLAPCIevtltpl--ksislpqRFCKSVCDrmvsnCPRLEEqmdcsnsflfpeigtfy----d 157
gi 198413544  104 FQRCEQq--IHQLTCAVIAPKCFflsrl------svssvPPCKRVCVevrerCSDLLIsgglq----------------- 158
gi 66820865    87 QGKCLNlnfAQFGICDIYFPSCVetsfg------islpkRLCKSVCKqivtdCPTLGVslncsdsnkfptigtly----n 156
gi 66806187    88 QNQCQDllfAEYGICNIYLSPCIittvapl--knislpqRLCNSACQrmvtnCPRLGEkidcsisflfpevgtly----n 161
gi 66825989    79 DLICKEn--IIKLFCISTYRECNsningi----sfplpsNPCQKNCFkvletCVPFLSffq------------------- 133
gi 66820580    83 SKECINp-sNYKIMCAMMFPECIeingtniv-kpitlpiYTCNSFCKealvtCSVPNTiascdggtnlpiqlpytpiewv 160
gi 66809559    85 SEKCKDsslTYQTLCSMYLKECEsftdnstl-ktvsipkRICRKTCNdvtklCNIESLfncsqne--------------- 148
gi 66809495    71 SASCQNa-yTFATLCSTYLPECEifidnstn-keiampkRVCLDTCNsvsknCQITSYfdcnqlepisklplfpke--ss 146
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                                
1IJX_A        100 ----------wpeslACDELPvyd----------------------rgvCISPEA 122
gi 66826381   178 ltdygftanggffpvPCSDPLatfenkst-------------tselieiCPSPLL 219
gi 66806175   158 lspygytidngtfavPCSDPTiffnqvss-------------nssfieiCPSPLL 199
gi 198413544  159 ----------wpvflDCQEFIecdi---------------------etvCRGRRS 182
gi 66820865   157 ltkygytenngfyqvECSNPTnyyyneins-----------tnnqfieiCPSPLV 200
gi 66806187   162 lsdygykangglyevPCFNPTadydnsss-------------lnefieiCPSPLL 203
gi 66825989   134 -------------gfSCQQNDtdgkdlypitenyynltsyggssnqsiqCSNPNQ 175
gi 66820580   161 kynltiyggvddyrvNCTDPTlisdsgs--------------sseievgCVEPLI 201
gi 66809559   149 ---------pinnlpLCPLNYsiydlslvn-----------gdsnyelqCYSPLS 183
gi 66809495   147 dynlttyggelnyrlDCYDPPksnet------------------tvigyCPFPLV 183

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