Conserved Protein Domain Family
ALDH_F20_ACDH_EutE-like

?
cd07081: ALDH_F20_ACDH_EutE-like 
Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins
Coenzyme A acylating aldehyde dehydrogenase (ACDH), an NAD+ and CoA-dependent acetaldehyde dehydrogenase, acetylating (EC=1.2.1.10), functions as a single enzyme (such as the Ethanolamine utilization protein, EutE, in Salmonella typhimurium) or as part of a multifunctional enzyme to convert acetaldehyde into acetyl-CoA. The E. coli aldehyde-alcohol dehydrogenase includes the functional domains, alcohol dehydrogenase (ADH), ACDH, and pyruvate-formate-lyase deactivase; and the Entamoeba histolytica aldehyde-alcohol dehydrogenase 2 (ALDH20A1) includes the functional domains ADH and ACDH, and may be critical enzymes in the fermentative pathway.
Statistics
?
PSSM-Id: 143400
View PSSM: cd07081
Aligned: 3 rows
Threshold Bit Score: 580.376
Threshold Setting Gi: 2498347
Created: 10-Oct-2008
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative
Feature 1:putative catalytic cysteine [active site]
Evidence:
  • Comment:conserved cysteine that aligns with the catalytic cysteine of the ALDH superfamily

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 71152980   9 LNALVERVKKAQReyasfTQEQVDKIFRAAALAAADARIPLAKMAVAESGmGIVEDKVIKNHFASEyIYNAykdekTCGV 88
gi 2498347   36 LDDAVAAAKVAQQgl--kSVAMRQLAIAAIREAGEKHARDLAELAVSETGmGRVEDKFAKNVAQARgTPGVec--lSPQV 111
gi 19858620   9 LDEKLKVIKEAQKkfscySQEMVDEIFRNAAMAAIDARIELAKAAVLETGmGLVEDKVIKNHFAGEyIYNKykdekTCGI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 71152980  89 LSeddtFGTITIAEPiGIICGIVPTTNPTSTAIFKSLISLKTRNAIIFSPHPraKDATNKAADIVLQAAIAAGapkDLIG 168
gi 2498347  112 LTgd-nGLTLIENAPwGVVASVTPSTNPAATVINNAISLIAAGNSVIFAPHPaaKKVSQRAITLLNQAIVAAGgpeNLLV 190
gi 19858620  89 IErnepYGITKIAEPiGVVAAIIPVTNPTSTTIFKSLISLKTRNGIFFSPHPraKKSTILAAKTILDAAVKSGapeNIIG 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     # 
gi 71152980 169 WIDQPsvelsnALMHHpdinLILATGGPGMVKAAYSSGk-PAIGVGAGNTPVVIDETADIKRAVASVLMSKTFDNGVICA 247
gi 2498347  191 TVANPdietaqRLFKFpgigLLVVTGGEAVVEAARKHTnkRLIAAGAGNPPVVVDETADLARAAQSIVKGASFDNNIICA 270
gi 19858620 169 WIDEPsieltqYLMQKa--dITLATGGPSLVKSAYSSGk-PAIGVGPGNTPVIIDESAHIKMAVSSIILSKTYDNGVICA 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 71152980 248 SEQSVVVVdsVYDAVRERFATHGGYLLQGkeLKAVQDVILknga------lnaAIVGQPAYKIAELAGFSVPENTKILIg 321
gi 2498347  271 DEKVLIVVdsVADELMRLMEGQHAVKLTAeqAQQLQPVLLknidergkgtvsrDWVGRDAGKIAAAIGLKVPQETRLLFv 350
gi 19858620 246 SEQSVIVLksIYNKVKDEFQERGAYIIKKneLDKVREVIFkdgs------vnpKIVGQSAYTIAAMAGIKVPKTTRILIg 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
gi 71152980 322 evtvvdesePFAHEKLSPTLAMYRAKDFedavEKAEKLVAMGgIGHTSCLYTDqdnqpARVSYFGQKMkTARILINtpas 401
gi 2498347  351 ett--aehpFAVTELMMPVLPVVRVANVa--dAIALAVKLEGgCHHTAAMHSRn---iENMNQMANAIdTSIFVKNgpc- 422
gi 19858620 320 evtslgeeePFAHEKLSPVLAMYEADNFddalKKAVTLINLGgLGHTSGIYADeikarDKIDRFSSAMkTVRTFVNipts 399
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*.
Feature 1                                                     
gi 71152980 402 qgGIGDLYnfkLAPSLTLGCGSwgGNSISenvgPKHLINKKTVAKR 447
gi 2498347  423 iaGLGLGGe--GWTTMTITTPT--GEGVTs---ARTFVRLRRCVLV 461
gi 19858620 400 qgASGDLYnfrIPPSFTLGCGFwgGNSVSenvgPKHLLNIKTVAER 445

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap