2VRO,1EYY


Conserved Protein Domain Family
ALDH_KGSADH-like

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cd07084: ALDH_KGSADH-like 
Click on image for an interactive view with Cn3D
ALDH subfamily: NAD(P)+-dependent alpha-ketoglutaric semialdehyde dehydrogenases and plant delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH family 12-like
ALDH subfamily which includes the NAD(P)+-dependent, alpha-ketoglutaric semialdehyde dehydrogenases (KGSADH, EC 1.2.1.26); plant delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH, EC=1.5.1.12 ), ALDH family 12; the N-terminal domain of the MaoC (monoamine oxidase C) dehydratase regulatory protein; and orthologs of MaoC, PaaZ and PaaN, which are putative ring-opening enzymes of the aerobic phenylacetic acid catabolic pathway.
Statistics
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PSSM-Id: 143403
View PSSM: cd07084
Aligned: 4 rows
Threshold Bit Score: 468.256
Threshold Setting Gi: 185177635
Created: 14-Jan-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
NADP bindingcatalytic
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:NADP binding site [chemical binding site]
Evidence:
  • Structure:2VRO; Aldehyde dehydrogenase from Burkholderia xenovorans Lb400 with NADPH bound in the cofactor-binding pocket, defined using 3.5 A.
    View structure with Cn3D
  • Structure:1EYY; Aldehyde dehydrogenase from Vibrio harveyi with NADP+ bound, defined using 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2VRO_B       43 LARAFSFAREDGGaalrALTYAQRAARLADIVKLLQAKRGDYYAIATANSGTtrndSAVDIDGGIFTLSYYAKLgaslge 122
gi 75248520 112 PERYLLYGDISTKaa-hMLALPKVADFFARLIQRVAPKSYQQAAGEVFVTRK----FLENFCGDQVRFLARSFAi----- 181
gi 11072185  97 GQALIDAAHAAMPgw-qRIGAQGRAGVCLEILERLNKRSFEIAHAVMLTTGQgw-mMAFQAGGPHAQDRGLEAVayayre 174
1EYY_A       32 VNQAATAAAKVARdf-rRLNNSKRASLLRTIASELEARSDDIIARAHLETALpevrLTGEIARTANQLRLFADVvnsgs- 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            ## #                         # ##          
2VRO_B      123 vhalrdgSAESLskd----rsFSAQHVLSPTrGVALFINAFNFPs--WGLWEKAAPALLSGVPVIVKPATataWLTQRMV 196
gi 75248520 182 -------PGNHLg--------QQSHGYRWPY-GPVTIVTPFNFPl--EIPLLQLMGALYMGNKPLLKVDSkvsIVMEQMM 243
gi 11072185 175 mkfipheTVWEKpqgknpplkMKKHFEIVGR-GVALVIGCGTFPt--WNTYPGLFAALATGNPVIVKPHQnaiLPAAITV 251
1EYY_A      110 ---yhqaILDTPnptraplpkPDIRRQQIAL-GPVAVFGASNFPlafSAAGGDTASALAAGCPVIVKGHTahpGTSQIVA 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                 ####  #                               
2VRO_B      197 ADVVDagi---lppGALSIICgs----saGLLDQirsfdVVSFTGSADTAATLRAHpafvqrgarLNVEADSLNSAILCA 269
gi 75248520 244 RLLHYcgl----paEDVDFINsdgk-tmnKILLEan-prMTLFTGSSRVAEKLALDlk-----grIRLEDAGFDWKVLGP 312
gi 11072185 252 RIAREvlaeagldpNLVTLAAfdkheatqALATHpa-vkSIDFTGGNAFGQWLISNakq----aqVYAELAGVNNVVIES 326
1EYY_A      186 ECIEQalkqeqlpqAIFTLLQgnqralgqALVSHpe-ikAVGFTGSVGGGRALFNLaherpepipFYGELGAINPTFIFP 264
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2VRO_B      270 datpdtpAFDLFIKEVVREMTVkSGQKCTAIRRAFVPea-----aLEPVLEALKAKLAKITVgnprndavrmgSLVSREQ 344
gi 75248520 313 dv----qEVDYVAWQCDQDAYAcSGQKCSAQSMLFVHen----wsKTPLVSKLKELAERRKLe---------dLTIGPVL 375
gi 11072185 327 t-----dQYKAMLRNLAFTLCLySGQMCTTTQAILVPadgidtdqGRKSYDEVCADLATSIDkflad-pavatAVLGAIQ 400
1EYY_A      265 sa---mrAKADLADQFVASMTMgCGQFCTKPGVVFALnt----peTQAFIETAQSLIRQQSPs----------TLLTPGI 327
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2VRO_B      345 YENVLAGIAALREe-----aVLAYDssavplidadaniaaCVAPHLFVvndpdna----tllhdvEVFGPVASVAPYRvt 415
gi 75248520 376 TFTTEAMLEHMENllqipgsKLLFGgkelknhsipsiygaLEPTAVYVpieeilkdnktyelvtkEIFGPFQIVTEYKkd 455
gi 11072185 401 SPDTLARIAEAPAhg----rVVRAStkieha----efpgaEVRSPLLLacdaad-----ekaymeERFGPIAFVVKVAdg 467
1EYY_A      328 RDSYQSQVVSRGSdd---giDVTFSqae----------spCVASALFVtssenwr---khpaweeEIFGPQSLIVVCEn- 390
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2VRO_B      416 tdtnalpeAHAVALARRGqgsLVASIYSNd--DAHLGRLALELadSHGRVHAIspsvqhsqtghGNVMPm------SLHG 487
gi 75248520 456 ------qlPLVLEALERMhahLTAAVVSNd--PIFLQEVIGNS--VNGTTYAGlr-------grTTGAP-------QNHW 511
gi 11072185 468 a-----aaVTLSERIVREhgaLTVGLYTTk--PEVVDAMTEATw-RAGVALSInl--------tGGVFVnqsagfsDYHG 531
1EYY_A      391 -------vADMLSLSEMLagsLTATIHATeedYPQVSQLIPRLeeIAGRLVFNgw--------pTGVEVgy----aMVHG 451
                       490       500       510
                ....*....|....*....|....*....|.
Feature 1                                      
2VRO_B      488 GPGRAGg---GEELgGLRALAFYHRRSAIQA 515
gi 75248520 512 FGPAGDp--rGAGIgTPEAIKLVWSCHREVI 540
gi 11072185 532 VGMNPA----ANAS-LSDSAFVANRFRVVQR 557
1EYY_A      452 GPYPASthsaSTSV-GAEAIHRWLRPVAYQA 481

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