2J6L,2JG7


Conserved Protein Domain Family
ALDH_F7_AASADH-like

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cd07086: ALDH_F7_AASADH-like 
Click on image for an interactive view with Cn3D
NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase and related proteins
ALDH subfamily which includes the NAD+-dependent, alpha-aminoadipic semialdehyde dehydrogenase (AASADH, EC=1.2.1.31), also known as Antiquitin-1, ALDH7A1, ALDH7B or delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH), and other similar sequences, such as the uncharacterized aldehyde dehydrogenase of Candidatus kuenenia AldH (locus CAJ73105).
Statistics
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PSSM-Id: 143405
View PSSM: cd07086
Aligned: 42 rows
Threshold Bit Score: 575.667
Threshold Setting Gi: 108805710
Created: 30-Oct-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
NAD bindingcatalytic
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Structure:2JG7: Acanthopagrus schlegelii Seabream antiquitin (alpha-aminoadipic semialdehyde dehydrogenase) in complex with cofactor NAD+, defined using 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2J6L_A        26 GVYNGSWGGRg--EVITTYCPANNEPIARVRQas-vaDYEETVKKAREAWKIWAdiPAPKRGEIVRQIGDALREKIQVLG 102
2JG7_A        24 GVYNGSWGGSg--EVITSYCPANNEPIARVTQat-laEYEETVQKTREAWKMWAdiPAPKRGEIVRQIGDALRKKIKVLG 100
gi 91200062    5 NYINGAFVDSassEVFESRNPAYCDEVLGTFPlssadDVNNAVLAAKTAYDTWRkiSRIRRGEYLDELAQLLKKDREAIS 84
gi 17231263    9 NYINGQWLNAateTTLNSHNPADKSEIVATFPrsqadDVDRAVAAARQAYGSWRkvPAPARAEYIFRVGELLLQHKEELA 88
gi 83815678   41 NYIGGRWTGAasqATFDNRNPADPDDHIGDFPdsapaDVDAAVQAAQDAFSDWGstPAPDRGKILKASGDLLAERKDEIA 120
gi 163847329   9 NLIGGEFVPAqsgKTFERRNPADTRDVVGIFAdsderDVHAAVEAAKAAFPQWSkvPAPKRGEILLRAAELLQARKEQYS 88
gi 94968487   16 NLIDGEWVESksgQTFENLNPADTREVVGIFQrsgkeDVEHAIDAASEAYKKWRlvPAPRRAELLFKAAAILEQRKEKYS 95
gi 77919097    6 NFIGGQWVPPstgEYGQSVNPAHDMEVVARYPlsaksDVDRAVQAAVDAFPGWRamPAPRRAEILFRAAEILCRRKDELG 85
gi 20091684   18 LHIGGESRDSatgETFDNINPATLENLATVQVag-seDVDRAVEAAEEGFRVWSevPAPRRAEVLFRTARILQERKEDLA 96
gi 15789939    5 HYINGEWVDGdgtETFDSRNPANGETLGTFQRgt-ttDVEAAIAAADDAEDEWQslSRIDRAEYLWDIYHELKDRHQELG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                      ####              
2J6L_A       103 SLVSLEMGKiLVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAM 182
2JG7_A       101 SLVSLEMGKiYVEGVGEVQEYVDVCDYAVGLSRMIGGPVLPSERPGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAL 180
gi 91200062   85 QLVSKECGKgIAEGRADVTEGIHMVQYIFGTTRMPHGDIIDSEIVEKDSFMRRRPKGVVAAITPWNFPFAIPLWLICPSV 164
gi 17231263   89 QLISREMGKpLTEARGDVQEGVDCAFYSAGEGRRLFGQTTPSEMPNKFAMTMRMPIGVCALITPWNFPVAIPCWKAMPAL 168
gi 83815678  121 RSMTREMGKpFFETKGDVQEAIDTAYYAASETRRLFGTTVPSELPDKMNMAIRRPLGVCGIITAWNFPVAVPSWKIFPAL 200
gi 163847329  89 RDLTREMGKpLFEAGGDIVEAIGMAQYAGSEGRRMHGVTTPSELPNKFQMSIRQPIGVVGLITPWNFPMAIASWKMLPAI 168
gi 94968487   96 QEMTREMGKvIKETRGDVQEAIDAGYYNAGEGRRMFGPTTPSELPNKFAMAVRQPLGVCAMITPWNFPMAIPSWKLFPAL 175
gi 77919097   86 QLVTREMGKvLSEGLGDVQEAIDMAYFMAGEGRRLQGETVPCELPNKDAKSFRVPWGVFALITPWNFPIAIPSWKIFASL 165
gi 20091684   97 RLMTEEMGKvLPETRGDVQEAIDIAIYAAGEGRRMFGETTTSELKDKFCMTVLRPIGVVGMITPWNFPLAIPGWKIMPAL 176
gi 15789939   84 EVVTKECGKeISEGKADVTEAWQMVEWAAGDARHPKGDVVPSEIPEKDAYMRRQPRGVVGCITPWNFPVAIPFWHMAVAL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                # ##                                      ##            ####  #  #      
2J6L_A       183 ICGNVCLWKGAPtTSLISVAVTKIIAKvlednKLPGAICSLTCGGAd--iGTAMAKDErVNLLSFTGSTQVGKQVGLMVQ 260
2JG7_A       181 TCGNVCLWKGAPtTPLTSVAVTKIVAEvleqnNLPGAICSMTCGGAd--iGTAMAKDErVDLLSFTGSTHVGKMVAMMVQ 258
gi 91200062  165 VEGNTVVLKPSReTPCVANKIAEYVHAa----GFPPGVINVIHGGCg---DALVRHSD-TQVILFTGSCEVGEGIKKIAA 236
gi 17231263  169 VCGNTVILKPAEdTPACATKLIEIFAAa----GLPPGVINLVHGVGeevgKALVEHPN-IDLVSFTGSSATGAYVGETCG 243
gi 83815678  201 AAGNTIVFKPSEdAPHSGLRFVQTLIDa----GIPDGVINVVHGADea-gQALVEHPE-VDAIGFTGSYEVGTAIAETCG 274
gi 163847329 169 VCGNTVVIKPGEdASVSTYNLVQCLMEa----GLPPGVVNIVTGYGpragQPLVEHPD-VPVISFTGSTETGRLVYELGA 243
gi 94968487  176 VCGNTAVIKPAQdTPLSTFNFVQALNDa----GVPKGVINIVTGYGgevgTPMTEHPE-VKAVSLTGSTAVGRIVGQAAA 250
gi 77919097  166 ICGNTVVFKPSSdSPLCATRLVEVLEEa----GMPPGVVNMITGAGetvgETLAMHPD-VQGVSFTGSCSVGEALACSVA 240
gi 20091684  177 IAGNAIVFKPASdTPLLAIKLVEILMEa----GLPPGVVNLVTGPGgstgKAIVQHPR-IKAISFTGSLETGKWIMEECA 251
gi 15789939  164 VEGNTVVWKPAEqTPWCGQIIAEMFADa----GIPDGVFNMVQGFGda-gARIVDHDD-IDTVLFTGSAEVGEEVARTVA 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 ###                               #                                    
2J6L_A       261 e-RFGRSLLELGGNNAIIAFEDaDLSLVVPSALFAAVGTaGQRCTTARRLFIHesiHDEVVNRLKKAYAQIRVGNPWDPn 339
2JG7_A       259 e-RFGRKLLELGGNNAIIVFEDaDLNLVVPSAVFASVGTaGQRCTTTRRLMLHesvHDAVVERIAKAYKQVRIGDPWDPs 337
gi 91200062  237 esYNKMCACEMGGKNAIIVLDGaNMEIAVNASILSAFKTsGQRCTSAGRLILHvnmLEEFEKRFVELAKRIKIGNPLDEe 316
gi 17231263  244 r-THKRVCLEMGGKNAQVVMEDaDLELALDGALWGAFGTtGQRCTATSRLILHrdiKEKFTTMLRERTSQLRLGAGTEPe 322
gi 83815678  275 r-LNTPVSLEMGGKNPMIVMDDaDLDLALEGAIWGAYGTtGQRCTATSRLICHesvHDELVAMIRDEAEALVLGDGNDAd 353
gi 163847329 244 r-RIKRVSLEMGGKNPLIVMPDaDLDLALDGVLWAAFGTtGQRCTATSRLIVHravAKELVERIVARAQSLRVGNGLDPa 322
gi 94968487  251 k-SFKHCSLELGGKNPMIVLDDaNLDLALEGALWGSFGTtGQRCTATSRIILQkgiYKKFADELVARARKLKVGNGLDEt 329
gi 77919097  241 q-LHRPIAMEMGGKNAILIMDDaDLDLALEGVLWGAFGTtGQRCTAASRIIVHekvYDEFLDRLVRAANAMRLGDGLEKd 319
gi 20091684  252 k-TMKRVSLELGGKNPVIIMDDaDLELALEGVLWGAFGTtGQRCTATSRLILHekiKDEFTARLLAKTKLLRVGNGLLPe 330
gi 15789939  238 ddPGKLAACEMGGKNGIVVTEKaDLDIAVHAAVMSSFKTtGQRCVSSERLIVHedlYDEFKQRFVEIAESVAVDDPLDEe 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                               #        
2J6L_A       340 VLYGPLHTKQAVSMFLGAVEEak------keGGTVVYGGKVMdr----pGNYVEPTIVTGLgh-daSIAHTETFAPILYV 408
2JG7_A       338 TLYGPLHTKQAVDQYLAAIEQak------qqGGTLVCGGKVMdr----pGNYVEPTIITGLah-daPIVHTETFVPILYV 406
gi 91200062  317 VFMGPVINQAATEKILRYNDFak------neGAEVLLDGSRLtgggydkGYFMSPFVYRMKnnpksRVLHEEVFGPHVAI 390
gi 17231263  323 TDIGPIINNRQLQRVHEYMNIar------eeGAKILIGGEIAtegqlqqGYFFQPTILDNVtp-qmRVAREEIFGPVVAL 395
gi 83815678  354 TDVGPLINQAAAETVHRYVEIgq------eeGATLEMGGAPAsvd-gldGHFYEPTLFTDVtp-dmTIAQEEIFGPVLAT 425
gi 163847329 323 TEMGPLVNEKQLQRVLNYIDIgk------qeGATLLCGGYRLtggdydyGYFIAPTVFTNVts-qmRIAREEIFGPVLSV 395
gi 94968487  330 VDMGPAVNENQMNTDLKYIEIgk------geGAKLAHGGHRLdkgdyahGWFLEPTIFTDVnh-kmRIAQEEIFGPVVAL 402
gi 77919097  320 TDVGPLINRRALNKVLNYIRIgk------deGARLCCGGNQAkhnglteGYFVEPTVFSNVtp-smRIAQEEIFGPVVCL 392
gi 20091684  331 TDIGPIINKAQLEKIERYVRIgm------eeGATLLLGGKAIdpg--lpGYFFEPTVFTDVrp-dmRIAQEEIFGPVLSI 401
gi 15789939  318 TFMGPAIEPAHVEKIQTYNDIareeaenvlvDRTELGDDEIPdgh--edGNWVGPFVYEVDydpdlRSITEEVFGPHVAL 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                     #                  
2J6L_A       409 FKFqn-eEEVFAWNNEVKQGLSSSIFTKdlGRIFRWLGpkgSDCGIVNVNIPtsGAEIGGAFGGEKHTGGGRESG---SD 484
2JG7_A       407 LKFkt-eEEAFAWNNEVQQGLSSSIFTKdlGRVFRWLGpkgSDCGIVNVNIPtsGAEIGGAFGGEKHTGGGRESG---SD 482
gi 91200062  391 IPVes-iDEAINVYNDTEYGLSCAVITEdfRKARRIRDd--CEYGLGYVNLPtiGAEVHLPFGGLKKSGTGLPSA---ST 464
gi 17231263  396 IEVst-fEEAIAILNDTKYGLSSSVYTRdiNRAFVAMRd--IEAGITYINGPtiGAEVHLPFGGVKQTGNGHREAg--TT 470
gi 83815678  426 FEVgs-yDEAVTVANDTQYGLSSSIYTQdvNKSFRAMRd--LEAGITYVNGPtiGAEAHMPFGGVKDTGNGQRDGg--YA 500
gi 163847329 396 IEVds-lDEAVAIANDVAYGLSSAIYTRdiNAAFRAMQa--LQAGIVYINAPtiGAEIHLPFGGVKATGNGHREAg--PT 470
gi 94968487  403 IPCdd-lDEAIEIANGIEYGLSSAIYTRdvNKSFRAMRd--LHAGITYVNAPtiGAEVHMPFGGVKATGNGHREGg--IG 477
gi 77919097  393 IKCds-yEQGIAIVNQSRFGLSTAIYTRdvNISARAEGd--LDSGLVYINAStiGAEIQLPFGGFKHSGSGHPEAggrMG 469
gi 20091684  402 ITVsg-lEEAIEVANNTRYGLSSAIYTEnvGKAFRAVKk--IEAGITYVNAPtiGAEVHLPFGGVKGTGNGFREAg--TE 476
gi 15789939  396 IEYsgdiERAVEIHNDTPYGLAGAVISEdyRQINYYRDn--AEVGLAYGNLPciGAEVQLPFGGMKKSGNGYPSA---RE 470
                        490
                 ....*....|....*.
Feature 1                        
2J6L_A       485 AWKQYMRRSTCTINYS 500
2JG7_A       483 SWKQYMRRSTCTINYS 498
gi 91200062  465 LIDAVTHRTAWTVNHD 480
gi 17231263  471 ALDVFTEWKSVYVDFS 486
gi 83815678  501 AFEFWTEHKTLYVDYS 516
gi 163847329 471 MLDVFSEWKSVYIDYS 486
gi 94968487  478 ALDFYTEWKAIYVDYS 493
gi 77919097  470 ALDFFSRIKVVYRDFS 485
gi 20091684  477 AIKEFTEIKAVYIDYS 492
gi 15789939  471 VIEAVTERTAWTLNNS 486

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