1AD3


Conserved Protein Domain Family
ALDH_F3-13-14_CALDH-like

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cd07087: ALDH_F3-13-14_CALDH-like 
Click on image for an interactive view with Cn3D
ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins
ALDH subfamily which includes NAD(P)+-dependent, aldehyde dehydrogenase, family 3 member A1 and B1 (ALDH3A1, ALDH3B1, EC=1.2.1.5) and fatty aldehyde dehydrogenase, family 3 member A2 (ALDH3A2, EC=1.2.1.3), and also plant ALDH family members ALDH3F1, ALDH3H1, and ALDH3I1, fungal ALDH14 (YMR110C) and the protozoan family 13 member (ALDH13), as well as coniferyl aldehyde dehydrogenases (CALDH, EC=1.2.1.68), and other similar sequences, such as the Pseudomonas putida benzaldehyde dehydrogenase I that is involved in the metabolism of mandelate.
Statistics
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PSSM-Id: 143406
View PSSM: cd07087
Aligned: 50 rows
Threshold Bit Score: 488.574
Threshold Setting Gi: 2494079
Created: 12-Oct-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
NAD(P) bindingcatalytic
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:
  • Structure:1AD3; ALDH3A1, class 3 rat liver aldehyde dehydrogenase complex with nicotinamide-adenine-dinucleotide, defined using 3.5 A.
    View structure with Cn3D
  • Citation:PMID 9095201

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1AD3_A         4 SDTVKRAREAFNSGkt----------rSLQFRIQQLEALQRMINENLKSISGALASDLGKne-wTSYYEEVAHVLEELDT 72
gi 153886605   5 QTLLDRQREFFLTDat----------kSAAWRLDQLDRMERLLRENQEAFCNALYQDFRKp--pFEQLFEITVPLGVIDY 72
gi 89096855   10 KSLPERQREDLFSAgs----------pSLEARKKQLSKLKTMIVDHEEAFTRALHADLGKpa-fESFSSEIAVLLNEIDH 78
gi 2494079    18 DEIVEISRNFFFEKqlklshennprkkDLEFRQLQLKKLYYAVKDHEEELIDAMYKDFHRnk-iESVLNETTKLMNDILH 96
gi 163789579  15 SIIQQRQKRRVSETsl----------sDIRYRKQQLVTFQLMLEENQTELLNTLYEDLGKpp-eEAYASEIAVLLQEIDF 83
gi 118400829  10 DPILNNLKKTFRTGkt----------rDLAFRKQQLRNLLTGIKEMEDEISEAVQKDLGYqdpkVAKFLNLLPTIGDIEY 79
gi 123439677  12 PTIVKELREHFKTRvs----------fDFKWREDQLNGLLKCLDEHKDDWVKAMYDDMGSh--hFEAELLIENVKTDISH 79
gi 118377439  14 EPTFQELRQTFLSQkt----------kSLAYRKTQLRNLLRGLTEMEQEFHKALELDLKCsp-fISFMTSYKITVSEIEH 82
gi 145516847  10 APTLKELKANFLTKks----------rPIPFRLQQLHNLLRGLKELRNEFYEAFQKDLGYkdqyFCELVQYQAVLTHIEC 79
gi 399361     68 QTICKTLKESYSTNal----------rHLDARKEVLYCLYRMVLDNKQAISNAIREDLHRd--vGMCVAEVNSVIHEINF 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                 ###                         #          
1AD3_A        73 TIKELPDWaEDEPVAktrq--tqqDDLYIHSEPLGVVLVIGAWNYPfNLTIQPMVGAVAAGNAVILKPSEvSGHMADLLA 150
gi 153886605  73 YRRHLVDLmAPQQVEippgleaegYRGMIYKEPYGPTLVIGPFNAPvLLLLDPAIAALAAGNPVTLKPANtTPTVAALLQ 152
gi 89096855   79 ICKHIAKWnRQSRSRylkm--gyiESIKRKRHPYGSVLIIGSWNYPlQLSLMPAIGAIAAGNRCVIKPSEhAPATAELLK 156
gi 2494079    97 LIEILPKLiKPRRVSdssp-pfmfGKTIVEKISRGSVLIIAPFNFPlLLAFAPLAAALAAGNTIVLKPSElTPHTAVVME 175
gi 163789579  84 LKRKLNQWqRTKKKHhvrl--ssvSKTSIQHHPYGSVLVISPWNYPlHLALLPAIGAMAAGNSCFIKPSEyAPATANLIA 161
gi 118400829  80 ILNNFESWaQKRSVDvslv--vgpGSGYIIPEPYGVTLVIGAWNYPfNTTVAPAANAIAAGNCVALKPSEmSPHNSNVMK 157
gi 123439677  80 TLKKFKSWlAPQSCSvawa--ltpGSASIVPEPYGVVCDFIPYNYPmYLGFATLCPILAAGNVCLFKPSSnTPHCAKLYQ 157
gi 118377439  83 TLKNLDQWvKARPLDttvl--sgpAKTYLKPEPYGVALVMSAWNYPlFTAIPPFAQALAAGNCVVLKPSElAPHTSNCIL 160
gi 145516847  80 DIKNIYKYtAKRSVStsim--aapGTSYLIPEPYGVVLVIGAWNYPiFTCIPQLSQAIGAGNAVVVKPSElVPHVSNILA 157
gi 399361    136 LRKNLNKYlKRKQVPtvca--qlfGKSFVEREPYGCVCVISPWNFPaNLSLIPCAGALACGNTVFLKMSKySMATSKLIA 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           #                   #                                        
1AD3_A       151 TLIPq-yMDQNLYLVVKGGVPe-TTELLKEr-FDHIMYTGSTAVGKIVMAAAAkhLTPVTLELGGKSPCYVDKDc---DL 224
gi 153886605 153 TLIPk-yFAPEAVTVVTGGREe-ISALLELp-FDFIFFTGSAAVGKVVMRAAAehLTPVILELGGQNPTVVDATa---NL 226
gi 89096855  157 KIINd-aFPPEQLLVVTGDAQt-ASQLTAAp-FDLIFFTGSGQTGKAVAEQAArqLTPVILELGGKNPCIIDETg---FS 230
gi 2494079   176 NLLTtagFPDGLIQVVQGAIDe-TTRLLDCgkFDLIFYTGSPRVGSIVAEKAAksLTPCVLELGGKSPTFITENfkasNI 254
gi 163789579 162 RLVEq-yFSPDNLMVVTGDASv-ASELLELp-WDFIFFTGSKKVGSIVHKAAAarQIPIVLELGGKNPCIVDETn---LT 235
gi 118400829 158 KLFDk-yLDKDCYTVIEGQVEv-AKAICYKp-WDHIIFTGSPQKGKLVAQAASqnLIPCTLELGGKSPTIVDKTa---NL 231
gi 123439677 158 TLFPq-yLDPKGVRVVCGPTRi-CDVILDQr-FDFIFYTGSPAVAKNVMRHAAehLTPCLLELGGKSPVYFDKNc---SL 231
gi 118377439 161 KLFNn-yMDKSAYRCIEGQVQv-SINITKLp-WGLIIFTGSPEKGKLVAKAASenLVPCILELGGKSPTVVDSDa---NL 234
gi 145516847 158 KLITn-yLDQSLYRAIEGGVNv-AINITKQh-FDLIIFTGGTEKGKLVAKAAAenLVPCILELGGKGPCIIDSSs---DL 231
gi 399361    214 ELCDk-yIPSEYLRCEYLTGReaIQECCSAs-FDYYFFTGSTYVGKLINQAAAekMVPATLELGGKNPAIVDKSv---NL 288
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                      # ##  #           
1AD3_A       225 DVACRRIAWGKFMNsGQTCVAPDYILCDpsiQNQIVEKLKKSLKDFyged-akqsRDYGRIINdRHFQRVKGLIDNq--- 300
gi 153886605 227 DIAIDRIAWGHNAIsGQWCIAPGYVYVHhsiADDFIARIKRSLTAMyged-psrsPDFARMISaHDAQRVANYIQPe--- 302
gi 89096855  231 KEAVREIVWGKFLNaGQTCIAPDTLFVHesiYEKTLNEISAAVSAFygeq-presSDYGRICTdDHFQKVIEFIGQg--- 306
gi 2494079   255 KIALKRIFFGAFGNsGQICVSPDYLLVHksiYPKVIKECESVLNEFypsf--deqTDFTRMIHePAYKKAVASINStngs 332
gi 163789579 236 PTVVQRIIWGKFLNaGQTCIAPDTVYIHesvYTEFLQLATDQIKAFygtq-pihhSRFGRIVHdKQVEKLKDYLEQg--- 311
gi 118400829 232 NVAVARIAQGKIGNsGQTCIAPDFAIVDqdiKDQFLSSLKEAMITQisnn-petsRDYNRMINeFHTKRMESMIKThg-- 308
gi 123439677 232 AKSVRRLIWGKIFNgGQTCVCPDYVMVHkdiMEQFKAEMVKAINELypnpdtaynDNITHIISkHHFDRLTKLIDNsg-- 309
gi 118377439 235 ENAALRVTQGRFLNaGQTCVACDYLFVHksiKAEFIKKLKEKIILFyged-pqksNDYNRIVNcQSTERLASLLNPedh- 312
gi 145516847 232 ALAGRRVVSTKLLNcGQTCVAPDYLLVEesiLDNVVNTFKQQIKDFygpe-tknsECLNRIVNeFHTNRIAELLNNhg-- 308
gi 399361    289 KVAAKRIAWAKSINaGQICVCVDHVFVPrsiKNEFCEAVKNSFIKFfged-qkksEDFGRIITkSAAKKMKEIIDQs--- 364
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                             # #                                        
1AD3_A       301 -----KVAHGGTWdqssRYIAPTILVDVdpqSPVMQEEIFGPVMPIVCVRsLEEAIQFINQREKPLALYVFSNn-eKVIK 374
gi 153886605 303 -----KVVHGGRFdipgRYVEPTVLYPSswdDPAMQQEIFGPVLPVLPYDdLDEVIETIKRKPKSLAAYIFSKd-qRAID 376
gi 89096855  307 -----DVRHGGSYdrsdRFIAPTVLTDIepgSPILQEEIFGPVLPVIPYTdMRTLLSSGRIQRDALTGYIFSKn-kDNIQ 380
gi 2494079   333 kivpsKISINSDTed-lCLVPPTIVYNIgwdDPLMKQENFAPVLPIIEYEdLDETINKIIEEHDTPLVQYIFSdsqTEIN 411
gi 163789579 312 -----KIYYGGQVdtanRFIEPTLLTNIpvdSSILREEIFGPILPVIPYTdLTTLVHQLKDYPDPLAVYVFSKd-rETSQ 385
gi 118400829 309 ----gQIYYGGKVdvskKFVEPTIIVNPkldSECMQDEIFGPIFPVIFYKnFDEVINFINDRPKPLALYYFGEn-kTHKD 383
gi 123439677 310 ----gNIIIKGFQdpekLFIGPTLIENPsmeADIMTTEVFGPVIPFFPVDnEDKAIEFINEREKPLAAYVFTSd-wNVFT 384
gi 118377439 313 ---kgQIIIGGKFdisdKYIAPTLIDQPsleSRVMKEEIFGPILPILEFTdIQTVVQFINDRPNPLALYYFGS---KHAQ 386
gi 145516847 309 ----gKVVHGGQFglkeKWIEPTFVVNPdpnSELMKNEIFGPILPIITYKnIEDAINFINSRPKPLALYYFGTn-kAHKN 383
gi 399361    365 -----DVYYGGEVdienKYVQPTILQNVkidDLCMKEEIFGPILPVIEYDtLDEVFEMVKQHPNPLACYVFTEd-nDMFE 438
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                               
1AD3_A       375 KMIAeTSSGGVTANDVIVHITVPtLPFGGVGNSGMGAYHGKKSFETFSHRRSCLV 429
gi 153886605 377 RFLGsVSFGGGCVNQTNLHCWIDsLPFGGVGLSGMGKYYGQAGFDALSNTKSLLI 431
gi 89096855  381 LFKEhMRSSTISVNQVIHHAASPhIAFGGVGTSGYGAYHGKAGFLAFSYEKTEYK 435
gi 2494079   412 RILTrLRSGDCVVGDTVIHVGITdAPFGGIGTSGYGNYGGYYGFNTFSHERTIFK 466
gi 163789579 386 FLKReLRSGAFSLNQVILHAVSShSPFGGVGASGFGRYHGMASLATFSYLKMDYE 440
gi 118400829 384 RLLNeTSSGHLSFNECVMHYINNtLPFGGVGNSGSGVIHGKLGFENCSHLKPVLD 438
gi 123439677 385 KFQQqTSSGALMQNDVVFHVSSPySPFGGVGNSGMGQYHGEIGVKTLSHLKPILT 439
gi 118377439 387 LFEEqTSSGSYSINDAIFQLTNPnLPFGGVGNSGSGKYHGLAGFDSCSHLKPVFN 441
gi 145516847 384 AILEsTSSGGVCINDCIFHLINQeLPFGGVGDSGYGVCGSKFGFDQCQHLKPVLE 438
gi 399361    439 HVIAnINSGAIYNNDSIVHLLNPnLPFGGNCQSGIGCYHGKYTFDTFSRPRAVCN 493

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