2IMP


Conserved Protein Domain Family
ALDH_LactADH-AldA

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cd07088: ALDH_LactADH-AldA 
Click on image for an interactive view with Cn3D
Escherichia coli lactaldehyde dehydrogenase AldA-like
Lactaldehyde dehydrogenase from Escherichia coli (AldA, LactADH, EC=1.2.1.22), an NAD(+)-dependent enzyme involved in the metabolism of L-fucose and L-rhamnose, and other similar sequences are present in this CD.
Statistics
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PSSM-Id: 143407
View PSSM: cd07088
Aligned: 18 rows
Threshold Bit Score: 674.365
Threshold Setting Gi: 21221910
Created: 12-Dec-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2IMP_A        10 YIDGQFVtwrgdawidVVNPATEAVISRIPDgqaeDARKAIDAAERAQPEWeaLPAIERASWLRKISAGIRERASEISAL 89
gi 168335143   7 LVDGKLVsaadgavikVTSSYDGSLVGTVPSfskeDARVSLEAAQAAKDAWasLTFVKRAEYVSELADIIDRHSDELVKL 86
gi 149370060   7 FINGKFVkststevteILNPCTEEVLSTIPYgsvkDANDALEAAQNAQHSWksLPAIQRAGYLNKMATVIRENRVFLAKT 86
gi 191639353  12 YINGKFMdsasgdvetVIDPSTGKKLWTAPAatieEARAAVDAAWAAKNAWrrVPAPTRGAYLRKLATLVREHEDELVKI 91
gi 87120747    7 FINNAFVpsitskampVYSPVNEAQVAQVALasaeDALGAVDIAAKAQKGWrqLTSIERAGFLHKLADALLARKDAIGQA 86
gi 78063682    7 YVNGRFVapesdtfivVHNPATEAPFARVPAatpaDALAAVDAAAAAQKAWrkLPSAERATYLHRFADALTARASEIGAA 86
gi 27468985   11 FINNEFIesqsketmdVINPATGEAFDTITLateeEVNDAIEKSQQAQLEWerVPQPTRAEHVKLLIPLLEKNRDEIAQL 90
gi 21221910   19 FVAGEYEldsshgtlpVINPANGQLVAEVPSssssTVDRAVTAAVAAQREWgrRSHVARAAVLEAVRDAIAVHADELARI 98
gi 14518348   12 YIDGEWIdattgesqeILSPTDETVVGTVQMgveaDAQIALEAAERAQKQWkkVPARKRADLLRTFAAEIKANKNQLAEL 91
gi 90022290    9 FINGEYIasqadgaidVLSPSTGKKVGDIPAgcveDAQLALDTANAAQKLWakKTNRERAKILRVFAANIRAAADDLAKL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                   ####                 
2IMP_A        90 IVEEGGKiqqLAEVEVAFTADYIDYMAEWaRRYEGEIIQSDrpgENILLFKRALGVTTGILPWNFPFFLIARKMAPALLT 169
gi 168335143  87 LTNEHGKtlaQAQGEVAVSAKFLRYAVESaRRVEGEVITSElenEHAFITRVPYGVVVGIVAWNFPLALAARKIGNALVC 166
gi 149370060  87 LAAEQAKvmgLAQVEIDVTADYFDYYAGFaRRIEGEIIQSDrakEHIFLHKSPIGVAVGILPWNFPFFVMARKVAASLIT 166
gi 191639353  92 LMLEQGKihaLAKTEIEFSADYFDYMANAaRVYSGDVMQSDnenENIIIARQPIGVAVGIIAWNFPFFLIARKMGPALVT 171
gi 87120747   87 LALESGKsleDATNEAVYAADITRYHAEWaRRIEGEIIPSDspsENLLLQREPIGVVACLIPFNYPVYTLLRKIAPALIT 166
gi 78063682   87 LAQESGKsveDASNEAVYAGQITRYHAEWaRRIEGEIIPSDtpdENLFLQREPIGVVACLIPFNYPVYTLLRKVAPALIA 166
gi 27468985   91 YVKEQGKtltQAYGEIDKSISFIDYMTSLsMSDKGRVLQNSianETIQIINKPIGVTAGIVPWNAPILVLMRKVIPAIVT 170
gi 21221910   99 VSVEQGKplsDARGETEGACAFFDFAISQkYRAVGSMMASEp-gRSLGVREEPIGVVAAILPWNFPVAIFARKVAPALMA 177
gi 14518348   92 LVREQGKllaVAKMEVEVTASFIEYACDGaRSIEGDIIPSDnpaEHIMIHKIPRGVVVAITAWNFPLALAGRKLGPALVA 171
gi 90022290   89 LVSEQGKllsVAQMEVEATATFIEYACDNaLTIEGDILPSDnpnEKIYIHKVPRGVVVAITAWNFPLALAGRKIGPALVT 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #  #                              #   ##            #  #  #  #            
2IMP_A       170 GNTIVIKPSEftPNNAIAFAKIVDe-iGLPRGVFNLVLGRGetVGQELAGNPkVAMVSMTGSVSAGEKIMATAAkNITKV 248
gi 168335143 167 GNTMVVKPPSetPLTVMKFAEFIEkesSIPKGVLSFVTGSGrvCGDALVRNEiTQLVTLTGSTGAGIEVFKAAAeNVVDV 246
gi 149370060 167 GNTCVIKPSCiaPNTILEWLELIQk-iELPSGVLNVVCGSGpiVGNALCKSPtTGIISLTGSVFAGQQVMEAASqNITKV 245
gi 191639353 172 GNTIVIKPSSdtPGLALAFAKLVDe-vGLPAGVANFVSGRGsiIGDDLAKNPkVGIISLTGSTASGKKVMAAAAnHVAKM 250
gi 87120747  167 GNSVVVRPSNntPSSAFEIAKAVQd-sGIPAGVVNILTMDHa-TAESVCTHPkVGMITLTGSVGAGRKVLEYSQvNIAKS 244
gi 78063682  167 GNTVVVRPSNhtPVSAFEIAKAAGd-aGFPPGVINILTMDHa-TAEALCTHPaVGMITLTGSVNAGRKVLDYCKaNIAKP 244
gi 27468985  171 GCSVVIKPSEetTLLTLRLAELFRa-sTIPAGLIQIVPGTGetVGTQLASHKdIQLISLTGSMRAGKSVYENAAqTVKKV 249
gi 21221910  178 GNAVVLKPSEltPLSALALARLCRl-aGVPDGLLSVVCGEGkdTGRALVTHPgVGMVTMTGSTRGGREILAQVAdQIIPV 256
gi 14518348  172 GNSVVLKPTQetPIATLELGNIANk-vGLPKGLINILTGQGsvLGNALVANPiTKMVSMTGSTPAGQQIFRTAAeNLIHV 250
gi 90022290  169 GNAIVVKPTQetPLATLALGELANa-aGIPAGVLNIVNGRGsvVGQHLCESPiTRLITMTGSTPAGQRIYRTSAdHLTPV 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2IMP_A       249 XLELGGKAPAIVMDDADLELAVKAIVDSRVINsGQVCNCAERVYVQkgIYDQFVNRLGEAMQAVqFGNPaerndiAMGPL 328
gi 168335143 247 HLELGGKAPFIVMDDADIDKAARCAAVARYDNcGQICTCNERMYVHekVYDEFKNKFVEHSKKYiVGDPtda-ntTIGPK 325
gi 149370060 246 SLELGGKAPAIVCADANLELAVKAVVDSRIIFsGQVCNCAERVYVEesIHDQFLEMVTAKMKAIkVEDAfsdnnpDMSAL 325
gi 191639353 251 SLELGGKAPAIVAKDADIDLAVQAIFDSRIDNnGQICNNAERIYVQedVADEFIKKMTAKMAAVkVGNPntdpdaEMGPL 330
gi 87120747  245 SLELGGKSPAIVEADADLEKAAREIVASKTTNcGQLCTAIERVYVHevIYDEFVALLKGQMSERqFGDRaqd-asFMGPL 323
gi 78063682  245 SLELGGKTPAIIEPDADLERAAAALVASKTTHcGQLCTAIERVYVHdsVHDRFVALLKEKMAAVrIGDRaed-atRMGPL 323
gi 27468985  250 NLELGGNAPVIVTSNADLDKAVNYIVTARINNaGQVCTCPERIFVHedVHDDFLNKVTSKMKSLtVGDPfde-ntDYGAI 328
gi 21221910  257 SLELGGKAPFIVFEDADLDAAVEAAADARLWNtGQVCTCNEVTYVHadLHDEFVRRVVDRFASVtPLDPfaa-gsRLGPL 335
gi 14518348  251 QLELGGKAPCIVFDDADLEQAVEGAFHSRFDNcGQVCTSNERLYVHesIYNEFMERFMEKVKGLkLGNPmda-atTIGPK 329
gi 90022290  248 MLELGGKAPFIVMEDANLESAVEAAFTTRYANcGQVCTCAERLYVHesIYPAFMDKLLEKVKAIkVGDPmaa-dtDMGPK 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #   #                                                                        
2IMP_A       329 INAAALERVEQKVARAveeGARVAFGGKAve----gkGYYYPPTLLLDvrqemSIMHEETFGPVLPVVAFDtLEDAISMA 404
gi 168335143 326 VSKAEVAKLKEMKEKSieqGGKVVYEMTAdnvp-taeGNWFYPTVLEVsdnknILMQEEIFGPMVAMMKISsLEEAIKYA 404
gi 149370060 326 VSKAQLDKVSEMVEFAkkeGAEIVLGGSRssq--fdkGYFYQPTLVSNvkqdmQIMQEEVFGPVLPVMKFStLDEAIALA 403
gi 191639353 331 INQGALDKVDGLVQRAveaGGQIQTGGHPadi---dgGFFYEPTVITNvaqdsEIVQNEIFGPVLPILTFKtIPEAIEMA 407
gi 87120747  324 INENARLNIHQMVERAiddGASLEVGGYIpe----gkGHFYPPTLLTNcrqdmEIVQEEIFGPVLPVLKYTdADQALELA 399
gi 78063682  324 VSASARAHIHGMVERAiaaGATLETGGAIpa----gpGFFYPATLLTGvrqdmEIVQEETFGPIMPVLRYStIDEAIAQA 399
gi 27468985  329 INQKQLDSIHEKVQDAiknGATLMTGGHQlk----rhGFFYAPTVLDNvrkddNVFKDEIFGPVLAITTYRdFEQVIEDA 404
gi 21221910  336 VAERERTRVQGMVDAAvaaGARVRTGGGRpdgeqyqsGAWFAPTVLTNvrpemDIARREVFGPVLPIIPFDaEAEVVSAA 415
gi 14518348  330 VNAKEVAHMEHLVTKSveeGATVAIGGKKpqgkafekGHWFEPTILTDvkqnmTIVHEESFGPILPVIKFSeFNEVIGYA 409
gi 90022290  327 VNQSEIENIDALVKKGieqGATLLHGGKRahvpgfegGNWYEPTLLGDvqqsnILVHEETFGPILPVVKINsIEQAIEYT 406
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                                                                                 
2IMP_A       405 NDSDYGLTSSIYTQnLNVAMKAIKgLKFGETYINREnFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVVYL 477
gi 168335143 405 NDCEYGLSAYLFSDsVKNAMIATQkLEFGELYINREnGELLNGFHNGYKKSGLGGEDGKYGLEGYLQKKMVYL 477
gi 149370060 404 NDSEYGLTSSIFSEnFNKVMHAAEeLQYGETYINREhFEAIQGFHAGWKKSGLGGADGKHGMEEYLQTKVVYA 476
gi 191639353 408 NDTVYGLTSSVYTRdLETASYVANeIEFGETYINRFnFEGIQGFHAGWKQSGVGGADGIHGVEEFTNTHVIYL 480
gi 87120747  400 NDHQFGLASVIYTEnYRTAMKVANnIEAGEIYINRTpADPYQGFHAGWKRSGLGGDDGKHGMLEYTQTRLVVL 472
gi 78063682  400 NDHQFGLSSVLYTEhYRTAMTVANaIEAGELYVNRTpADPYQGFHAGWKRSGLGGDDGKHGMLEFTQTRLVVM 472
gi 27468985  405 NDTNAGLSSYIFSEnLTEVMTATErLKFGEVYANCEaEEVVNGYHAGWRESGLGGADGIHGFEEYYNTTVSYI 477
gi 21221910  416 NSTAYGLTAYVYTRdLSRAMRMIDaLEFGEVYVNQAgPEQVQGFHTGWKSSGLGGDDGPHGYEKYLRRKTVYV 488
gi 14518348  410 NDCEYGLAAMVFTNdMNKIMRLNDeLEFGEIYINRGhGEQHQGFHNGYKLSGTGGEDSKYGFEQYMEKKTFYI 482
gi 90022290  407 NDSEYGLSTYLFTQnLKYIHQYIAeVEAGEVYVNRGiGEQHQGFHNGWKLSGAGGEDGRYGLEQYLEKKTVYF 479

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