1WNB


Conserved Protein Domain Family
ALDH_ABALDH-YdcW

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cd07092: ALDH_ABALDH-YdcW 
Click on image for an interactive view with Cn3D
Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like
NAD+-dependent, tetrameric, gamma-aminobutyraldehyde dehydrogenase (ABALDH), YdcW of Escherichia coli K12, catalyzes the oxidation of gamma-aminobutyraldehyde to gamma-aminobutyric acid. ABALDH can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency.
Statistics
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PSSM-Id: 143411
View PSSM: cd07092
Aligned: 16 rows
Threshold Bit Score: 671.73
Threshold Setting Gi: 111019883
Created: 14-Dec-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Structure:1WNB; Escherichia coli YdcW gamma-aminobutyraldehyde dehydrogenase complexed with NADH, defined using 3.5 A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1WNB_B        42 VYNPATGDVLLEIAEasaeQVDAAVRAADAAFAEWgq--tTPKVRAECLLKLADVIEENGQVFAELESRNCGKPlh-sAF 118
gi 183222015  23 IEDPATGKKIATVVDasatDVDKAAKAAHKAFYDGrwsglTPSERSKAIWKLADLLEEKTKEFAKWESLNAGKPyknlSL 102
gi 86608200   22 IENPATGEKLAEAVDaspaDVDRAVQAAQTAFYDGrwsklTPGERSLALWKLADLIEARAPELARVESENTGKPyeflSL 101
gi 29829134   36 VVDPATGEEVYRYELagtaDVDAAVAAARAAFPGWaa--tTPGDRSDALHRFAAVLADRAEEFARAESLQCGKPlk-lTR 112
gi 83950154   21 VLDPATGTQVAEVAEatpeQIAAATRAAHEAFESYrl--sTPSERAAHLLAVADVIEANIEELAELETLDVGKPwp-mAR 97
gi 134100311  43 LVDPSTGEEFGISPLtrwmDVDAVMGVAAAAFESWsq--tTPRRRQQLLLRIADAMEERSEELVAAECRNTGKPra-vVR 119
gi 21224008   27 VVNPATGEAYATAPLsgqaDVDAAMAAAAAAFPAWrd--lVPAERQKALLKIADAFEERAEELIAAEVENTGKPig-lTR 103
gi 37526251   25 LISPVTGETYARSPNatiaDVNEAYASAKEAFKIWgr--sTPSARQQALLALADAVEKNSERLIEAQSRNTGQLkh-lIA 101
gi 119961977  21 FFDPATGQQIGTAPDsdaaAVDAAFQAAAAAFKRYkr--tTPGTRQSLLLQLADLIEANVDRLLEAEVACTGKPsa-lTK 97
gi 169627916  12 IVDPRTGEGYEFQPDsthgEVDAAFSAAHEGWRNWrg--tTPAERQIALIAFADAIESQSDQLVAIEQRNTGKTr--eQA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       ## #                       # ##  
1WNB_B       119 NDEIPAIVDVFRFFAGAARclnGLAAGEYLEgHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEiT 198
gi 183222015 103 AGDIPFAIDNIRFFATAARdvhGSRANEYQPgYTSILRREPVGVVGQIAPWNYPLLMAVWKFGPALAAGCTVILKPAPgT 182
gi 86608200  102 GGDLPFAVDNLRFFAAAARdihGFSAGEYAKgYTSLFRKEPVGVCAQITPWNYPLMMAVWKIGPALAAGCTVVLKPAPaT 181
gi 29829134  113 EFDVPGTIDNTSFFAGAARhlqGQSAGEYSGdHTSYIRREPIGVVGSIAPWNYPLQMAAWKVLPAIAAGNTIVLKPAEiT 192
gi 83950154   98 DEEMPLTIDTFRFLAGAARtmgGSAAGEYVAgHTSMIRRDPIGPVASIAPWNYPLMMAAWKIAAPLAAGCTMVLKPSEiT 177
gi 134100311 120 DDELPTAVDLIRFYAAAARvqeTGAATEYQPsRTSFARREPIGVCAQVTSWTHPLLLAAAKFAPALAAGNTVVLKPAEtT 199
gi 21224008  104 SEEIPPMVDQIRFFAGAARmleGRGAGEYMEgLTSFVRREPIGVCAQVAPWNYPMMMAVWKFAPALAAGNTVVLKPSDtT 183
gi 37526251  102 SEEVAASVDHIRFFAGAARfleGKATAEYLPdMTTSIRREPLGVVGQVTPWNYPLMMAVWKIAPALAAGNTVVLKPSDtT 181
gi 119961977  98 ELEILRGADQLRFFAGACRvvsGTAQTEYVEgFSSTIRREPIGVVAQITPWNYPFMMAIWKIGPALAAGNTLVLKPADtT 177
gi 169627916  88 SDELSGALDEMRFMAGAQRalqGPLAGSYVPgTVSTSSRESLGVCAQILPWNYPLASAISKLAPALAMGNTSVLKPAApT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                   #    #             ###  #  #              # #        
1WNB_B       199 PLTALKLAELAKd-IFPAGVVNILFGRGktvGDPLTGHPkVRMVSLTGSIATGEHIISHTAssIKRTHMELGGKAPVIVF 277
gi 183222015 183 PITTLMLAELTKkaGIPDGVINIVTGGNa-tGQAIVDHPlVRMVSLTGSTGTGKNIMKSASdsLKRVHLELGGKAPLVVF 261
gi 86608200  182 PLTTLMLGELIAeaGIPPGVVNIVTGGNa-tGQALVEHPqVRMVSLTGSTATGKQVMRTAAdtLKRVHLELGGKAPFIVF 260
gi 29829134  193 PLTSLLFAEAATraGIPDGVVNIVTGAGrdaGEHLVAHPdVAMTSFTGSTAVGRRVAEIATstVKRLHLELGGKAPFVVF 272
gi 83950154  178 PLATLRLAELLAd-VLPRGVLNVIHGGGasvGDALINDPrMEGISITGSPATGMAAMRAASrqIRHVHLELGGKAPVIVL 256
gi 134100311 200 PLSSSLLAEIASe-VLPPGVFNLICGDRd-sGRAMVAHEvPGMFSITGTVRSGMEVAGSTAadLKRAHLQLGGKAPAVVF 277
gi 21224008  184 PASTALMADIIGs-IVPKGVFNVVCGDRd-tGRLMVEHEtPAMASITGSVRAGMSVAESASkdLKRVHLELGGKAPVVVF 261
gi 37526251  182 PESTLLLAELAAp-FFPTGAFNVVLGNAs-aGALVVSHKtPAMVSITGSVRAGLQVASSAAanLTRAHLELGGKAPVVVF 259
gi 119961977 178 PWSTLVLGELAQq-VYPAGVVNIVCGGRe-aGAAMVDHDiPEMVSITGSTRAGAQVMSAASktLKDVHLELGGKAPAVVF 255
gi 169627916 168 PCSVQALLAIASe-TLPPGVVNAVFGGRe-tGQYMVAHHiPALISLTGSVRAGHEITRAAG--LKVLHLELGGNCPVIVL 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                               #                                              #         
1WNB_B       278 DDaDIEAVVEGVRTFGYYNAGQDCTAACRIYAQkgIYDTLVEKLGAAVATLksgapddestELGPLSSLAHLERVGKAVE 357
gi 183222015 262 DDvDINVFAAKATFGATCNSGQDCTAATRIIVPkaLQKKITEAVVDAMKAVkvgdpfgdktEMGPLISAIHRERVIGFMD 341
gi 86608200  261 EDaDVETVAAKATFAATVNTGQDCTAATRVYVHesKLAQAQEAIVEAMRKVtvgspfeagvEMGPLVSAAQRERVMGFVE 340
gi 29829134  273 DDaDLDAAVHGAVAGSLINTGQDCTAATRAYVQrpLYEEFVARTAALMETVrlgdpfahgtDLGPLVSHAQRDRVAGFVD 352
gi 83950154  257 GDaDIGALAETIRYGSFFNAGQDCAQPCRLMVEasVYDKVLQAVTDQVGQIrigapraegtEMGPIVSEIQRDRVAGFID 336
gi 134100311 278 GDaDLDRAVRSIAEAAFGNAGQSCTAASRVLVSaeVHDEVVERLCELAAAMrpgppqdldaAFGPLNSLGQLESVQAHLE 357
gi 21224008  262 EDtDIPKAVEGISEAGYFNAGQDCTAATRVLVHesVHDEFVSALAKAASEIktgqpddedvMYGPLNNPNQLKQVSGFIE 341
gi 37526251  260 ADaDMDKAVETIATAGYFNAGQDCTAASRVLVHesVYDTFVAKLVAAAKATrfgypedeeaLYGPLNNARQLEQVKGFIA 339
gi 119961977 256 ADvDIQRTASEIALAAFFNAGQDCTAVTRVLVHqdIHTEFAAALADAASALkvgg---sdaDLGPLNSAAQLERVEGFMS 332
gi 169627916 244 GDvDVEAVAHEIAEAALYNAGQDCTAAARLIVAseVVDEFVAALTREFLAS----------RTVPLATREHLDRITALLA 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                   #                                    
1WNB_B       358 EakatgHIKVITGGEKrk--gnGYYYAPTLLAGalqddAIVQKEVFGPVVSVTPFDnEEQVVNWANDSQYGLASSVWTKD 435
gi 183222015 342 Rak-kqGAKILTGGGIpkgldkGYFFEPTVVTEvkqnfDIVQNEIFGPVLTIQTYDkEEEAVKLANDVNYGLASSIWTKD 420
gi 86608200  341 Rak-aeGAKVLTGGRIpsqlaqGYYYEPTVIANvdqkaEIVQSEVFGPVLTLGSFReEAEALRLGNDVLYGLAASVWTQD 419
gi 29829134  353 Rar--aYARVVTGGEIpeelkdGAYYRPTLIADaaqdsEIVQSEIFGPVLVVLPFDsDDEGIRLANDTPYGLAASAWSRD 430
gi 83950154  337 Rar--gHAEIATGGASge--gpGYFYQPTVVANvdndaEIAASEVFGPVVTLSRIKdADEALRIANAAPYGLASSVWTRD 412
gi 134100311 358 Rlp--eHARIAAGGARrg--erGYFFEATVVTGveqddELVQNEVLGPLLTVQSFAsEQEALELANGVRYGLVASVWTRD 433
gi 21224008  342 Rlp--aHAKVEAGGHRvg--dkGYFYAPTVVSGlkqddEIIQREVFGPVITVQAFRdEDQAVEWANGVEYALASSVWTKD 417
gi 37526251  340 Rlp--aHACIETGGRQae--rsGYYFEPTVITGleqhdEAIQTEIFGPVITVQKFRdEQDAIEKANDVKYGLASSVWTRD 415
gi 119961977 333 Rlp--aNARVLSGGKRtg---tGFHFEPTVIDGvfqsdEVVCDEIFGPVLTVQPFAtEEEAIELANGTKYALASSVWSEN 407
gi 169627916 314 Rvp--kTARVECGGRRad--apGLYVEPTVVTNvaqddEIVTEEIFGPVVTVQQFEsADEAVALANDTEYGLAASIWTTE 389
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                                                  
1WNB_B       436 VGRAHRVSArLQYGCTWVNTHfmLVSEMPHGGQKLSGYGKDMsLYGLEDYTVVRHVMV 493
gi 183222015 421 VARAMRVAKqLEFGTVWVNDHlpLASETPHGGFKQSGFGKDLsIESVGDYLITKHVMV 478
gi 86608200  420 IGRAMRLAAdLEFGTVWINDHipIASEAPHGGFKQSGFGKDLsAEAVRDYQITKHVMI 477
gi 29829134  431 VYRANRATReIKAGCVWVNDHipIISEMPHGGYKASGFGKDMsAYSFEEYTQIKHVMF 488
gi 83950154  413 LSAAMRLSSqLRYGMTWVNTHgvPTPEMPWAAMKGSGTGCDMsIYALDAYTSVRHVMV 470
gi 134100311 434 HSRAMRLSRkLQTGTVWINTHhpFTAEMPHSGFKHSASARDFgRYGLEEYSRIKHVMS 491
gi 21224008  418 HGRAMRMSKkLDFGCVWINTHipLVAEMPHGGFKKSGYGKDLsGYGFEDYTRIKHVMT 475
gi 37526251  416 HGRALRLSReLDFGTVWINTHipLTAEAPHGGFKSSGYGKDLsAYGFDEYTRIKHVMS 473
gi 119961977 408 HGVVTRVSNeLDFGAVWINCHqvIPAEAPHGGFKHSGTGKDLsVYGLEDYTRIKSVTT 465
gi 169627916 390 HSSAVALSQrIDAGTVWINTHgvYATEMPFGGFKSSGYGKDLsPLALENYSRVKHIMT 447

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