Conserved Protein Domain Family
ALDH_F21_LactADH-like

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cd07094: ALDH_F21_LactADH-like 
ALDH subfamily: NAD+-dependent, lactaldehyde dehydrogenase, ALDH family 21 A1, and related proteins
ALDH subfamily which includes Tortula ruralis aldehyde dehydrogenase ALDH21A1 (RNP123), and NAD+-dependent, lactaldehyde dehydrogenase (EC=1.2.1.22) and like sequences.
Statistics
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PSSM-Id: 143413
View PSSM: cd07094
Aligned: 6 rows
Threshold Bit Score: 625.227
Threshold Setting Gi: 51317969
Created: 29-Oct-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 37538023   13 MDVINPYSLEVIKkipalsreEAKEAIDTAEKYKEVMKn-lPITKRYNILMNIAKQIKeKKEELAKILAIDAGKpikQAR 91
gi 75247698   24 LDVTNKYTGEVGAkvqlathdDVDKAIDAAVAAAPAMAa-lGAFERKAILEKTVAELKkRAEEIAQILTMESGKpikDAR 102
gi 51317969   14 TTVHDRWTGEPVGtvp---rdGAEEAAAAVAALAAGRRa-tTPQQRSAVLTRAADMLTaRAEEFSTLITAESGVcrkETL 89
gi 20094544   18 IVVENPYDGSEVGrvla-pevDVEALLKDAREGQRRWRe-rPTYEVREALAEAAHLLKkHEDELAELIALEGGKpirDAR 95
gi 116250081   2 LEVVQAFDRKHIAdlptddaaALESKLETARARFLNRNdwlAPHERMAVLRRLADLVGlQREVFAKRIACEGGKpytDAL 81
gi 2494080    58 IAVHSPYDGSLLGsveatdpaDIDRLLATARRGAEISRn-lPRHKRASILEGAAQMVEsRHDAFAEIIVREAGKtivQAR 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #                         
gi 37538023   92 VEVERSIGTFKLAAFYVkehRDEVIPSd------dRLIFTRREPVGIVGAITPFNFPLNLSAHKIAPAIATGNVIVHHPS 165
gi 75247698  103 GEVARTIDTFQVAAEESvriYGEHMPLdisarnkgPQGIVKKFPIGPVSMVSPWNFPLNLVAHKVAPALAVGCPFVLKPA 182
gi 51317969   90 REVSRAAGNLRVAAAEAeriRGESIPLpd----gtRLAVTLPEPVGVVLGITPFNRPLNQVVVKAAPALAAGCPLLLKPS 165
gi 20094544   96 YEVYRTREVLRLSAAEAerlYGETLPGdaqrgrtaELILTVREPVGVVLSITPYNFPLLLPTHKLGPALAARCSVVHKPA 175
gi 116250081  82 VETDRAIDGIRNAADVLrtrGGVEIPMgltqasdnRRAWTIQEPIGVVAAISAFNHPLNLIVHQMAPAIATGCPVIIKPA 161
gi 2494080   137 KEVLRCVNTLKLSAEEAkrnAGEIVPFdaytgseqRQGWFTRDPLGIITAITPYNDPLNLVAHKLGPAIAGGNAVMLKPS 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #    
gi 37538023  166 SkaPLVCIELAKIIENalkkyNVPLGVYNLLTGAGEvvGDEIVVNEkVNMISFTGSSKVGELITKKa-gFKKIALELGGV 244
gi 75247698  183 SrtPLSALILGDILVPd---rGAAKGAFSVLPVSRAd-ADMFTVDErFKLLTFTGSGPVGWDMKARa-gKKKVVMELGGN 257
gi 51317969  166 EktPLTALAFAELLVEa----GCAKDMLAVVTGEPGevGPPLAAHPdVAMVTFTGSVATGHAVAAQa-aGKRQLLELGGN 240
gi 20094544  176 TvtPLSSLRLAEILLDa----GVEPLALQVVVGPGAelGEELARAD-FDALSFTGSRSVGEHLREIs-pIPRITLELGGN 249
gi 116250081 162 AatPLCCLELVKLVHEa----GMPEGWVQAFLPESRvlSSAFASDArIAFLSFIGSAEVGWRLRANlapGTRCALEHGGV 237
gi 2494080   217 NltPFSAIKLVGALREa----GLPEEVITISHGDREl-VTAMIAAReVRMVSFTGGFATGEAISRAa-gLKKLAMELGGN 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                   #  #                                                 
gi 37538023  245 NPNIVLKDa-DLNKAVNALIKGSFIYaGQVCISVGMILVDesiADKFIEMFVNKAKVLnVGNPLDEkTDVGPLISVEHAE 323
gi 75247698  258 APCIVDDYvpDLDYTIQRLINGGFYQgGQSCIHMQRLYVHerlYDEVKAEFLAQVKKLkVGNPFEDdTFIGPMISEKDAT 337
gi 51317969  241 DPLFVLPDa-DLRRAAKLAADGSCATaGQSCRGIKRVFVWeevADEFTALLEPAVAAKrAGDPRREdTDLGPLVSEEAAL 319
gi 20094544  250 DPVIVDETa-DVEAAAEAAVRGACYHaGQVCIAVERAIVVedvYEEFLEAAVEVAESLkVGDPLDEdTDVGPLIDDGAVE 328
gi 116250081 238 APVIVDRSa-DLDAIIEPLAKGGYYHaGQVCVSVQRIYVHaelKEAFIERFAARVEQLrVGDPTHAeTEVGPLITPAEAT 316
gi 2494080   291 APVIVMNDc-DFDKAVEGCVSGAFWAaGQNCIGAQRILIQselYGRFRDAFVAATKKLkAGDPLQEdTDVGPMISKQVAE 369
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 37538023  324 WVEKVVEKaideGGKLLLGGKRdkALFYPTILEVDr-dNILCKTETFAPVIPIIRTN-EEEMIDIANSTEYGLHSAIFTN 401
gi 75247698  338 RVEDWVKEavekGGKLLCGGSRkgAVMQPTVLEDVpmdAMARKEEIFGPVVLFYKYSdFKEAVKECNNTHYGLQSGIFTK 417
gi 51317969  320 VVERRIARavrdGARLVTGGERdgALVRPAVLDHVppdTELVTEETFGPVAPVIRVRdADEAVRLSNGTAYGLQAGVLTR 399
gi 20094544  329 KVRRHVEDaverGAEILTGGEPegRLFPPTVLADVpedALVAREETFGPVLPVIRAKdFEEAIRIANSTDYGLHAAVFTE 408
gi 116250081 317 RVETWIDEaataGARRIGGGRLsdTTLKPAILVDPprdTKVSTHEIFGPVTCIYGYDeVEDAIAAANSLPVAFQASIFTR 396
gi 2494080   370 RTEAAVNEaikaGATLLCGNYRegSLYHPTVLEGTpltCRLWHEEVFAPVVMLAPFDtLDKGIEMANDPDYSLHAGIFTN 449
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    
gi 37538023  402 diNKSLKFAEnLEFGGVVINDSslFRQDNMPFGGVKKSGLGREGVKYAMEEMSNIKTIII 461
gi 75247698  418 dlNKAFYAFEhMEVGGVILNDSpaLRVDSQPYGGLKDSGIQREGVKYAMEDYLETKVLVM 477
gi 51317969  400 dsAAFWDIAArLRVGAVNLGEGphFDSPHIPFGGVKSSGVGREGIRYAIAEMTVTKTVTL 459
gi 20094544  409 rlDRAVKATRkLEAGGVIVNEStiYRADYMPFGGVKASGVGREGVPQAVREFTEEKTVVI 468
gi 116250081 397 dlDVAFNAAEkLDASAVMVNDHsaFRTDWMPFAGRRESGYGVGGIPFTAREMTAEKMIVF 456
gi 2494080   450 dlNVALEAANrIEVGGVMINDSsdYRFDAMPFGGFKYGSMGREGVRFAYEDMTQPKVVCI 509

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