Conserved Protein Domain Family
ALDH_SSADH1_GabD1

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cd07100: ALDH_SSADH1_GabD1 
Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like
Succinate-semialdehyde dehydrogenase 1 (SSADH1, GabD1, EC=1.2.1.16) catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde (SSA) to succinate. SSADH activity in Mycobacterium tuberculosis (Mtb) is encoded by both gabD1 (Rv0234c) and gabD2 (Rv1731). The Mtb GabD1 SSADH1 reportedly is an enzyme of the gamma-aminobutyrate shunt, which forms a functional link between two TCA half-cycles by converting alpha-ketoglutarate to succinate.
Statistics
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PSSM-Id: 143418
View PSSM: cd07100
Aligned: 99 rows
Threshold Bit Score: 607.535
Threshold Setting Gi: 118357582
Created: 12-Oct-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 160388392  25 VDAAIARAHRRFADYRqtSFAQRARWANATADLLEAEADQAAAMMTLEMGKtlaAAKAEALKCAKGFRYYAENAEALlAD 104
gi 194365602  30 LEAILDRGQAGFAAWSarSLEQRAEVLRAMAAVLRRDREKLAALATAEMGKvqaESLAEIEKCAVLCDWYADNGAQFlRD 109
gi 170694579  34 VERMLEDNAAAYRLWRgtPMAVRVATYRRLAATLRERSEALAALITQEMGKtlaAARAEIAKCASAIDWIAEHGPAFlAD 113
gi 149918800  28 LEGRVARAHAQQRDWAarPLAERADALRALGAHLRTIRGEAAATMTAEMGKplaQAQGELDKCAWLCEWLAEHGPAMlAD 107
gi 182416051  25 AFAIVARAERAAQPWRstALAERARTLRAVGRELRRRRDDLAALLTAEVGKpirQSRAEIEKCAAGCEYFAAHAARAlRP 104
gi 31790980   73 VDSALALTNGAFQYWRhsAMSDRVQLLRNVAGALRQQARELAEMMTSEMGKpvdQGLAEVEKSARLCEWYAEQGPAFlQR 152
gi 93006682   26 VNNIVEASHQAFLEWRktSHKERAKVINSIGETLMKYKEELSRLMTEERGKlysQSLQEIDLCKAICDYTAEKGVAAlAD 105
gi 85707678   26 ACAKVDACHEAFESWKlkSLEERAEVLRGLGQALRDNKEELAQLMTDEVGKligDSRDEVELCASICDYTAENGPSElAD 105
gi 120435313  29 MNSAVKACHEAFLEWKnkSAEERGKVIANIGKKLDEHKDELVKLMTSEMGKllkQGEQEVELCSGICDYTAKNGPESlKD 108
gi 206686835  26 AIQKLESAQEAFLDWRklSHAERAPYLTKIAERLRASADELAVLMTRETGKllkDGKREVEICAAILEYTAKHGPDVlAD 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      #                                                 
gi 160388392 105 EPADaak-vgaSAAYGRYQPLGVILAVMPWNFPLWQAVRFAAPALMAGNVGLLKHASNVPQCALYLADVIArgGFPDGCF 183
gi 194365602 110 EPTQvp----dDKAYVSYLPLGVVLGIMPWNFPYWQVMRAAVPILMGGNGFLLKPAENIVGTAQLLDAAWRdaGLPDGTF 185
gi 170694579 114 EPAPve---gdDQVHVSYLPIGSILAVMPWNFPLWQVIRASGPIMLSGNGFILKHAANVMGSAYALQDAYEaaGFPVGLF 190
gi 149918800 108 EPRSrvavegsQRSYVAHRPMGLLLAIMPWNFPWWQALRFAAPALLAGNTALLKHAPNTTGCALAIEAALLaaGFPEGCL 187
gi 182416051 105 QHPIga----pRHARVVFEPLGIVLGIMPWNFPFWQTFRAAAPALMAGNVLLFKPAPSTAGCALAIEAVFDa-VAPKGLL 179
gi 31790980  153 EPTLve----gNKAFVDYLPLGPVLSVMPWNFPVWQVLRGAVPILLAGNSYLLKPAPNVMGCALLLQQILSrvGVPEGLF 228
gi 93006682  106 DERDie---glKKGIVTYQPIGVIYGMQPWNFPAYQVFRYTIANLMAGNSILLKHAANVTGSGLLIEKIFHesDLPNDLF 182
gi 85707678  106 EQRDps---naGRGIVTYSPIGVVYGIQPWNFPAYQVIRYAIANLMTGNGVLLKHASNCTGSGLKIAEIFEkgGLPADLF 182
gi 120435313 109 EERElp---egGKGYISYSPIGVIYGIQPWNFPAYQVVRYSIANLMAGNGVLLKHAENVTGSALLLEKIYIeaGLPENLF 185
gi 206686835 106 EDRThgt--dgARGIISYQPIGVIYSIQPWNFPLYQPVRVLAANLMAGNACVLKHASICTGSGLRLRELCIeaGLPEDLF 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                       #                              # 
gi 160388392 184 QTLLVSSGaVEAILRDPrVAAATLTGSEPAGQSVGAIAGneIKPTVLELGGSDPFIVMPSaDLDAAVSTAVTGRVQNnGQ 263
gi 194365602 186 IAANISREgTSRAIADDrIAAVTLTGSVAAGRSIAAQAGqaLKKVVLELGGSDPFIVLADaDLDAAVEAAVASRFQNtGQ 265
gi 170694579 191 ANLNADNEtVAHVIEDPrVAAVTLTGSMRAGSAVASTAGraLKKTLLELGGADAFIVLADaNIDLAVKAAIEARFQNaGQ 270
gi 149918800 188 ETLVASHGqVAGLIADRrVRGVTLTGSTRAGRSVAALAGqhLKKTVLELGGSDPYLILPDaDLDHAAAVCAKARLFNsGQ 267
gi 182416051 180 RTLLVETDaVATLIADArVRGVTLTGSTRAGRAVAALAGgaMKPGVFELGGSDAYLVLDDaDLDHAAAVCAQARLVNsGQ 259
gi 31790980  229 AVVNADNDgVAQAINDRrIAAVTVTGSVRAGAAIAALSGaaIKKCVLELGGSDAFIVLADaDIDAAVKGAIAGRFMNnGQ 308
gi 93006682  183 RTILIDHDqSEKLIGNDkVRGVTLTGSDGAGSIVGQQAAkaIKKAVLELGSNDAFIVLEDaDLELAVQTCTLARLINnGE 262
gi 85707678  183 TVLVIDHDtSDAIIAHDkVRGVTLTGSDGGGKHVAEEAGkvLKPLVLELGSNDAYLVLEDaDIDKAAEVCARARLYNnGQ 262
gi 120435313 186 KVLLISHDqSDSVIENKlVRGVTLTGSPDAGKIIGKKAGenLKKTVLELGSNDAYIVLEDaDIDLAVKTCVEGRLYNnGE 265
gi 206686835 184 QVVLIDHGtSDTLIAHPlVRGVTLTGSDGAGRHVGSVASkaLKKTVLELGSNDAYLVLEDaDIETAVKYSVIGRLYNnGE 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                                              
gi 160388392 264 SCIAAKRFIVHadiYDDFVDKFVARMAALrvgdptdpdtDVGPLATEQGRNEVAKQVEDAAaaGAVIRCGGKRLdrpgWF 343
gi 194365602 266 VCIAGKRIIVEdavYDRFVAQFCQKVQALaigdgreagnRIGPMARQDLLEQLDAQVRASVdaGAKLLVGGHQLdrpgAF 345
gi 170694579 271 VCLAAKRFIVErpvAEEFTRKFVAAARQVvagdphdpasTIGPMARADLRDELHGQVQRTIeaGATLLLGGSKVegagNY 350
gi 149918800 268 TCVAAKRFLVCepvAEAFTEAFLAQLRAAvvgdptdpttTVGPLARADLRAGLEDQVERSVaaGARVLHRSEVPd--sPG 345
gi 182416051 260 SCIAAKRFIVLaavRGEFERRFVAHMTAAkvgdptdpatDVGPLARADLCDQLHRQVKRSVqrGARVLLGGAPApgagFY 339
gi 31790980  309 LCISAKRIIVEapvFDAFRDKFVSAVKEMkigdpresgtWIGPMARYDLRDELDSQVQATLkeGATLLLGGHVLpgegNY 388
gi 93006682  263 TCVAAKRFIVVdslYDEFRKRIVEEFASKkagdpmddssDLGPLARKDLQEKLHAQVEESVskGATISVGGKLPegkgSF 342
gi 85707678  263 TCINGKRFIVTdavYDEFVDKFVAKFEAIkigdpnsddsDMGPMARTDLREDVQGQVDKSVenGATIACGGKIPdgpgAY 342
gi 120435313 266 TCVAAKRFIVVdkvYDKFKEAFVEQMSQIkagdptkedsDIGPMARKDLRDELHEQVEESVkkGAKILCGGKKPdgdgFF 345
gi 206686835 264 TCVSAKRFIVAdkvYDAFVSAFVDQMKTVkmgdptdedtQLGPLSSDAQFETVKEQVDESVakGAKALCGGKAPdrtgAF 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 160388392 344 YPPTVITDIsk--dmALYTEEVFGPVASVFRAAnIDEAVEIANATTFGLGSNAWTRdeTEQRRFIDd-IVAGQVFINGMt 420
gi 194365602 346 YAPTVLADVep--gmQAFDTETFGPVASISRARdADHAVELANQSEFGLSGNLWSGdrARAMQLARr-LQTGGVFVNGFs 422
gi 170694579 351 YEPTVLADVap--gmAAFDEETFGPVAAITVADdAEHAIELANTSDYGLGGSLWTSdvARAQRIARr-LETGGVFINGFs 427
gi 149918800 346 AYHPVVALGsvdetnPAAREELFGPVAAIMTVRdEAHAVAVANRSDYGLGAAVFSRdvERAEAIARdqLDAGACFVNGMv 425
gi 182416051 340 YEPTVLSRVrp--gmPAFDEELFGPVAAVISARdETEAIALANRSIYGLGAAVFTRdrRRARRIAEq-LEAGFIVTNDFv 416
gi 31790980  389 YAPTVLSDVkp--gmTSFAQELFGPVASLIQADnAEHAVVMANDSEFGLGGSLWSRdlAVAQKLASr-IETGGVFINSPs 465
gi 93006682  343 YPATILENVek--gqPAYDDELFGPVASLIRAKdQDDALRIANDSRYGLGGAIFSKdeEKAIRLANeqFDTGMVYINGYg 420
gi 85707678  343 YPATVLTDVap--gqPAYDDEIFGPVASVIRAKdDEDAMRLANDSRYGLGGGILSGdtDRAIEMAKkhFDTGMIFINTYg 420
gi 120435313 346 YPATILDELkp--gmPAYDDELFGPVASLIKAKdAKDAMDIANSSRFGLGGGIFSKdeEKARELAKyhFDTGMVFINSFg 423
gi 206686835 344 YPATVLVDVap--gmPAYDDEIFGPVAAVIRAKdNEDAMRIANDSRYGLGGGIFSQdeERALRLARdhFDTGMIRINSFg 421
                        410       420       430
                 ....*....|....*....|....*....|....*.
Feature 1                                            
gi 160388392 421 vSYPELPFGGVKRSGYGRELSAHGIREFCNIKTVWI 456
gi 194365602 423 aSDPRVPIGGVKKSGFGRELSHFGIREFVNAQTVWF 458
gi 170694579 428 aSNPRIPVGGVKKSGYGRELSHFGLREFTNAQAVWA 463
gi 149918800 426 rSDPRVPFGGVKDSGYGRELGRHGMLEWVNAKTVWV 461
gi 182416051 417 rSDPTLPFGGVKQSGYGRELGDWGVTSFVNVKTVIG 452
gi 31790980  466 fSDPRVPIGGVKKSGFGRELSHFGLREFTNTQTVWM 501
gi 93006682  421 lANPALPFGGVKNSGHGREHGGFGIKEFVNIKGVHV 456
gi 85707678  421 vADPSMPFGGVKNSGYGREHGGFGVKEFANAKSIFV 456
gi 120435313 424 lAKPNMPFGGVKDSGYGREHGGFGLHEFVNVKAIML 459
gi 206686835 422 aADPNMPFGGVKDSGYGREHGGFGMKEFVNVKAIYL 457

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