3EK1


Conserved Protein Domain Family
ALDH_F5_SSADH_GabD

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cd07103: ALDH_F5_SSADH_GabD 
Click on image for an interactive view with Cn3D
Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like
Succinate-semialdehyde dehydrogenase, mitochondrial (SSADH, GabD, EC=1.2.1.24) catalyzes the NAD+-dependent oxidation of succinate semialdehyde (SSA) to succinate. This group includes the human aldehyde dehydrogenase family 5 member A1 (ALDH5A1) which is a mitochondrial homotetramer that converts SSA to succinate in the last step of 4-aminobutyric acid (GABA) catabolism. This CD also includes the Arabidopsis SSADH gene product ALDH5F1. Mutations in this gene result in the accumulation of H2O2, suggesting a role in plant defense against the environmental stress of elevated reactive oxygen species.
Statistics
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PSSM-Id: 143421
View PSSM: cd07103
Aligned: 140 rows
Threshold Bit Score: 553.579
Threshold Setting Gi: 168334179
Created: 12-Dec-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
3EK1_A        52 VTNPADGSVIGTVPSlsvaTIKEAIDASAKALSGWaakTAKERAGILRKWFDLIIANADDIALIMTSEQGKPLaEARGEV 131
gi 17989214   30 CLTDPADGRELTIAPragrAEALQAAAAEKGFAEWsalSALERSKIMRRAADIMRERADAAARIMSMEQGKPLsEARGEW 109
gi 110636091  28 VIDPSNEEVLGSYRSaapeDLQELLDSAAAGFEKWrrtSAYERCEILHKVAAALRENAQEIGSLLTLETGKILsESITEV 107
gi 207082954  24 VINPATEEVLGHASKassaDVQRALQSAEQGLKVWrkiPPWQRSYVLRKIADKMREKKDLLAKWMTLENGKPLaEGIGET 103
gi 182679743  24 VLDPATGASLGEVASadtaDVEEAIAVASVALKSWratPAWTRADLLHAVADVMRDRLEEAARIITLESGKPLaQARREW 103
gi 198252992  22 VISPVTETPLGDVTTataaDSKRAINAAASALAPLramGGFARADAMHRIADEMTARGDEAALMISTETGKPLaQAGREW 101
gi 20804006   26 VINPATEKVVASVASatvsDLDEALASAERSRKAWcsrPAKERGEILVAAARVLATQIEPAARDLSAEQGKTIaEATGEY 105
gi 167746722  20 VINPADNTVVDSFCSatkeQAEEALETAQETFKTWgktSVMERCRLLSKFADLVEEHQDEISRLNSLETGKPYgEAYGDT 99
gi 109897221  22 IINPANDKVVAEVSVadgaLALKALEAADAAYDSWsstSISERVEWMMKLKTALKENETHLRECIHLEMGKSWaSTQGDF 101
gi 168334179  20 VYNPATGEVLAEFKSvsseQCEEALVAADAAFKIWskaSIAEREKVILAFRSDLISVQDELVALLMLETGKPLnNATYDY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          #                             
3EK1_A       132 LYAASFIEWFAEEaKRVYGDTIPapq---ngQRLTVIRQPVGVTAAITPWNFPAAMITRKAAPALAAGCTMIVRPADlTP 208
gi 17989214  110 LGSADLLDWFAEEgRRVYGRIVPsra---pnIQIQVLKHPIGPVAAFTPWNFPAWNTMQKVAPALGAGCSVVIKPASdTP 186
gi 110636091 108 RGAADHFDWSGEEgRRLYGYTVParr---aeSRLRVELEPLGIVFALIPWNFPLGTSARKVAPALAAGCSVILRPPEeAP 184
gi 207082954 104 NGAADIFEWNAEEtKRIFGQTIEsrf---edTRVHVYYQPVGVVAALSPWNFPLILAARKISTALAAGCSVIIKPDTiTP 180
gi 182679743 104 NLSIDQFRWFAEEtRRIYGRIVEsra---pgGRIEILHEPVGIVAAFTAWNFPAVLVARKIAPALAAGCSVIVRPSDeCP 180
gi 198252992 102 VLSVDQFRWYAEEaRRIYGRVVEsrv---pgGRFEITKEAVGIVGAFTAWNFPASLPARKIAPALAAGCPVVLRPSSqTP 178
gi 20804006  106 ARAVETLEWNGTH-AEELSATIPl------gPNRMIVPEPLGVVAAFTPWNYPAVLITRKLAPALAAGCPVILKGAEeTP 178
gi 167746722 100 GFCLNVLRFHAEEaKRVYGTTLNdynsqrgsVYHMVEKRPVGVVVGHLAWNYPMYNAALKIGPVIGSGCTAVLKPSSqTP 179
gi 109897221 102 EMLLDSLDFFASDiQKQAAETLEdke---gtHSHVLVRESVGVVAAFLAWNFPLLNLAYKLGPALASGCPIVVKPSLkTP 178
gi 168334179 100 EMLIDCLYFFNEEnKRLYGKTISnrt---nsHLNIIDHVPLGVVVGYLAFNFPILNLGYKLGPILASGCTCVLKPSSlTP 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                            #           
3EK1_A       209 LTALALGVLAEkAGIPAGVLQIVTGKAreiGAELTSNDTVRKLSFTGSTEVGRLLMAQCAptIKRISLELGGNAPFIVFD 288
gi 17989214  187 GTAWLIGKCLLeAGLPPKAVSVIWGTTselSDALIKAPEIRKVSLTGSTRVGRIVAAQAGeyLKKVTMELGGHGPVIVAA 266
gi 110636091 185 ATVEAFVRCCQeAGLPPGVLNMVLGSPkdvVEPLMASFSVRAVTFTGSTRVGKILIQQAAdtVKHLVLELGGHAPAIVLP 264
gi 207082954 181 GIVMELVDICReCGVPPGAINLLSGDPpsiASQLIQSDIIKKISITGSVRVGKLILKQAAdkVQRVTMELSGHSPFIVFD 260
gi 182679743 181 GTAMHLVDCLRqAGVPKGVVNLVVGPVkntYAPLVASPLVRKITLTGSTAVGQQMIRDSAatVKRVSMELGGNAPLIVFD 260
gi 198252992 179 GVAMVMVDCIRaGGLPDGAMNLVVGSTadtYGPIMADPRVRKVSLTGSTRVGQQMIRDAAetVKKVSMELGGNAPCIIFD 258
gi 20804006  179 SVAVHIVESLRqAGVPDGVVNLVFGVPvhiSRHLLSSPIVKVLTFTGSTAVGKQLAMLAAnnLQRCILELGGHSPVIVCE 258
gi 167746722 180 LATLFLGKLITeAGIPDGVINILAGSSselGYALNSSTIPRLIGLIGSTDTALKVMSDSAtsVKRFSFELGGNAPTIVSE 259
gi 109897221 179 LSALAVGEICQqIGLPAGVVNIVCGPDqeiGDAISSSPIPALLTLIGSTETGKHVMQQGAtsIKRYSMELGGNAPVLIFD 258
gi 168334179 177 LTSLKIGEIAN-KHFPAGVINIIAGKSgvvAPVMNKSAIPKMMTMIGSSRAGKSVIRDSAdyLRHYSLELGGNAPAVVCK 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           #  #                                                         
3EK1_A       289 DADLDAAVDGAMVSKYRNAGQTCVCANRIYVQrgVYDKFAEKLAAKVKELk--VGNGTEpgvVIGPMIEEKAITKVKAHI 366
gi 17989214  267 DADLDHLIPLAVQWKFRNCGQVCVSPTRFIVEasIHDEFIRRFSEKARELk--VGKGVEegaQMGPLTSQNQLETVLSMV 344
gi 110636091 265 DADPKKVGVAAARAKFRNAGQVCVSPSRFIVHekIVEPFTQAMVEETRSIk--LGSGFDagaQMGPLTTARQRERVERLV 342
gi 207082954 261 DADVKKATDMAIAAKFRNNGQVCISPNRFYIHenKKNEFIDLFIEKTKKLk--IGNGMDpdtQLGPLTTQKRLNEVEALV 338
gi 182679743 261 DVDVDAVLDIATPTKYGNAGQICVAPDRFYVHesIHDRFIEGLAQRAKALr--LGHGLDdatQMGPLINQRRIDAMESIV 338
gi 198252992 259 DADLGAALDACVPSKFGNAGQVCVTPDRFFVHdsLHDTFVAEFAKRAAALt--LGDGLDddvEMGPLINAGRMTEVDAIV 336
gi 20804006  259 DADLAKAIPAISEYKFECAGQSCNAPSRILVArtLYEEFLSRMTEAARKIr--IGLPDDpatEMGPMANARRIEAMQRLT 336
gi 167746722 260 SADLAAAADTVASMKMGNSGQMCVDHNRIYIHesVYDQFCDMMLERLEKYk--VGQGADegmIIGPMINQSAQKTMEDLV 337
gi 109897221 259 DADVDLAADIVCGLKFENAGQICVAPNRVFVHrdVAEIFYQKVLARTQAVk--VGFDRNdaiDMGPVIDQQAWQRIDALV 336
gi 168334179 256 DADVAKAAAEISDLKYGNAGQVCVSPNRVFVHknVADEFVEEVLAFVKKIklkVGDDSNe-vLMGPIASEEYAQGMVAFT 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
3EK1_A       367 EDavskGAKLITGGKEl-----gGLFFEPGILTGvtsdmLVAKEETFGPLAPLFAFDtEEEVIAQANDTIFGLAAYFYTE 441
gi 17989214  345 EDaltkGAKIETGGNRig---dtGNFYEPTILSGmtaemLAMNEEPFGPLALVMRVHsLDEAIAESNRLPVGLGAYLFTS 421
gi 110636091 343 EDarskGARILAGGQRpsg-fnrGFFFEPTVLGDvpdtaLIFEEEPFGPVAPIIPVRsVQEAVEKANAVKWGLAGYLFTS 421
gi 207082954 339 EKtkqeGAKVLLGGKRpag-fnkGFFYEPTIFDEvkddfTIMKEEPFGPLVPMLSFKsFDEVIERANNHELGLCSYVCTN 417
gi 182679743 339 ADaesrGGRIATGGQRpag-qnkGFFFAPTVISGlpdnaKALAEENFGPIAAVTPFSdPESVYERANASEFGLAAYVFTR 417
gi 198252992 337 QEavaaGAKLETGGQRaag-fnvGHFYEPTVLSNvtddmRVFADENFGPIAAISRFSgDDEVWARANASTMGLSAYAFTR 415
gi 20804006  337 KDavdrGAHIETGGTRld---gaGFYWPPTILTGvpkdaRVLHEEPFGPILTVAPFDtLDEAIGEANDTEYGLAAYFFTD 413
gi 167746722 338 EDavdkGARLVLGGKIpegmpegSAFFEPTLLLDcnrsmKVYQQEIFGPIAALSKYSdYDEILAEAADTDGGLSSYLFSH 417
gi 109897221 337 NDavakGAEVLIGSGRpah-lpkGAFYAPTVLKGvtrdaNIYREEVFGPVISILTFDeEAQVVKDANDTDAGLSSFIFTA 415
gi 168334179 335 EDaiakGAKLLAGGKRtg----vGYFFEPTVLLGvtnemRVYKEEVFGPIMSIIPFDdSDDIVALANDTEYGLAAYVYTK 410
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    
3EK1_A       442 NFSRAIRVSEaLEYGMVGHNTGliSNEV-APFGGVKQSGLGREGSKYGIEEYLETKYICS 500
gi 17989214  422 SMTTAHRVQNhLQAGMLGVNHFalALPE-TPFGGVRDSGFGSEGGLEGIEAYLTTMTVTT 480
gi 110636091 422 SLADATKVSEaMQVGMVGLNTFaaAAPE-APFGGVKESGYGRECGLEGIREFVSSKLIHT 480
gi 207082954 418 SMETAHLASEqLETGSVAVNTGfvAIAE-APFGGIKQSGYGREGGSMAIKDYLNVKYTHL 476
gi 182679743 418 DPARMREAVSrIETGMVAVNSTalAAAE-APFGGIKFSGMGREGGSEGILDFLNVKLAQV 476
gi 198252992 416 SPERARRAAAtLKAGMVGINSFalAASE-APFGGTNYSGLGREGGSEGIEDYLDTKLLQI 474
gi 20804006  414 AADTQRKLTNsLSAGAVSVNYLkgVSAD-APYGGVKQSGYGYEGGEQGVRSFQILKMVNG 472
gi 167746722 418 DTKEIAKAVEiFNSGEVLINVDgiGDVEfLPHCGIGNSGLGCDNSLWSLDEYFELKRVKI 477
gi 109897221 416 NEERAQRIAKrLRFGEVHVNGVk-YAIH-LPHCGVKQSGVGVDCSHLSLEEYFTVKRIST 473
gi 168334179 411 DLDCALELGSaIEAGSVSINEPl-YDFN-LPHGGLKESGIGKDCSLYSLEEYYYVKRLSI 468

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