Conserved Protein Domain Family
ALDH_F16

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cd07111: ALDH_F16 
Aldehyde dehydrogenase family 16A1-like
Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.
Statistics
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PSSM-Id: 143429
View PSSM: cd07111
Aligned: 12 rows
Threshold Bit Score: 766.173
Threshold Setting Gi: 74728442
Created: 14-Dec-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 74728442   19 YGPVPESHacalaWLDTQDRCLGHYVNGKWLkpehrnsVPCQDPITGENLASCLQaqaeDVAAAVEAARMAFKGws-aHP 97
gi 156120387  19 YGPAPESHacalaWLDTQDRHLGHYVNGQWLkpehrssVPCQDPITGENLASCLQaqseDVAAAVEAARASLENws-tQP 97
gi 119717751   7 YAPAPESR-----AVVDIKPSYGLFVNGAFVdgh-gasFKTISPATEEVLAEISEadesDVDAAVKAARTAYDKvwsrMP 80
gi 196003516  42 YGPAPESPdvayaWLDDHHRSFGHFIDGKWLnpedrkrYDSRCPATGEKLASTVQgnqeDVEVAVSAARKAFVKws-aLP 120
gi 156376445  40 YGPAPEASnavnaWLTSHGRTFGHFINGKWVkpegrkvYESKNPATGEVLASTTQgetqDIEDAVKAARTAFQSws-kLP 118
gi 72155909   27 YGPNPEAPssaqaWLESHDRKLGHFINNKWVrpenrktYTTRGPAAGEPLATTVQgeeeDVELAVSSAEKAYESws-kLP 105
gi 83815360   22 YAPAPQSA-----DHVRLDDRYGPFIDGEFRevd--eyFPSINPATEEPLAEVGLadeaVVDEAVGAARTAYEShwrdLP 94
gi 198437608  18 YGPAPESAdvakkWLSQHKDSLGHFINGEWVkpenrktYTTCSPATGEALADTIQgeeeDVNLAVSCAKTAFQSws-qLP 96
gi 121609642  13 YGPCLEAAapvhsWLDAHAHSFRHFIHGEFVapaqneyFEVFNPATEERLARVAHgsdaDIDQAVAAARQALPAws-gLS 91
gi 159900311   3 YGPAPEAAapaheWLDAHSRRFGLYINGTWTevanerlFDSINPANRSVLAQVTQassdEVNAAVAAAKAAFPAws-qTS 81
gi 13474007    3 YGPAPEARneadaWLAARDFGKALFIDGAWKaasggktFDTSEPSSGKLLAKVSDasaaDIDAAVAAATKALPKws-aSS 81
gi 147900524   3 YGPAPEAAniaqaWLDSHQRSFGHFIDGKWLkpegrktYTTKNPATGEALATTIQgedeDVETAVKAARKAFESws-kLP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 74728442   98 GVVRAQHLTRLAEVIQKHQRLLWTLESLVTGRavreVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM---GVIGLILP 174
gi 156120387  98 GAIRAQHLTRLAKVIQKHQRLLWTLESLVTGRavreVRDRDVPLAQQLLQYHAVQAHTQEEALAGWEPM---GVIGLILS 174
gi 119717751  81 GRERAKYLYRIARIIQERSRELAVLESLDNGKpikeSRDVDVPIAAAHFFYYAGWADKLEYAGHGRDPQp-lGVAAQVIP 159
gi 196003516 121 AHVRARHLYSVARHVQKHMRLFAVIESLDNGKpireTRDCDIPIVIRHIYHHAGWAQLADTEMRGWKPV---GVVGAITP 197
gi 156376445 119 GHARARHLYSIARHVQKHARLIAVLESMDNGKsvreTRDCDIPNVARHLYHHAGWAQLMDTEMQGWKPV---GVVGGIVP 195
gi 72155909  106 CHVRARHIYSIARHVQKHHRLIAVVEALDNGKpireTRDADIPIVIRHLYHHAGWAELMDTEMANWKPV---GVVGAIVP 182
gi 83815360   95 GKERAKYIYRIGRMIKEKSREFAVLESMDGGKpireSRDMDIPLVAAHFFHYAGWADKLEYALPGPGRPrslGVCGQIIP 174
gi 198437608  97 AHTRARHLYAVARNVQKHHRLIAVIEALDNGKsireTRDCDIPLVARHFYHYAGWAQFSDTEMREWKPV---GVVGAIVP 173
gi 121609642  92 GHQRARYLYAIARHLQKHARFFAVLETMDNGKtireSRDIDIPLVVRHFYHHAGWAQLLDSEFPAHQAV---GVCGQIVP 168
gi 159900311  82 GHVRARYLYALARQIQKHSRRFAVLETLDNGKpireTRDIDIPLVARHFYYHAGWAQLQESDLAGYEPL---GVVGQIIP 158
gi 13474007   82 GYARAKVLYAIGRAMQRHQRLFAVLESIDNGKpireSRDIDVPLAIRHFIHHAGWAQALDRDFPGHKGV---GVVGQIIP 158
gi 147900524  82 CHVRARYLYSIARTVQKHQRLLSVIESMDNGKpireSRDCDVPLVVRHFYHHAGWAQLRDTEMNGWKPL---GVIAAIVP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                                              
gi 74728442  175 PTFSFLEMMWRICPALAVGCTVVALVPPa-SPAPLLLAQLAGelGPFPGILNVVSGPAslVPILASQPgIRKVAFCGAPE 253
gi 156120387 175 PTFPFLDMMWRICPALAVGCTVVVLVPPa-SPTPLLLAQLAGelGPFPGILNVISGPAslGPVLAAQPgVQKVAFCGAIE 253
gi 119717751 160 WNFPLLMLSWKIAPALACGNTVVLKPAEttPLSALLFAEICQqaDLPPGVVNIVTGAGgtGQALVGHPgVDKVAFTGSTE 239
gi 196003516 198 WNFPLMLLIWKVCPALAMGNTVVLKPATytRLSALLLAEVCAeaGLPPGVFNVVTGNGafGHNLATHPdVDKVGFTGSTE 277
gi 156376445 196 WNFPLMLLCWKVCPALAMGNTVVLKPATytRLSALLFAEICAeaGLPPGVFNVVTGNGafGSQLAGHPdVDKVAFTGSTE 275
gi 72155909  183 WNFPLMLLIWKVCPALAMGNTVVLKPATytRLSALLFAQICAeaGLPPGVLNIVTGNGafGSKLALHPrVDKVAFTGSTE 262
gi 83815360  175 WNFPLLMAAWKLAPALATGNTVVLKPAEttPLTALKLAEVIQeaGLPPGVVNIVQGAGevGSALVEHPdVDKIAFTGSTG 254
gi 198437608 174 WNFPLMLLTWKVCPALAMGNTVVLKPATftRLSALLFAEICHeaGLPPGVFNVVTGNGsfGSKLALHPdVDKVAFTGSTP 253
gi 121609642 169 WNFPLLMLAWKVAPALAAGNTVVLKPAEftPLTALAFAELCVevGLPAGVLNIVTGDGhtGASLVNHAgVDKIAFTGSTA 248
gi 159900311 159 WNFPLLMLAWKIAPALAMGNTVVLKPAEwtSLTALAFAEICHeiGLPKGVVNIVTGDGkvGEQIVKHPdIAKIAFTGSTE 238
gi 13474007  159 WNFPLLMLAWKIAPALAAGCTVVLKPAEftPLTAILFAEICEraGVPKGVVNIVQGGPeaGAAIVNHPgIQKIAFTGSSE 238
gi 147900524 159 WNFPLMLLTWKICPALAMGNTVVLKPATytRLTALLLAEICAeaGLPPGVFNVVTGNGafGGKLADHPdVDKVAFTGSTE 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          #                                #  #                         
gi 74728442  254 EGRALRRSLAGeCAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSD---RGPGGLRLLIQESvWDEAMRRLQERMGRL 330
gi 156120387 254 EGRALRRTLAGwVPELGLALGAESLLLLTEVADVDSAVEGIVDAAWSD---RSPGGLRLLIQEAvWDETMRRLQERMGRL 330
gi 119717751 240 VGKAIARSVAGtSKRVTLELGGKAANIVFDDAPIDQAVEGIVDGIFFNqghVCCAGSRLLVQESiAEDLLERLKARMSTL 319
gi 196003516 278 VGRILRQATAGsGKKISLELGGKSPFVVFDSADLDSAVEGVVDAIYFNqgqVCSAGSRLIVQEScAELLIKKIKERMTHL 357
gi 156376445 276 VGKLLRQLTAGsGKKLSLELGGKSPFVVFDSADLDSAVEGVVDAIWFNqgqVCSAGSRLLVQETcAQRMIKKIKERMTHL 355
gi 72155909  263 VGQILRRATAGtGKKLSLELGGKSPFVVFESADLDSAVEGIVDAIWFNqgqVCSAGSRLIVQETvMSKMVAKLRERLMHL 342
gi 83815360  255 VGKHIQKQLAGtKKRLTLELGGKGANIVFEDAPIDQAVEGIVDGIYFNqghVCCAGSRLLVQESvAEEVTRKLRDRIATL 334
gi 198437608 254 VGQTLRRLTAGtGKKLSLELGGKSPVIVMDTADIDSAVEGIVDAIYFNqgqVCSAGSRLLVQENiFDDVIQRVKERLKHF 333
gi 121609642 249 VGRLIRRATAGtDKKLSLELGGKSPFIVFDDADLDAAVEGVVDSIWFNqgqVCCAGSRILVQESvAARFGDKLRARMRKL 328
gi 159900311 239 VGKIIRSATAGsGKKLSLELGGKSPFIVFDNADLDSVVEGVVDAIWFNqgqVCCAGSRLLVQENiADKLIGKLRTRMEQL 318
gi 13474007  239 VGKIIRKATAGsGKKLSLELGGKSAFIVFEDADLDSAVEGLVDGIWFNqgqVCCAGSRLLVQEGiAEALIAKVKTRMSRL 318
gi 147900524 239 VGRTLRKATAGtGKKLSLELGGKSPFIVFDTSDLDSAVEGIVDAIWFNqgqVCSAGSRLLMQESiSEDLVRRLKQRMSHL 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 74728442  331 RSGRgLDGAVDMGARGAAACDLVQRFVREAq-sQGAQVFQAGDVps-eRPFYPPTLVSNLppasPCAQVEVPWPVVVASP 408
gi 156120387 331 RCGHgLDGAVDMGARGAAARDLAQRYVSEAq-sQGAQVFQAGSEps-dSPFFPPTLVSDLppasPCTQAEVPWPLVVASP 408
gi 119717751 320 RMGDpLDKNTDIGAINSGEQLKRIRELSEVgdaEGAERWEVACDlptkGFWFPPTIFTGVsqahRIAREEIFGPVLSVLT 399
gi 196003516 358 RLGDsLDKAIDMGAIVDPSQRKSVDMMVQEakaDGAHVYQACACmpstGCYYPPTLITNVqtvsKIVQEEVFGPVLVVLT 437
gi 156376445 356 RLGDpLDKSIDMGAIVDPSQQKSVAKMVEEaraEGAEVYQKCASlp-sGCYYPPTLITNVqpvsKIVMEEVFGPVLVVLT 434
gi 72155909  343 RVGDsLDKSVDMGAMVDPSHLKTVTEYVEDarrEGAEIIQNPDCipkkGCFYPPTLITNVqtssRVVMEEIFGPVLVVLP 422
gi 83815360  335 RVGDpLDKNTDIGAINSKPQLEKIRRLVDVgerEGADKFQPECNlpddGFWFPPTFFTNVtqshRIAQEEIFGPVLSVTT 414
gi 198437608 334 RIGHsLDKAIDMGAIVSQAQYNTIKEYVDDaraTGADVFQPDIPlpakGLFYPPTLITNVqtvsRVVREEIFGPVLVALP 413
gi 121609642 329 RIGNpLDKSNDVGAIVDRVQLQRIRQMVESgraDGLSCWQTALDapssGHFFAPTFFEDVpaahALAQEEIFGPVVISMG 408
gi 159900311 319 RIGDpLDKAIDIGAIVAPAQLQKIEQLVAEgenEGSIKWQPSWAcptdGYFYPPTLFTNVapasTLAQVEIFGPVLVTMT 398
gi 13474007  319 RVGSpLDKNTDIGPLVDLTQLDRVKGLVAEgakQGAVCWQPDAAlpssGYYHLPTLATGVspanILAQEEVFGPVLATMT 398
gi 147900524 319 RLGDsLDKTIDMGALVDETQKKTIEEFVEEaraEGADVFQSPGPipkkGLFYPPTLITGVnttsRCVREEIFGPVLVAMT 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 74728442  409 FRTAKEALLVANGTPRGGSASVWSERLGQALELGYgLQVGTVWINAHgLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPS 488
gi 156120387 409 FRTAKEALAVANGTPRGGSASVWSERLGQALELAYgLQVGTVWINAHgLRDPAVPTGGCKESGSSWHGGQDGLYEYLRPS 488
gi 119717751 400 FRTPAEALEKANNTPYGLSAGVWTDKGSLILKMAAsLRAGVVWANTFnKFDPTSPFGGYKESGYGREGGRHGLEAYLRSP 479
gi 196003516 438 FRTPKEAIALSNNTVFGLGASVWTENLSLALEVALsIRAGSVWVNGHnLFDAAAGFGGMRESGFGRDGGKEGLYEYSVPA 517
gi 156376445 435 FRTAKEAVAIANNTNFGLGASVWTENLSLAMEVGLsMKAGAVWINGHnLFDAAAGFGGYRESGYGRDGGKEGLYEYVCPT 514
gi 72155909  423 FRTAKEAVALANNSNYGLAGSVWTENVSLGLEVALsIKAGAIWINAHnMFDAAAGFGGYRHSGYGRDGGKEGLYEYVVPS 502
gi 83815360  415 FRTPEEAVERANNTEYGLASGIWSDKGSKLFSISQaLKSGVVWGNTYnKFDPASPFGGYKESGFGREGGMHGLLPYLERP 494
gi 198437608 414 FRTAKEAGNLGNNTNYGLAASVWSENLPTALELAItLKAGTVWVNCHnLFDAAAGFGGYRESGFGRDGGKEGLYEYVMPK 493
gi 121609642 409 FRTLDEAVALANHSRYGLAASLWSENIDVCLTVAAqLAAGVVWVNGAnMFDAAAGFGGYRESGFGREGGREGMHEYLVPK 488
gi 159900311 399 FRTPDEAIAIANNTRFGLAASIWSEDINVALHAAArVKAGVVWINSTnLFDAAAGFGGYRESGYGREGGKEGLYEYLKKS 478
gi 13474007  399 FRNTEEAIELANNTRYGLAASVWSENVNLALHVAPqLKAGVVWVNGTnMFDAACGFGGYRESGFGREGGREGMFEYLTAK 478
gi 147900524 399 FRTAKEAIALGNNTPYGLAASVWTENLPLALEVALsIKAGTVWVNGHnMFDAAAGFGGYKESGFGRDGGKEGLYEYVRPS 478

                 ....
Feature 1            
gi 74728442  489 GTPA 492
gi 156120387 489 GTPA 492
gi 119717751 480 HEGA 483
gi 196003516 518 WLTR 521
gi 156376445 515 WQER 518
gi 72155909  503 WMEK 506
gi 83815360  495 SQSW 498
gi 198437608 494 WERT 497
gi 121609642 489 WLHA 492
gi 159900311 479 EVKK 482
gi 13474007  479 LPLG 482
gi 147900524 479 WESR 482

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