Conserved Protein Domain Family
ALDH_SNDH

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cd07118: ALDH_SNDH 
Gluconobacter oxydans L-sorbosone dehydrogenase-like
Included in this CD is the L-sorbosone dehydrogenase (SNDH) from Gluconobacter oxydans UV10. In G. oxydans, D-sorbitol is converted to 2-keto-L-gulonate (a precursor of L-ascorbic acid) in sequential oxidation steps catalyzed by a FAD-dependent, L-sorbose dehydrogenase and an NAD(P)+-dependent, L-sorbosone dehydrogenase.
Statistics
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PSSM-Id: 143436
View PSSM: cd07118
Aligned: 11 rows
Threshold Bit Score: 742.617
Threshold Setting Gi: 69937957
Created: 14-Dec-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 1486252    34 RSSPAHDVPVTRIPRct-reDLDEAVAAARRAFENgswaglAAADRAAVLLKAAGLLRERRDDIAYWEVLENGKPIsQAK 112
gi 13472679   60 RKSPGHGFTVSRYAQag-eaEVEAAVQAAHKAFETgpwprmKAGERAAILFRAADLIEARLEDIARLDALESGKPIaQAR 138
gi 121610501  41 RRSPAHGQLVAVYAEag-vpDAQRAIGAARQAFDKgpwpllKGAERARILRHVADGILARRHALARMESLENGKPLaQSL 119
gi 118591969  40 RLSPSHGSVVTQAAKgg-vrDVDAAVSAARLAFDKgrwsrtSGKERATLLLKIADLIDRERERIAYWETLESGKPIsQAM 118
gi 116670410  35 RLSPAHEVEVTSFPEgg-heDVNRAVTAARKALDRgwr-qsTGSERSKLLLKVADLVRRDAEALSLAETLETGKPItQSR 112
gi 198263786  34 RESPAHSRVVSIYAAat-kdDTDVAISAARCSFDSgnwayaYAGDRAAVLRAVAQKIRDNVEELALVETLESSKPIgVSR 112
gi 187918903  39 RKSPGHGVPVTATPRac-vdDLNAAVASARRAFDDgrwsrlSGEQRATVLLKTARLIRDKVETLAYLETLESGKPIgQSR 117
gi 188533393  38 RIGPAHGIVVANYPEgs-keDAGLAISAAHRALDKewa-tlTASERAKLLLKVAEGIAARVDEMAMIECLETGKPLsQAH 115
gi 13471129   31 RRSPATGDLVARYADgt-peDVDLAVEAARIAFEDgpwprmSGMERAEVLNRLADLIRTNRDRLVRIEVEEVGKPVrFAR 109
gi 69937957   25 RHSPAHGAALADFAAgt-aeDLDAAVRAAREAFEHgpwrqmPATQKAAILNAWGDLIAADLERLAVIEAEESGKPIrFAR 103
gi 16262570   40 RVSPGHAGEVVGTWPeasadDVRKAVAAARKAFDAgpwprmSGAERSRLMFKVADLILARQEELALIESLEVGKPIaQAR 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          #                             
gi 1486252   113 GEIDHCIACFEMAAGAARmLHGDTFNnLGEGLFGMVLREPIGVVGLITPWNFPFMILCERAPFILASGCTLVVKPAEvTS 192
gi 13472679  139 GEIGGAVDIWRYGASLARtLHGESYAnLGDAMLGVVLREPIGVVSIITPWNFPFLIVSQKLPFALAAGCTAVVKPSEmTS 218
gi 121610501 120 AEIEGAADLWQYAASLARnLHGDSYNtLGAATLALVLREPIGVVGIITPWNFPFLIVSQKLPFALAAGCTAVVKPAEvTS 199
gi 118591969 119 AEIEGASDIWRFAASLARtMHGESYNsLGSDMLGLVLKEPVGVVSIITPWNFPFLIVSQKLPFALAAGCTAVIKPSEmTP 198
gi 116670410 113 NEVSGTAELWEYAASLARnTHGDAHNaLGQDTLAMVVHEPIGVVGMITPWNFPLLIISQKLPFALAAGNTAVIKPSEsTS 192
gi 198263786 113 GEVMFAAELWDYAAGQARgLHGDSHNnLGPDMMGMVLREPIGVVGIITPWNFPLLILSERLPFALGAGCSVVVKPSEfTS 192
gi 187918903 118 GEINAAAGIWEYAAGLARvVHGDSHDtLGADLFGLTVRQPIGVVGIVTPWNFPFFILSERLPFVLAAGCTAVVKPAElTS 197
gi 188533393 116 GEVSGCVDLWRYAASLARtLHGESYNnLGDSMLGVVVRQPVGVVTMITPWNFPIWILSQKLPFALAAGCTVVIKPSEfTN 195
gi 13471129  110 GDIDGAAGLTRYAASLAMqMAGLTYTnIGDGKTALISREAVGVVALVTPWNFPALILSQKVPFALAAGCTVVLKPSEfTP 189
gi 69937957  104 GEIEHSVSMLRYAAALGMqLHGEAFEnVGPQALGLVSREPRGVVGMIVPWNFPMVTLFQKLPYALAAGCSVVVKPSElTS 183
gi 16262570  120 GEIGFCADLWSYAAGQARaLEGQTHNnIGDDRLGLVLREPVGVVGIITPWNFPFIIASERVPWAIGSGCTVVLKPSEfTS 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                             #          
gi 1486252   193 ATTLLLAEILAdAGLPKGVFNVVTGTGrtvGQAMTEHQdIDMLSFTGSTGVGKSCIHAAAdsnLKKLGLELGGKNPIVVF 272
gi 13472679  219 ASTFVLGDILLeAGLPAGVVNILAGLGadvGAPMVSHPlVEMVSFTGSTRVGKMTMASAAq-sLKKVSMELGGKNGQIVF 297
gi 121610501 200 GTTVMLGEILLeAGIPAGVVNILVGQGavvGEAMVSHPdVDMLSFTGSTAVGKQAVARSAa-tLKKVALELGGKNPQIVF 278
gi 118591969 199 ATTVILGELCIeAGIPAGVVNIVLGYGdpvGTAMTADKrVDMVTFTGSTGVGKAIVKAAAg-tLKKVSLELGGKNPQVIF 277
gi 116670410 193 ATTVMLGQLIReAGFPAGVVNIVTGGRv-vGAAIAEHPgIDMISFTGSTGVGKGIASAAGr-dLKKVELELGGKNPQIIT 270
gi 198263786 193 GTSLMLAQYLVdAGLPKGVCNILAGDGaivGQTIIDSHdVDMVAFTGSSRVGKMAIKASAg-nIKKLSLELGGKSPSVVF 271
gi 187918903 198 TTTLKLAALLTeAGLPDGVVNVVTGLGavvGQALAEHMdVDMMSFTGSTPVGRSVLAAAGg-nMKKVGLELGGKNPQIVF 276
gi 188533393 196 GTTLMLGEILIeAGLPRGVVNIVTGLGeevGAPLSTHElVDMVSFTGSTRVGTLIAAEAGr-rLKKVSLELGGKNPQIIF 274
gi 13471129  190 GSAFEIAALAAeAGVPAGAFNVVSGYGataGDHLTGHMgIDFVSFTGSTRTGSRVVGNTSr-hLVKSSVELGGKSANIVF 268
gi 69937957  184 GTALEVAKLAIrAGLPKGVYNVVTGTGgavGEAMTRHPeVDMISFTGSTKVGKAIARTCAd-sVKRVALELGGKAANVVF 262
gi 16262570  200 GTSIRLAELAReAGIPDGVFNVVTGYGdpaGQVLAEDPnVDMVAFTGSVRVGTKLGEIAAr-tVKRVGLELGGKGPQIVF 278
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            #  #                                                        
gi 1486252   273 ADsNLEDAADAVAFGISFNtGQCCVSSSRLIVErsvAEKFERLVVPKMEKIrVGDPFDpetQIGAITTEAQNKTILDYIA 352
gi 13472679  298 PDaDLEAAADAAVFGGFFNaGECCNAGSRLIVHeaiADDFLSAVKALTARVtVGDPLDdqtKVGAMISSDHLAKVTDYVT 377
gi 121610501 279 ADcDWEAAVDAAVYGIFFNaGQCCNSGSRILVQdavADKFAEAVIARSRQVrVGDPFDertQVGAITTERQLHTILAHVE 358
gi 118591969 278 PDaDLESAVDAVVFGVYFNaGECCNSGSRIIVHediAEAFLKATVELSRKVpFGDPLDpstKVGAIITPDHQSKIDKYVR 357
gi 116670410 271 ANaDFTAAVDAGVFGGYFNvGQCCNSGSRLIVHrsiADEFASAVVERAQHMrVGDPLKaetLVGSLVNDAQLAVVERYVA 350
gi 198263786 272 ADcDIDAAIDGVLKAANVNmGECCIAGSRLLIQdsiADAFQAKLAARLKDLkMGDPFDptsRIGAIINDRQYAQISSYVD 351
gi 187918903 277 ADaDLDDAADAIAFGICFNaGQCCVSGSRLVVHrsvEEELVARVKAVFEKVrVGDPLDasnHVGAIVEARQFDKIRGFID 356
gi 188533393 275 PDcDWDAAVDAVVFGVYFNaGECCNSGSRILVHkdiADKFTRAVVEKSRLVrVGDPLNpevKIGAIINENQMITIEKAIQ 354
gi 13471129  269 ADaDLEAAADGALMGVFFNnGECCVSGSRLFVQssiADDFIAKVIARSRKMkVGDPFDddtDVGALIDRNHLAKVTGFVK 348
gi 69937957  263 ADaDLDAAVDGVLFGYVLNqGEECVCGARLLIEesvADAFVSRLVERTRKIrTGLPLDedaDQAAMIHEAQFDQVMDYLE 342
gi 16262570  279 ADaDLDAAADGIAYGVYHNaGQCCISGSRLLVQegiRDALMERLLDISRKVaFGDPLNertKIGAMISEAHAEKVHSYVT 358
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 1486252   353 KgkaeGAKLLCGGGIvdf---gkGQYIQPTLFTDVkpsMGIARDEIFGPVLASFHFDtVDEAIAIANDTVYGLAASVWSK 429
gi 13472679  378 AaageGSNVYSGGKQlas---naGQYLDPTIIRGVtedMAIAREEVFGPVLSVLTFEsIEKALHIANNTPYGLSAGVWSA 454
gi 121610501 359 GarqaGATVALGGARld----rpGLYMEPTVLTGVtrdMAIARQEVFGPVLSMLRFGtLDEAVDLANSTLYGLSAAVWSQ 434
gi 118591969 358 DaaeaGATVRLGGEAlsvp-glaGQFYQPTIVADVksdMPIAREEVFGPVLSVLTFKtLDEAIDLVNDADYGLSAGVWSE 436
gi 116670410 351 EgrdaGAHLLTGGDRldt--glnGRFYQPTVFTDVtahMTIATDEIFGPVLSVLPYDtLEEAIGIANSTSFGLSAGIWSN 428
gi 198263786 352 IavkeGATMVCGGDQda----ydGLFFPPTIIADVrpeMRVAREEIFGPVLVMMTFQdRDEAIKLANATDYGLAAYVWTQ 427
gi 187918903 357 AgrrdGAQLVHGGEStsh---geRFFIQPTLFRNVqpqSALAQEEIFGPVLSVTSFDtFEEAIQLANGVPYGLAASIWTR 433
gi 188533393 355 SardqGAEILLGGERips---rqGLFLEPTIVGNVtpgMDIAREEVFGPVLSILTFEdKDQAIKIANDTCYGLSASVWSK 431
gi 13471129  349 SgieeGAQLVLGGNVaag---avGHFHEATIFDRVephMTIFREEIFGPVLSITRFDtVDDAVRLANDTAYGLSNYIWSK 425
gi 69937957  343 IgkaeGATVAVGGGRaeegalakGYFVMPTIFTDVspdMRIFREEIFGPVLTVTTFKtVDEAVTLANDTVYGLGNGLWTK 422
gi 16262570  359 AgitsGAELLLGGERigr---eaGLYYAPTVFAGVtpdMSIAREEIFGPVLSTLTFKtADEAVALANATEFGLSASVWST 435
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                                                                   
gi 1486252   430 dIDKALAVTRrVRAGRFWVNTImsGGPETPLGGFKQSGWGREAGLYGVEEYTQIKSVHI 488
gi 13472679  455 sIDTCMSVARgVRSGTVWVNTFmeGYPELPFGGYKQSGLGRELGKRAVEDYTEEKTIQF 513
gi 121610501 435 dINTCITAARrIEAGTVWVNTFleGHAELPFGGYRESGIGRELGRFAAEDYTETKTVHL 493
gi 118591969 437 nVHTCLEFARrAHAGTVWTNTWmdGFAELPFGGMKESGQGRELGKYGLDEFLEAKTVTM 495
gi 116670410 429 dINEALTAARdLRAGTVWVNRWmdGYPEVPFGGYGHSGIGRELGRQALAEFSELKTIQL 487
gi 198263786 428 dLANALYCTRhIKAGRVWVNSAldGFPEMPLGGFKQSGNGRETGRYGIEEYTELKSVHL 486
gi 187918903 434 dLQGAISSFReVQAGRIWVNCTitGGPEMPIGGVKQSGIGRETGRYGVEEYTELKSVHV 492
gi 188533393 432 dIDICLEAARkIKAGTVWVNTFldGSPELPFGGFNQSGLGRELGRHAVEDYTEQKTIQL 490
gi 13471129  426 nIDTVLTVAKrLKSGWVQANTIidGAPQLPLTGVKGSGFGYEMGQAGFEEFTQLKTLLI 484
gi 69937957  423 dLDKAILVARrLRSGTVFVNTFleTSVQMPFGGFKQSGIGRENGIDGLLEYTEVKSTFI 481
gi 16262570  436 nLETALQTIRrIRAGRCWINSVidGTPELPIGGYKKSGLGRELGRYGFDEYSQFKGVHV 494

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