3FG0


Conserved Protein Domain Family
ALDH_BADH-GbsA

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cd07119: ALDH_BADH-GbsA 
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Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like
Included in this CD is the NAD+-dependent, betaine aldehyde dehydrogenase (BADH, GbsA, EC=1.2.1.8) of Bacillus subtilis involved in the synthesis of the osmoprotectant glycine betaine from choline or glycine betaine aldehyde.
Statistics
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PSSM-Id: 143437
View PSSM: cd07119
Aligned: 13 rows
Threshold Bit Score: 808.46
Threshold Setting Gi: 78061385
Created: 14-Dec-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:
  • Structure:3FG0: Staphylococcus aureus Betb binds NAD, contacts determined at 3.5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
3FG0_A        36 YIDGEWvesankntRDIINPYNQEVIFTVSEGtkeDAERAILAARRAFESGEWsq-eTAETRGKKVRAIADKIKEHREAL 114
gi 164660921  12 FIDGKWcasserktRATYNPYDASVIMHVDEAtadDAKRAVTSAKTFFNTSDWph-kTYEERCALLDRMADTLQQHKAEL 90
gi 29828164    5 FIDGEWvrgatgttREVVNPFDATVVRSVDEGdatDVDRAVTAARRAFHAADWaa-aPTQRRADVLFRVAEYLLRDIEEI 83
gi 124522287  14 YINGEWidadnretRAIKNPANGETIAIAPEGttrDAHEAVDAARKAFESGIWsg-iPAQERAAYLFQVADKIDENAKAL 92
gi 167034021   7 FIAGQWrephsgryREILNPANESLLALAPEAgaqDVDAAIDAARHAFDHGPWpq-lPPSERSAWLLRIAAAIEADAAQL 85
gi 73539655    7 YIDGRWqsplegstRDILSPADESVIAQAAEGtraDARIAIAAARRAFDGPWRq--tTIRDRARLLNRIAALIDRDAEEL 84
gi 78061385    7 YIDGAWqpaaaggqRAIIDPATGEAIARVAYGsaaDAGHAIRAARAAFDAGEWph-lPAEERAACLRRLANALRDEAPAL 85
gi 111018876  15 FVDGQWirsssgetRDCINPADGSVVATVDEAspeDATRAVAAARAAFDQGTWpc-tPVAERTALVARIADLLERDKETL 93
gi 150019744   7 YINGEWveaiskktRDVINPANGQVIAKTTEGgieDTKLAIAAAKESFYGKGEwrrmNAQARADILLQIADKIAEKRDKF 86
gi 163941096   6 FVDGKWvaalsgarRNIINPATGEVIATSAHGsadDAKIAIKAARKAFDSGIWsg-lSADERADYLYKIADRLEENTAEI 84
gi 148358448   7 YIDGKFtlaksgttRDIFDPANGELIARVPESakeDAILAIKAARKAFDEGEWrk-sLALDRGKLLFKLADLIRANAKML 85
gi 94968563   15 YIDGKFvesatgklFPVYDPSTEEVIAECPAGnaaDVDRAVAAARTAFDDGPWna-tTAQERGRVLFRIAEKIRQHTAEL 93
gi 2829486     6 FIDGEWisaekeqiRSIINPFNQEEIATVSEGgreDAIKAIAAARRAFDKGEWss-lSGLERGKIVLKIAELIRRDLEEL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                          #####         
3FG0_A       115 ARLETLDTGKTLe-ESYADMDDIHNVFMYFAGLAdk-dgGEMIDspi--pdTESKIVKEPVGVVTQITPWNYPLLQASWK 190
gi 164660921  91 ARIETIDTGKTLg-ESEIDIDDVTQVFRFYAKEAiklaqDKQVTgplipesVKSRIVHEPVGVCVLITPWNYPILQLCWK 169
gi 29828164   84 ARDETLNTGKTLa-EARIDVKDVSNAFRYFAEMAgk-daGRVVDag---pdVLSRVVHEPVGVCALIAPWNYPLLQASWK 158
gi 124522287  93 TRLETLDNGKPLr-EASYDIADAAACFRYYAGLItk-pdGFTYHva---dpMQAMVVREPVGVCGLIVPWNYPLLMSVWK 167
gi 167034021  86 ARLETLNTGKTLc-ESEADMACVVATFRYYAGLLea-rtDRAHPhap--dhVISVTRHEPVGVCALIVPWNYPLLQTAWK 161
gi 73539655   85 ARFESLNTGKTLt-ESRTDMGDIAATFRYFAGLVas-esGAVNEap---hhVISRTLREPVGVCGLITPWNYPLLQAAWK 159
gi 78061385   86 ARIETANTGKTLa-ESSSDVHDAASAFDYFASLAvt-etGSMNAak---phVISVTLREPVGVCGLITPWNYPLLQAAWK 160
gi 111018876  94 ARIETLDTGKTLe-ESRIDIDDVVSVFRYYAQLAav-eaDALVDvgr--peVISRVVREPIGVCVLIAPWNYPLLQISWK 169
gi 150019744  87 AMLDTIDNGKPLr-EAEGDIDDGIHCFRYYAGLItk-pyGGVYDvndgfgqMHSYTVHEPVGVCGQITPWNYPFLMAVWK 164
gi 163941096  85 ARLETANNGKVIraTTYIDIPVSIQCFRYYADLIkg-mkKESYTrd---daSETIIIHEPIGVCGLIVPWNFPLMLAVWQ 160
gi 148358448  86 AELETRNCGKPLp-EAEFDVTDAANCFEFYGGLAtk-ihGETMSvp---anSFSYVVREPIGVCGQIIPWNFPLLMAAWK 160
gi 94968563   94 AEIECRNSGKPIv-EAEYDIADCATCFEYYGGLAtk-itGQVNPvp---dnAVSLSLKEPIGVAGQIIPWNYPLAMAAWK 168
gi 2829486    85 AELESLDTGKTLe-ESKADMDDIANVFQYYAGLAdk-dgGEIISspi--pdSESKIIREPIGVCGQITPWNYPLLQASWK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #  #                             #   #             # ##  #  #      
3FG0_A       191 IAPALATGCSLVMKPSEITPLTTIRVFELMEevGFPKGTINLILGAGseVGDVMSGHKeVDLVSFTGGIETGKHIMKNAA 270
gi 164660921 170 LAPALATGNVVIIKPSEVTPLSSVYLVKLLLeaGFPPHSVQILTASGasVGPVLTESAdVDLVSFTGGLSTGRSIIRSCA 249
gi 29828164  159 VAPALAAGNTFVLKPSEITPLTTIAMMRLIEeaGAPPGVANLVLGAGatVGSAMTVHPeVDLVSFTGGLGTGRRIMESAA 238
gi 124522287 168 IAPALAAGNTIVFKPSEVTPVTAMKLFEIFEeiGLPKGVANMVMGAGpvVGEEIVTHPeVDMISFTGGTKTGKHLMRQAA 247
gi 167034021 162 LAPALAAGNTVILKPSELTPLSALHLTALLAalALPAGVFNLVCGDGt-VGHHMALSDrVDMVSFTGGAQAGAKVMQAAS 240
gi 73539655  160 IAPALGAGNTVIIKPSNLTPLTTHHFTKLIAelDLPAGVFNLVTGGAe-VGAELAESRdVDLVSFTGGAFAGESIMKAAT 238
gi 78061385  161 LAPALVAGNTVVVKPASLTPLSTHRLVELAHdaGLPRGVLNLVTGGAd-VGDALAASPqVDLISLTGSNAAGASVMRAAA 239
gi 111018876 170 VAPALAAGCTMVLKPSEVTPLSTIAFTALIAeaGVPAGVVNLVQGSGavLGAALTGTPdVDFISFTGGLATGRVILETAA 249
gi 150019744 165 LAPAIAAGNSVVFKPSSNTPLSTIALFEIFDeiGLPKGSVNLVLGSGgtVGQEIAESNdIDMVTFTGSTEVGQSIARAAV 244
gi 163941096 161 IAPALAAGNTIVIKPADVTPVSVFKLFEIIEevGLPDGVANLVLGPGskVGNELAESHdVDKIAFTGGTKTGQSIMRAAA 240
gi 148358448 161 LAPALAAGNTVVLKPSELTPITALELFKLIDqcGFPAGVVNLITGPGmgVGEELASNSmVDKVAFTGGSATGRKIMQAAT 240
gi 94968563  169 LAPAIAAGCTVVIKPAEQTPLTLLELAKHFEevGLPNGVVNVVTGYGeeAGAPIVAHKdVDKIAFTGSGSVGKLIMREAS 248
gi 2829486   161 IAPALAAGNTIVMKPSEITPLTTIKVFKLMEeaGVPKGVANLVLGPGatVGDELAVNKdVDLISFTGGIETGKKIMRAAS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                # #                               #                                     
3FG0_A       271 nnVTNIALELGGKNPNIIFDDaDFELAVDQALNGGYFHaGQVCSAGSRILVQnsIKDKFEQALIDRVKKIkLGNGFdadt 350
gi 164660921 250 etVKRCTVELGGKNPNVVFADcDLDWAIDNVLTAVFVHsGQVCSAGARLIVEesIADKLVDGVVKRAQNIvMGNGLdass 329
gi 29828164  239 reVKNIALELGGKNPNVVFDDaDFEAAVDHTLDASFLHsGQVCSAGSRLLVQdsWHDRFVRELADRASRIrLGNGLdpht 318
gi 124522287 248 dtLKKVSLELGGKSPNIIFADaDFETAVDYALYGIFSGaGQVCSAGSRILVEesLYERFVSHFVERAAKIkVGPGDdpdt 327
gi 167034021 241 gnFKRLALELGGKNPNIVFADaDLDVALDQALNAVFFNaGQVCSAGSRLLLQasVHDRFVARLVERIDAIvLGDGFdsrt 320
gi 73539655  239 gnFKRIGLELGGKNPNIVFADaDLDVAVDYALNAAFFHaGQVCSAGSRLMIEdsIYDAFVAKLAERLPRIaIGNGFhaet 318
gi 78061385  240 gnFKRVSLELGGKNPNLVFADaDVDTALDYALNAAFFNaGQMCSAGSRLLVErtLHDAFVDALAARIAAIrVGRGDddat 319
gi 111018876 250 knVTKVAVELGGKNPHIVFADaDGDDSVDQVLTGVFLHsGQVCSAGTRLIIEesIADRFVAALAARAEKIrMGNGLdpts 329
gi 150019744 245 gnLKKVGLELGGKSPNIIFADaDFEGAVEWAMVGIFFNqGEVCSAGSRIIIEesIKDKFVARLAEKANAMtIGNPVnn-p 323
gi 163941096 241 gnMKKITLELGGKSPLIVFDDvDFETAVDNAMFGIFHNaGQVCSAASRLLVQetIYDKFVERLAERANKIvVGNGEseni 320
gi 148358448 241 gnLKKTSLELGGKNPNIVFADcDLEMAIDGALFGAFANqGEVCSAGSRLLVErsIHKKIVEGMLKKIPNIkLGHGLdagv 320
gi 94968563  249 atLKRVSLELGGKSPNIFFADaDFEAAIDGALFGVFINqGEVCSAGSRILVErpIYKKFVEAMTEKAKKIkLGAPLdrdt 328
gi 2829486   241 gnVKKIALELGGKNPNIVFKDaDLEVAVDQALNAVFFHaGQVCSAGSRLLVEdaIHDQFLAELVKRAKRIkLGNGFhaet 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    #                                                     #             
3FG0_A       351 EMGPVISTEHRNKIESYMDVAkaEGATIAVGGKRpdrd---dlkDGLFFEPTVITNcdtsMRIVQEEVFGPVVTVEGFEt 427
gi 164660921 330 ETGPLVSAEHLAKVESYVQLAreEGAVIRCGGRRpdpktfphlaKGYFFLPTVIDKcnrtMRIVQEESFGPILTVERFAd 409
gi 29828164  319 ESGPLSSAEHRAKVEKYIDLGrsEGARLVTGGRRpddp---dlaHGFFLLPTIFDDcdrsMRIVQEEVFGPVVTVETFRt 395
gi 124522287 328 EMGPLVSEEHMKKVLSYIEIGkqEGATLALGGNRllen---gldKGYFVGPAVFVDvkqnMRIVQEEIFGPVVVIQKFKd 404
gi 167034021 321 RMGPLISAAQRNRVLSLIQAAqgEGARLRAGGQRptda---hleKGFWLRPTLLSDvqadMRIAREEIFGPVITVERFTd 397
gi 73539655  319 QMGPVQSAQQHEKILRMVQAGvaEGARLVYGGKRpegd---vyrKGYWLQPTLLADvtadMNIAKDEIFGPVVTAERFRs 395
gi 78061385  320 RMGPVISAQQRDRVLALIGEAarDGARIVCGGRApagd---afaTGFWVEPTLIAGvrttMAIAREEVFGPVLTVEAFDs 396
gi 111018876 330 RTGPLVSEAHREKVERYVALGlsEGARLVTGGARpadp---alaDGSYYLPTIFDHcdrtMRLVQEETFGPILTVERFTt 406
gi 150019744 324 DMGPLVSKEHMETVLKYIEIGknEGATLVCGGERyteg---ecaEGYYVRPTIFDNctsdMTIVKEEIFGPVVTIQTFKt 400
gi 163941096 321 EMGALTNEFHMNEVLHYIQRGieEGAKLVCGGKRlten---gldRGFFIAPTIFADvnenMCIVKEEIFGPVLVVQKFKd 397
gi 148358448 321 KMGPLVSSAHREKVESYVKLGmeEGAKLLCGGKRptgs---efaKGHFFEPTIFDEvkstMRIAREEIFGPVLVVIPFDt 397
gi 94968563  329 KMGPLVSKDQYERVREYQEIGk-KEAKVASGGNRpsg-----faKGYYVEPTIFYDvdnsARIAREEIFGPVASVIPFDn 402
gi 2829486   321 ESGPLISAEHRAKVEKYVEIGieEGAKLETGGKRpedp---elqNGFFYEPTIFSNcnsdMRIVQEEVFGPVLTVETFSs 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
3FG0_A       428 --EQEAIQLANDSIYGLAGAVFSKdIGKAQRVANKLKLGTVWINDFHpYFAQAPWGGYKQSGIGRELGKEGLEEYLVSKH 505
gi 164660921 410 gdERTAIMLANDTKYGLAGGVQSKdQARAERVARRLRHGTVWTNTYGvYTAQSEWGGYGMSGNGRELGSKGLDEYVEVKH 489
gi 29828164  396 --EDEAVELANDTRYGLAAGVWTGeASRAQRVAARLRHGTVWINDFHpYLPQAEWGGYGQSGVGRELGPTGLREYQEIKH 473
gi 124522287 405 --EAEAVKLANDTVYGLAGAVFSNdGAKALRVIKKIRSGITWINSYHpTYNEAPWGGYKQSGIGRSLGTFGLEEFQEIKQ 482
gi 167034021 398 --EAHAVRLANDTPYGLAAGVWTGdLGCANRMARRLRVGTLWVNDYNlAFPQAPWGGFKASGIGRELSATGLEEFSELKH 475
gi 73539655  396 --EDDALRAANDTPYGLAAAVWTRdLDKANRMSRALRFGTVWVNDYHpYFPEAPWGGYKASGIGRELARIGLDEYTELKH 473
gi 78061385  397 --EDEAVALANDTPFGLAGAVWTRdFARANRVMRRLRAATVWINDYNvTLPGAPWGGYKASGIGRELSRSGLDEYTELKH 474
gi 111018876 407 --EEEALRLGNDTEYGLAAGVRTAdSARGERMVRGLRHGTVWLNDFGyYTAAAEWGGFKMSGNGRELGPTGLAEYQETKH 484
gi 150019744 401 --EEEAIALANDTVYGLAGAVFTSdGTIALKVIKEIRAGITWINCYNpTFNEAPWGGYKMSGYGRELGVHGLEEYQEIKQ 478
gi 163941096 398 --EEDAIQKANDSIYGLAGAVFTEdMDLAKRVISKLRAGITWINSYHlAYVEGPWGGYKQSGIGRALGVAGLEHFMETKQ 475
gi 148358448 398 --EEEAIRIANDTDYGLSGAVWTKsVTRAHRVTSQIRAGILWVNHYHpTYNEMPWGGYKQSGAGRELGLYGIESYLEVKQ 475
gi 94968563  403 --EADGLKIANDTPFGLAAAVWTRdIFKAFRMVKKIRAGIVWVNHMQpTYYEAPWGGYKQSGFGRELGPWGVEEYLETKQ 480
gi 2829486   398 --EEEVIELANDTIYGLAGAVWSKdIEKCERVAARLRMGTVWINDFHpYFAQAPWGGYKQSGFGRELGKIGLEEYTEVKH 475
                        490
                 ....*....|...
Feature 1                     
3FG0_A       506 ILTNtnpqlvNWF 518
gi 164660921 490 IWSEtkpakmNWF 502
gi 29828164  474 IYQNlspgpsGWF 486
gi 124522287 483 ININlqveptGWF 495
gi 167034021 476 VLLNcepralNWF 488
gi 73539655  474 SYINlapkamGWF 486
gi 78061385  475 AYLNfeaspqRWF 487
gi 111018876 485 IWHNtsptaaGWF 497
gi 150019744 479 ININltpgpiGWY 491
gi 163941096 476 INIHqhanpvGWY 488
gi 148358448 476 VNINldetpiGWY 488
gi 94968563  481 VHINlseqpiGWY 493
gi 2829486   476 VYRNtkpaavNWF 488

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