Conserved Protein Domain Family
ALDH_EutE

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cd07121: ALDH_EutE 
Ethanolamine utilization protein EutE-like
Coenzyme A acylating aldehyde dehydrogenase (ACDH), an NAD+ and CoA-dependent acetaldehyde dehydrogenase, acetylating (EC=1.2.1.10), converts acetaldehyde into acetyl-CoA. This CD is limited to such monofunctional enzymes as the Ethanolamine utilization protein, EutE, in Salmonella typhimurium. Mutations in eutE abolish the ability to utilize ethanolamine as a carbon source.
Statistics
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PSSM-Id: 143439
View PSSM: cd07121
Aligned: 21 rows
Threshold Bit Score: 611.934
Threshold Setting Gi: 198256520
Created: 1-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative catalytic cysteine [active site]
Evidence:
  • Comment:conserved cysteine that aligns with the catalytic cysteine of the ALDH superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2498347    31 GVFasLDDAVAAAKVAQQgl---kSVAMRQLAIAAIREAGEKHARDLAELAVSETGMGRVEDKFAKNVAQARGTPGVEcL 107
gi 51246891   38 GVFdeLDDAVAAAKAACKli---dTVAMRTRVVEVMRRAARMNARPLAEKAVAETGMGNIEDKVLKTLLVANSTPGPEiL 114
gi 90414628   34 GIYptLDGAVAAAKSAQRei---rTLALRDDIILAVRRTAKKHAKELSEMAVAETGFGRVEDKVAKHLLVAHRTPGTEiL 110
gi 32472043   37 GIFgnASDAVAAARRAFEqlr-qrPMEDRKRVIDIIRKISIENCEELGLMEMRETGIGRPEHKIEKLRALGELSPGTEfL 115
gi 149176725  39 GVFrsVDQAVAAATAGQKqll-naTLADRAKALEIVRQICTSQADELGRMEMEETKIGRLDHKIEKLHLIKSIPGMEF-L 116
gi 75378610   35 GVFenVENAISSAVHAQKilslhyTKEQREKIITEIRKAALQNKEVLATMILEETHMGRYEDKILKHELVAKYTPGTEdL 114
gi 163762382  60 GVFpdVDQAVHAAAGSQKewv-krPVSERRVILEAMKQTVDSQKERYSELAVEETGLGNVADKIAKHELIITKTPGVEdL 138
gi 16803205   36 GVFdtVDEAVQAAVIAQNsyk-ekSLEERRNVVKAIREALYPEIESIAARAVAETGMGNVADKILKNTLAIEKTPGVEdL 114
gi 150018866  16 GVFssVNDAVLAAVGAYNqys-kfTLNERQEIINSIKEKLLSRVEEIAYMTVEETGMGNVHDKIEKLILAIKKTPGIEdL 94
gi 92110356   29 AIFqtVDEAVCAAHQAFLrfq-qcPLKTRSAIISAIREELMPRLTELAEESASETGMGNKEDKYLKNKAALNNTPGIEdL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2498347   108 SPQVLTGDnGLTLIENAPWGVVASVTPSTNPAATVINNAISLIAAGNSVIFAPHPaaKKVSQRAITLLNQAIVAAGGpeN 187
gi 51246891  115 QPTAITGDdGFTLIENAPWGVIASVTPSTNPGSTVINNGISMISGGNAVVFAPHPaaKRITQEAIKLMNKAIAEETGinN 194
gi 90414628  111 VPQAVSGDaGMSLMENAPWGVIASVTPSTNPSCTVINNAISMIAAGNAVVFAPHPaaKKVSQYAIQLVNKASESVGGpaN 190
gi 32472043  116 QTKAFSGDhGLAIIERAPFGVIAAITPVTHSLPTITGNAVSMIAGGNAVVVNPHPsgRLVAAEGVRRFNEEIAREVGidN 195
gi 149176725 117 KTEAVSGDyGVSLTEYAPFGVIGAITPVTHSLPTLACNFINMVAAGNTLVVNPHPggAKIACEGVRRFNRAIYQATGlqN 196
gi 75378610  115 TTTAWSGDnGLTVVEMSPYGVIGAITPSTNPTETVICNSIGMIAAGNAVVFNGHPcaKKCVAFAVEMINKAIISCGGpeN 194
gi 163762382 139 RTDAVSGDhGLTIEEDAPFGVIGAVTPVTNPTTTVIHNSLVMLAAGNAVVFNVHPssKATCQRVVSDLNAAIKDAGGpqN 218
gi 16803205  115 YTEVATGDnGMTLYELSPYGVIGAVAPSTNPTETLICNTIGMLAAGNAVFYSPHPgaKNISLWLIEKLNTIVRESCGvdN 194
gi 150018866  95 ITEVRTGDnGMTLYELSSYGVICAIHPCTNPCATLISNTIGMLAAGNGVVHCPHPraIKVSKYVTEIISIAIRERCGidN 174
gi 92110356  108 TTTALTGDgGMVLFEYSPFGVIGSVTPSTNPTETIINNSISMLAAGNSVYFSPHPgaKYVSLKLITTIEDIAFRCSGihN 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2498347   188 LLVTVANPdietaqRLFKFpgigLLVVTGGEAVVEAARKHTnKRLIAAGAGNPPVVVDETADLARAAQSIVKGASFDNNI 267
gi 51246891  195 LLVCIKEPsldaaqRLFTYpginLLTVTGGEAVVKAARKVTdKRLIAAGAGNPPVVVDETADLARAAESIYIGASFDNNL 274
gi 90414628  191 ICTSVATPslenaqALFTYpgigLLVVTGGDAVVDAARKVTdKRLIAAGPGNPPVVVDETADLERAAISIVQGASFDNNI 270
gi 32472043  196 LICVIAEPtlesaaELFGHrdvaLICVTGGPAVGRAALNSG-KRAIVAGPGNPPVVVDETADLDNAARCIIQGGAYDNNL 274
gi 149176725 197 LVTIVETPtletadEIFNHrgipLLVVTGGPGVARAALAAK-KRAIVAGPGNPPVVVDETADIENAAKSIIIGAAYDNNL 275
gi 75378610  195 LVTTIKNPtmesldAIIKHpsikLLCGTGGPGMVKTLLNSG-KKAIGAGAGNPPVIVDDTADIEKAGRSIIEGCSFDNNL 273
gi 163762382 219 LITMIAEPtldtlnQLAGHqeirLLVGTGGQGLVRSLLQSG-KKAIGAGAGNPPVIVDETADIEAAAKAIILGASFDNNI 297
gi 16803205  195 LVVTVEKPsiqaaqEMMNHpkvpLLVITGGPGVVLQAMQSG-KKVIGAGAGNPPSIVDETANIEKAAADIVDGASFDHNI 273
gi 150018866 175 LVVTLNENsitctnEIMTHpdisMVVTTGGNNVLRQAMASG-KKVIGAGPGNPTTIVDETGDIKKAARDIVRGASFDNNI 253
gi 92110356  188 LIVTVSEPtfaateQMMAHpkisVLAITGGPGIVAMGMKSG-KKVIGAGAGNPPCIVDETADIVKAAEDIINGASFDYNL 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                                              
gi 2498347   268 ICADEKVLIVVdsVADELMRLMEGQHAVKLTAEQAQQLQPVLLkniderg-----------kgtvsrDWVGRDAGKIAAA 336
gi 51246891  275 ICANEKEIIVVesVADQFKREFVAAGAFEISLEQAEAIGKTVLldygtd------------kcranpKWVGRDAYKLAEL 342
gi 90414628  271 VCATEKEIIAVasIADELKAQMCRHGAYEVTPEQAEAIARVVLkcypgd------------kptanpKWVGRDAAKLAEA 338
gi 32472043  275 LCIAEKEVFVVdsVFDDMMAAMRRAGAVQLDQAQIAKLTSVAItqvgddn-----------hdaaakDFIGKDASVLAAA 343
gi 149176725 276 LCIGEKEVFAVesIFDQLMSAMGRHGGFQLNAQQVEQLTSLAFappkepg----------ghailnrDLIGKDAAVLAGM 345
gi 75378610  274 PCIAEKEVFVFenVADDLISNMLKNNAVIINEDQVSKLIDLVLqknnetq-----------eyfinkKWVGKDAKLFLDE 342
gi 163762382 298 LCIAEKEVFALdvIYDDLIYHLLQEGAYMLSESELSQVMKTVLvgdapieaakscsvsvrpdlhiakAWVGKEASAILKA 377
gi 16803205  274 LCIAEKSVVAVdsIADFLMFQMEKNGALHVTNPSDIQKLEKVAvtdkg---------------vtnkKLVGKSASEILKE 338
gi 150018866 254 MCISEKSIVAVssIADLLVEELVRNKVYYVDNDEEMLKLTVATltsdm---------------tlnkTLEGKSANEILKA 318
gi 92110356  267 PCIAEKSLIVVasVADYLIQQMQSFGALLLNHEQTEKLRAICLpdgs-----------------ankKLVGKSPSALLEA 329
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 2498347   337 IGLKVPQETRLLFvet--taeHPFAVTELMMPVLPVVRVANVadAIALAVKLEGGCHHTAAMHSRNIENMNQMANAIDTS 414
gi 51246891  343 IGVTIPAGCKLLFvdvkgdarHPFAVTEQMMPLIPVVRARNFdqALEWALMLERGLSHTAGLHSTNIHNMERMAKAVNTS 422
gi 90414628  339 AGIDVPADTRLLIfda--dksHVFAVIEQMMPILPLIRAANAdqAIDWAVELESGNRHTAAIHSKNIDVLTRMAYEMDCS 416
gi 32472043  344 AGVKVPESCELIFget--dehHPFVSVEQMMPFIPFVRARDVdhAIAMAKHYEHGFRHTAIIHSRNVHNMTKMGKELDTT 421
gi 149176725 346 IGVSVPAGTELLYget--dtnNPFVPEEQMMPFVPFVRCRNAdhGIELAKEFEHGFRHTSMIHSRNIETITKMGRIMDTT 423
gi 75378610  343 IDVESPSNVKCIIcev--nanHPFVMTELMMPILPIVRVKDIdeAIKYAKIAEQNRKHSAYIYSKNIDNLNRFEREIDTT 420
gi 163762382 378 ATGKDLPVKLLICdve---atHPFVQLEQMMPVLPIVRMPDFdaAVEAAVKAEKGNRHTAVIHSKNVDRLTQFARRIETT 454
gi 16803205  339 AGIACDFSPRLIIvet--ektHPFATVELLMPIVPVVRVPNFeeALEVAIELEQGLHHTATMHSQNISRLNKAARDMQTS 416
gi 150018866 319 AGIVCERDIKLIVvnt--ikqHPFATVEMLMPLVPLIRVKNFeiALDTALEIEQGFRHTATIHSQSIERLNVAAKVMQTA 396
gi 92110356  330 ASLPLPAKAPRLLiavv-dadDSWVTCEQLMPMLPIVKVNDFdsALALALKVEDGLHHTAIMHSQNVSRLNLAARVMQTS 408
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
Feature 1                                                       
gi 2498347   415 IFVKNGPCIaGLGLGGEGWTTMTITTPTGEGVTsARTFVRLRRCVLV 461
gi 51246891  423 LFVKNGPHIaGLGAGGEGWTSMTISTPTGEGVTnAATFVRLRRCALV 469
gi 90414628  417 LLAKNGPAIaAIGAGGEGWTTMTISTPTGEGVTnALTFTRKRRCTAV 463
gi 32472043  422 LYVKNGPCMaALGLGGEGYLSFSIAGPTGEGVTtPDTFTRERRCSMI 468
gi 149176725 424 LFVQNGPCGaALGNGGEGYASFSIATPTGEGVTnPMTFTRFRRSTTV 470
gi 75378610  421 IFVKNAKSFaGVGYEAEGFTTFTIAGSTGEGITsARNFTRQRRCVLA 467
gi 163762382 455 IFVKNASSLaGVGFGGEGYATMTIAGPTGEGITsPRTFTRKRRCVLA 501
gi 16803205  417 IFVKNGPSFaGLGFRGEGSTTFTIATPTGEGTTtARHFARRRRCVLT 463
gi 150018866 397 VFVKNGASLvGIGCNGEGDTSFTIATITGEGTTtARHFARRRRCSLT 443
gi 92110356  409 IFVKNGPSWaGIGVGGEGFTTFTIATPTGEGTTsARTFARSRRCVLT 455

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