Conserved Protein Domain Family
ALDH_F20_ACDH

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cd07122: ALDH_F20_ACDH 
Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like
Coenzyme A acylating aldehyde dehydrogenase (ACDH, EC=1.2.1.10), an NAD+ and CoA-dependent acetaldehyde dehydrogenase, functions as a single enzyme (such as the Ethanolamine utilization protein, EutE, in Salmonella typhimurium) or as part of a multifunctional enzyme to convert acetaldehyde into acetyl-CoA . The E. coli aldehyde-alcohol dehydrogenase includes the functional domains, alcohol dehydrogenase (ADH), ACDH, and pyruvate-formate-lyase deactivase; and the Entamoeba histolytica aldehyde-alcohol dehydrogenase 2 (ALDH20A1) includes the functional domains ADH and ACDH and may be critical enzymes in the fermentative pathway.
Statistics
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PSSM-Id: 143440
View PSSM: cd07122
Aligned: 68 rows
Threshold Bit Score: 517.815
Threshold Setting Gi: 108797177
Created: 1-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative catalytic cysteine [active site]
Evidence:
  • Comment:conserved cysteine that aligns with the catalytic cysteine of the ALDH superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 71152980    9 LNALVERVKKAQReya-sfTQEQVDKIFRAAALAAA--DARIPLAKMAVAESGMGIVEDKVIKNHFASEyIYNAykdeKT 85
gi 73540570   30 VAEVVARARHAQRefa-raDQATIDTAVAAAAWAIMepARNRRLAECAVADTGLGNVEDKIRKNYRKTLgLLRDlhgrKT 108
gi 126699960  16 INGYIERARKAQRefe-cyTQEQVDKIVKIVGKVVY--YNAEYLAKLAVEETGMGVYEDKVAKNKSKAKvIYNNlkdkKS 92
gi 34540484    3 IKEMVSLARKAQKeyqathNQEAVDNICRAAAKVIY--ENAAILAREAVDETGMGVYEHKVAKNQGKSKgVWYNlhnkKS 80
gi 186682489 155 VEVMLDKALLAQKeiq-twSEERIDALLLVIASSIA--QHAESLATATVKATRVGDILDKVTKNKIASLgIYRSlvgkSG 231
gi 88797336  138 VDAMVARSVVAQNsiq-tlPEDQIDAMIGDIADAVN--RESWNLAEAAILETGMGVVNHRVQKILLGTMeVAASlmgqTG 214
gi 111026478  12 LDTVLDRAQVAATafe-ayDRSQVDRIVRAVANVAL--QNARQLAEKAADETGFGVAEDKVAKNEAVSSgFVREygdlDF 88
gi 108797177  17 AGHMLERARWAARaya-dyDQAAVSAITTAVADAAY--GAADRFAAEAVAETGMGVVADKVLKNQACSRgILDYyreqDF 93
gi 121607654  25 GLLQLDRAEWAARdfa-qfDREQVLRVAEAVAKAAH--DNAAFYAEWAVRETGYGVVEHKQKKNESVAYpLLDFyrdlDL 101
gi 189425928  16 EGNMLEQAQVAARefa-kfSPQAVDKIVEAVAAVAA--ERSAFYAEWIVRETGYGVVEHKTIKNEGSSAgLVNFykgqNF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 71152980   86 CGVLSeddtFGTITIAEPIGIICGIVPTTNPTSTAIFKSLISLKTRNAIIFSPHPraKDATNKAADIVLQAAIAAGAPkD 165
gi 73540570  109 VGVILqdaeTGITEIARPVGVVAAITPSTNPGATPANKIINALKCGNSVIVAPSPkgQGTCELLLSFIHAEFAKAGLPaD 188
gi 126699960  93 VGIIDidreTGITKVAKPVGVVAAITPCTNPIVTPMSNAMFALKGRNAIIITPHHkaIGCSTKTVEMINEELEKIGAPeN 172
gi 34540484   81 IGILNiderTGMIEIAKPIGVVGAVTPTTNPIVTPMSNIIFALKTCNAIIIAPHPrsKKCSAHAVRLIKEAIAPFNVPeG 160
gi 186682489 232 CGFISnnkiNNVCEIASPMGIIFGMIPMTNPVATAVFKALICIKSRNALILSFPLstKNVGTLVCEIIQEALIRQDAPvE 311
gi 88797336  215 SGALQie-sPMVDAMSVPMGVILGLIPVTNPVETLVFKTLISLKSRNAIILSSHRkaRQVSDRTVSIIRSVLSRYQVNpD 293
gi 111026478  89 VSHRAdn-eKKLLLSPKPAGVIFAVTPSTSPVANLYFKVLSSLLTRNAVVISPHPaaVQTSLEAAQLLSRAATEAGAPeG 167
gi 108797177  94 VSPRVdp-dSKIVEIPRPAGVVLALTPTTNPVSTVYFKVLLALMTRNAVVVAPHPraKRCSADAARLLADAAIAAGAPdG 172
gi 121607654 102 VHPRVde-aRKMVEIPKPAGIVLALTPATNPVATVYYKVMLALLSRNAIVISPHPaaSRCCNDAARKLDAAAHAAGAPpG 180
gi 189425928  93 CGYEIdt-eKKVVKIARPAGVVLALVPSTNPVATTYYKILLSLMSRNAVILCPHPaaKGCIVGSADELTAVAEKAGLPkG 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 71152980  166 LIGWIDQPsve-lsnALMHHpdinLILATGGPGMVKAAYSSGkPAIGVGAGNTPVVIDETADIKRAVASVLMSKTFDNGV 244
gi 73540570  189 LVQMLRSPvskaataELMRQa--dLIVATGSQANVHMAYTSGtPAFGVGAGNVASIIDASATLDDAAAKIVRSKTFDNAT 266
gi 126699960 173 LIQILDQQsre-ntrNLISSa--dVVIATGGMGMVKAAYSSGkPALGVGAGNVQCIIDRDVDIKEAVPKIIAGRIFDNGI 249
gi 34540484  161 MVQIIEEPsie-ktqELMGAv--dVVVATGGMGMVKSAYSSGkPSFGVGAGNVQVIVDSNIDFEAAAEKIITGRAFDNGI 237
gi 186682489 312 LIQWLKHRssreqteILMKHknvsLILATGGASMVKAAYSSGtPAIGVGPANTPTLICADANIQHAARTIIVSKSFDNGL 391
gi 88797336  294 LVQIPSQAprreltsLLMSHpdiaFILATGGPGMVRSAYQSGtPSIGVGKGNAPVWVCDDADVKTAAKQIVDSKSFDNGI 373
gi 111026478 168 AIQILNKPsvp-lieAAMGDarvnLILATGGSAVVRAAYRSGtPAIGVGPGNAAVVVDETADLERAADQISASKAFDNSV 246
gi 108797177 173 IVQVVEEPsip-lveALMADertdVIVATGGTGVVRAAYSSGtPALGVGPGNVPVLVDASADITAAAKRIVDSKAFDNSV 251
gi 121607654 181 LIQCIERPsip-lvdTLMRSpqvaVVMATGGGPMVRAAYSSGnPAIGVGPGNAPAYIDTSADMRKAARMIVSSKSFDNSV 259
gi 189425928 172 VIQVVREPsia-lleTMMKSdqvnLILATGGPGVVRAAYSSGnPAIGVGPGNVGHYVDGTGSLDKAALDIAISSGFDNNL 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                                              
gi 71152980  245 ICASEQSVVVVdsVYDAVRERFATHGGYLLQGk-eLKAVQDVILknga--lnaAIVGQPAYKIAELAGFSVPE---NTKI 318
gi 73540570  267 SCSSENSLVVLdaVYKPMLRALAAVGGVLLTSt-eKARLQALMWqngk--lvgEATGQSARRIAELAGLERVRdqqPTML 343
gi 126699960 250 ICSGEQSVIVAeeMFDKIMDEFKNNKGFIVRDkvqKEAFRNAMFvnks--mnkDAVGQSVHTIAKIAGVEIPE---DTKI 324
gi 34540484  238 ICSGEQSIIYNeaDKEAVFTAFRNHGAYFCDEa-eGDRARAAIFenga--iakDVVGQSVAFIAKKANINIPE---GTRI 311
gi 186682489 392 ICGSEHNLIVDarVRKNFIKVLEQEGAAILTHe-eKSYFSTVAFedksnrlqaKIIGQSAAKIAVMANIKRDY---HIKL 467
gi 88797336  374 VCGSENNLIADrsVYDDLRRALEAQGAAVLEAk-eVVRLNNAVLeggk--lcgDWMGKGASLICQQAGIERPY---PIRL 447
gi 111026478 247 LCTAESVLIMVesIASRMNELLVRRGAHLCRPd-eTRRLRNYMYpkgk--fntEVVGRPAREIAKKAGITVAE---GTQL 320
gi 108797177 252 LCTNESVLIVEdsVADALRSAMTRAGAHILDAd-aTERLRAYMFadgh--lntDVVGRDAAWIAGQAGIRVTP---KTRV 325
gi 121607654 260 LCTSESVLLVQqkDAQRFERELRAAGAHLCQEr-eVERLRAYLFpdgd--lnpAAIGKSAVWIAREAGLKVLP---ATQV 333
gi 189425928 251 GCTSDSVALVErdVADAMLEALSRNGVLKLEDkddIEKVRNVLYpdgg--fnpAAIGKSAAWIANEAGISINE---DIKI 325
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 71152980  319 LIgevtvvdesePFAHEKLSPTLAMYRAKDFedavEKAEKLVAMGgIGHTSCLYTDqdnqpARVSYFGQKMkTARILINT 398
gi 73540570  344 LVeesgv-gsdfPFSGEKLSPVLTLYRAADFaaavDTVSRLYDYMgAGHSVSLHTSn---pRQAQQLGLELpVARVIVNQ 419
gi 126699960 325 IVieadgpgeedIIAKEKMCPVISAYKYKSFeegvAIAKANLNVEgKGHSVSIHSNt---vKNIEYAGENIeVSRFVINQ 401
gi 34540484  312 LVveargvgaedVICKEKMCPVMCALSYKHFeegvEIARTNLANEgNGHTCAIHSNn---qAHIILAGSELtVSRIVVNA 388
gi 186682489 468 IIvpneflsldnPYAYEKMAPILSLFTVQNEiegiDLCRSILQIEgKGHTAIIHTKn---kAVVRRFGLEMpASRILVNS 544
gi 88797336  448 IAvpqsvfdqnsPWLREKLAPIVSLMGVESEaealSVARRVLALEgRGHTAIVHTQd---aERIERYAKACdVCRVLVNS 524
gi 111026478 321 LLapidsirddePLTHEKLSPVLAVMTVSNFdqalAAAASLVDIVgVGHSAVIHSEd---pQHVLDYSHRLpVHRVAVNI 397
gi 108797177 326 LVapfdhviseeMLAHEKLSPVIGMTTVPDAargiRAARAVVRIGgAGHSAAIHSEn---aSVITEFATQVpVLRVSVNV 402
gi 121607654 334 LVanvqhigvdePLTKEKLCPVLALYAVDSFeratRSAQMILRLSgAGHSAAFHGNd---pQKALDFAARLnVYRVVVNA 410
gi 189425928 326 LCvevdkiddkdIYTREKLFPVLGFLRIDGLdaayRAAEAMIAMGgAGHTAAIHSKd---sDKIVAWSQLP-VYRIATNG 401
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
Feature 1                                                         
gi 71152980  399 PasqGGIGDLYNfkLAPSLTLGCGSWGGNSISenVGPKHLINKKTVAKR 447
gi 73540570  420 AhcfATGGNFDNg-LPFSLSMGCGTWGGNNFSdnLGWRQYLNITRIAEP 467
gi 126699960 402 CcatSAGGSFFNg-LAPTNTLGCGSWGNNSISenLDYKHLINISRIAYY 449
gi 34540484  389 PsatTAGGHIQNg-LAVTNTLGCGSWGNNSISenFTYKHLLNISRIAPL 436
gi 186682489 545 PgvhGIIGLTSA--LDPSFTLGCGTFGGNSTTdnVTYSNLLNLKRVAYY 591
gi 88797336  525 PgtqGCIGACNG--LELSWTLGCGTAGGSSTSdnVTYRHLQNTKRIARA 571
gi 111026478 398 GgslGNAGIGTG--LPLTMSIGTGFAGGSSLGenLAPEHLVQWKRAAYP 444
gi 108797177 403 GnstGSSGLETN--LAPSMTIGTGFVGRSSIGenLRPDNLMNWARIAYN 449
gi 121607654 411 PcaqGASGFATH--LPPTFMIGTGYFGRSCVGenVGPQHLVHWTRLAYN 457
gi 189425928 402 PaplVASGFASG--LAPTMTVGTGFFGRSSVCenVGPQHLIHWTQIAYS 448

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