Conserved Protein Domain Family
ALDH_PAD-PaaZ

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cd07127: ALDH_PAD-PaaZ 
Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like
Phenylacetic acid degradation (PAD) proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida) are putative aromatic ring cleavage enzymes of the aerobic PA catabolic pathway. PaaZ mutants were defective for growth with PA as a sole carbon source due to interruption of the putative ring opening system. This CD is limited to bacterial monofunctional enzymes.
Statistics
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PSSM-Id: 143445
View PSSM: cd07127
Aligned: 7 rows
Threshold Bit Score: 910.705
Threshold Setting Gi: 88703308
Created: 29-Oct-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
NADP bindingcatalytic
Feature 1:NADP binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to structure 2VRO: Aldehyde dehydrogenase from Burkholderia xenovorans Lb400 in complex with NADPH, defined using 3.5 A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 11072185   12 QLFDKHHATLEAAVQaihaRGYWTPYPe-mPSPKVYGETAQDDGRRAVEAcFGQDFDLGQPGRSGWMASERSPYGVE-LG 89
gi 28974558   11 ELFDHHRDTLERAVQaiaeRGYWSPFP---ESLRQYPEEAVMGAQAEFEAlLGRHFALAGPQPIGRSGAERSPYGFE-LG 86
gi 119718712   8 ALFDRHRARLDAAVAacasREYYSAFDe-sPSPRVYGETAAAEGKAAFEAwLGSPFPLPTPGAQGSVATERSPYGVD-LG 85
gi 88811269    4 EFFTKHRATLEQAIEitrcRDYWSPYPe-vPSGKIYGEAAAAAGQAAFEGrLHQRFVLQQPGSVADVGDEVSPYGFG-LG 81
gi 21222244    9 QLIARHRPTLDLALEtirtRAYWSPHPehpKAYGENGSLDTAAGKAAFDAlHGTRLDLGQPGTDGWVGGEVSPYGVE-LG 87
gi 33596311    4 DFFERHQPMLQKALEaaaqRGYWSPFPe-sPSPRNYGETAAQDGQAAFEAlRGKPFALDLPQASGAVGGEVSPFGFE-LG 81
gi 88703308   12 ALVEKHAATLDAAMDavmsRKSWSPFKd-sPSSKIHGEEKPPAGKAAFEArLNQRFDIDLPGITGWSGEEVSPFTREpLG 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 11072185   90 VRYPvc-dGQALIDAAHAAMPGWQRIGAQGRAGVCLEILERLNKRSFEIAHAVMLTTGQgWMMAFQAGGPHAQDRGLEAV 168
gi 28974558   87 VTYDqy-dTDELLERQQKALPGWRDAGARARVGACLEILQRLNALSPALAHAVMHTTGQaFMMAFQAGGAHAQDRGLEAL 165
gi 119718712  86 VSYPravdVDALLSAARAGMKGWRDAGPDGRTGVCLEILARLHARIFELANAVQHTSGQaFVMAFQAGGAHALDRALEAI 165
gi 88811269   82 VRYPkt-eLDQLLPAMQASLPAWRDAGAEARAGVCLEILARLNKRSFEMAQAVMHTTGQgFVMAFQAGATHAQDRGLEAI 160
gi 21222244   88 VEYPha-dLDVLLPAMRAGQKAWRDAGAELRAMVCLEILQRIAARTMEFAQAVMHTSGQaFMMAFQAGGPHAQDRGMEAV 166
gi 33596311   82 ITYPqv-aPEALVAASSKALEQWRRAGPRAWVGVSLEILQRLNRRSFEMAHAVQHTTGQaFMMAFQAGGPHAQDCGVEAV 160
gi 88703308   91 ITYPlc-ePEALIASAKTAMADWSKASPGLRIALCLEVAEQLYDNNFEMAHAVMHVAGQsYTQAFSGSGPNALDRGIEAL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                  ## #                       # ##       
gi 11072185  169 AYAYREMKFIPHETVWEKPQGknpPLKMKKHFEIVGRGVALVIGCGTFPTWNTYPGLFAALATGNPVIVKPHQnAILPAA 248
gi 28974558  166 AYAWRAMAEVPETACWIKPQGkqdPLLLDKRWHIVPRGLSLVIACSTFPTWNTYPGLFASLATGNPVLVKAHPgAILPVA 245
gi 119718712 166 AYAWTEMTRTPATAIWEKPGRg-gPLRMEKTFTVVPRGVALVIGCNTFPTWNSWPGLFASLVTGNPVVVKPHPaAVLPLA 244
gi 88811269  161 AYAYEAMSRIPPHSRWIKPQGkhePLRMDKTFHVVPRGLALLIGVSTFPTWNGYPGLFASLVTGNPVMVKPHPaTVLPLA 240
gi 21222244  167 AYAYVEQSRTPETAEWTKPQGkrdPLALTKRFTPVPRGIGLVVGCNTFPTWNGYPGLFASLATGNAVLVKPHPrAVLPLA 246
gi 33596311  161 TYAWQEMSRIPGVALWEKPQGkhdPIKMEKRFTVVPRGIALVIGCSTFPTWNGYPGLFASLATGNTVIVKPHPgAILPLA 240
gi 88703308  170 AYAAMAMDKVTPAAEYHRQFGr-dQVALEKTYTLVPRGVGLVICCASFPTWNAYPAMFASLATGNPVIVKPHPiAILPMA 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                     ####  #                            
gi 11072185  249 ITVRIAREVLAEAGLDPNLVTLAAfdk-heATQALATHPaVKSIDFTGGNAFGQWLISNAkQAQVYAELAGVNNVVIEST 327
gi 28974558  246 MSVKVAQEVLGELGFDPALVSLVVdtpeapVAQRLALDPrVRLVDFTGSNAFGEWLEQHArQAQVFTEKAGINTLIIDST 325
gi 119718712 245 ISVQVCREVLAEAGFDPDLVLLAAeepedrLAATLAVRPeVRLIDFTGGNAFGDWLEANAgQAVVFTEKAGVNTVVVDST 324
gi 88811269  241 LTVEVAQEVLAEAGFDPWLVALVAdsreapVTKELARRPeIRLIDYTGSTAFGNWLEEHCrQAQLYTEKAGVNSVIVDST 320
gi 21222244  247 LTVQVARHVLTEAGFDPNLVALAAerpgegIAKTLATRPeIRIIDYTGSTAFGDWLEANArQAQVYTEKAGVNTVIVEST 326
gi 33596311  241 LTVQVAREVLGEAGFDPDVVLLAAhpagddTAQRLALDPaVRIVDFTGSSANGNWLEQNArQALVYTEKAGVNQVLIDST 320
gi 88703308  249 IVVERCRAVLSAFGFDPNLVTLAAdtiaepIAGHYVDHPdVQIIDFTGSPRYGSHLEKTVtGKQLFTETAGVNSVVVESV 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 11072185  328 dQYKAMLRNLAFTLCLYSGQMCTTTQAILVPaDGIDTDQGRKSYDEVCADLATSIDKFLADPAVATAVLGAIQSPDTLAR 407
gi 28974558  326 hDLKAVAKNLAFSLSLYSGQMCTTTQAIYVPrDGIRNGDEQLSFDQVADTLASAINGLLSDNDRACAVLGAIQSEATAAR 405
gi 119718712 325 sDFAAMCQNLAFSFALYSGQMCTAPQNVYVPaAGIATEDGVRSPAEVGAGIGAALQGLLGDDARAVELLGGIVNDGVLAR 404
gi 88811269  321 dNLQGLVHNLAFSLSLYSGQMCTTPQNIYVPrDGIETEQGWLGADEFAQAIAEGITRLLADGERAAELLGALQSENTARR 400
gi 21222244  327 dDYQGMLANLAFSLSLYSGQMCTTPQNLLIPrDGIRTDQGAKSYDEVTADLARAVDGLLGDDARANALLGAIVNPDVKAR 406
gi 33596311  321 dDLKGVARNLAFSLALYSGQMCTAPQNIYVPrDGIQTAEGRVGFDEVAAALGAALDKLAGDPAKAVELTGAVQNDATVAR 400
gi 88703308  329 dDLVASMRAIARASSLFSAQMCTSPQVVFVPkDGIQTRDGHASFDAVAQCIVDEIDALAANPKVAAGIMGAVQAQLSLDV 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 11072185  408 IAEAPAHGr-----VVRASTKIEHAEFPGAEVRSPLLLACDaad---ekAYMEERFGPIAFVVKVAdgaaAVTLSERIVR 479
gi 28974558  406 IADCRALGe-----VLLDSEVREHPQFPGARVRTPLLLKVDasd---raAYAQERFGPIAFVIATDdsahSLRVAREVIA 477
gi 119718712 405 LEKAGRGH------VLVPSREVAHPAYADATVRTPMLVGLTaed---sdVYESECFGPVAYLIETEgtdqSIDLFRHTVL 475
gi 88811269  401 IAEAARLGe-----VVLASEPRGHPRFADARVHTPLLLKVGaep---sdRYDREWFGPIAFVVATEstdeSIERSRGSAL 472
gi 21222244  407 LEAAAGLGe-----VALASREVTNPEFPDAVVRTPVIVKLDgakpedeaAYTSECFGPVSFAVAVDsadhAVELLRRSVR 481
gi 33596311  401 IGKARQLGl----pVLADSKALAHPQFEQARVHTPLLLRADag----ndALGQEWFGPIAFVVATDstahSIELAGASVR 472
gi 88703308  409 VTEASQMAggeglrILREGEAYAHPDFPKALTRTMMVIAGDssh---qaMYAEERFGPVLFVVATDsadaAAQEATELAR 485
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 11072185  480 EHGALTVGLYTTkPEVVDAMTEATWRAGVALSINLTGGVFVNQSAGFSDYHGVGMNPAANASLSDSAFVANRFRVVQRRH 559
gi 28974558  478 EKGAMTLGVYSTdAAFLYQAESLARDVAVALSVNFDGGVFVNQSAAFSDFHATGGNPAANASITDGAFVSRRFVTVQSRR 557
gi 119718712 476 AHGAMTAAVYSTsPEVVEQVREAALEAGVALSENLLGGVFVNQSAAYSDFHGTGANPAANAAYTDGAYVASRFRVVQSRR 555
gi 88811269  473 AHGAITWSVYATeAAVLERTQHAALEAGVALSCNLTDGVYVNQSAAFSDFHATGANPAANACLCDAAFVANRFRVVQTRR 552
gi 21222244  482 EKGAMTVGAYTTdPEVEEAVQEVCLDEAAQLSLNLTGGVYVNQTAAFSDFHGSGGNPAANAALCDGAFVANRFRVVEVRR 561
gi 33596311  473 QHGALSLSAYTTdEAVASRVQDMAEHSGVSLSLNLTGGVFVNQTAAFSDFHGTGANPAANAALSDSAFVANRFRVVQTRR 552
gi 88703308  486 TRGTISCYMYSTdEDFIDRWVDVYAAVGANLSINLTGAMWINFAAAYSDYHVTGLNPAGNACLADLSFVASRFRIAQRRR 565

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