2VRO


Conserved Protein Domain Family
ALDH_MaoC-N

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cd07128: ALDH_MaoC-N 
Click on image for an interactive view with Cn3D
N-terminal domain of the monoamine oxidase C dehydratase
The N-terminal domain of the MaoC dehydratase, a monoamine oxidase regulatory protein. Orthologs of MaoC include PaaZ (Escherichia coli) and PaaN (Pseudomonas putida), which are putative ring-opening enzymes of the aerobic phenylacetic acid (PA) catabolic pathway. The C-terminal domain of MaoC has sequence similarity to enoyl-CoA hydratase. Also included in this CD is a novel Burkholderia xenovorans LB400 ALDH of the aerobic benzoate oxidation (box) pathway. This pathway involves first the synthesis of a CoA thio-esterified aromatic acid, with subsequent dihydroxylation and cleavage steps, yielding the CoA thio-esterified aliphatic aldehyde, 3,4-dehydroadipyl-CoA semialdehyde, which is further converted into its corresponding CoA acid by the Burkholderia LB400 ALDH.
Statistics
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PSSM-Id: 143446
View PSSM: cd07128
Aligned: 20 rows
Threshold Bit Score: 678.607
Threshold Setting Gi: 162451893
Created: 29-Oct-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:NADP binding site [chemical binding site]
Evidence:
  • Structure:2VRO; Aldehyde dehydrogenase from Burkholderia xenovorans Lb400 with NADPH bound in the cofactor-binding pocket, contacts determined at 3.5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2VRO_B         6 LKNHVAGQWIAGtg---aGITLTDPvTGVALVRVSseGLDLARAFSFAREDGGAALrALTYAQRAARLADIVKLLQAKRG 82
gi 149920675   5 LDSYLQGSWKAGeg---dPRSLINPtTEATVATIRsvTRSLADAVAYGRETGGKSLrAMSFAERGAMLKGMAKALHEARE 81
gi 23016776    4 LQSYLAGRWQDGag---sGAQLKDPvSGEVLATASgdGLDMAEALAHARTKGGPVLrALSFAARAGLINAVAGVLAENRE 80
gi 23492514   23 VPSYLSGQWVTPdnp-trIAEVADAsTGEIVARVStdGLDIGAAVAYARDMGQKNLrELTLHERALKLKELALYLSEHKQ 101
gi 62425616    5 LSSYVAGDWHAPsgspegARAVHDAtNGQLTHHVSssGIDFAAVDEYARTTGVAELqKLTFHQRGVILKKLGAYLMERAK 84
gi 134100081   4 LRSFVNGDWHVPse---dGAPLHDAvTGEEVARISsaGIDIAGALEYGRARGGPVLgELTFHQRAALLKVLASHLLEHRE 80
gi 15807371   11 PASYVYGQWHANk----dGQTLLDAvYGRPVAVISseGVDFAQALAYGREAGAGLR-KLTFHTRARMLKALGNYLMERKE 85
gi 28974571    7 LQSFIGGRWIGQq----gAQALRSAlDGHTVARTHeeTLDFTEAVEHGRRHGIAALmAMDFQQRAARLKALGKYLSERKE 82
gi 171060238   6 LQSHIGGRWIGTq----aAQTLRSAiNGQPVAATHadAIDFGEAVAYARRTGLPGLlALDFQQRAQRLKALAKYLNEHKE 81
gi 2764822     4 LASFLSGTWQSGrg---rSRLIHHAiSGEALWEVTseGLDMAAARQFAIEKGAPALrAMTFIERAAMLKAVAKHLLSEKE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       #
2VRO_B        83 DYYAIATANSGTtRNDSAVDIDGGIFTLSYYAKLGASLge------vhALRDGSAESLsKDRSFSAQHVLSPTrGVALFI 156
gi 149920675  82 ELIDIAIQNGGNtRGDAKFDIDGGISVLSHYAYLAKELgkdskgndkpWLIEDEPVEVyRGSKIRAEHILLPRhGLAVHI 161
gi 23016776   81 RYNSIALANSGNtALDAALDVDGGIGTLKYYASIGRKLge------ahLLAEATDDQLtKDEAFRGRHIWTTIqGVAVHI 154
gi 23492514  102 ELYEIAYCTGAT-KRDNGVDIDGGISTLFTYSSKGRRElpn-----adVIIDGPTEVLsKDSSFQGTHIYTPLpGVAVQI 175
gi 62425616   85 DYHEISFTTGTT-KRDGFVDIEGGIGTLFTYSGVARRQmpn-----stVHLDGGIERLsKNGTFVGRHILTSRqGLALQI 158
gi 134100081  81 ELYALSARTGAT-LGDSKFDIDGGIGVLFGYSGKGRREmpn-----akVYVDGAVEPLgKGGTFVGQHICTPLrGVAVQI 154
gi 15807371   86 DYYALNLLTGAT-RRDGWVDIEGGIGTLFSYSSMARRElpd-----erFLPDGKVEVLgKGGTFMARHLLVPReGVAVQI 159
gi 28974571   83 QLYAISHHSGAT-RADSWVDIEGGAGTLFAYASLGARElps-----gnVVHEGPAIPLgKTNKFAGSHILVPRgGVAVHI 156
gi 171060238  82 QLYAVSAHTGAT-RTDSWIDIEGGTGTLFAYASAGSNElps-----gnLLHEGPVLNLsKKGGFAATHILVPRgGLAVHI 155
gi 2764822    81 RFYALSAQTGAT-RADSWVDIEGGIGTLFTYASLGSRElpd-----dtLWPEDELIPLsKEGGFAARHVLTSKsGVAVHI 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # #                       # ##                                             #### 
2VRO_B       157 NAFNFPSWGLWEKAAPALLSGVPVIVKPATaTAWLTQRMVADVVDAGILPPGALSIICGssaGLLDQIrsfDVVSFTGSA 236
gi 149920675 162 NAFNFPAWGMMGKAAVALLAGMPVLCKPATsTAWLAHRMVQILVDAGLVPEGAFQLLMGsagDLLDHLgpqDVVAFTGSQ 241
gi 23016776  155 NAFNFPSWGLWEKAAVSLLAGVPFLAKPATaTCLLAYEMVKDVVEAGVLPEGALSLLCGggrDLMDHLqpgDVVAFTGSA 234
gi 23492514  176 NAFNFPVWGMLEKFAPSFIAGVPSLVKPATpTGYVTQACVRLMVESGILPEGSIQLISGsarDLLDHLdyrDHVAFTGSA 255
gi 62425616  159 NAFNFPVWGMLEKFGPMFVAGVPVIVKPATdTAHLTRAVVADMVESGLLPDGAIQLIAGdvtPLFDHLaeqDAIAFTGSA 238
gi 134100081 155 NAFNFPVWGPLEKFAPAFLAGVPTLVKPASqTAYLTHRLVELIVESGVLPEGSLQLVCGgvgDLLDHLtdqDLVSFTGSA 234
gi 15807371  160 NAYNFPVWGMLEKLAPAFIAGMPSLVKPAPqTAYLTERVVRDIIASGILPEGSLQLVTGdpgDLLDHLleqDMVAFTGSA 239
gi 28974571  157 NAFNFPIWGMLEKFAPSFLAGMPCIVKPATaTSYITEAAVRLMHESGLLPAGSLQLIIGgtgDLLDRLqgqDVVTFTGSA 236
gi 171060238 156 NAFNFPIWGLLEKFAPSFLAGMPCIGKPATaTSYLTEALVRLIDASGLLPAGALQLVIGgtgDLLDRLdgsDVVTFTGSA 235
gi 2764822   155 NAFNFPCWGMLEKLAPTWLGGMPAIIKPATaTAQLTQAMVKSIVDSGLVPEGAISLICGsagDLLDHLdsqDVVTFTGSA 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                                              
2VRO_B       237 DTAATLRAHpafvqrgARLNVEADSLNSAILCADatpdtpAFDLFIKEVVREMTVKSGQKCTAIRRAFVPea-aLEPVLE 315
gi 149920675 242 AVGLQIKTHanviargVRVNLEADSLNSVVIGPDveegteLFDLVIRDLAVEMTQKAGQKCTATRRVFVPeg-aVDSIKE 320
gi 23016776  235 DTAAQLRSNpnviaanIRFAVEADSLNLCALGPDakpdgaEFAAFIKEVSREMTVKAGQKCTAIRRILVPrd-rMDAVVD 313
gi 23492514  256 TTAATLRAHdnvqhagLRFSAEADSVNAAILGEDatpdtpEFDAYVKTLFNELTSKAGQKCTAVRRAIVPtgliDDVAFA 335
gi 62425616  239 NTAKHLGGLdcvrdrgTRFFAEADSLNFSLLGPDaapgteEFDLFISGVVAEMTIKAGQKCTAIRRTFVPeq-hKEAVAE 317
gi 134100081 235 ATGQRLRAHpnvaarsVRFNVEADSLNCSVLGPDaapgtdEFDLFVKQLVTEMTVKAGQKCTAIRRALVPag-rVDDVVQ 313
gi 15807371  240 ATANKLKVHpnivarsIPFNAEADSLNAAVLGVTvrpkdpEFALFVKEVAREMTGKAGQKCTAIRRPLVPch-lVDPVVE 318
gi 28974571  237 DTAARLRVNanlvrnsIPFNAEADSLNCAILAPEitpddpEFDLFVKEVAREMTTKAGQKCTAIRRAIVPar-yIDAVAE 315
gi 171060238 236 DTAAKLRVHpnivrhsIPFNAEADSLNCAILAPDvspddeEFELFVKEVAREMTVKAGQKCTAIRRAIVPrq-hLDAVAE 314
gi 2764822   235 ATGQMLRVQpnivaksIPFTMEADSLNCCVLGEDvtpdqpEFALFIREVVREMTTKAGQKCTAIRRIIVPqa-lVNAVSD 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2VRO_B       316 ALKAKLAKITVGNPrndaVRMGSLVSREQYENVLAGIAALREeaVLAYDSsavpli---dadaniAACVAPHLFVvndp- 391
gi 149920675 321 ALFDRLDQIKIGDPsdkaNRMGPLTSKRQLEDARAGVKTLSAd-AEILRGnpersegfagveagtGYFLEPIVLLgkpdk 399
gi 23016776  314 GLKAALAKALMGDPrtegVRMGPLVSRAQAMAAWGGLETLKAetQVVAGGgnd----------dgGCFVPPTLLLcnnp- 382
gi 23492514  336 LADRITAKIVVGDPrdekTTMGPVVSVEQRDDVAAAVDKLIAagGTVRLGgpe---------eldGAFFAPTILTfdna- 405
gi 62425616  318 ALLAKLETQGVGDPreksTRLGPVVSDKQRNDVLDAIDEITSagAHVLTGgreasde--laqnlgGAYVAATVLQaddp- 394
gi 134100081 314 AASERLSKVVVGNPaspeVRMGALASLEQREEVRRSLKALLAa-GTLVHGdpervev-agadaerGAFLPPMLVRcddp- 390
gi 15807371  319 ALRAELAKVTVGDParddVRMGALVSVEQRERVRETLEKLGQd-AEVVIGggagell--ggdrekGAFLDPTVLLcrnp- 394
gi 28974571  316 RLHARLAKVVVGDPsvegVKMGALASHAQQADVAARVETLLAg-SDLLFGardgfap-lgegvaeGAFFAPTLLRsrdp- 392
gi 171060238 315 KLRARLAKTTVGDPslegVRMGPLASHAQQADVAERVALLLQg-CEQVYGakdgaap-qgtgvaeGAFFSPTLLLsrqp- 391
gi 2764822   314 ALVARLQKVVVGDPaqegVKMGALVNAEQRADVQEKVNILLAagCEIRLGgqad-------lsaaGAFFPPTLLYcpqp- 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2VRO_B       392 --dnatLLHDVEVFGPVASVAPYRvttdtnalpeAHAVALARRGQGSLVASIYSNDDAHLGRLALELadSHGRVHAISPs 469
gi 149920675 400 vadpqaAFHQHEVFAPVSTLLPYDge-------lATAAKLIAMGNGSLVTTVYTDDRKWLAQAVAEMgpYLGRIVVANEk 472
gi 23016776  383 --laatAVHEVEVFGPVATLMPYDs--------vEQAVELARRGGGSLAASVFSGDCAFLADFVPAIatSHGRVLVVDGs 452
gi 23492514  406 ---dadAVHDTEAFGPVVSIIGYSd--------tADAIRLAARGQGSLVASVITHDPALANQFAMGIaaHHGRLHFLDRd 474
gi 62425616  395 ---wvdAVHDVEAFGPVTSLITYSs--------tAEAVRLAARGRGSLVGSVVTHDAEFATEFVRQVapWHGRILVLDRd 463
gi 134100081 391 ---draEPHEVEAFGPVSTIMPYDs--------aAHAVELARRGLGSLAGSVVSADADFAREVVLGAasRHGRLLVLNRh 459
gi 15807371  395 --leakGPHELEAFGPVATLMPYDt--------lDDAITLAKMGRGSLAASVVTFNRHEATELVLGIasTHGRVLVLNRa 464
gi 28974571  393 --haegGAHDIEAFGPVSTLMAYDd--------lDEAIALAARGKGSLVASLVTKDPQVAAKVVPAAaaLHGRLHILDRe 462
gi 171060238 392 --lqhdAVHDVEAFGPVSTLMAYDg--------iDEALALAARGRGSLVGTLVTKSPAIAARVIPVAaaLHGRLLVLDRe 461
gi 2764822   386 --detpAVHATEAFGPVATLMPAQn--------qRHALQLACAGGGSLAGTLVTADPQIARQFITDAarTHGRIQILNEe 455
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                                
2VRO_B       470 vqHSQTGHGNVMPmSLHGGPGRAGGGEELGGLRALAFYHRRSAIQAASAAIGTLTQ 525
gi 149920675 473 haGASMAPGCVFPvANHGGPGRAGGGAELGGVHGMSLYMQRVAVQGGASQLARLLG 528
gi 23016776  453 vaASHSGHGVVMPhCTHGGPSRAGGGEELGGLRGLRFYMQRSAVQGSRAMLDAMTQ 508
gi 23492514  475 daRTSTGHGSPLPhLIHGGPGRAGGGEELGGIRGVKHYMQRTAIQGTPDHLTAITG 530
gi 62425616  464 daEESTGHGSPLPnLIHGGPGRAGGGEEMGGLRGVEHFMQRTAIQASPDMLTAIGG 519
gi 134100081 460 naRESTGHGSPLPaLVHGGPGRAGGGEEMGGVRGVLHHMQRTAVQADPDTLTAVTG 515
gi 15807371  465 daKESTGHGSPLPqLLHGGPGRAGGGAEMAGLAGVKHHMNKVAVQADPTTLAAITK 520
gi 28974571  463 saAESTGHGSPLPqLKHGGPGRAGGGEELGGLRAVKHYLQRAAVQGSPSMLMAVTG 518
gi 171060238 462 aaVESTGHGSPLPmLKHGGPGRAGGGEELGGMRAVKHYLQRTAVQGSPTMLAAITG 517
gi 2764822   456 saKESTGHGSPLPqLVHGGPGRAGGGEELGGLRAVKHYMQRTAVQGSPTMLAAISK 511

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