Conserved Protein Domain Family
ALDH_YwdH-P39616

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cd07136: ALDH_YwdH-P39616 
Bacillus subtilis aldehyde dehydrogenase ywdH-like
Uncharacterized Bacillus subtilis ywdH aldehyde dehydrogenase (locus P39616) most closely related to the ALDHs and fatty ALDHs of families 3 and 14, and similar sequences, are included in this CD.
Statistics
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PSSM-Id: 143454
View PSSM: cd07136
Aligned: 47 rows
Threshold Bit Score: 690.397
Threshold Setting Gi: 31544915
Created: 1-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
NAD(P) bindingcatalytic
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to structure 1AD3, class 3 rat liver aldehyde dehydrogenase (ALDH3A1)
  • Citation:PMID 9095201

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 732362      6 PSIISKHKAYFAAGhtrPLESRLNILRKLKQAVRTHEADLIAALYQDLHKSeqEAYSTEIGIVLEEISFVMKRLRKWsKP 85
gi 124004853  34 KALTDKQRAYFAQGntkSYDFRLERLRKLQEVIEAHEEAIIEALQKDFKKSpfETYATEIGFVLGEIAHARSNLASWmGA 113
gi 23099312    8 QSIVENQRAYFNHGntvDYSFRKQQLEKMKVMLKEYESHIFQALKHDLNKSkhEVITSELAILYSEIDSMLKNLRQWmQP 87
gi 89891473    8 KLTHQSHQEFFKSQqtkDVNYRITALKKLKAVIEQKEQQVYKALAADLGKSefEAFITEYQVITGELDKYIKKTKKWaSP 87
gi 88712739    1 MDILKRQREFFMTQqtkDVSFRKKALKKLQKEIISREDAICDAVYADFKKPkfETLATETQFVLAELKLVLKNLELWaRP 80
gi 163755186   6 SDIVLAQKDFFKTRktqDVYYRRKSLKKLLKVVKKRENDICEALYADFKKPkfEAVLTETGIVLTELKLTIKKLKSWaRP 85
gi 83858096    4 TNVVDAQKQYFKTGatlPISFRLAALKKLRKEITAQENAICEALHLDFKKPyfEAVITETSIILKELDEFISNLKSWsKT 83
gi 86131845    4 PSILENQRAFFATGqtkDIAYRKAALVRFRESIKNHEQDIIDALAADFKKPafETVATEISVVIKEINLAIKEIWKWqMP 83
gi 158334512  15 QELVKNQRQYFRSNatlPVEFRIEQLEKFRDLIHRYEDELYAAIDKDFGKSkyHTQLTEIFPLFEELEIAIKNVRKWvKP 94
gi 149372589   2 TNYIEAQKAFFITQatkDVSFRIKQLKKLAKLLDDNEAALHKAIHDDFKKSafENYVTELAFVQHDIKEAIRNIDQWtRV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    ###                         #                       
gi 732362     86 KRVKtplthlgSKSIIIPEPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISsvFPTDYVA 165
gi 124004853 114 KKVGgsllnfpSGSYIYSEPYGICLILGAWNYPLQLTFGPLVGALAAGNCAIVKPSELAANTSAVMAKMISenFDEAHIK 193
gi 23099312   88 DKVTnpithkgSKSYIMKEPLGVILVIAPWNYPLQLSLAPVIGAIAAGNTVIIKPSEHAPHTSELVAEMIQntFDSSFVT 167
gi 89891473   88 RKVRpsllnfpSKARQYSEPYGNTLIISPWNYPFQLALAPLIGAVAAGNTVILKPSEFSTATSQLLEEIVNesFDAQHVK 167
gi 88712739   81 QRKSatlmnwpSSDWIYSEPYGAVLIIAPWNYPFQLALAPLIGAIAAGNTVVIKPSEATPNTSKITAEIIEavFPKEHAA 160
gi 163755186  86 KRVFpsllnfpSSDRIHSEPYGTTLVIAPWNYPYQLALAPLIGAVAAGNTVVLKPSELTPNTSQILEEIITevFEEDHVK 165
gi 83858096   84 EKVTssllnfpSSAYIYKEPYGNTLVISPWNYPFQLAIAPLIGAVAAGNTVILKPSELTLHTANILSSIIAkvFDKGHVT 163
gi 86131845   84 KKVKasllnfpSSAAVHYEPYGTALIIAPWNYPFQLAVGPMIGAIAAGNTVVLKPSELTPNTANLLEKIITevFDPAYVN 163
gi 158334512  95 RKVStnllnqpGKSYIVPEPLGVTLVIGAWNFPYNLSLVPVIGSMVAGNTTILKPSELPAETSRVMAKLINenFDPNYLR 174
gi 149372589  82 QDVQtnianfpAKSYIIPEPLGTCLVIGAWNYPYQLSLAPAVAAIAAGNTVIIKPSEMPSNTARVMATLINkaFDPRVLK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                 #                                                        
gi 732362    166 MAEGGPDvSTALLQQpFDYIFFTGSVAVGKIVMEAAAkqLIPVTLELGGKSPCIVHKDaDIQLAAKRIVFGKFTNaGQTC 245
gi 124004853 194 VVEGGKEvAEKLLAEkLDYIFFTGSVRVGKIVMQAAAqhLTPVTLELGGKSPCVIDKTaNLDLAAKRIAWGKFLNgGQTC 273
gi 23099312  168 VVQGAKVeTEALLKQrFDHIFFTGGAAIGKIVMRAASefLTPVTLELGGKSPAIVDEDaNIQVAAKRIVWGKYTNaGQTC 247
gi 89891473  168 VIQGDADvAKELTSLkWDYIFFTGSPPVGKAIYQAAAkhLTPVTLELGGKNPCVIHESaSLKVAARRIVWGKFLNaGQTC 247
gi 88712739  161 VVEGGIEvSQNLLAQkWDYIFFTGSTNVGRIVYESAAkhLTPVTLELGGKNPCIVDESaSISLAAKRIVWGKFINaGQTC 240
gi 163755186 166 VVQGGVDiSQKLLAErWDYIFFTGSVNVGKIVAKAAAphLTPVTLELGGKNPCIVDLHsDFKLTAKRIVWGKFLNaGQTC 245
gi 83858096  164 VVQGDKDvSQELLSKvWDYVFFTGSVRVGTIVAKACAehLTPVTLELGGKNPCIVHESaKIATTARRLVWGKFINaGQTC 243
gi 86131845  164 IVQGDKEvAQELLKQrWDYIFFTGSVPVGKIIYKAAAehLTPVTLELGGKSPCVVDETaRIQQTARRIVWGKFVNaGQTC 243
gi 158334512 175 VVEGAIPeTTALLNQrFDKIFFTGSPQVGRIVNQAAAphLTNVTLELGGKNPALFAEDaAVDVGVKRLIWSKFVNsGQLC 254
gi 149372589 162 VIEGGVAeTTALLNQdFDKIFFTGSTTVGKIVYKAAAekLIPVTLELGGKSPAIITKDaNLKMAAKRLIWAKFLNaGQTC 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                  # ##  #                               
gi 732362    246 IAPDYLFVHediKTKLTEEMKRAIREFygpqpernPQYGKIVSERHYQRLLSFLNDgIPLTGGQSdpnhHKIAPTILEQV 325
gi 124004853 274 VAPDYLLVHkavKPRFMQLFKEHIKAMygddpqqsPDYPRIINQGHYKRLVGYLKEgRILTGGDTndkeRYIAPTVLDQL 353
gi 23099312  248 VAPDYILVHekaKFKLLKAMKKYIKSMygkdplqnDAYTRIIHEGHFDRLTNFLSNgTIVHGGEYnrdtLSIEPTILDKI 327
gi 89891473  248 IAPDYILVHnsvKLEFIEHVKAEIINFfgknpkesPDLPRIIREQHFRKLIEMLEDqKIISGGQHdintLYIAPTLLDEP 327
gi 88712739  241 IASDYILVHksvKEKLIDALKQNITKGygeniedsPDFSRTVNQKHYNGLKKMLEGeEIIFGGNTndedNYLSPTLVNEP 320
gi 163755186 246 IAPDYLIVQaqaKFDFLKVLMEEIKLAygenpqesTDYTRIINEKNFDRLAKMLENqEVLHGGIVdkddLYIAPTLLDEP 325
gi 83858096  244 IAPDYILVHtsiKKVLVTALKKEIEAFygsdpeqsPDFARISHKGNFERLSKMLKDsKLICGGTTneedLYISPTLLDEP 323
gi 86131845  244 IAPDYILVHssvKDALLKAIDIEITKAygadpkisKDFARIINEKNFERLSEMLENaTIYKGGQTdkndLYIAPTVLNDV 323
gi 158334512 255 LAPDYVLVHksiKDRVLERMVHEIKKHnys--venKNFVRIINARNFDRVAALIDPdKVYYGGETnreeRIIQPTVMHNV 332
gi 149372589 242 IAPDYILIHkskQETFLKYAVAEIEKAkya--fenGNYVQIINDKNFDRLFKMLDAsKTYIGGQNnkkdRYIAPTVLTNI 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 # #                                                                    
gi 732362    326 rddSPVMQEEIFGPILPLFTYRnIGEVIEKVQSRPKPLALYLFTTnkEIERAVLGnLSFGGGCVNDTLMHVATPYLPFGG 405
gi 124004853 354 nwdDQVMQEEIFGPILPILEFEtIEEVAQQIAHHPKPLALYLFSEdaDHQKYITEnVSFGGGCINDTVAHLVNTNMPFGG 433
gi 23099312  328 twdEAIMQEEIFGPILPVLTYTnIEDALYQIKLREKPLALYYFGEneKMQQQVMEyVSFGGGAINDTIYHLANPHLPFGG 407
gi 89891473  328 qrdSNVMQEEIFGPILPVISYKnQGDIIQWIDSYEKSLGAYIFSNnnRFEQWFIQrFSYGGGVINDSIVQFVNERLPFGG 407
gi 88712739  321 kldSTLMHGEIFGPILPIIAYEtEDDIHKYIMNYGKPLATYVFSNnkKFQKRIINnYSFGGGAINDTVIQITNKKLPFGG 400
gi 163755186 326 dldSDVMLDEIFGPILPIQVYAtLDDISNIIARYEKPLALYVFSNdkKFANRMIErHSFGGGAINDTVVHFVNHRMPFGG 405
gi 83858096  324 alnSNAMETEIFGPILPIISYTtEEDIHKYVSHYHKPLSFYVFAEqkAFADKLLKkYSFGGGVKNDSIVHFVNKNLPFGG 403
gi 86131845  324 svtDTVMQDEIFGPILPVLTYDkKEDIALVINAMEKPLSAYVFSRkrSFKSWFNTtFSYGGGAMNDTLIHFINDKLAFGG 403
gi 158334512 333 svdDAVMQDEVFGPIIAVLEYEtLDEAFEIIKSFEKPLAGYLFSNdkTTKQRFLSeIPFGSGAINDAVMQITNSNLPFGG 412
gi 149372589 320 swdHPTMKEEIFGPILPVISYYeIDEVFTNVRKFPKPLSLYVFTSnsKTKSRVLNeLSFGGGAVNEAVMHISNPHLPFGG 399
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
Feature 1                                                         
gi 732362    406 VGESGIGSYHGFDSFNTFTHKKSVVKqtNRFDFAFRYPSSKNGLRMIRK 454
gi 124004853 434 VGDSGIGSYHGRSSFQTFSHQKSVMKkaTWLDVPLRYAPYKGKMKWLKM 482
gi 23099312  408 VGTSGMGNYHGKASFDTFSHQKSIMKqtTKFDIPFRYPGGKITSNIVKK 456
gi 89891473  408 VGNSGIGNYHGKKTFETFSHMKSMVHrgTWLDIPIKYAPYSGKLDIVKR 456
gi 88712739  401 VGASGMGAYHGRTSFDIFSHQKAIIKkaNWLDAPLRYPPYNLPMKLVKK 449
gi 163755186 406 VGHSGIGSYHGKGSFDTFSHKKSITKrgTWLDVPIRYAPYKGKLKILKI 454
gi 83858096  404 VGQSGMGAYHGKRSFETFSHKKSVVKrgTWIDIPLKYAPYKNKLKWIKS 452
gi 86131845  404 VGHSGIGSYHGEKSFYTFSHAKSVVKrgTWLDVPVRYAPYKGKLSLLKK 452
gi 158334512 413 VGNSGMGRYHGEYSFECFSHLKSILEkaNFFESDLKYYGHSDTQMKWIR 461
gi 149372589 400 VGTSGIGTYHGKAGFDCFTHYKSILDkpTWLELPIKFSPYSKTKLAWLR 448

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