Conserved Protein Domain Family
ALDH_CddD_SSP0762

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cd07138: ALDH_CddD_SSP0762 
Rhodococcus ruber 6-oxolauric acid dehydrogenase-like
The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid, and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and other similar sequences, are included in this CD.
Statistics
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PSSM-Id: 143456
View PSSM: cd07138
Aligned: 63 rows
Threshold Bit Score: 573.295
Threshold Setting Gi: 33599734
Created: 2-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
NAD bindingcatalytic
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to structure 3B4W: the Mycobacterium tuberculosis aldehyde dehydrogenase with bound NAD

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 16209569    9 LYINGSWVAStsktvieVLNPATEEVIGTVPDgtaaDVDAAVAAARAAFDGWa---sTPVDKRAQYLRAIAAGIADRSDE 85
gi 119476030   7 FYIDGQWTAPhgkhvlsILNPATSVPCVAMACa---NETDVNAAAEAAFRAFpawsaTPSDQRALLMMGIADEMENRADD 83
gi 87122739   12 VYIDGNWRRTkstqlysLINPATQDSIAQVTMasvkDVEDAVAAAHKAFASWs---nTSAQTRANYMNAIADEMQTRYQD 88
gi 71280481    7 LYINGDWQLPntedtidVINPANSELCAKTPSasiaDVDKAIAAAKYAFAQWs---aTTPAERSQLITAIADEMQNRIDD 83
gi 158316299  31 IFIDGEWVSSagtgtltVINPATEEPLATLPRghvdDVDRAAQAAARAFESWs---rSTVDDRIDMLTRIADILDTRAEE 107
gi 69937629   13 NFVGGKWIPAqatgeieVINPTTEEVFAVVPEgtagDVAPAVEAAATAFPGWs---eTTIEQRADMLRKFARLTEARAEE 89
gi 69937585    6 ILVGGTWVPSeaearieAINPATEEVVARIPDgtsgDVDRATAAAVASFERWs---qSSLDERKAVLNRLADLIDRDREP 82
gi 158316232   7 IYLDGTWVTPdgteevsVPNSTTGKEIGTIRLgsekDVTAAVEAARTAFTTWs---dTPIAERIRILDEMTRILTSRHSE 83
gi 148557194  10 YLAGGAWIEAtanppipVVNPANGAVIGEAPCctadDVDRAVAAARAALPGWa---aTPVADRLARLSALREALAARGDE 86
gi 32141323   25 HWIDGRAVTGsgp-lidVVNPADESVIAHLHEatadDVDMAVDAAVAAIPGWa---aTPPRHRADVMRRLAEGLQKRSEE 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                     #####              
gi 16209569   86 LARTISAEMGAPlsfAQAMQVPLPINSFSHAAAVaeSFPFErt--eGSSVIVREPIGVVGAITPWNYPLHQIAAKVAYAL 163
gi 119476030  84 LVQAHVETMGIPrhqAMEVQIAGPIDAMRYFASLaaTMGEPed--rGGYLISHEPVGVCALINPWNYPLLQMIGKVAPAL 161
gi 87122739   89 LIEAHVLSMGCPahlVGAYHLDCAIDAMRYYAKL--AFNMEketrrESVLLTQKAIGVCALINPWNYPLHQLVGKLAPAL 166
gi 71280481   84 FASAISTSMGCPkhlAFDIQVQGAIDAFRGYADMtsYVDESst--eHGVMQCHSAVGVCVLINPWNYPLSQLVGKIGPAL 161
gi 158316299 108 LARTIVSEVGTPitlARGSQSATAINDLRIAAASlkDIVWEer--fDDTIVRRIPAGVAGAITPWNGPMRMIALKAGAAI 185
gi 69937629   90 LTFTGVSEVGQPaaaARVFQTQGAVGELDLMAEIlpEMDWNip--eGKAVVRRVAGGVVGAITAWNGPLRSVISKAGAAM 167
gi 69937585   83 LLRNMVAESGLPitpAGRSQVDGASDELRLMAEVvdQIDWAth--yGSSRVVRQAAGVTGAITAWNAPLRSIISKAGAAI 160
gi 158316232  84 LSDLFSQEVGTPtaqAGAFQGLATSLFGMYAQKAs-TFDYEdr--rGNITVLREPIGVVGAITPWNFPLLLMCLKVAPAL 160
gi 148557194  87 LALLITRQMGTPigfSRAAQIGLPLRTFDITIAA--MAALEee-rtARSRILRDPAGVVAAITPWNFPLHQIAAKVVPAL 163
gi 32141323  101 LAATITLEMGAPiafSRQAQVGFPVASTLAAIAAaeRFEWSer--iENSLVVREPVGVVGAITPWNFPLQQLVTKVVPAM 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                #                                    #             ####  #  #           
gi 16209569  164 AAGNTIVVKPSEvaPLNAWMLAEIIDaAGVPAGVFNLVSGTGpvVGEALASHHeVDMISFTGSTNAGKRVSELAAqtVKR 243
gi 119476030 162 AAGCTMLAKPAEqtPTSDIIMAEIFDkVGLPAGVFNLITGLGaeVGPLMASHPrVDMVSFTGSNRSGISVAIEAAptVKR 241
gi 87122739  167 AAGCTLIEKPAEqtPLTDLIMAEIMHkVGLPAGVFNLIFGHGheIGPLLAEHPkVNMVSFTGSTRAGIEVAKNAAssVKR 246
gi 71280481  162 ATGCTIVAKPAEqtPLQDLILAEIFDkVGVLAGVFNVITGYGfkIGEHLCSHPdVDMVSFTGSTGAGIKVAQAASttVKR 241
gi 158316299 186 AAGCTMVLKGTEvaPLSAFLFAEAAAeAGLPRGVFNLVSGTGpeIGEALATHPlVDIVSLTGSVRAGSRVMELASrsVKR 265
gi 69937629  168 AAGCTVVVKPSEvaPMTAYIFAEICEeAGLPPGVFNLVSGTGpvVGEAIVAHPaVDIVSLTGSVRAGRRVMEVAAqdIKR 247
gi 69937585  161 AAGCTVVVKPSEvtPLSAIALADLFGeAGAPDGVFNLVLGRGpvIGEAIASHPdIEVVSLTGSVRAGQRVMELASrmVKR 240
gi 158316232 161 AVGCTAVLKPAHiaPLSAYALAEAADaAGLPRGVLNVVPGGPr-AGEALVAHPdVDMISFTGSTKAGRRISAVAGetIKR 239
gi 148557194 164 AAGCTVVLKPSEitPLDARIFAELVEgCGFPAGVFNMLFGAAe-TGAALVAHPqVDMVSFTGSTAAGRHIGAQAGrdLKK 242
gi 32141323  179 LAGNTVVLKPSElsPLSARMFAEIATeAGLPNGVFNVVQGTGpvVGEALSRHPkIDMISFTGSTRAGKSVSSAASvtVKR 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ###                               #                                          
gi 16209569  244 VALELGGKSANIVLDDaDIDELMPNAVQWAMINsGQTCSALTRLLVPraiLTEAETAAKTIAEAYtvgapddpdtTLGPL 323
gi 119476030 242 VCQEMGGKSALIITEDaDLHTAVRYGVENVMLNtGQTCDALTRMLVPasrYQEAIDQAVIVADEQvvgdpddpltTMGPL 321
gi 87122739  247 VCQELGGKSAFIITQDaDIEAAVRYGVEDVMANtGQTCNALTRMLVPksqYQKVIEVAKQVALEHtvgdprlaetNMGPL 326
gi 71280481  242 VCQELGGKSPFIITDDaDLAAAVRYGVEDVMINsGQTCCALTRMLVPeslYQQAIVIAKAVAEENvvgdpqdenvTMGPL 321
gi 158316299 266 VALELGGKSANIILADaDLEKAVVDGLGDAFRNsGQVCGGLSRMLVPrgrLAEAEEIAAAKATSYvigdpldeatTLGPV 345
gi 69937629  248 VHLELGGKSANILFEDaDIDHAISVGIEDAFRNaGQVCGGLTRILVPrtlLAKVEEAAKAKAESFvigdpfdpatTLGPV 327
gi 69937585  241 VHLELGGKSANVVLRDaDVERAVQVGIEDAFRNtGQACGALTRVVVPrpsLAKAEAAAVAKVESYvvgdpmdpatTIGPV 320
gi 158316232 240 VTLELGGKSALVVLDDaDLQAAVTTGMQSVTTNnGQGCACLTRVVVPrarLAEAEEMARAFAESTvigdprdpatTLGPM 319
gi 148557194 243 AALELGGKSANILLDDaDLSVAVPQAIGQCFVNgGQTCAALTRLIVPrakRAAVEALAVEAAARWlpgdpeqpstRLGPL 322
gi 32141323  259 VALELGGKAAHIVLPEaDLDSAVARGLAFAWANaGQACGAYVRMLVPedlQTAVVDRLRTAAQEYvvgdpadeatRIGPL 338
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 # #                    
gi 16209569  324 VSATQLKRVRGYIDRGvqEGATLITGGSEpveglavGYYVKPTIFSEVtpdMTIHREEIFGPVLSIAPYDtEEDAVRIAN 403
gi 119476030 322 ASEQQCQRVRDYIKQGiaEGARMVAGGAElptslegGAYVLPTLFADVrndMVIAREEIFGPVLCIMSYEtIDEAVDIAN 401
gi 87122739  327 ASAKQHQVVKDYIQLGleEGASLLTGGAElperldkGYYIKPTIFTQVtpeMRIAQEEIFGPVLCILTYDdIEEAITIAN 406
gi 71280481  322 SSSLQQKRVLDYINIGikEGAELVTGGPEiparlqqGAYVMPTIFTNVtndMTIAQEEIFGPVLCMIPYSdEQEAIKIAN 401
gi 158316299 346 VSDAQRDRVRRYIQTGvdEGLRLVAGGPEapehldrGYYVQPTVFTGDn-sSRLAQEEIFGPVVIIIPFDdTDEAVAIAN 424
gi 69937629  328 ATAAARERIRGYINLGqrQGARMITGGAEppmglnrGFFVKPTVFSGDn-sMRIAQEEIFGPVVVIIPFDgEDDAVRIAN 406
gi 69937585  321 ATASQFRRVRDYIDIGqaEGARLLVGGSDrpkglnrGYYVNPTVFTGDn-fMRIAREEIFGPVVVIIPYEdETEALQIAN 399
gi 158316232 320 ASAEHRDRVDGYIRTGidEGARLVSGGPGapdrwsgGFFVRPTVFTVEdvsATIAQQEIFGPVQVLIPHDgDDDAARIAN 399
gi 148557194 323 SSLRQRERVAAMVARAleDGATALIGGTAapegfekGAWFAATVLSGVtpaMEIAREEVFGPVLVILDHDgEEDAIAIAN 402
gi 32141323  339 ASETQRRRVDDYIRRGiaDGATLVTGGPGrpegfetGAYVRPTIFSDVapeSVIAQEEIFGPVLVVIPYTdDEHAVEIAN 418
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                  #                            
gi 16209569  404 DSEYGLRGGVWSRdVDRARAVAArMRTGQVMINGGeFNPNAPFGGYKQSGTGREFGTHGLEEFLEIKSLQF 474
gi 119476030 402 DSEFGLSSGVFAAnDSDAIAIARrMRAGQCFIQGGfFRLEAPFGGYKQSGNGREWGEAGLAEYQEIKAIIR 472
gi 87122739  407 DSQYGLSSAVYAKdAETALAIAKrLEAGQSYIQGSyFSMHAPFGGVKQSGNGREWGEEALEEYVETQAIIY 477
gi 71280481  402 DTVFGLSSGVFAKdANAALQIARkIRAGQSYIQGTyFNSHAPFGGFKQSGNGREWGVEGLREFIEVQSIII 472
gi 158316299 425 DSDYGLAGAVWAAdPARARDVGRrIRTGRVRINGApIDMRAPHGGLKRSGIGREMGRYGIEEYLEYQSLIS 495
gi 69937629  407 DSAYGLAGGLWCRdVERARAIARrIRTGRVRINGTpLEKRAPHGGFKHSGIGREWGRYGIEEFLEYQSIIG 477
gi 69937585  400 DCDYGLAGAVWAAdTDRARAFAQrMRAGRIRVNGTaISKYAPHGGFKLSGIGREWGRYGIEEFLEYQSIHG 470
gi 158316232 400 ATVYGLAGAVFGTdPDRIRRVTRlMRTGKVDINGTtFDPEAPLGGYRQSGNGREFGDYSLEEFLETKAVAD 470
gi 148557194 403 DSAYGLSGGVWSAdPARAERVAArLRTGQVMINGAmLDMEAPFGGVGQSGIGREYGRYGLEEYFNLKAITG 473
gi 32141323  419 GTVYGLNAAVTGD-EDHAMAIAVrLRVGQVDVNGGrHNFQAPFGGYKQSGNGREMGRAGLEEFLETKAITS 488

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