Conserved Protein Domain Family
ALDH_F2BC

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cd07142: ALDH_F2BC 
Arabidosis aldehyde dehydrogenase family 2 B4, B7, C4-like
Included in this CD is the Arabidosis aldehyde dehydrogenase family 2 members B4 and B7 (EC=1.2.1.3), which are mitochondrial homotetramers that oxidize acetaldehyde and glycolaldehyde, but not L-lactaldehyde. Also in this group, is the Arabidosis cytosolic, homotetramer ALDH2C4 (EC=1.2.1.3), an enzyme involved in the oxidation of sinapalehyde and coniferaldehyde.
Statistics
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PSSM-Id: 143460
View PSSM: cd07142
Aligned: 7 rows
Threshold Bit Score: 900.706
Threshold Setting Gi: 168029889
Created: 2-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
NAD(P) bindingcatalytic
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 118595573  51 VEHTQLLIGGRFVDAVSGKTFpTLDPRNGEVIAQVSEGDaeDVNRAVAAARKAFDEGPWPKMTAYERSKILFRFADLIEK 130
gi 116786856  61 VKHTQLLIDGQFVNAASGKTFpTFDPRTGDVIANVAEGDapDVNRAVKAARKAFDVGPWPKMTAYERSCIMLRFADLLEK 140
gi 75313899   55 VSHTQLLINGNFVDSASGKTFpTLDPRTGEVIAHVAEGDaeDINRAVKAARTAFDEGPWPKMSAYERSRVLLRFADLVEK 134
gi 168029889  22 VQYTKLFINNSFVDSVSGKTFpSIDPRSEEVAVEVAQAAaeDVDRAVKAARKAFEEGPWPRMPGCERAGIMNRIADLLDE 101
gi 27527741   41 NLPNKLFINNKWVDAKSGKTMgVEDPRNGEEILRVAEGDsaDVDLAVKAARKAFDEGAWPRMTGKERGRLIYKLADALEA 120
gi 118595574  17 IKFTKLFINGQFIDAASGKTFeTIDPRNGEVIATIAEGDkeDVDLAVNAARYAFDHGPWPRMTGFERAKLINKFADLIEE 96
gi 168067494  47 VKLTKLLIDGEFVDAASGKTFpTIDPRSEQVIAHVAEGDveDVNRAVRAARKAFDHGPWPKMPPFQRQRILLKYADLLDQ 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                             ## ##      
gi 118595573 131 HNDEIAALETWDNGKpyeqSAQIEVPMLARVFRYYAGWadk-ihGMTMPgd-gpHHVQTLHEPIGVAGQIIPWNFPLLML 208
gi 116786856 141 HNDEIAALETWDNGKpyeqASLVEVPMAVRLFRYYAGWadk-ihGLTVPad-gpYHVQTLHEPIGVAGQIIPWNFPLLMF 218
gi 75313899  135 HSEELASLETWDNGKpyqqSLTAEIPMFARLFRYYAGWadk-ihGLTIPad-gnYQVHTLHEPIGVAGQIIPWNFPLLMF 212
gi 168029889 102 HKDELSALDTLNMGKvydmARLGEAPLAIGLFRYYAGRwcdkaqGMTLPtn-gpFHAYTLHEPIGVVGSILPWNAPFYLL 180
gi 27527741  121 NAEAFARLETLDNGKplniSRIADVPLSVDHFRYYAGWadk-ihGKTIPvd-gpHMAYTLHEPLGVVGAIIPWNFPLLMA 198
gi 118595574  97 NIEELAKLDAVDGGKlfqlGKYADIPATAGHFRYNAGAadk-ihGETLKmtrqsLFGYTLKEPIGVVGNIIPWNFPSIMF 175
gi 168067494 127 HADELAALETMDSGKpyeqARYAELPLMSRQFRYFAGWadk-ifGTTGPsd-giHAVQTLHEPIGVVGQIIPWNFPLVMY 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        #  #                            ##   ##            ####  #  ##  
gi 118595573 209 SWKLGPALACGNTVVLKTAEQTPLSALLVGKLLHEAGLPDGVVNIVSGFGataGAAIASHMdVDKVAFTGSTDVGKIILE 288
gi 116786856 219 AWKVGPALACGNSIVLKSAEQTPLTALYAAKLFHEAGLPPGVLNIVSGFGptaGAAIARHMdIDKVAFTGSTETGKAVLE 298
gi 75313899  213 AWKVGPALACGNTIVLKTAEQTPLTAFYAGKLFLEAGLPPGVLNIVSGFGataGAALASHMdVDKLAFTGSTDTGKVILG 292
gi 168029889 181 AMKVAPALACGNTIVLKPAQQSPLSALLIAKLAAEAGLPDGVLNVVTGYGd-tGMHIASHMdVDKVAFTGSTQVGRQIMQ 259
gi 27527741  199 AWKLGPALAAGNTIVLKPAEQTPLSALLIAKLAAEVGFPEGVINVVTGFGptvGGPLASHKlVDKTAFTGSTEVGKIVAR 278
gi 118595574 176 ATKVAPAMAAGCTMVVKPAEQTSLSALFYAHLSKEAGIPDGVLNIVTGFGstaGAAIASHMdVDKVSFTGSTDVGRKIMQ 255
gi 168067494 205 CWKVAPALAAGNTIVLKTAEQTPLSAILAGKLALEAGIPPGVLNIVSGYGptaGASIAEHMdIDKVAFTGSTEVGKLVMA 284
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ###                               #                                 
gi 118595573 289 LASksnLKAVTLELGGKSPFIVCEDADVDQAVELAHFALFFNqGQCCCAGSRTFVHErVYDEFVEKAKARALKRnVGDPF 368
gi 116786856 299 LASksnLKPVTLELGGKSPFIVCEDADVDQAVELAHFALFFNqGQCCCAGSRTFVHEsIHDEFVEKAKARCLSRvVGDPF 378
gi 75313899  293 LAAnsnLKPVTLELGGKSPFIVFEDADIDKAVELAHFALFFNqGQCCCAGSRTFVHEkVYDEFVEKSKARALKRvVGDPF 372
gi 168029889 260 AAAqsnLKPVNLELGGKSPFIIFGDADMDAAVESAHQAIFYNqGQMCVAGSRTFVHEsVYDEYLERAKARAEKRvVGDPF 339
gi 27527741  279 LAAe-qIKPCTLELGGKSPIIVCPDVDVDRAVADAHMALFFNhGQCCAAGSRVYVHEkIYDEFVEKATKAAANHsVGDPF 357
gi 118595574 256 AAAasnLKKVSLELGGKSPLLIFNDADIDKAADLALLGCFYNkGEICVASSRVFVQEgIYDKVVEKLVEKAKDWtVGDPF 335
gi 168067494 285 AAArsnLKPVTLELGGKSPMIICEDANVDEAVELAHFALFFNmGQCCCAGSRTFVHEsIYDEFVEKSKARALKRvVGDPF 364
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                        # #             
gi 118595573 369 ksgiEQGPQVDSEQFNKILKYIKHgv-eaGATLQAGGDRLGSKGYYIQPTVFSDVkdDMLIATDEIFGPVQTILKFKdLD 447
gi 116786856 379 rkgvEQGPQIDQEQFNKILRYIKAgk-esGAKLVTGGDQIGTKGFYIMPTIFSEVqdDMAIATDEIFGPVQSIIKFKtLD 457
gi 75313899  373 rkgiEQGPQIDLKQFEKVMKYIKSgi-esNATLECGGDQIGDKGYFIQPTVFSNVkdDMLIAQDEIFGPVQSILKFSdVD 451
gi 168029889 340 kpgvEQGPQQADEAQFNKVMSYIRagkdeGARLITGGERVGSKGYYIQPTIFSDVqdDMKICREEIFGPVMSVIKFKtVE 419
gi 27527741  358 sgqyDQGPQVDNAQFSKILSYVEHgk-aeGAKLNVGGCRVGNKGYYVAPTVFSNVtdNMKIAREEIFGPVQSILKYStFD 436
gi 118595574 336 dstaRQGPQVDKRQFEKILSYIEHgk-neGATLLTGGKAIGDKGYFIQPTIFADVteDMKIYQDEIFGPVMSLMKFKtVE 414
gi 168067494 365 rkgvEQGPQVDKDQFHKVLGYVESgm-eqGANLITGGGRLGSKGYYIKPTIFTDVkeGMKIFDEEIFGPVQSIAKFKtLD 443
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                    #                                     #                            
gi 118595573 448 EVIARANNSRYGLAAGVFTQNLDTAHRLMRaLRVGTVWINCFdVLDASIPFGGYKMSGIGREKGIYSLNNYLQVKAVVT 526
gi 116786856 458 EVIKRANASRYGLAAGVFTQNIETANTLTRaLRVGTVWVNCFdIFDAGIPFGGYKMSGTGREKGIYSLQNYLQVKAVVT 536
gi 75313899  452 EVIKRANETKYGLAAGVFTKNLDTANRVSRaLKAGTVWVNCFdVFDAAIPFGGYKMSGNGREKGIYSLNNYLQIKAVVT 530
gi 168029889 420 EVIQRSNQSEYGLGATVMSKNVDIINTVTRsLKAGIVWVNTYgILTPSAPFGGYKSSGFGRENGAYALANYQQVKSVIM 498
gi 27527741  437 EVIRRANASDYGLASGVFSKDLDTVNTLVRgLHAGTVWVNCYnLFDSAVPFGGFKTSGIGREKGEYALSNYTKVKAVYM 515
gi 118595574 415 EGIKCANNTKYGLAAGILSQDIDLINTVSRsIKAGIIWVNCYfGFDLDCPYGGYKMSGNCRESGMDALDNYLQTKSVVM 493
gi 168067494 444 EVVQRANNTVYGLAAGIFSNNINTVNTLSRaLRAGTIWVNCFdVFDATIPFGGYKQSGIGREKGKYVLESYTQVKAVVT 522

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