Conserved Protein Domain Family
ALDH_LactADH_F420-Bios

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cd07145: ALDH_LactADH_F420-Bios 
Methanocaldococcus jannaschii NAD+-dependent lactaldehyde dehydrogenase-like
NAD+-dependent, lactaldehyde dehydrogenase (EC=1.2.1.22) involved the biosynthesis of coenzyme F(420) in Methanocaldococcus jannaschii through the oxidation of lactaldehyde to lactate and generation of NAPH, and similar sequences are included in this CD.
Statistics
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PSSM-Id: 143463
View PSSM: cd07145
Aligned: 10 rows
Threshold Bit Score: 665.203
Threshold Setting Gi: 41033583
Created: 2-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 37538023   13 MDVINPYSLEVIKkipalsrEEAKEAIDTAEKYKEVMKnlPITKRYNILMNIAKQIKeKKEELAKILAIDAGKPIKQARV 92
gi 146304537  17 ITVMDPGKGKPLNevsvagrEETRHAIELADQAFDHFSrlALKERTKILERAAEIMEkRSEELARTLTAESGKPIRDARV 96
gi 15898448    7 IEVRSPSNLNVIGtvkrmhkDEVRGEIEEAYKGFEIISkmPLYKRTAILRKVSEILErEQERLAKLLAMEAGKPIRDSRV 86
gi 41033583    9 VVVVNPATEEVLAvlpsasrEEVRRAIDEAEDAFYRWSelPLRERAKLLRRAADLIE-ADDTLINTLVAESGKPIRDARA 87
gi 159040665   5 IPVYEPATGEVLAyvpdmsiNEVRDAISKAYDALPRIQsiPAYERAKLLMKVAQAIRaRKEELARLLTREIGRPIKSTRL 84
gi 116621196  18 FAVRNPANGEIIDtvpqagpPDVHAAIEVARLGKAVMAalPAHARCEILKRASQTIErRAEELSQLLTSENGKPINQCRF 97
gi 146303890  16 ISVRNPATMETVDtvpllsrEQVKEAIESAWTALDALNslLIAKRSRLLLQVSQLIReNLQELAITMTRETGRPIKSSKG 95
gi 193806041  13 IDVFDPYTLENIEkitaldrEETKSAIEVAEKNKEIMKnlSPSKRYSILMKIAEQISlKKDLFAKTISIDVGKPIKQSKI 92
gi 193806040  13 IEVKNPYNNEIIGyipslsrNETKEAIKIAEEHKSTMKnlSPTIRYNILMKIASELSkNKRELAKLITIDVGKPIKQSII 92
gi 148642527  16 AEVKNPYNGEVIDtvpvshlNNVDLAIDAAVNAKDSIQemSAFKISNKLYAVYEKLKdNKDELAELLTKEVGKPINESVV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #                      
gi 37538023   93 EVERSIGTFKLAAFYVk-eHRDEVIPSDd---------RLIFTRREPVGIVGAITPFNFPLNLSAHKIAPAIATGNVIVH 162
gi 146304537  97 EVTRAIHLFRSAAQEVrlvLEGATFRVDgyeyppgnerRMVMSVREPLGVVGAILPFNFPANSFAHKVAPNLAVGNTVVV 176
gi 15898448   87 EVLRASRLFRHAAEEVgmvLEGKNYRVDayeyppgnenRIVVSTREPIGVVTAILPFNFPINSFAHKVAPALAVGNSVVV 166
gi 41033583   88 ELRRAIEIFRASAEEAkyiLEGKIPRVDaydyplanenRIAMEVREPMGVVAGALSYNNPASTFAHKIAPVIAAGNTVIA 167
gi 159040665  85 ILERTARIYELAAQELphvLTGEFIPLEaydypagnekRIAFIRREPVGVVGAITPFNFPPDSMAHKVAPALAIGNTVVL 164
gi 116621196  98 EIGVTARLFSDFAEEAk-rIRGQYLPMDnvpg---lerMVAYTLRHPIGIVVGIIPFNYPAELFAHKIPGALAAGNSVIV 173
gi 146303890  96 EIERTAQIFELASSEVrrvFEGKYIPLQeyefpagnerRMALITREPIGVVGAITPFNFPAASFAHKVAPSLAVGNSVVF 175
gi 193806041  93 EVDRTLTALKLSAFYAk-eLRGETINSEn---------GLIFTKKEPLGVVGAITPFNFPLNLITHKIGPAIATGNSVVL 162
gi 193806040  93 EVDRTITTFKFSAFYSr-eLRGETIPFDd---------GMVITKREPVGLVGAITPFNFPLNLFAHKIAPAIAMGNSIVA 162
gi 148642527  96 EVNRSIETLKLSAEEAk-rIYGETVPLDggin---gkgFFAFTQRVPLGVVAAITPFNYPLNLSIHKIAPAIACKNTVII 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       #
gi 37538023  163 HPSSkaPLVCIELAKIIENalkkyNVPLGVYNLLTGAGEvVGDEIVVNEkVNMISFTGSSKVGELITKKAg--FKKIALE 240
gi 146304537 177 KPSTstPITGVLLGEILYEa----GLPKGVLSVLPGGGDtVGAEIVENRrVKGITFTGSTPVGTSIASKAvttGKRVMME 252
gi 15898448  167 KPSIntPLAAIEMKKILVEa----GLPDSAVRVVTGYSSeIGDEIITHPlVGLITLTGSTQTGLKIASKAvslGKRIIME 242
gi 41033583  168 KPSShtPLTALKMAQILQKa----GVPQGVVQVVVGSGEeIFNEFVDNPkVVGISFTGSTAVGLQVAAKAagrGKKFMIA 243
gi 159040665 165 KPSRnsPLTETEIAKIITEv----GFPEGSINVVTGDSSmIGDEFVNNPkVSLITFTGSSKVGLNLASRAilmGKRVIME 240
gi 116621196 174 KLPEqcPLTVLMLGEILLDa----GLPPEGMQMLTGYPQeMGDELLTHPdVGMISFTGSASAAKLIACKAagtLKRLAFE 249
gi 146303890 176 KPSSltPLTQLKLGELVSR-----VFPPGAINVVTGDSSmIGDEFVTNPkVSVITFTGSASVGLGLASRAireGKRVIME 250
gi 193806041 163 HPSSkaPIVAIYLTKIIEHvlkqmDVPRGIFNLATGNGDiVGDEISKNDnINMVSFTGSVEVGESISKNAk--MKKVALE 240
gi 193806040 163 HPSSkaPMITIELTKIIEKvlkskKIPLGVFNLLTGEGHiVGDEIVKNNkINKLSFTGSVEVGESITKKAg--FKKITLE 240
gi 148642527 172 KPPInaPLTVMKFAELVNE-----EFPDGVINTVTGYGSeVGDALVTSPkVDKISFTGSVATGLLIASRAg--MKKVTLE 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                       #  #                                             
gi 37538023  241 LGGVNPNIVLKDADLNKAVNALIKGSFIY-AGQVCISVGMILVDesIADKFIEMFVNKAKVLNVGNPLDEkTDVGPLISV 319
gi 146304537 253 MGGSDPIVVFKDADLERAVSISVRARFEY-AGQNCNAGKRILVQeeIYEKFLKEYVNRVKSLRVGDPMDEsTEMGPVISA 331
gi 15898448  243 LGGSDPIIILEDANIERASSIAVRARFEY-AGQNCNAGKRIIVReeIYDKFVKAFNDKARALKVGDPLDEtTDVGPVINK 321
gi 41033583  244 PGGSDPAIVFADADLEAAASIIARARFEN-AGQNCNATKRVFVErkVYDKFLDILRRKIAAIKVGDPMDEsTEMGPVISD 322
gi 159040665 241 LGGSDAMIILEDADLNKAVQAATVGRFDY-AGQFCNATKRLIVRdeVYDEFIKRLTESVSKLKIGDPLREdTDVGPLISR 319
gi 116621196 250 LGGTDAMIVLEDANLEAAADAVVHGRLTNgAGQICCAAKRILVQesVYSRFLDLLIERVGKINMGDPLLDeTNLGPMISP 329
gi 146303890 251 LGGSDAMIVLEDADLKRAVKSALLGRYDF-AGQFCNATKRVIVRkeIEDKFSALLREEVSKLRIGDPLDEnTDLSPLISG 329
gi 193806041 241 LGGNNPMIVLKDSDIKLAAKSAVKSKFLN-AGQVCISVGQVLVEeeVLETFTKHVIEETKKLILGNPLDTkTDIGPLISP 319
gi 193806040 241 LGGNNPMIILKDANINKAVESCMSGKFLN-SGQVCISVGRVLIEqeVADEFINKIVEKVKKLKIGNPLDEdTNISSLISL 319
gi 148642527 245 LGGNDPLVVLKDADIDRAVNGVMNGAYLN-AGQVCMGVKRIIVDesIADEFTQKLVRETKKIKMGDPMDKnTVLGTLIDE 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 37538023  320 EHAEWVEKVVEKaideGGKLLLGGKRd---kALFYPTILEVDr---dNILCKTETFAPVIPIIRTN-EEEMIDIANSTEY 392
gi 146304537 332 SVVKDLENAVLDsetkGGVIHRGMAGtg--gYYFAPTVVENAnl--dMVIMKREIFGPVAPIAKFSdWKEAVELANSTEY 407
gi 15898448  322 ESVENLNSVLADakakGGKVEILNKGpe-sgSFFPLTMVTNPsl--dMLVLKSEVFGPIVPIVSVKsDEEAIRIANSTEY 398
gi 41033583  323 KMVKAMEGIVADavekGGKLLYGGRRmqrkgYFFEPTLVAFDgrppeAKAFREEVFGPVLPVAPFEdEREAVELANWTQY 402
gi 159040665 320 EAVETMEFFVNDalskGGRIIYRVSGvpergFYYPPTILEAPf---nSAVWIEEVFGPVLPVARVKdDDEAVELANRTEY 396
gi 116621196 330 QAVDKAHDQVRQslemGARCLTGGERid--gCFYQPTVVVDVtp--eMPVMRDEVFGPVAPIYTFKdAESAVRIANDSPY 405
gi 146303890 330 EARERMKLFLDDavskGGEIIYKGEVqe-rgNYFPPVILRLRpf-sdLKVLKEEVFGPILPIVSVDsDDEAVDVANSTEY 407
gi 193806041 320 ESALRIENLIKKsvneGGEVLIGGNRq---nSLISPAVINIDe---nNILSKIETFGPVLPILKVKdSEEAVSIANNSKY 393
gi 193806040 320 DSAERVEKLINKsigqGGKLICGGKRe---nSIIYPTILEITa---dNILANIEIFAPVLPIIRVNdMNEALNQANNSNY 393
gi 148642527 324 DAARMVEETVNNavkaGAKILTGGKRd---gAFYEATVLDNVtp--dMDVVVNETFGPVAPIIKVKsTDEAIKVANDTEY 398
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1                                                                                
gi 37538023  393 GLHSAIFTNdINKSLKFAEnLEFGGVVINDSslFRQDNMPFGGVKKSG---LGREGVKYAMEEMSNIKTIII 461
gi 146304537 408 GLQASIFTSdLKLALKMSReIRAGAVIVNDStrLRWDSLPFGGVGLSGi--GSREGVRSTMLAMTEEKLISL 477
gi 15898448  399 GLQSAIFTNdVNRALKLSReLKFGAVIINDStrLRWDSLAFGGFKKSS---IGREGVRETMLEMTENKLIAI 467
gi 41033583  403 GLQSAVFTSdYKRAFRVARaIKAGAVMINDStrVRFDALPYGGVKMSGlsaGWREGVRSTMLLFTEIKYYVL 474
gi 159040665 397 GLDASIFSRnFSRAYKLATrIKAGTIFINDTtrLRFDNLPFGGFKKSG---IGRESVRDTMIEMSEVKVISY 465
gi 116621196 406 GLQASVFSEnISNALKVAHkLEVGGVVINGSgaFRPGNIPFGGFKQSG---IGRESIVETVLDMTEETTIVI 474
gi 146303890 408 GLDASIFTKdFGRALRIASrLKVGTVVINDTtrLRWDNLPFGGTKKSG---IGRESVLDTMLEMTETKLIVY 476
gi 193806041 394 GLQAGVFTNdINKAMKIADsLEYGGIMINSSptFRKDNMPFGGVKKSG---LGREGIKYTVEEMCETKTIVI 462
gi 193806040 394 GLHSGVFTQdINKALYFADnLEYGGVLINNSptFRIDNMPFGGIKHSG---LGREGIKYAIDEMSEIKTIIV 462
gi 148642527 399 GLQAGVFTEnFRDGLRCANeIEAGTVFVNKQstFRTDNMPFGGFKNSG---TGKEGVKYAVEEMTKEKLIGL 467

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