Conserved Protein Domain Family
ALDH_PhpJ

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cd07146: ALDH_PhpJ 
Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like
Putative phosphonoformaldehyde dehydrogenase (PhpJ), an aldehyde dehydrogenase homolog reportedly involved in the biosynthesis of phosphinothricin tripeptides in Streptomyces viridochromogenes DSM 40736, and similar sequences are included in this CD.
Statistics
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PSSM-Id: 143464
View PSSM: cd07146
Aligned: 9 rows
Threshold Bit Score: 647.109
Threshold Setting Gi: 111225712
Created: 2-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 51317969   14 TTVHDRWTGEPVGtvp---rdGAEEAAAAVAALAAGRRa-TTPQQRSAVLTRAADMLTARAEEFSTLITAESGVcrkETL 89
gi 111225712  20 AEVRNPYTDEVVGtvv---raSPEQALEAARGLAGVRSe-LTAYDRSNILTATAELLHRERDDFASTISQESGLaimDAR 95
gi 48869212   11 LLIKNPYTGETIHel----evDSISAISEIIDTSYNYRshLSRSQRADILKKCAMYLEKDKDEAASLITSETGLskkDTC 86
gi 167565302  28 LIVSNPYDGEAIAel----plENGDDARRKLQTAARFTstLSRHDRIAVFEKAIALLAAEKRDASILITLESGLcrkDTM 103
gi 91789081   35 IEVKHPYSGKIVAtv----pkATLDDVRRALRIARDYRstLTRHDRYRILMKAGELVAHRRDEIARLITLESGLclkDTQ 110
gi 170296784  24 IEVLYPYTDEVVGtv----paGTAEHARKAFEIAANYKskLTRYERSEILKKAGRLIGEKREDLAKWLTLELGIchqHAI 99
gi 162450822  26 ILVRYPFTGEVIGsv----prLDEGTVLEALASVSSGPprLSRHERSEILLRAAAHIEAQAGAVARLITWESGLclkDTA 101
gi 171915429  20 LEVFNPWDGSRVGsv----arITRSQLDEVIASHLAPHgpLTRYERATILNRTHDLLNGRREELARIITREAGLclkETR 95
gi 89093051    5 YSLVNPFDNSPLGeyeytpwaTLENQLAMLKEGQLSQRk-TAAFQRAGVLNKLAALLKEHSEEMATLITQETGKtilDSR 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #                        
gi 51317969   90 REVSRAAGNLRVAAAEAeriRGESIPLpd----gtRLAVTLPEPV-GVVLGITPFNRPLNQVVVKAAPALAAGCPLLLKP 164
gi 111225712  96 REVDRAATQLRYCAEEGkriTGEAIRTdvtsarqrRLAITTREPI-GVVCAVTPFNRPLNQVVTKVAPAIAANNRVVVKP 174
gi 48869212   87 YEIGRTINVLLSGVNEIlssEESIMDCdlyegfkeRKIISIREPLdGIIYAITPFNHPINQVAHKVIPAIATNNRIILKP 166
gi 167565302 104 YEIERVINVLRAAIAELnrdDSQTFSCdnattadkRKIFTVREPLrGVVAAITPFNHPMNQIAHKICPAIASNNRVVLKP 183
gi 91789081  111 YEVGRASDVMLFAANQAlvdDGQVFSCdltahgksRKVYTLKEPLlGAITAITPFNHPLNQVIHKIAPAVATNNRVVLKP 190
gi 170296784 100 YETKRAQDVYDFAAAQVlndDGEIFSCdlthngkaRKIFTKREPV-KAISAITPFNHPLNMVSHKIAPSIATNNCMVCKP 178
gi 162450822 102 YEVRRALDVLRFSAYEAlrdDGQCLAFdisangkpRRGYTLREPL-RLVTAITPFNHPLNQVAHKVAPSVASGSSMVLKP 180
gi 171915429  96 YEVGRACDVFSFAAMEAlrdDGQTFSCdisptgkaRKIFTHREPL-SLVAAITPFNHPLNQVAHKLAPAIAAGAPIILKP 174
gi 89093051   84 VEMMRAYNAAIASAEEArqiQGESLDSdayapaggKIGVVCWKPL-GTILCITPFNFPINIAIHKIGPAYAAGNTILFKP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                               #        
gi 51317969  165 SEKTPLTALAFAELLVEaGCAKDMLAVVTGEPGevGPPLAAHPdVAMVTFTGSVATGHAVAAQAAGKRQLLELGGNDPLF 244
gi 111225712 175 SEKTPLSAIRLVDALLRsGLPPDLIALVCGEPGelVDALIHSGhIDMLTFTGSTRVGRLLAASAGMIRQTYELGDSGALV 254
gi 48869212  167 SEKTPLSAIYFRDLLYKcGLPKEMFSLVIGNPKilYERMISDLrISMVTFTGGVDVGKSIACTAGYRKIVLELGGNDPLI 246
gi 167565302 184 SEKTPLSALYLLDLFREaGLPEPMFDVVIGAPDvvGAELVRNDqVELVAFTGSVAVGKRIAEMAGYRRTILELGGNDPLI 263
gi 91789081  191 SEKTPLAAYLIADILYEaGLPPQMLSVVTGDPAeiADELLTSPdVDLVTFTGGVAIGKYIAGKAIYKRQILELGGNDPII 270
gi 170296784 179 TELTPLTCLALADILYEaGLPPEMFQVVTGLPQdiGEEMITNEnIDIITFTGGVPVGKIIADKAGYKRQALELGGNDPLI 258
gi 162450822 181 SEKTPLSAIYLASVLHEsGLPPGMLSVVTGDPAeiGRALVTHPaVELVSFTGGVEIGKRIASLLGYRRAVLELGGNDPLI 260
gi 171915429 175 SEKTPLTAARLAEVLYEaGLPGWMLSVVHGSLEeiTTPLIQDErVELVTFTGSASVGKKIAATAGYKKLCLELGGHSPMI 254
gi 89093051  163 GPQNTASAQLLVKLCYEaGMPENTLQLCMPEFSd-LDRLNAHPdVNAINFTGGTAAANAISAAAGYKKLLLELGGNDPLI 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                 #  #                                                   
gi 51317969  245 VLPDa---DLRRAAKLAADGSCATAGQSCRGIKRVFVWeeVADEFTALLEPAVAAKrAGDPRREdTDLGPLVSEEAALVV 321
gi 111225712 255 IMADa---DIPAAVAAATAGAFATSGQSCRGVKRIIAHedVADEFVRELAAAASALvVGDPGDPaTDIGTLIDRHAASEV 331
gi 48869212  247 IMPDa---DLERATDLVVRGSYSNSGQRCTAVKRVLAHksIVHDLNYLVAEKSKAWvTGDPMQSaTMMGTVIDEEAAIRI 323
gi 167565302 264 VMEDa---DLDRAAQLAVKGSYKNSGQRCTAVKRILVErtVAGRFTELLVEHSRRWkIGDPMDEhVDIGTLIDDAAAIEC 340
gi 91789081  271 VMDDa---DIEEAATLAASGSYKNSGQRCTAIKRILVQesVADRFVELLVEKTRALkYGDPFDPaMDMGTVIDEPAAIHF 347
gi 170296784 259 ICNDlsdaDLEKAATIAVAGATGNSGQRCTAIKRILVQesVADRFVPLVLEKAKKIkFGDPQNPaTELGCVIHSTAAELF 338
gi 162450822 261 VLDDa---DLDEAVRLAAYGCYRNSGQRCTAVKRLIVSerVADELAGRLAAASAQIkVGDPLDPaTDMGTVISEAAARQL 337
gi 171915429 255 ILEDa---DLDLAAKLACEGSFRNSGQRCTAVRRLLVHekVIQEFTDRFVKLAATYvHGDPAEEsTVVGTVIDEPAAIAL 331
gi 89093051  242 VMDDg---DLEAATTAAINHRFATAGQRCTAAKRLFIHanVYEAFRDLLVEKSSKLvVGDPMKDdTFVGPVINQGAADQI 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 51317969  322 ERRIARAVrdGARLVTGGERdGALVRPAVLDHVppdTELVTEETFGPVAPVIRVRd-ADEAVRLSNGTAYGLQAGVLTRd 400
gi 111225712 332 EARVARAVaaGARVLCGARRvGAQYWPTVLDHVprdADLVRLETFGPTAPVIRVKd-FPEAVEVVNDSRYGLQAGIFTNn 410
gi 48869212  324 QNVVNGAIdqGARLLSGNQRnGALLSPTVLTNVdpkMQLVTQETFGPVTPIITFEt-ISEAIAIANSTAYGLSSALCTNr 402
gi 167565302 341 ARRVDEAIdaGARVLLGHRRdGAAYAPTVLDRVdpaLRLVQQETFGPVSPVIAFSg-LDEAVAIANSTRYGLSSGVCTNr 419
gi 91789081  348 EKVVNEAIaqGAKLLVGNVRrGALYAPTVLDHVrpgMTVVREETFGPVSPVIRFKt-LDEAIAIVNGTAYGLSSSLCTNr 426
gi 170296784 339 ENRVLDAEkqGAKILYHPGRqGALLPPIVIDYVpheCELVMEETFGPIIPIVRVPdnDEEVMAISNSTEFGLSSGVCTNd 418
gi 162450822 338 EAAAEDTLarGARLLFGNERrGALYGPTVMDHVprdAPSVQRETFGPHAPILRVRd-IDEAIAVANGTSYGLSAGVCTNd 416
gi 171915429 332 EGAVLEAVgkGAAVLLGGSRqGAQMAPTILENVprsAYLATNECFGPLAPIFPVKd-LDDALEFSNATAYGLSSAIVTNs 410
gi 89093051  319 RTLIEQAIedGASVALGNQYeGAFVYPTILENVsptSEIMVEEAFGPVMPLYKFEs-VEEIIPIINNTAYGLQAGVFSQn 397
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                    
gi 51317969  401 sAAFWDIAArLRVGAVNLGEGPHFDSPHIPFGGVKSSG-VGREGIRYAIAEMTVTKTVTL 459
gi 111225712 411 lEHARRAAElFDVGAVVVNGGPQFESPNIPFGGVKDSG-IGREGARYAIEEMTRVKTLVI 469
gi 48869212  403 lDWIKEFSSrLNVGTMNVWEVPGFRTELSPFGGIKDSGlGLKEGVRESMKNYTNIKTISL 462
gi 167565302 420 lDYITHLIAnLDVGTVNVWEVPGFRLESTPFGGVKDSGlGSKEGMQEAIKNFTNLKTYSL 479
gi 91789081  427 lDTITRVVQeLHVGSVNVREVPGYRLEMTPFGGIKDSGlGYKEGVLEAMKSFCNTKTYSL 486
gi 170296784 419 lHRAISYINgLDVGTCNIWEQPGYRIETSPFGGIKDSGnGVKEGVTEAMKFFTNVKTYSL 478
gi 162450822 417 lGRVHRLVReLRCGTVNVREVPGYRSELSPFGGIKDSGiGIKEGVVEAMKAMTNVKLYTV 476
gi 171915429 411 mDAVIKTVKtLKVGTVNVNEIPGYRLELSPFGGVKDSGlGIKEGVIEAMKFMTTVKTFSL 470
gi 89093051  398 lATIKELYEqLDVGTLAANDGPGFRTEHFPFGGVKESG-IGREGIKYAIREMSYTKTLVI 456

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