Conserved Protein Domain Family
ALDH_F21_RNP123

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cd07147: ALDH_F21_RNP123 
Aldehyde dehydrogenase family 21A1-like
Aldehyde dehydrogenase ALDH21A1 (gene name RNP123) was first described in the moss Tortula ruralis and is believed to play an important role in the detoxification of aldehydes generated in response to desiccation- and salinity-stress, and ALDH21A1 expression represents a unique stress tolerance mechanism. So far, of plants, only the bryophyte sequence has been observed, but similar protein sequences from bacteria and archaea are also present in this CD.
Statistics
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PSSM-Id: 143465
View PSSM: cd07147
Aligned: 18 rows
Threshold Bit Score: 673.189
Threshold Setting Gi: 21224028
Created: 1-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 75247698   24 LDVTNKYTGEVGAkvqlathdDVDKAIDAAVAAAPAMAaLGAFERKAILEKTVAELKKRAEEIAQILTMESGKPIkDARG 103
gi 88601771   19 IPISNPYSLVTFAevcaagpdEIEEAIRIAEQGAVRMAaLPAHKRSELLFHLVRLMEEEADILTDIIVREGGKVRkFAAA 98
gi 94968559   27 VEIHSPFDHKVIGqvfygssaHVEAAIRASVEAFQITRkLGSYERERILSAISQKLSEQREDFAHTIALEAGKPIkTARQ 106
gi 148657593  23 YTVACPYDGSPVAvvhraapaDLEQAIQAAVEAFRTTRrSPLHRRAAALRAIAAGIEARAEELARTIALEAGKPIkQARI 102
gi 117924137  17 LKVYNPYNDQLVDtvaqcgphEIDRALDGAVDALEQTSrMQPYERAACLAKIRDGIAARGAEFARVLSLENGKTLaESTL 96
gi 126178509  20 LDVRFPYTGEVVGrvclagsdDVEDALRCAERGFSLTRrLPAHRRSEILYNLADLIRERSAELTGTIMLEAGKTRaLAES 99
gi 66826255   31 LEVIDKFTNEIASkipmadkeMIEQSIVIAQKACEPMRqLSAATKKQILLNIANDLEKRADEFAKAIVVEVGKPLvDANA 110
gi 149200054  19 TESTCVYSQKKFAevslanpeHIEQAIEIGHKAKNSMKnLSAHQKRKVLLECRDLFEVNFEDLAETITLESGKTInESRA 98
gi 10443299   19 IDVQYPYDGRTVAsvfvpsaeQVEEAVAAMHAARDVVGaTSAHRRASALSHVADRLEQRSEEAAQVIVLESGKPIkWARV 98
gi 21224028   20 FDVTSPWDGTTVGtvslptdaQVEEAVAAAYAVRDEFAaTPAHVRAAALDHVGRRLAERTEEIARLISAENGKPVkWARG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                              #                         
gi 75247698  104 EVARTIDTFQVAAEESvr-iYGEHMPLdisarnkGPQGIVKKFPIGPVSMVSPWNFPLNLVAHKVAPALAVGCPFVLKPA 182
gi 88601771   99 EVARAIGTIRISAEEAvr-iHDQMVPMdgypageGRIAMIMRVPVGIVLAITPFNLPLNQICHKAGPALAAGNSCIIKPP 177
gi 94968559  107 EVERAIYTFKVAAEEStr-iEGEYLHLdtieatkGRWGIVRRFPIGPIFAITPFNFPLNLVAHKLAPAIAAGCPVILKPA 185
gi 148657593 103 EVARSIVTFSTAADEAtr-sNDEALRLdaapggeGRQAIVRRFPVGPVAAITPFNFPLNLVAHKVAPAIAAGCSVVLKPA 181
gi 117924137  97 EVARAVATFDIAVGEAtr-iYGEAYDLginpmgsGRRALVRKYPIGVVSAIAPFNFPINLAVHKIAPALAVGCPVVLKPA 175
gi 126178509 100 EVVRARETIEVSAEEArr-iDGTILPLdwnaageGRVGCLRRFPLGPVLAITPFNFPLNLACHKLGPAIGAGDSVVLKPA 178
gi 66826255  111 EVGRAIDTFTCAAEESir-qYGEQIPLdissrnlGFQGITKRFPVGPISMIAPFNFPLNLCAHKIAPSIAAGCPFVLKPS 189
gi 149200054  99 EMQRVISTFDYASIEVmk-mDGEVLAMdthanseEFECLIKRFPKGLCTFITPFNFPINLIAHKVAPAIAAGCPFIIKPS 177
gi 10443299   99 EVARAASTFRWAAEEArr-wSGTLQRLdtdaggaGRLALVRRFPRGSLLAITPFNFPLNLVAHKVAPAIAVGVPVIIKPA 177
gi 21224028  100 EVGRAVSVFRFAAEEArrfnGGEAQRLdtdaggqGRLALTRRFPKGVVLGIAPFNFPLNLCAHKIAPAIAAGAPLILKPA 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                               #        
gi 75247698  183 SrTPLSALILGDILVPd-rGAAKGAFSVLPVSRAdADMFTVDERFKLLTFTGSGPVGWDMKARaGKKKVVMELGGNAPCI 261
gi 88601771  178 SaTPLTGLKFGELLIRa--GFPKEAVSVIPCRSDiAERLATDKRISCLSFTGSPSVGWHLRSItPARHVTLELGGNAAVI 255
gi 94968559  186 PqTPITALKLARVIHEs--GWPAGALTVMPLSNEdASLLVTDERIKLLTFTGSSIGWDLKSKA-GKKRVLLELGGNAAII 262
gi 148657593 182 SqTPIVALKLAEIIASs--GWLPEALSVLPLASRdAAPLVEDERFGLLTFTGSPVVGWEMKRRaGRKRVTLELGGNAGVI 259
gi 117924137 176 SlTPLTALMMAEVVEAs--GWPKQAFSVVPCNRSaGQMLVEDERIKLLSFTGSPEVGWKMKSEaGKKKVVLELGGNAGLI 253
gi 126178509 179 SaTPISSLMLGEMALDa--GIPPEAVSVVPCHTDlAERMVRDDRVACVSFTGSPAVGWHLREIaGRKRVGLELGGNAAVV 256
gi 66826255  190 DrTPISAMLLGELLAKqtpLLPEGAFSILPTTHQdASILSKDERFKLCSFTGSPAIGWKIKNEaGKKKVVLELGGDAACI 269
gi 149200054 178 DkTPICALKFAEILKQt--SLPKEAFSVLPCSNEdSLKLVKDERISFLSFTGSEKVGWMLKGLaGKKSVCLELGGIASCA 255
gi 10443299  178 PsTPLSSLFLGQLLAEt--DLHQGSWSVLPVPNSqMEHLILDPRLPIISFTGSGPVGWDIKSLvPRKHVTLELGGNAAAV 255
gi 21224028  180 PaTPLSGLILGELLAEt--DLPAGSWSILPVPNDkMPALVQDERLPVISFTGSETVGYAIMDSvPRKHCTLELGGNGAAV 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  #  #                                                  
gi 75247698  262 VDDYv---pDLDYTIQRLINGGFYQgGQSCIHMQRLYVHerLYDEVKAEFLAQVKKLK--VGNPFEDdTFIGPMISEKDA 336
gi 88601771  256 VHDDa----DQTLAASRIIEGAYSHtGQVCISVQRVFIQrtIAYRFIYELVSRCNALV--TGDPEDPaTDVGPMITPDKA 329
gi 94968559  263 IHSDa----DLRFAAERCAHGAFGYaGQSCISVQRILVEksVYSEFRQMLVNAAGKLK--TGDPLDEaTDVGPLIRESDA 336
gi 148657593 260 IHSDa----DLAFAAARCVVGGFSYaGQSCISVQRIFVHasVYDAFMELFVPQVQALK--VGHPLDEaSDLSALINPSEA 333
gi 117924137 254 IDHNv---kDWDHLIQRAILGAFYQcGQVCISVQRIFVHqdVMGEFRARFAKAAQALV--IGDPLDAkTTLGPVIDRANV 328
gi 126178509 257 VHEDa----DIPFAAGRIVAGAFSNaGQTCIAVQRVYLHrpIYEEALALLVERARALT--TGDPREPgTDVGPMISAPAA 330
gi 66826255  270 VDSAtq-qsRLPSIAQRILFGGFYSqGQSCISVQRVFIHdsLYDQMKQLLIDGAKPLIqrMGDPMDPtTFVGPMITEHDA 348
gi 149200054 256 VYPDt----DLANASKNILTAAFGQaGQSCISLQKLYIHneVKESLIKLLVDGCKDIV--LGDPSDQkTKLGPLINEDSL 329
gi 10443299  256 VCSDwsseqDLEWAAQRIALFANYQaGQSCISVQRVYVPreLYEVFTVLLSRHIGALR--QGNPNDDaTDVGPVINEASA 333
gi 21224028  258 VLADwasdeDLDRAATRIATFSNYQgGQSCISVQRVIADaaVYDRLLPRIVAAVEAQV--TGDPNDDaTDVGPLVSEAAA 335
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 75247698  337 TRVEDWVKEAVekGGKLLCGGSRk----GAVMQPTVLEDVpmdAMARKEEIFGPVVLFYKYSdFKEAVKECNNTHYGLQS 412
gi 88601771  330 KEALQRIEEAVsqGARVLCGGRLs----GHLLLPTIIADTtpdMAVNCEEVFAPILTVTPYEsFEDAIAMVNDSRFGLQA 405
gi 94968559  337 LRAESWVKEAVaqGATLLCGGTRk----GSLLEPTVLTNTrpeMLVNCREIFAPVVTVEAYDdFNEALRQVNNSPFGLQA 412
gi 148657593 334 VRVSAWLNEARsaGAEFVTGGMVe----GGVVAPTIVARAapeLRVNCQEIFAPVVTVQPYTtFEEALAAVNNSEFGLQA 409
gi 117924137 329 ERLQGWIQEALdqGAALVTGNTIadvgaGNSMTATILEEVdagCRINADEAFGPVVTLTPVQsMDEAFHLVNNSRFGLQC 408
gi 126178509 331 ETAFAKVEDAIagGAKVLVGGTRd----GPLFKPTILVDTtpdMAVNRTEVFAPVVTVAPYEtFEEAIAFANDTEYGLQA 406
gi 66826255  349 KRVESWVNNAVskGANVLVGGKRn----DHFMQPTILENLpldTEISCKEVFGPVFFIERFNdFKQVVQRVNSSEFGLQA 424
gi 149200054 330 QRVQKLINQSVktGTEIITGGKRr----NNSFEPTILTKLdinDPISTQEVFAPLFIVEEFNnSDELFQIINKSPYGIHV 405
gi 10443299  334 IRIEQWIDDAVhaGAKILVGGRRn----GTSLEPTLLADVplaARILRDEAFGPVVSITPFDsLDSAFAAVNDSDFGLQT 409
gi 21224028  336 ERVEAWVREAVdaGAKLLTGGKRd----GASYAPTVLTELpadTTLAHEEVFGPVLSVQRVTgEAEAFAAVNDSKYGLQA 411
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                                         
gi 75247698  413 GIFTKDLNKAFYAFEhMEVGGVILNDSPaLRVDSQPYGGLKDSGIQREGVKYAMEDYLETKVLVM 477
gi 88601771  406 GIFTKDLGLAIHASKtIQCGAVLINDIPtFRIDSMPYGGVKESGIGREGPYYAIREMTEERLVII 470
gi 94968559  413 GILTRDAQRIFTAFNgLDVGGVVAGDVPtFRIDHMPYGGIKDSGLGREGVRYTIEEMTEPKLLVM 477
gi 148657593 410 GVFTRDVGRIFQAYEeLEVGGVIINDVPtWRIDPMPYGGVKQSGFGREGLRYAIEEMTERKLLVV 474
gi 117924137 409 GLFTQDFATVMRALDqLEVGGVIHNDVPsFRVDSMPYGGVKDSGLGREGVKYAMEDMLEPRVLVY 473
gi 126178509 407 GIFTHDSRRIAQAFEeLRVGGLVVNDIStFRMDHAPYGGVRGSGIGREGPKYAIEEMTEERMMIF 471
gi 66826255  425 GVFTDDIHKAYYAFNnIEAGAVVINDIPsVRVDAQPYGGVKESGFGREGIRHTIEEYTELKLMIL 489
gi 149200054 406 GIYSSNIKLAMRAWNeLECTSVVFGHVPtWRSDKMPYGGIKNSGCGREGLKYAIEEMTELKSLVI 470
gi 10443299  410 GVFTRDIRTAFRAHRdLEVGGVIIGDVPsYRADQMPYGGMKDSGIGREGVRSAMDDFTVEKVLVL 474
gi 21224028  412 GVFTHDLQAAFRAHRaLEVGGVVIGDIPsYRADQMPYGGAKQSGVGREGVKFAMDDYTYERVLVL 476

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