Conserved Protein Domain Family
ALDH_VaniDH_like

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cd07150: ALDH_VaniDH_like 
Pseudomonas putida vanillin dehydrogenase-like
Vanillin dehydrogenase (Vdh, VaniDH) involved in the metabolism of ferulic acid and other related sequences are included in this CD. The E. coli vanillin dehydrogenase (LigV) preferred NAD+ to NADP+ and exhibited a broad substrate preference, including vanillin, benzaldehyde, protocatechualdehyde, m-anisaldehyde, and p-hydroxybenzaldehyde.
Statistics
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PSSM-Id: 143468
View PSSM: cd07150
Aligned: 11 rows
Threshold Bit Score: 670.577
Threshold Setting Gi: 118468557
Created: 2-Jan-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:catalytic residues [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 206677247  24 FDDTNPNDGSLWAripdatcqDARRAIDAAQAAFPAWAaLKFQDRANIMLKVAQIIEKRAGDYIPAAQFEgGGWYGKGVY 103
gi 70607586   22 KVKTSPIDNSPLAeiavgdreDAKRAIDSAYEAFKGWSsLTAMKRSEYLLKLEETIRANEGDLINTLIVEgGGTYKKAWG 101
gi 109900194  21 DTSYNPATSEPYAvvqlasvqDATDAIASAHQAFQTWKdVLPSVREKILLDIADAFERRADEFKDLLIDEaGSSMLKAGY 100
gi 154499863  35 MEDRNPADGSVMAmvhmggrqDAEKALAAAYAARGKWAaTAPDVRERILLRAANEMEARAEGLTQLMIAEsGSARYKAWG 114
gi 160938328  20 AEDKNPADDSVFArvhfaggaEVEEAIAAAQRAWRPWAdTPAAQKEQILLKAADWMQEHIDEVADVLMGEsGSAFGKAYF 99
gi 18313376   19 RPKHSPIDGSVIAetpvskreDAKAAIDAAYDALKAWSqLPAIKRAEYLYKLYEIIKSREEELINILMVEgGGIYKKAWG 98
gi 10957001   21 FDDLNPVDDSVYSrvpagtaeDVNRAVENAHQAYLQHRdLPAAVREGWIAKAAEIMERDTAKFADVLVDEiGSPIAKAGF 100
gi 206679783  27 FEVLNPLDDSPYAyaakgsgnDVRQAVAAAKAAFTSFKeTTPTERERWLLRVAEIMEVRQKDLVDCLIDEiGSPVQKAMF 106
gi 189423978  22 FDDFNPYTGEILTtvangsqqDALLAVNAAADAFPDWAaVAPSQKRLLFLKAADLLEKRKDELIDLLAREtGAARPFAAY 101
gi 118468557  34 FDDADPWSGEVYArvarcgrqEAAAAVQAAADAYPAWSqTTPREKARLFRAAAAVVARRRDDLAVTLAREtGTTKVNADF 113
gi 56478490   21 LDDLNPATSEVWGrvhqasaaDLERAIAAAYRARESWGnTLANEREAILLRAADALQKRIPDVAAVLIDEaGSTYGKAMF 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         #                              
gi 206677247 104 ETKVMPEMLKAAAAVCYapiGEVLPSl-nGKVSNAVRFPMGVISVISPWNMPGILATRPFSVPMAMGNTIVLKPSEEtPY 182
gi 70607586  102 EVVFTERLVRNAAEMARhfkGETIPSdseGIISMTFRKPKGVVGAITPWNYPLSISMKKVAHSLAIGNTVVLKLSSE-TP 180
gi 109900194 101 ETHHAPSFLRGMAGECRrvkGETYQSdypGLKSYSIRRPLGVVLSIAPFNFPLLLAIRKIGWALAAGNTVVLKPSEV-TP 179
gi 154499863 115 EVMGSAGILRVAAGECRrlhGEVLQPggaGQMSMAVRSPLGVVLGITPFNYPMILAIKKLAYALAAGNTFILKPSPL-TP 193
gi 160938328 100 EAGFAVDILRTAAGECRrvfGQVQQQe-aGEISMIRRLPLGVVAGIAPFNFPLLLALKKVAFALAAGNTFVLKPASA-TP 177
gi 18313376   99 EVVFTERLVRNAAELARhygGKTLQSdaeGVVSMVFKRPKGVVGVITPWNYPLSISMKKIAHALATGNTIVYKPASE-TP 177
gi 10957001  101 ETRFAVSFLRAAIGVPRrirGETIPSdtpGRFSMSLRQPVGVVAGITPFNVPLIKGIKQSAMALATGNAFVLLPSEA-AP 179
gi 206679783 107 EFTKGLTMIRAAAGMCRnvrGETIPSdrpGTFSMSIREPLGVVAVITPFNVPLIKTTRLVANALAVGNTVVHLPSEM-AP 185
gi 189423978 102 QAAAGPNYLREAGSQAHrvtGTILPSe-tTKVSMVMRHPVGVVAGISPWNCPVVLSLRAVCFAMAYGNTVVLKPSEEsPV 180
gi 118468557 114 QITLTIELIEQAAGWVYlpaGEVLRSdfaDTSQTVVRRPLGVVASFTPWNGATILSWRAALSPIAAGNTVVVKPSELaPV 193
gi 56478490  101 EASFVVNLLRSAAGECRritGETMPSdspGVFSMSVRRPLGVIAGIAPFNFPFLLATKKVALALAAGNTFILKPASY-TP 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                               #        
gi 206677247 183 QGGLFFAEVMEEAGVPPGVFNVITCSRdnvaeVGDEMVDNPkVKGVAFTGSAAVGRRIAAKCGaHLKKACIELGGKDSLI 262
gi 70607586  181 IIGVKIAELVQRAGLPKGVVNVVTGPGs---aVGDEIVTNKrVSHVTFTGETNTGREIASKAGhSLKTVTLELGGSDPLI 257
gi 109900194 180 VIALKLAEVMTEGGLPKGVLNVIPANGa---eLGDVLIADErVRKVTFTGSTRVGKSIALACAkYHKPITLEMGGKNPFI 256
gi 154499863 194 ATGLAIAGVFEAAGLPSGVLNVVPGRSe---vIGDMLVDDPrVRMVTFTGSSAVGRSIAVRAArDLKKVAMELGGKNPLI 270
gi 160938328 178 VSGVMIAKALDGAGIPKGVFNLVPGSGe---eVGNKLIEDErIRMVAFTGSTAVGRGIASKASvLFKKYSLEMGGKNPLI 254
gi 18313376  178 VTGFKIAEMIHQAGFPKGVFNLVVGPGs---tVGDEIVVNKkVSHVTFTGESATGREIASKAGgALKTVTLELGGSDPLI 254
gi 10957001  180 MIADLLAKLWKEAGVPDGLFNVVYGNGa---eIGDVLTGHPkVASITFTGSSRVGKHIAEIAArNLKKYTLELGGKSPLV 256
gi 206679783 186 HLSLIFAEIVAEAGIPEGVYNVVTGMGa---eIGDDLTSHKdIDFVTFTGSTVVGQHINEICAkNKTPNTLELGGKSPTI 262
gi 189423978 181 SGGILLAELFEEAGFPKGVFNIVTHGYgrsseVGDLFIQDRrVKRISFTGSTRVGRELAEKCGrHLKRIALELGGNDPLI 260
gi 118468557 194 SAGLQLAEIMEEAGFPAGVVNVVTHGPgeagpIADEFFDNPlVRCINFIGSVPTGRMLAERAGaTLKRSVMELGGYNPLI 273
gi 56478490  180 VTGLKIAEIFEAAGLPKGVLNVVPVQGs---vLGNTFVADPrVRMITFTGSTEVGRELSAEAGrHFKRITLELGGKSPMI 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                              #  #                                                      
gi 206677247 263 VLEDaDMERATSSASFGAFMHQGQICMSVEKVLVQeqVFDEFLKGFVARAAKLkTGNTADkaNVIGPLINDRQAARVKHQ 342
gi 70607586  258 VLDDaDVNLAVKIAVFGAFFHQGQICTSSKRIIVSekVYEAFVKKFVERVSQLkVGDPRDrtIEQGPLISKRQVESMIEF 337
gi 109900194 257 VLADaDVDYAVDAATFSNFMHQGQVCMTGSRVIVEdaVYDEFVRKFTAKVSALgYGNPRDpgVIVGPLIRPTQTEFIKKQ 336
gi 154499863 271 VLKDfDPVQAADIAAYGAFCHQGQVCMATSRIIVEgdGYQPFCDALVCRAEGLkVGDPREedTIIGPLIQPEKWKFIDGQ 350
gi 160938328 255 LLKDfDVEQAVRIAGFGAFFHQGEICMCTSRLIVEepVYDPFCEAFAAYARTMkVGDPHQkdTIIGPLIKQEQCQIIDSQ 334
gi 18313376  255 ILDDaDLNLAVRIAVFGAFFHQGQICTSSKRIIVHerVYDVFVKKFVERVSQLkVGDPRDrtVEQGPLISPRQADEMERF 334
gi 10957001  257 ICADaDLDKAVNAALFSIFMYQGQVCMGASRIYVErsIFDQFTKAFAAATGRAnSGDLRDptTMLGPIISERQRDRVRRH 336
gi 206679783 263 VLADaDLDKVMPLAARSVFMFAGQACIASSRFYVErpLYDEFVKQFSFIIGKLgMGDLRDpnTVIAPAISPRQRERIKSH 342
gi 189423978 261 VLNDaDMDHAVNAAIFGRFLHQGQVCMNAKRLIIEktVAQEFTARFVARTSALkVGNPLDaaTVIGPLINHKQYETLEGQ 340
gi 118468557 274 ILEDvDLDYAVRVAAFSAFFHQGQICLNARKILVHrdIYDEFVARLVAKAESLtSGDPLHadTFIGPLITPAAVELVHAR 353
gi 56478490  257 VLKDaDVDYAVNAAAFGIFLHQGQVCMANSRLIVEapIFDVFCDKLATKIAGFkVGDPRDpqTVIGPLIDRKQCAVLDRH 336
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 206677247 343 LEDAVAKGAKIAIGGGVnGRFVEPTIVTNVTsdMDIWRDETFGPVAVVVPFKdDFEAVAMNNDTEYGLSAGIISRNeHRA 422
gi 70607586  338 YEDSVKRGGKIMTGGKWdGNYFYPTVVTDVDrnFRIMKEEVFGPIRPVLRVKdDEEAIEVANDTEYGLSAAVVTRNvTRA 417
gi 109900194 337 VEKAVEQGAKINVGGHYeGNVFQPTVISDVTsdMSIFHTECFGPVASVIKASdYLHALALANDSEYGLTSAVITNDlQMS 416
gi 154499863 351 IEDALSKGAKLLTGGRHeGPWYWPTVLADVTpeMRIFHEETFGPVTSVMRAKdPEEALALCNDNEYGLSAALLTHNlELA 430
gi 160938328 335 IQDAVSKGAVLMTGGTHeGNFYQPTVLKDVTpdMRIFYEESFGPVTSIIKAVdAQDAVRLCNDNQYGLSSSLLTNDlSKA 414
gi 18313376  335 YQDAVSRGGRALTGGKRaGAYFWPTVFVDVDrnFRIMREEVFGPIRPVVPVKnDDEAVEVANDTEYGLSAAVVTTNiNRA 414
gi 10957001  337 IDDARSKGAAVLAGGEWsGNSCAATILSGVTaeMTVFEEETFGPVTSLFPFDtLEEALELANNTEYGLSASIFTRDlDKA 416
gi 206679783 343 IDDARAKGANVIGGEWE-GNRCQPTLLTDVSedMAVCRTETFGPVTAIYPIDsYEEGLEKANDTEYGLSSAIFTKDiDKA 421
gi 189423978 341 VNRAVAEGAELLCGGYGnGLCYHPTVLGNVRedMSIFHEETFGPVAPIIVAEdADDALRLANSSAYGLSAGILTNNmQQG 420
gi 118468557 354 VNDAVAKGARLLTGGTYdGPVYAPTVLVDVPddAVVSSEETFGPVVVVHPVDtAEEAIEIANRPLYGLSSAILSGDtHRA 433
gi 56478490  337 VADAVAKGAKLLHGGKSdGAFYQPTILAGVTpdMVVFREESFGPAVSVIRAAdSEDALRLANDSCYGLSSGLITNDlQKA 416
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                               
gi 206677247 423 MQMATlLETGMCHINCSpINDEAHAPFGGAKASGMGRYGgRWSQESFSETRWITL 477
gi 70607586  418 FKFVEqIESGMVHINDVtMLEESHIPFGGIKASGIGREGgEYSFRETTYERWTTI 472
gi 109900194 417 IFFSEnLESGMVHINGPsIRDEAVVPFGGVKNSGMGREGgTFAMDEFTELKWITV 471
gi 154499863 431 WSMGLrMEAGMVHINDTtFLSGTTAPSGGVKFSGFGREGgRYSMEDFTELKWLTM 485
gi 160938328 415 MSLSLdMEAGMVHINNAtVSDNSTVAFGGVKNSGVGREGgSYSIDEFTELKWITV 469
gi 18313376  415 FKIAEaIESGMVHINDVtMLEESHVPFGGIKASGFGREGgEWSFHETTYDRWLTI 469
gi 10957001  417 LAFAQrAEAGMVHINAPtLHDEPHVPFGGTKASGFGREGtEADLEIMTEWKWVTI 471
gi 206679783 422 FHFARnSNAGMCHINGPtIHDEAHVPFGGNGESGVGREGtDADMEAMTELKWVTV 476
gi 189423978 421 LALARrIESGACHVNDSpLYGETHAPLGGVNNSGWGKFG-IEAMHEFTEQQWVTL 474
gi 118468557 434 TKLAEsLRSGVVRVNLPtIDDEIQAPIGGVRDSGWGRSG-PWALQDFTDLVAIAV 487
gi 56478490  417 FDLSLrLEAGMVHINDSsIMDEPHVPFGGVKDSGFGREGgHHSMDEMTELKWITV 471

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