1R0O,2HAN,1R0N


Conserved Protein Domain Family
NR_DBD_EcR

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cd07161: NR_DBD_EcR 
Click on image for an interactive view with Cn3D
DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
DNA-binding domain of Ecdysone receptor (EcR) family is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. EcR interacts with highly degenerate pseudo-palindromic response elements, resembling inverted repeats of 5'-AGGTCA-3' separated by 1 bp, upstream of the target gene and modulates the rate of transcriptional initiation. EcR is present only in invertebrates and regulates the expression of a large number of genes during development and reproduction. EcR functions as a heterodimer by partnering with ultraspiracle protein (USP), the ortholog of the vertebrate retinoid X receptor (RXR). The natural ligands of EcR are ecdysteroids, the endogenous steroidal hormones found in invertebrates. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, EcRs have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 143535
View PSSM: cd07161
Aligned: 7 rows
Threshold Bit Score: 148.486
Threshold Setting Gi: 38492975
Created: 2-Feb-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Structure:1R0O_B,Zn binding site of Ecdysone Receptor defined by 3.5 A contacts.
    View structure with Cn3D
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the co-ordination of a single zinc atom.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #  #             #  #               #     #         #  #                     
1R0O_B         6 EELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQC 85
gi 2738906   186 EELCLVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYQCKYGNNCDIDMYMRRKCQECRLKKCLSVGMRPECVVPEYQC 265
gi 146400031 191 EELCLVCGDKASGYHYNALTCEGCKGFFRRSVTRKAIYHCKYGESCDIDMYMRRKCQHCRLKKCMEIGMRPERLRADSRV 270
gi 215493730  60 EELCLVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYQCKYGNNCDIDMYMRRKCQECRLKKCLSVGMRPECVVPEYQC 139
gi 215513483 207 EELCLVCGDRSSGYHYNALTCEGCKGFFRRSITRSNVYHCKYGKHCEMDMYMRRKCQECRFTKCLSIGMKPECVIPESQC 286
2HAN_B         8 EELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQC 87
1R0N_B         6 EELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQC 85
                         90
                 ....*....|.
Feature 1                   
1R0O_B        86 AMKRREKKAQK 96
gi 2738906   266 AIKRESKKHQK 276
gi 146400031 271 PLVVIPEDQCR 281
gi 215493730 140 AIKRESKKHQK 150
gi 215513483 287 NIKRQQKLQRE 297
2HAN_B        88 AMKRREKKAQK 98
1R0N_B        86 AMKRREKKAQK 96

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