Conserved Protein Domain Family
2DBD_NR_DBD2

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cd07179: 2DBD_NR_DBD2 
The second DNA-binding domain (DBD) of the 2DBD nuclear receptor is composed of two C4-type zinc fingers
The second DNA-binding domain (DBD) of the 2DBD nuclear receptor (NR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. NRs interact with specific DNA sites upstream of the target gene and modulate the rate of transcriptional initiation. The proteins contain two DBDs in tandem, probably resulting from an ancient recombination event. The 2DBD-NRs are found only in flatworm species, mollusks and arthropods. Their biological function is unknown.
Statistics
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PSSM-Id: 143548
View PSSM: cd07179
Aligned: 6 rows
Threshold Bit Score: 102.581
Threshold Setting Gi: 219466968
Created: 5-Feb-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
zinc bindingputative DNA
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the co-ordination of a single zinc atom.
  • Comment:contacts derived from related proteins

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  #             #  #                      #      #         #  #                
gi 39653635   567 CRVCGGRSSGFHFGALTCEGCKGFFRRTEGSSn-------SLVCVGGQnaCTITPRSRNACKSCRFRRCLAAGMSKKGSR 639
gi 88595434   174 CRVCSGPSSGFHFGALTCEGCKGFFRRTVLSNv-------RLECPGNNd-CPITPANRNMCKSCRFQRCLAVGMSKTGSR 245
gi 88595436   479 CRVCGAKSSGFHFGAITCEGCKGFFRRTINERes-----qRYTCRNGGn-CAVTGATRNNCKSCRYRRCLAVGMSKHAVV 552
gi 219466968    1 CKVCGAESSGFHFGVDTCEGCKGFFRRSQLKTkngtyeyeSYRCSKSKd-CAINVVTRNLCRYCRYAKCLAVGMSKEGQY 79
gi 72084364   110 CWVCGEKSNTFHYGILSCEGCKSFFARASSNHi-------SYNCPTKQ--CVINKETRNRCMYCRWKKCVAVGMSKTASK 180
gi 39984732   567 CRVCGGRSSGFHFGALTCEGCKGFFRRTEGSSn-------SLVCVGGQnaCTITPRSRNACKSCRFRRCLAAGMSKKGSR 639

                  ..
Feature 1           
gi 39653635   640 IG 641
gi 88595434   246 IG 247
gi 88595436   553 SA 554
gi 219466968   80 NL 81
gi 72084364   181 LG 182
gi 39984732   640 IG 641

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