Conserved Protein Domain Family
Pat_PNPLA9

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cd07212: Pat_PNPLA9 
Patatin-like phospholipase domain containing protein 9
PNPLA9 is a Ca-independent phospholipase that catalyzes the hydrolysis of glycerophospholipids at the sn-2 position. PNPLA9 is also known as PLA2G6 (phospholipase A2 group VI) or iPLA2beta. PLA2G6 is stimulated by ATP and inhibited by bromoenol lactone (BEL). In humans, PNPLA9 in expressed ubiquitously and is involved in signal transduction, cell proliferation, and apoptotic cell death. Mutations in human PLA2G6 leads to infantile neuroaxonal dystrophy (INAD) and idiopathic neurodegeneration with brain iron accumulation (NBIA). This family includes PLA2G6 from Homo sapiens and Rattus norvegicus.
Statistics
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PSSM-Id: 132851
View PSSM: cd07212
Aligned: 16 rows
Threshold Bit Score: 434.837
Threshold Setting Gi: 13384434
Created: 10-Feb-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ## #                             #                                        
gi 6685712    480 LLCLDGGGVKGLIIIQLLIAIEKASGvatkdlFDWVAGTSTGGILALAILh-SKSMAYMRGMYFRMKDEVFRGS----RP 554
gi 3877169    747 LISMDGGGIRGLVIIQTLIAIEERLGddifkyFDWSAGTSTGSLIMAGLAt-GKSLREMQQTYLLLKDRVFDGIm---PP 822
gi 156394320  210 ILTLDGGGIRGLVLTQLLSAIEEVSGqsinslFDWISGTSIGGIIALALVh-GKSVSFCQGFLFRMKDKVFKGP----RP 284
gi 85857482   563 LLCLDGGGIRGLVLVQMLLEIEKLSRtpiihmFDWIAGTSTGGILALALGc-GKTMRQCVGLYLRMKEQCFVGS----RP 637
gi 13384434   171 LLALDGGGIRAVITIQMLIHIDYLLGgklvekLDDIAGTSCGGVITLLLStnNRNIEETRKLLLDMRDRVFIRGadkaVP 250
gi 94733619   430 LLCLDGGGIKGLVLIQLLIALEKEAGrpirelFDWVSGTSTGGILALAIVh-GKSMEYLRCLYFRMKEQVFKGS----RP 504
gi 170589421  667 LLSLDGGGIRGLVIIQMLLELEKMMGepffsyFDMVAGTSTGGIIAAALAl-GKTLRDCQQIYLRLKDLIFDSWa---RP 742
gi 115752635  418 VLCLDGGGIKGLILTQMLAAIEKASGkkivemFDWIVGTSTGGILALALSq-GFSVEECRKLYMALKDEVFTGS----RP 492
gi 198420305  439 VLCLDGGGVRGLVLSQILMAIERETGkqcrdlFDWISGTSTGGFLAMALLm-GKSAIEAQRLYFRFKDKVFVGS----RP 513
gi 3880573    693 VLGLDGGGIRGLVTVQMLICLEAFLDrplidyFDWIGATSTGCYIMSTMMt-GGSLRKAQRYYLMFKDQLFDSWt---RP 768
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 6685712    555 YESGPLEEFLKREFGEh--tKMTDVRKPKVMLTGTLSDRqPAELHLFRNYDAPetvreprfnq-----------nvnlrp 621
gi 3877169    823 YDTVQLEKFIQDQFGTg---TVWEIPYPRLMISAVNSEKlPVRLEMARNYKPAkdva----------------------- 876
gi 156394320  285 YDTEPLEKLLQETFGEn--tKMTAVTHPKTLVTAVLADRrPATLYFFRNYNMPedlepirkn-------------npfpp 349
gi 85857482   638 YNSEFFESILKDNLGEf--nVMTDIKHPKIMVTGVMADRkPVDLHLFRNYTSAsdilgivtpi-----------nnrrip 704
gi 13384434   251 KYSSNGMEYIARHVTTwedsKMSSIKRHRAIVTVADTRMvPPQLLLFRSYRPEmpeeace-----------------hyk 313
gi 94733619   505 YESGPLEEFLKNEFGEn--tKMTDVTHPRVMVTSVLADRhPGELHLFRNYDPPalqrdppyks-----------tatfqp 571
gi 170589421  743 YNTSLLELFIQAEVGTd--mTLASVPWPKMILTTVRADCfPVRLELMRNFRLPlsdeens-----------------slg 803
gi 115752635  493 YNSDKLESFLKDTFGAe--tTMDKYTYPRILVSGTLGDRsPPALHLFRNYDAPetssawiaan-----------qepflp 559
gi 198420305  514 YNSEPMEDFLKKEFGEdt-tMESLQHGPRLLITAALADRkPIHLHLFRNYNLTdpiskslktksfskklsdaemkkltcd 592
gi 3880573    769 YDTKTLETFIQRAFGAd--rLMGDIKYPRFFCTTVRADTfPVQLELLRNYRLPisekenn-----------------dlg 829
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        #                                                
gi 6685712    622 paqPSDQLVWRAARSSGAAPTYFRPn-GRFLDGGLLANNPTLDAMTEIHEYNqdlirkg------qankvkKLSIVVSLG 694
gi 3877169    877 petPKEMPLWMALRRSTAAPVLFKPseDRYIDGGIISNNPALDLMSEVHAYNrelqlsg------rksdavQMNVLVSFG 950
gi 156394320  350 ppvPAVQQVWRAARGSGAAPTFFRAm-GRFLDGGLIANNPTLDVLSEVHKYYcvhephn-----kkgpgnsNIGLVVSLG 423
gi 85857482   705 ppqPSEQLVWRAARATGAAPSYFRAf-GRFLDGGLIANNPTLDAMTEIHEYNmalrsag------reseaiPVSVVMSLG 777
gi 13384434   314 fldPTKVELWKTLRCTTAAPYFFESf-NGLSDGGLIANNPTLALISDFFLTNkleksfakssserenrgnwKIGCVISLG 392
gi 94733619   572 ltvPQEQLVWRAARSSGAAPTYFRPm-GRFLDGGLLANNPTLDAMTEIHQFNkalkaqg------rdedvtRLGVVVSLG 644
gi 170589421  804 yadPADTLLWKALRRTSAAPTYFSSvdNRYIDGGIISNNPALELLSELAFWNttnhflt-----ssennaiQLGCLLSVG 878
gi 115752635  560 vlkPSEQLMWRAARSSGAAPTYFRPm-GRFLDGGLIANNPTLDALTEIQEYYmykksq--------gepvrKIGAVVSLG 630
gi 198420305  593 atsSLKQLLWEAARSSGAAPTYFRPm-GPYLDGGLVANNPTLDTLTEIHKYNkelvrt-------gagdykKIGLVLSIG 664
gi 3880573    830 ftdPNELTIWKATRRSSAAPTYFSAseGKFIDGGMISNNPVLDLMSDIGFYNttcqkmr------ipekmvDMGCVLSVG 903
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 6685712    695 TGRSPQVPVtcvdvfrpsnp---welaktvfgaKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDImLD 771
gi 3877169    951 TGQIPSTVIetlsidsns-------plqsiktiKNLAAMFIDQATASEGAPVARSRQWADSLEIPFFRFSAPLSKNIfLS 1023
gi 156394320  424 TGVPPPEHVptfdvfkpetm---wdatnvllgaRALGLLMVDQATATNGAVVDRARAWCEMIGSQYFRFSSPMSADVgLD 500
gi 85857482   778 TGHIPVTELkdidvfrpesi---wdtaklaygiSTIGNLLVDQATCSDGRVVDRARAWCSTIGIPYFRFNPQLSEDIaMD 854
gi 13384434   393 TGVFPTEKI------------------------DGIDLIVAHACTASNGQPVRYAREWCHSINAPYFRFSPHLSQGIsLD 448
gi 94733619   645 TGKPPQVAVnsvdvfrpsnp---ielaktfvgvKELGKMLVDCCTDSDGCAVDRARAWCEMADINYHRLSPQLSQEVmLD 721
gi 170589421  879 TGAIPTMPLstsnleiss------npyssavaiKNLGVILVEQVTATEGAPVERARSWCHNMNVPFFRLSAPLHKDIpMD 952
gi 115752635  631 TGLTALKPIahveimrpnsavdllsaakslaagANLIDIMVEQVTESRMRAVDRARAWCFSIGTPFFRFSPPLSQEIsMD 710
gi 198420305  665 TGQMKTTTArsldlnwsssp---ialmntalagSELAQMMVDVCCQSNDYVVERAKAWCETMDASYFRLNPFMEDEVqLN 741
gi 3880573    904 TGITPICPVdpsvfemnd-------lfgmlrgmKNLSLVVIDQATATEGAPITRSRTWCHSLGVPYYRLNAPIFKDViLD 976
                         330       340
                  ....*....|....*....|..
Feature 1                               
gi 6685712    772 EVSDTVLVNALWETEVYIYEHR 793
gi 3877169   1024 STSDLDVCTMMWDSFIYCRKHR 1045
gi 156394320  501 ETDDRILVKMLWETRVYILQNL 522
gi 85857482   855 EKDDQKLINMLWHTKAYMHANR 876
gi 13384434   449 EIDLEKVMQVMWETEQYVASHR 470
gi 94733619   722 EVSDAVLVDMLWETQMYLYEHR 743
gi 170589421  953 TRDDTDIARMMWDCVQYCNTMR 974
gi 115752635  711 ETRDHVLSKMLFDTQCYIQKNK 732
gi 198420305  742 ETNDEILLNLLWDTQVYLQENK 763
gi 3880573    977 TNDDYDLAKIMWDSVVYSHTHK 998

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