Conserved Protein Domain Family
Pat_Fungal_NTE1

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cd07227: Pat_Fungal_NTE1 
Fungal patatin-like phospholipase domain containing protein 6
These are fungal Neuropathy Target Esterase (NTE), commonly referred to as NTE1. Patatin-like phospholipase. NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This family includes NTE1 from fungi.
Statistics
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PSSM-Id: 132865
View PSSM: cd07227
Aligned: 4 rows
Threshold Bit Score: 554.411
Threshold Setting Gi: 158563949
Created: 12-Feb-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          ## #                        #                                  
gi 2501686   1361 RLARILSGQAIGLVLGGGGARGISHLGVIQAIEEQGIPVDvIGGTSIGSFVGGLYAKDydlvpiygrvKKFAGRISSIWR 1440
gi 158563949 1200 RLARRLCGKSVGLVLGGGGARGIAHVGIIRAMEEAGIPIDmVGGTSIGAFIGGLYARHadvvpifglaKKFAGRMASMWR 1279
gi 158563854 1304 RIARRLCGQQIGLVLGGGGARGISHIGMLQALEEFGIPIDaIGGCSIGSFVGGLYAREtdlletagrtKQFSGRMGSMWR 1383
gi 6434012    999 RLARRICGKAIALVLGGGGARGISQIGILYALEEAGIPFDiIGGTSIGAFNGGLYAWEadlvpmfgraKKFCGRMANLWR 1078
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 2501686   1441 MLTDLTWPVTSYTTGHEFNRGIWKTFGdtrIEDFWIQYYCNSTNITDSvqeihsfGYAWRYIRASMSLAGLLPPLe-ENG 1519
gi 158563949 1280 FAFDLTYPSASYTTGHEFNRGIFKTFGktqIEDFWLEYYCNTTNISKSrvefhtsGYAWRYIRASMSLAGLLPPLc-DEG 1358
gi 158563854 1384 ILSDVTYPFVSYTTGHEFNRGIYKAFYnthIEDFWIPFFANSTNITHSrmevhrtGYAWRYVRASMTLAGLLPPLs-DNG 1462
gi 6434012   1079 FVLDVTYPQAAYTTGHEFNRGIWKTFGeihIEDFWLPFYANTTNITHSrmdihssGYAWRYIRASMSLAGLVPPMlsDSG 1158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                                                                           
gi 2501686   1520 SMLLDGGYVDNLPVTemrarGCQTIFAVDVGSaDDRTPMEYGDSLNGfWIIFNRWNPFSshpniPNMAEIQVRLGYVASV 1599
gi 158563949 1359 SMLLDGGYIDNLTVSrmkslGSDVIFAVDVGSlDDNTPQAFGDSLSGvWAFFNRWNPFSsvpnpPTLAEIQARLAYVSSV 1438
gi 158563854 1463 NLLVDGGYMDNTPIQplrenGIRDIIVVDVGSvDDTSPRDYGDSVSGwWIFFNRFNPFYer-rvLSMTEISSRLTYVSSV 1541
gi 6434012   1159 DMLLDGGYMDNLTVShmqslGASSIFAIDVGSeDSREPMHYGDTVSGvWALISRWIPFIpktsfPSLAEIQSRLTYVTSV 1238
                         250       260       270
                  ....*....|....*....|....*....|
Feature 1                                       
gi 2501686   1600 NALEKAKntPGVVYVRPPIEEYATLDFSKF 1629
gi 158563949 1439 GELERAKtmPGCIYMRPPIDDYGTLDFGKF 1468
gi 158563854 1542 KTLEGVKatPGCHYIAMPVQQFDTLGGFKR 1571
gi 6434012   1239 ATGEKVKsmPGCFYMRPPVKDFPTLEFGSF 1268

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