Conserved Protein Domain Family
Pat_NTE_like_bacteria

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cd07228: Pat_NTE_like_bacteria 
Bacterial patatin-like phospholipase domain containing protein 6
Bacterial patatin-like phospholipase domain containing protein 6. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. This group includes YCHK and rssA from Escherichia coli as well as Ylbk from Bacillus amyloliquefaciens.
Statistics
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PSSM-Id: 132866
View PSSM: cd07228
Aligned: 11 rows
Threshold Bit Score: 255.276
Threshold Setting Gi: 124516488
Created: 23-Feb-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active sitenucleophile
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the crystal structure of semet patatin (1OXW)
  • Comment:catalytic dyad is formed by Ser and Asp
  • Comment:oxyanion hole is formed by two Gly and one Arg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               ## #                        #                                            
gi 197624980   4 VGLALGSGGARGWAHIGVIRALQEEGIGISgIAGASIGALVGAMYCAGelddledfvr---dlrwrdlltYFDMVFPTSG 80
gi 20808254    5 VGLILGGGAARGYAHLGILKRFEEENIPIDfIVGISMGAIIGAIYASGhnvdklisda--kkinmlkfisLLDFKASRTG 82
gi 89895415    3 RGLVLGAGGARGLAHLGFLQVLEEESIKVDcIVGCSIGAVFGALWAAGmdlyrlerl----ityqgfskrLWDLAVSRDG 78
gi 163811908   9 IGIALGGGAARGIIHIGVLEVLEKEGVPLDlVTGTSMGAIIGALYASGhkpqemkeiv--snlswkqlmpLFDLAAPRAG 86
gi 206900109   6 IGVALGSGGAKGLSHIGVLKVLEENNVEISfVTGSSIGAIIGALYAKGyspkdieklanniaenkqqfynLFDFSKSLQG 85
gi 6648033     6 IGLALGSGGARGLAHLGVLSSLHKHQIEVDmIAGSSMGALVGSFYAAGhdvatmkkv-----akafkrrlYADYTVPKLG 80
gi 13471054   37 ISLALGGGCARGWAHIGVLRALDEAGIEVSmIAGTSIGALVGGCYLAGkldeleefar---sltkrrifgLLDLNLRGSG 113
gi 124516488  13 IGIALGSGSARGWAHIGVLRSLEEQGIVPDiVCGSSVGALVGAAAATGcmdrletwir---elkrvdvvgYMVRSFMRSE 89
gi 54040012   17 VALALGSGGARGYAHIGVIQALRERGYDIVgIAGSSMGAVVGGVHAAGrldefahwak---sltqrtilrLLDPSISAAG 93
gi 84027903   19 IGLALGSGAARGWSHIGVINALKKVGIEIDiVAGCSIGSLVGAAYACDrlsaledwvt---sfsywdvlrLMDLSWQRGG 95
gi 26107965   19 IGLALGSGAARGWSHIGVINALKKVGIEIDiVAGCSIGSLVGAAYACDrlsaledwvt---sfsywdvlrLMDLSWQRGG 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                 #      
gi 197624980  81 LLDGNRVyellse-hmqamrIEDAAIPFCCVATDLIRGkevqlrSGCMVDAVRASISVPGIFTPFcdgdRFLGDGGIVNP 159
gi 20808254   83 LVKGEKIekylrg--yvkesFEELNIPLYIVATDIQTGkgvvfkEGDLIKAIRASISIPAFFEPVeyngTKLVDGSIVDS 160
gi 89895415   79 LVKGEKVleamrl-ltrdltFAELRIPLAVVATDLETGervvfrEGSVAHAVRASISIPGIFKPYryqgRLFVDGAVKNR 157
gi 163811908  87 FLSSRKIksylke-ligdvtFSELKKPFACVAADVKTGqevlfnEGSVIDGVIASMSLPIIFRPVknktRFLVDGGIITP 165
gi 206900109  86 IIKGDKIleyldt-ilegvtFDKLKKPFTPIAVDLITGekvyiqEGKVAEGIRASMSIPVIFQPFswknRLLIDGGVLSP 164
gi 6648033    81 FLKGDRVrqlvha-ytfgkpIEELQIPLGIVACDLQTGekivfrKGSVSDAVRASISIPGIFIPQrldgRLLVDGAVVDR 159
gi 13471054  114 LFGGMKLdarlre-hvagvrFEDLPKPFVSVASEIRTGheiwlsNGSLITAMRASYALPGVFEPVncngRMLVDGALVNP 192
gi 124516488  90 SIQSEKYlgeifgqalaetrIEDLPKRFGSIATDLDTGqevwlrKGSLLSAISPSIAFPGLLNPVhhdgRWLVDGGLVNP 169
gi 54040012   94 ILRAEKIldavrd-ivgpvaIEQLPIPYTAVATDLLAGksvwfqRGPLDAAIRASIAIPGVIAPHevdgRLLADGGILDP 172
gi 84027903   96 LLRGERVfnqyre-impeteIENCSRRFAAVATNLSTGrelwftEGDLHLAIRASCSIPGLMAPVahngYWLVDGAVVNP 174
gi 26107965   96 LLRGERVfnqyre-impeteIENCSRRFAAVATNLSTGrelwftEGDLHLAIRASCSIPGLMAPVahngYWLVDGAVVNP 174
                        170       180
                 ....*....|....*....|
Feature 1                            
gi 197624980 160 VPVDVARd-lGAELVIAVNL 178
gi 20808254  161 EAIELAAs-lGADIIINCDV 179
gi 89895415  158 LPIQVAKd-mGAKKVLAVDV 176
gi 163811908 166 IPARVVRn-mGADFVIAVNA 184
gi 206900109 165 LPVKDLKmlyKPDIIIAVSL 184
gi 6648033   160 IPVSVVKd-mGADIIIASDV 178
gi 13471054  193 VPVSVCRa-yEQPLVVAVNL 211
gi 124516488 170 VPVSLCRa-lGADIVIAVNL 188
gi 54040012  173 LPMAPIAg-vNADLTIAVSL 191
gi 84027903  175 IPISLTRa-lGADIVIAVDL 193
gi 26107965  175 IPISLTRa-lGADIVIAVDL 193

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