3CT8,2RK0


Conserved Protein Domain Family
VOC_BsYqjT

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cd07242: VOC_BsYqjT 
Click on image for an interactive view with Cn3D
vicinal oxygen chelate (VOC) family protein similar to Bacillus subtilis YqjT
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319906
View PSSM: cd07242
Aligned: 5 rows
Threshold Bit Score: 142.242
Threshold Setting Gi: 159795524
Created: 23-Feb-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 2 residue positions
Conserved feature residue pattern:H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:Zn(II) binding site
  • Structure:3CT8_A; Zn(II) binding site of a putative glyoxalase from Bacillus halodurans
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #    
3CT8_A        20 XLHHVEINVDHLEESIAFWDWLLgelGYEDYQsw-----srGKSYkhg-ktYLVFVQTEdrfqtptfhrkrTGLNHLAFH 93
2RK0_A         5 GVSHVSLTVRDLDISCRWYTEIL---DWKELVrgrgdttsfAHGVlp--ggLSIVLREHdgggtdlfdetrPGLDHLSFS 79
gi 283811789   4 AVHHVEIWVPDLSRAVSSWGWILgrlGWKDGDgw-----pgGQTWtsp-dgSYLVVEQSpamtatehdrlrPGMNHLALN 77
gi 219116877  19 GFSHVGLAVSDLHASFKFFEALGf-nKVGGVDt--------YPSFflsdgsSFLTIWQTdedatpfdrranVGLHHMALK 89
gi 1731080     3 HIELYVSDLEASRRFWGWFLKEL---GYKEYQkw-----ssGISWkkd-rfYLVIVQAKepflepeyhrcrVGLNHLAFH 73
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                                           #    
3CT8_A        94 AASREKVDELTQKLKERGDPILyedrhpf---aggpnhYAVFCEDPNRIKVEIVAP 146
2RK0_A        80 VESXTDLDVLEERLAKAGAAFTptqe--------lpfgWILAFRDADNIALEAXLG 127
gi 283811789  78 ASDRAEVDGIVAEAAGHGWTLMfadrhpy---aggpqhYAAFLHNEDGYQLEIVAP 130
gi 219116877  90 LPSMEALDEAYTSVSKIEGVRTtgegafapealegtpwHHAMVFEPSGIRIELTFH 145
gi 1731080    74 AESKLQVDQMTEKLTAKGYRVLyrdrhpf---aggdghYAVFCEDPDRIKVELVAP 126

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