2R6U,3OXH,3OXH


Conserved Protein Domain Family
SgaA_N_like

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cd07247: SgaA_N_like 
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N-terminal domain of Streptomyces griseus SgaA and similar domains
SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.
Statistics
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PSSM-Id: 319911
View PSSM: cd07247
Aligned: 68 rows
Threshold Bit Score: 80.3861
Threshold Setting Gi: 158530279
Created: 23-Feb-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2R6U_A        26 IVHFEIPFDDGDRARAFYRDAFGWAIAeip-----dmdYSMVTtgpvgesgmpdepgyiNGGMMQrge-------vtTPV 93
gi 15601178    7 INYVEFAAKDLESTKAFFSKVFGWSFVdyg------peYAAFSne------------glDGGFFKaelss--rtengGAL 66
gi 15965689   10 IDYVEFNVTDIAASKAFYGSAFGWTFTdyg------peYCEFAdg------------rlTGGFTTlgpv-----rsgGPL 66
gi 26990741   10 IDNIEFNVSDISRSKAFYGSVFGWAFTdyg------ptYTEFSdg------------rlTGGFTTgepv-----rpgGPL 66
gi 32472444    8 INYIEIPATDMAKTKVFFETCFGWKFTdyg------peYTAFDkst-----------glDGGFYQsdkss--ltsngSAL 68
gi 170296766   5 VVWTEIPVTDLQKSTDFYGKVFGWNMQitnmgpnevatFNALTda-------------dPNSVARhlypgt-paarsGST 70
gi 196191641   7 INYLKLPTKDIEKTKAFFTQIFDWKFKdfg------sdYTVFSna------------gvEGGFFQsdksv--stesgSVL 66
gi 198262702   6 IDYVELPASDLHAIKAFYQAAFGWRFIdyg------deYCALDga------------glDGGFFKaplss--stangAAL 65
gi 206686837   9 LVWGELPVSDLDAAVTFYSKVTGADLSidts---gpnpIAMFKta------------deASGVALhlypgrpagdgrGPT 73
gi 222437589   9 NVWMEIPVSDLDKAIVFYNNVFQTELNlvtdm--gpnpFAMFPtse----------engVAGHLYpgkpa---dkgtGPT 73
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
2R6U_A        94 VTVDVES-IESALERIESLGGKTVTGRTPvgnmGFAAYFTDSEGNVVGLWE 143
gi 15601178   67 LIFYSSD-IEATLEKVVKNGGHIIRPIFEfp-gGCRFHFTEPSGNEFAVWS 115
gi 15965689   67 VIIYADQ-IEDAQRRVEAAGGKIVKPIFTfp-gGRRFHFADPDGYELAVWS 115
gi 26990741   67 VILYADD-LEATQQRIEAAGAKISRATFAfp-gGRRFHFIDPDGYELAVWT 115
gi 32472444   69 VVFYSNE-LEATMAKVQSSGGTVIQEIFSfp-gGRRFQFTDPSGNEFGVWS 117
gi 170296766  71 IHTAVPEtVEDAAKRCVAAGGQVMGPVIDil-qGRFQYATDLDGNSIALIE 120
gi 196191641  67 IVLYSET-LEETQSQIEEAGGKVTKPIFSfp-gGRRFHFSDPSGNEYGVWS 115
gi 198262702  66 VVLYSED-LEASQQAVEQAGGTIIKPIFSfp-gGRRFQFTDPCGNELAVWS 114
gi 206686837  74 LHLTAEGaLEDVMERVTDAGGKVVSETIAip-pGRFFYATDPDGNSLGFFK 123
gi 222437589  74 IHIACPDtLEETMERFAKAGGEVISDPIPip-aGRFAYGIDPDGNSIGMFA 123
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