Conserved Protein Domain Family
VOC_BsCatE_like_N

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cd07255: VOC_BsCatE_like_N 
N-terminal of Bacillus subtilis CatE like protein
Uncharacterized subfamily of VOC superfamily contains Bacillus subtilis CatE and similar proteins. CatE is proposed to function as Catechol-2,3-dioxygenase. VOC is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319918
View PSSM: cd07255
Aligned: 13 rows
Threshold Bit Score: 162.096
Threshold Setting Gi: 262335464
Created: 20-Feb-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
putative metal
Feature 1: putative metal binding site [ion binding site], 2 residue positions
Conserved feature residue pattern:H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:predicted based on homologous proteins in the superfamily.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                            #           
gi 222420152   9 KHVNRIELNVaDIDRQTDFYHnilGLQVLktaPTQTTLIIge--eDEIVLNKiengr-faqmTEAGLFHIAILLDDVTDL 85
gi 29375255    9 IGIQQVTLKVaDLDKMVNFYTktiGLKLLkqgEGRAWLAPqg-tnDAILVLKeltag-eenqGTTGLYHIAFLLPTRKDL 86
gi 30021634   12 TRIGHVEFKVkDLERQIAFYEnvvGLEVIkqeGNKAYLSGkg-gkNALLVLEkledgvlqepRTTGIYHVAFLVPTREAF 90
gi 116494648  10 TRVDFVALKVaNLTLVSQWYQqvaRLDLLrqnGSTIYLGTrlnqqVLVVLHQitgl--qaqqPVTGLDHFAILLPNPGAL 87
gi 27382384   46 MRVGMVTLRVkNLDTVADYYRdviGLTVMersASAAKLGTag--iTLLVLEArpdaa-ieprNAAGLYHTAFLMPTRKDL 122
gi 15806765   10 THLGPVTLLArDLEGLTAFYAgllGLSTApdgSGRVVLSAhg--tPLLRLEAapdlp-rapvSRPGLYHTAFLLPTRADL 86
gi 15964739   23 AYVDRSHLVVsDLETVSSWYQriiGLSPIeanISGVTLGVag--rPLLTLTSdgnav-raprNAPGLFHHAFLVPDRTEL 99
gi 163848338  10 THIGTVALTVtNLERSLAFYQnliGLRLHqrtAQTAHLGVgg--pDLLILYEqpay--rryrGVCGLYHVAILVPSRYEL 85
gi 262335464   7 LRIRALTLRVrDLNVQRAFYHellGLSVRepaADRLVLAPes-gtFTLELIAdpsap-lrpwPTIGLYHFALLLPDRTAL 84
gi 22538215    9 HSIESITLKVnDLENLVNFYSdiiGLTVIdksSTRALLGVnq-kiPLIILEKtel----ekhSTYGLYHTAILVPDEYHL 83
gi 125718390  46 IYLGEVALYVaDVARQKDFYQrvlGLELLeeqDGQVALGRdg--qVLVRLLAtgdr--qtvkSAYGLYHLALLLPSRQAL 121
gi 1486247     8 THIGYAKLTIrSLERSLQFYCnviGFQVLkktDRQAELTAdg-krVLLILEEnpsavvlpelSVTGLYHFAILLPDRKEL 86
gi 239938766   8 THIGYAKLTIrSLERSLQFYCnviGFQVLkktDRQAELTAdg-krVLLILEEnpsavvlperSVTGLYHFAILLPDRKEL 86
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                                                                  #          
gi 222420152  86 GALIKHLFQHN-----------------------IAISGGDHLVSEaIYFSDPEGNGIEVYIDRPADLW 131
gi 29375255   87 GNMLLWLLQEN-----------------------VQIGAADHGYSEaLYLSDPENNGIEIYWDKPEEVW 132
gi 30021634   91 ASALFGVLRNKnvidspaeqegrytysneilpisRLNSASDHTYSEaFYLQDLEGNGIEIYVDRPRDRW 159
gi 116494648  88 GAAYRIVAKNQ-----------------------TVTTAFQTGYREgFIAHDPEGNGVAFTIDRAIEQY 133
gi 27382384  123 ARWLVHAASHRv----------------------PLSGFADHLVSEsVYLDDPEGNGIEVYADREPSQW 169
gi 15806765   87 GRWVAHAAGLG-----------------------SGLGSGDHLVSEaFYLSDPEGNGIEVYADRPREGW 132
gi 15964739  100 GRWLVHAAESGv----------------------QLQGASDHLVSEaIYLADPEGNGIEIYRDRPREEW 146
gi 163848338  86 ARALARLFRAR-----------------------YPNAPTDHIMTKaTYLDDPDGNGIEIYCESPEDGV 131
gi 262335464  85 AAVAARLLAQSv----------------------FFEGAADHAVSEaLYFRDPEGNGLELYTDRPPEQW 131
gi 22538215   84 SLALNHLLSQHi----------------------PLEGGADHGYSNaIYLSDPEGNGIEIYNDKDISMW 130
gi 125718390 122 ADILKHLSEDKv----------------------PMVGGADHGYSEaIYLEDPEGNGIELYRDKPQADW 168
gi 1486247    87 GIALARLIEHG-----------------------IAIGHGDHAVSEaLYLSDPDGNGIEMYADRPRSTW 132
gi 239938766  87 GIALARLIEHG-----------------------IAIGHGDHAVSEaLYLSDPDGNGIEMYADRPRSTW 132

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