Conserved Protein Domain Family
PpCmtC_C

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cd07258: PpCmtC_C 
C-terminal domain of 2,3-dihydroxy-p-cumate-3,4-dioxygenase (PpCmtC).
This subfamily contains the C-terminal, catalytic, domain of PpCmtC. 2,3-dihydroxy-p-cumate-3,4-dioxygenase (CmtC of Pseudomonas putida F1) is a dioxygenase involved in the eight-step catabolism pathway of p-cymene. CmtC acts upon the reaction intermediate 2,3-dihydroxy-p-cumate, yielding 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate. The CmtC belongs to the type I family of extradiol dioxygenases. Fe2+ was suggested as a cofactor, same as for other enzymes in the family. The type I family of extradiol dioxygenases contains two structurally homologous barrel-shaped domains at the N- and C-terminal. The active-site metal is located in the C-terminal barrel and plays an essential role in the catalytic mechanism.
Statistics
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PSSM-Id: 319921
View PSSM: cd07258
Aligned: 3 rows
Threshold Bit Score: 237.097
Threshold Setting Gi: 74484311
Created: 18-Mar-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
putative metalputative active
Feature 1: putative metal binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H EClick to see conserved feature residue pattern help
Evidence:
  • Comment:predicted based on homologous proteins in the same family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                        #                     
gi 74484311  145 GHVVIGSENFEGSRDSLVDDFGFRVSDLIedRIVFMRChPNPFHHTFAVGpassSHFHHVNFMVTDIDDIGKALYRIKQH 224
gi 5360706   139 SHVGLNSTNPRRDEAFWTKVCNARVSDRI--GDIALMR-VNAIHHTVALApaagPGIQHINHQVQSNDDVLRSYYHLSEQ 215
gi 639283643 139 SHIGLNSTDPVRDEQFWTQVCNARVSDRI--GDIPLMR-VNAIHHTIALVrapnAGIQHINHQVGSSDDVLRSYYFLNEK 215
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                     #                               
gi 74484311  225 DIKVVFGPGRHPPSDSVFFYFLDPDGITVEYSFGMeeFAEHGARPPRYMepvPESLDAWGA 285
gi 5360706   216 RVPIVFGPGRHPTSGARFLYFKGPDGMVFEYSVGVdeIEDEATHRPRQFgfePSSLCMWGS 276
gi 639283643 216 CVPIVFGPGRHPTSGARFLYFKGPDGMIFEYSVGVdeIEDEATHRPRQFgfePTSFCMWGA 276

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