2KJZ,3RHE,3SK1


Conserved Protein Domain Family
EhpR_like

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cd07261: EhpR_like 
Click on image for an interactive view with Cn3D
phenazine resistance protein, EhpR
Phenazine resistance protein (EhpR) in Enterobacter agglomerans confers resistance by binding D-alanyl-griseoluteic acid and acting as a chaperone involved in exporting the antibiotic rather than by altering it chemically. EhpR is evolutionarily related to glyoxalase I and type I extradiol dioxygenases.
Statistics
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PSSM-Id: 319922
View PSSM: cd07261
Aligned: 7 rows
Threshold Bit Score: 171.815
Threshold Setting Gi: 345110927
Created: 23-Feb-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interface
Conserved site includes 44 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:2KJZ: Agrobacterium tumefaciens putative glyoxylase family protein forms a homodimer, contacts at 4A
    View structure with Cn3D
  • Structure:3SK1: Pantoea agglomerans Phenazine Resistance Protein Ehpr forms a homodimer, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #####            #####   #   ##    # ## ##  #          #  #########       ##  ##
2KJZ_A        28 FTILYVdNPPASTQFYKALLGVDPVEssPTFSLFVLANGmKLGLWSRhtvepkasVTGGGGELAFRVENDAQVDETFAGW 107
3RHE_A         9 LVLFYVkNPAKSEEFYKNLLDTQPIEssPTFAXFVXKTGlRLGLWAQeeiepkahQTGGGXELSFQVNSNEXVDEIHRQW 88
3SK1_A        16 LQLVYVsNVERSTDFYRFIFKKEPVFvtPRYVAFPSSGDaLFAIWSGgee--pvaEIPRFSEIGIMLPTGEDVDKLFNEW 93
gi 211958728   6 SVILYVdDVEKSTEFYTDVLQSGPIErfQEFSLFSLGEDvTLGLQSAegidpkpqPSFGGFELSLSDVSREEVDQVYALW 85
gi 117620029   6 FTILYVaNPARSTLFYRELFGRPPVEesPTFAMFVFESGaRLALWSSatvepavtQTAGAMELAFALPNDTAVDRQSAEW 85
gi 28898511    6 SFVLYVeNIHVSQTFYSRLFDCEVTLlsPTFASMPLSHSvKLTLKQSdaltpismVKGGGAELSLSVADGHQLELVYNKW 85
gi 15963979    6 LIVLYVmDPPASVEFYRKLLGKEPTAtfPTFSSFEMQDGfVLGLWARekvqpqpiGDGSRAEVAFMVKGEEAVRARYEEW 85
                         90       100       110
                 ....*....|....*....|....*....|....*..
Feature 1                  ##  # # #  # #       # ### 
2KJZ_A       108 KASG---VAMLQQPAKMEFGYTFTAADPDSHRLRVYA 141
3RHE_A        89 SDKE---ISIIQPPTQXDFGYTFVGVDPDEHRLRIFC 122
3SK1_A        94 TKQKshqIIVIKEPYTDVFGRTFLISDPDGHIIRVCP 130
gi 211958728  86 KEKG---IPILMEPVDLDFGYTFVATDPDGHRLRVCA 119
gi 117620029  86 QARG---LTLIQAPTRMEFGYTCMALDPDGHRLRLYC 119
gi 28898511   86 KEMG---VDFIQPPMTSVYGLNFVATDPDKHRIRVFI 119
gi 15963979   86 RAMG---LPIAQELTRMDFGPTFVALDPDGHRLRVCL 119

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