4Z04,4QB5


Conserved Protein Domain Family
VOC_like

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cd07262: VOC_like 
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uncharacterized subfamily of vicinal oxygen chelate (VOC) family
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319923
View PSSM: cd07262
Aligned: 41 rows
Threshold Bit Score: 101.536
Threshold Setting Gi: 159489807
Created: 25-Feb-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4Z04_A        10 LDHIGFNIADMKKSRAFYDA-ALSPLGIGHAMef----gDWVGYGrn-------gkPEFWIGaqkg---aklEGVLHVAF 74
gi 196188469   2 IGYITLGTNNLERAERFYNV-LLKELGATQTFkt----gSSVSWGfge------krPMLTITqpfdrkpasaGNGVMVAL 70
gi 211959465   2 IGYITLGTNDLERACSFYDA-ILGKMGATRVFenn--rlYAWSFGeg--------kPLIVLNtpydgqeasiGNGTMVAL 70
gi 214031488   2 IAYITIGSNDLPRAKAFYQA-ILPPLGYDFSEg-----rEGLSFVlpvpegeqpsaPDVYVKrpfdgapataGNGMMVAF 75
gi 206687030   2 IAYTTVGAGDIARGTVLFRVpASPGYAVEEGP-------AGLRYTlpanpgqppalPDYYVKppfggrpasaGNGSMTAF 74
gi 221536096   2 DLYTTYGTNDLLRAIRFYDA-IFAVLGQPRLPgw---idGWAGWGtdp-----dsgTGFWVCepfdgapantGNGTMIAF 72
gi 221235546   2 ISYITIGASDPDRAGAFYDA-ALGALGNQRLWrq----gDWIGYGpdp------ehATVMICspengepakaGNGIMIGL 70
gi 15890715    2 FSHVTVGTDDLQRAGRFYDA-VLAPLGLIRRTitpdggpAALCWVath-----aplPRFYVYspfngeaataGNGGMVAF 75
gi 15964510    2 LLYVTLGSNDLETAGAFYDR-ALAPLGLKRRKed----eVEIGYGaeg-----dvrCRLWVVtpfnreaatiGNGSMVAL 71
gi 222439685   2 LSGVCIGTNDMAKAAEFYDA-VFATIGVTPAFqg----eHERGYAetd------grVTIFIVtpynnkpatfGNGTQFIF 70
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
4Z04_A        75 SAGTrSEVGRFYEAAIAAGGRDNGKPGLRphyhPDYYAAFVLDPDGHNIEVVC 127
gi 196188469  71 MAKSrYVVDSFHAKALALGGKDEGAPDFRg---DDFYVGYFRDLDGNKLNIFC 120
gi 211959465  71 RVEDrETVENLHALALQLGGKDEGPPGPRg---EAFYGAYCRDLDGNKLNFHC 120
gi 214031488  76 QARTqAEVRDLHGAALAAGGQDDGAPGFRaaysAGFYVGYLRDPDGNKIALFS 128
gi 206687030  75 EERTqKQVREPHAAALLAGGSDEGQPGFRadygPLFYVGYLRGAQGNKIAHFS 127
gi 221536096  73 PAQSaGQVRRFHAAGLENGGSDEGKPGIRphygPDFYVAYLRDPDGNKLSCFY 125
gi 221235546  71 KADSpQQVDAFHAAALAHGGVCAGPPGLRptygEGYYLAYVRDPDGNKLSAFF 123
gi 15890715   76 LAPSkGAVNNAYAGGLAHGGTDEGGPGPRphygDGYFGAYLRDPDGNKVHIVH 128
gi 15964510   72 EAESrAAVDAFHAAALAGGGTDEGAPGLRpf-hANFYAAYVRDPDGNKLSAVC 123
gi 222439685  71 HAADkDGVRAFHSAALNNGGTDEGSPGPRdy-hPDYYGAYVRDPDGNKLHISI 122
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