4HC5,4G6X


Conserved Protein Domain Family
VOC_like

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cd07263: VOC_like 
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uncharacterized subfamily of vicinal oxygen chelate (VOC) family
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping
Statistics
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PSSM-Id: 319924
View PSSM: cd07263
Aligned: 19 rows
Threshold Bit Score: 123.561
Threshold Setting Gi: 21225903
Created: 25-Feb-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HC5_A        16 SATIIVSDQEKALDFYVNtLGFEKVFDnq-ldPNXRFVTVVPPGA-QTQVALGlpswyed-----------grkpggyTG 82
gi 171473771   8 LITVPVSDQDAAKQFYVEqLGFEVSQDsq--mGPMRWLEVAPKGS-PVSFALLpsvlgv--------------pvgglKG 70
gi 21225903   12 TVGIRVADQRKATEFYVGeLGFEVRRDvp--fGGGRWIEVAPPGA-TTTVALVpeg--------------------vpGG 68
gi 16077783    7 TVAVYVEDQQKAKQFWTEkVGFDIAADhp-mgPEASWLEVAPKGA-ETRLVIYpkammk-------------gseqmkAS 71
gi 30020242    7 QIMLYVNNQDEAVNFWTEkVGFHVVAEed-nkQGMRWIEIAPTNGaETSIILHnkeviskm---------spelnlgtPS 76
gi 16803908    7 QVMLYVENQAAVRDFWVEkLDFVVVSEev-vnGEIQWIEIAPTKGvETTFVLQnkkkvaem---------npemnlgtPS 76
gi 29375339    7 KIMLYVNNVEESSQFWQT-FGFVEKERee--vDGTLVVEIAPSESaEAIIVLYdlafiqkh---------spevagntPS 74
gi 119370549   7 HIALVVNDYDEAIDFYVNkLKFDLIEDtyqaeQDKRWVVVSPPGSnGVSLLLAraskpeqhd-------fignqaggrVF 79
gi 21224821    7 QCFIAVDDHDRALAFYRDvLGLEVRNDvg--yEGMRWVTLGSPAQpDVDIVLEppladpnasaadkqamadllakghlRG 84
gi 21220708    7 VIPLPVTDIDRARDFYRDkVGFHVDIDqe-vmPGMRIVQLTPPGS-GCSIALGdaiwdmaqg-------qtrpepgsyQG 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
4HC5_A        83 ISLITRDIDEAYKTLTERGVTFTkppe-xxpWGQRATWFSDPDGNQFFLVE 132
gi 171473771  71 VQLFTDDLDGDCESLRAAGVKVDgpn---arPWGRDANFSDPDGNGFVLMS 118
gi 21225903   69 IRLATRDADADHADLRARGVDADaevlrtgpGVPHMFAVRDPDGNDLIVVE 119
gi 16077783   72 IVFECEDIFGTYEKMKTNGVEFLgep--nqmEWGTFVQFKDEDGNVFLLKE 120
gi 30020242   77 LMFFSENLDQLYTDLTNKNVTVGemv---tmPSGKVFNFADSEGNYFAVME 124
gi 16803908   77 ILLFGSNVAELYEEYKNKGITVGdlv---dlPMGRVFNFSDNEGNYFAICE 124
gi 29375339   75 LMFASDDIIGLYKKMQEAGVTVGemv---qlPTGLVFNFADNDDNYFAVMG 122
gi 119370549  80 LFLNTDDFWRDYNRMQLDGIKFVrpp--qeqDYGTVAVFEDLYGNLWDLLQ 128
gi 21224821   85 IILATDDVDATFEHVRAAGAEVLqepv-dqpYGVRDCAFRDPAGNMVRLHR 134
gi 21220708   78 LQLCVADIKAAHAELTARGLEVSepvqyapdDGATFMYFKDPDGNGWAIQE 128
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