3G12


Conserved Protein Domain Family
VOC_like

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cd07264: VOC_like 
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uncharacterized subfamily of vicinal oxygen chelate (VOC) family
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319925
View PSSM: cd07264
Aligned: 16 rows
Threshold Bit Score: 106.647
Threshold Setting Gi: 32473952
Created: 25-Feb-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3G12_A         7 ITSITINTSHLQGMLGFYRIIGFQFTASKVDkg-seVHRAVHNg----VEFSLYSIQNPQrs-----------qIPSLQL 70
gi 32473952   19 IGLLVIRSDNMEAAARFYSALGMLLEKHSHPpcgehYSTVDDN-----CVFEICQRKPEQp------------pTTACFF 81
gi 74509188    3 IKYATIIVDEMEESVKFYRDVMGFTVDSHYDlg--aSGEITILrgegeAMVELIKNPTDK--------------PGFFSI 66
gi 15607686    5 ASRMLLRPADYQRSLSFYRDQIGLAIAREYG-----AGTVFFAg---qSLLELAGYGEPDhs----------rgPFPGAL 66
gi 283812960  16 IGYVILYVSDLDASIAFYRDVLGLPHRFTDAg----YAEFGTTa----PRFALYERRRAEwltgg-----pvapGPAAEI 82
gi 159029295  17 EAFIALGTSNFDRSVQFYRQLLQQEPSPYLAa---vYAEFRLIn----LKLGLFCPKESHreef------sdsrGSGMSI 83
gi 148807613   7 TATTVLPVDDAARARRFYTEKLGLPHRGMTDd----GSELLGSdg--gPMLQLMPVSDGKh-------------SEHTAL 67
gi 196192236   5 TAHTRLFVDDVAACAQFYKDVLKFKPRTLQVek--gYAEFEITe---nMWISLFCQREMAei----------lrTSDRPV 69
gi 21220380    3 LAQVRLLVTDFPSCYRYYRDVLGLKPQFESEdg--pYAKFTPDgg--aAGIALQDRAQMArvlggl---adepaGHRSLV 75
gi 29346581    3 FSNVRLLVKDFAGCFKFYTEQLGLEPAWGDEns--gYASFKVAdg--iEGLALFVSDWMApsagnadkqqpvgmREKLMI 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
3G12_A        71 GFQITDLEKTVQELVKIPGAMC-----------ILDPTDMPDGKKAIVLDPDGHSIELCEL 120
gi 32473952   82 GINVENVEVAVGTVLKSGGLVK-----------RLPANSEWGRTAIITDLDGHSVMLIENA 131
gi 74509188   67 GMEVDDLEATLNDLRSRGARVL-----------MEPTPITVGLLAFIEDPNGVRIALIEHR 116
gi 15607686   67 WLQVRDLEATQTELVSRGVSIA-----------REPRREPWGLHEMHVTDPDGITLIFVEV 116
gi 283812960  83 VLLTDDVDAQARRLGKLGVPIL-----------TGPADRPWGHRTVHLADPDGFIVELAQE 132
gi 159029295  84 CFEVESLEKAIEYWSEIGYGAR-----------GEISQASHGPEIYIYDPDGNRLIFHQST 133
gi 148807613  68 SFEVTDIEKTVRDMEARGVAFQdydlp--nlktENHICTTDSEKCAWFMDTEHNILCVHEK 126
gi 196192236  70 AENVQDKVCLILNVHNLDDIYHelrqagvsfdePPTQNNEFSLKVAYFRDPAGNLIGLFEA 130
gi 21220380   76 VLRVDDLDRYCEEITARGAEFV-----------HGPAPMTDRMRVAHLVDPAGNLVELQEW 125
gi 29346581   79 SFSVDNVDETFVALKAKGVTFIs----------EPTDMPDWGMRTLYLRDPEENLIELFTP 129
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