1K4N


Conserved Protein Domain Family
VOC_EcYecM_like

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cd07268: VOC_EcYecM_like 
Click on image for an interactive view with Cn3D
Escherichia coli YecM and similar proteins, a vicinal oxygen chelate subfamily
Uncharacterized subfamily of vicinal oxygen chelate (VOC) superfamily contains Escherichia coli YecM and similar proteins.The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319929
View PSSM: cd07268
Aligned: 5 rows
Threshold Bit Score: 230.051
Threshold Setting Gi: 66808849
Created: 26-Feb-2009
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
putative metal
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: putative metal binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H KClick to see conserved feature residue pattern help
Evidence:
  • Comment:predicted based on similar proteins in the same superfamily.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                     #                                                  
1K4N_A        20 DLPRFIHALDELSRrlgln---itplTADHISLRCHQNATAERWRRGFEQCGELLSENXINGRPICLFKLHEPVQVAHWQ 96
gi 2506680    14 DLAIFERKIQHLAKemtid---lshyEIDHLALRVNSEQSAKNWLILLLKCGRILSDNIVNGRKIYLIELEKPVKFANQF 90
gi 24373739   19 AWPAFETKILSLLNtlgla---dkglYCDHVALRVNTIVAADALKQAFSERGRIISDNKINGRSILIIELDNPLRLGSFT 95
gi 66808849    9 DYNSFLDTIFELLIkggfkenelkelPIDHICYRVSTNEFYNEKKEQLNQLGELLVETEIGGRMISTFKLNKPIQYKDKS 88
gi 225200663  16 ELSLFEENMTLLADslgmd---laiyPTDHVSLRCHELALAEQWRIGLSQCGKCISDNVINGRPIYLFQLETPLTILNQS 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            #                                                           
1K4N_A        97 FSIVELPWPGEKRYPHEGWEHIEIVLPGdpetlnarala--------llsdeglslpgISVKTSSPKGehERLPNPTLAV 168
gi 2506680    91 VDIIELPLPKNKKYPIEGWEHIEIVMPFlpkesinewin--------rvnmyflxltqLTIKVSEPKVdgERLPNPSIAV 162
gi 24373739   96 IDCVELPYPGDTHYPQEGWEHIELVLPStaqdcdslsqnigqlcppllpllqgqssapIKVKFSSPKSekERLANPTIAF 175
gi 66808849   89 IPLIELPAPKKNRINYDGLEHIEMVINEpfqsfvd----------------nhpspidENLKFNWVLHalNKDINPDVEC 152
gi 225200663  93 VSIVELPFPTNKKYEYQGWEHIEQVISVepselvsrvm----------sflpqmlpenVSLKISEPKGekERLPNPTVAI 162
                        170       180       190
                 ....*....|....*....|....*....|.
Feature 1                        #              
1K4N_A       169 TDG---------KTTIKFHPWSIEEIVASEQ 190
gi 2506680   163 SFTdkt----vnHTCIKVHPYSIKKYLRFSK 189
gi 24373739  176 KQA---------DVCIKLHPHGIKAVIASEQ 197
gi 66808849  153 EFIdprikneirTISVKFHHQSLEEVVKYEI 183
gi 225200663 163 SNG---------KVTVKYHPYSLLEIVESEC 184

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