2W01,1FX4,1YBU,1Y10,1YK9,1WC0,1AB8,3ET6,1CJK


Conserved Protein Domain Family
CHD

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cd07302: CHD 
Click on image for an interactive view with Cn3D
cyclase homology domain
Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.
Statistics
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PSSM-Id: 143636
View PSSM: cd07302
Aligned: 928 rows
Threshold Bit Score: 68.3747
Threshold Setting Gi: 123412494
Created: 30-Sep-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:nucleotidyl binding site
Evidence:
  • Structure:1WC0; Arthrospira adenylyl cyclase with bound alpha,beta-methyleneadenosine 5'-triphosphate
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              # ######                                  # ###  #                         
2W01_A         14 PITILTSDLRGFTstseglnpeevVKVLNIYFGKMADVIthhgGTIDEFMGDGILVLFGapts--qqdDALRAVACGVEM 91
1WC0_A         27 LITILFSDIVGFTrmsnalqsqgvAELLNEYLGEMTRAVfenqGTVDKFVGDAIMALYGapeemspseQVRRAIATARQM 106
gi 24213770   156 NVTVLFTDMAGFTkiaesmspeelLSELDLFFREFDLITkkhgMEKIKTIGDSYMAAGGlpiv--nntHSIDAVLCGLEF 233
gi 218779134  292 SVTILFADFVDFTahaekispeelIDDLEASYALFDEIVeargLEKLKTIGDSYMCAGGltvl--nenHAMDCVQAGLDM 369
gi 88714187   221 DITVLFTDFENFTklvasisaitlVNELNDIFGRFDEIMaeteVEKIETIGDSYMAACGleke--manHAANCIRAAQMM 298
gi 126648455  239 NVTVLFADVKNFTivsegllpdqlVALLDTYFQRIDAIIqkhgLEKIKTIGDAYLAAAGvpkg--nkaTARDVVAAALEI 316
gi 42525675   842 AVTVLFADVVGFTewsghntpdavISGLNSLFTHFDGIMdlygCERIKTLGDGYLACSGltn---eknHAERVVDAAVAM 918
gi 206684670  167 KVSVVMLDFVNFTdfasrtdptvtLGELNDIFTAFDRIVeqygCERIKTIGDAYLAVAGmpep--mpeHATAVAHCATRF 244
gi 225117252  164 PVSVLMLDFVGFTemvasqdpsvtVTELNDIYSAFDRIGeqfgCERIKTIGDAYITVAGlpdp--tpdHAKAIANTAIRF 241
gi 170739810  173 DVAVLFIDLVGFTawchrqtpdvvVAEIQRLAEAFEIVAhehgLENIKTIGDAFMATANllrp--hadPVEAAIRCASDM 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                          ###   ##  ##                   
2W01_A         92 QLALRevnqqvt------glglqpLEMGIGINTGEVVVGNigsekrtkYGVVGAQVNLTYRIESYTtgGQIFISSTTLEA 165
1WC0_A        107 LVALEklnqgwqerglvgrnevppVRFRCGIHQGMAVVGLfgsqersdFTAIGPSVNIAARLQEATapNSIMVSAMVAQY 186
gi 24213770   234 QKFMRlkkkere------nnhlpfWELRLGIHSGSVVAGVvgtk-kfaYDIWGDSVNTASRMESSGipGEVNISQETFEK 306
gi 218779134  370 VESIKaikqarq------alginsWDVRVGIHTGPVVAGVigqt-kfsYDVWGEAVNLASRMEANGipNKVNISEATYLQ 442
gi 88714187   299 LSYLEernks----------heikWKMRVGIHSGTVVAGVvgkk-kfaYDLFGDTINTASRIEFAGevGKINISSSTYEQ 367
gi 126648455  317 QKTNDaykvlre------teglpfFDFRIGINTGTVVAGVvgdk-kyvYDIWGDAVNTAARIEENSapGRVNISAFTHQV 389
gi 42525675   919 LRSLEtfnke----------ndscFSIKIGISSGAITGGIvgvh-kyiFDVFGDTVNTAFRLESVTspTACTVSESTAAL 987
gi 206684670  245 LRYLErrnqs----------hqhkWQARIGLGTGSAVGSVvgiq-kyvYDVFGPAVNLASRLQVFAnpMKIVAPEEMKAA 313
gi 225117252  242 VRYLTrrnls----------hphqWQCRIGLSSGSVVGSVvgiq-kyvYDIFGPAVNLASRLQEFSepMQISVQDEVAQV 310
gi 170739810  251 VAVAAaga--------------pgWRLRAGIHIGSVVGGIvgrt-kftFDLWGDTVNVAARLSGLGggCTLHLSREAFAR 315
                         170       180
                  ....*....|....*....|....*...
Feature 1                         #           
2W01_A        166 agdrvhvNGNRTv-QPKGvkdPVVIWDV 192
1WC0_A        187 vpd-eeiIKREFl-ELKGidePVMTCVI 212
gi 24213770   307 ikd-ffiCDYRGkiKAKNk-gEIDMYLV 332
gi 218779134  443 vkd-qfqCDPRGmiRLKGi-gKAQMYLV 468
gi 88714187   368 ikn-dfkCLSRGkiFAKGk-gDLEMYFV 393
gi 126648455  390 vke-hfeLEERGliSAKNk-gKIEMFWV 415
gi 42525675   988 irg-kygLHKRPdqNLKGk-gLIPCYYV 1013
gi 206684670  314 lse-efrVTDIGpeDIKGi-gEVNLINV 339
gi 225117252  311 lkd-qfdIENMGskDIRGf-gEQDVWRL 336
gi 170739810  316 lad-qraVRPIGnvMLKGk-gEIEVYCR 341

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