3C37


Conserved Protein Domain Family
M48C_Oma1-like

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cd07324: M48C_Oma1-like 
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Oma1 peptidase-like, integral membrane metallopeptidase
This family contains peptidase M48 subfamily C (also known as Oma1 peptidase or mitochondrial metalloendopeptidase OMA1), including similar peptidases containing tetratricopeptide (TPR) repeats, as well as uncharacterized proteins such as E. coli bepA (formerly yfgC), ycaL and loiP (formerly yggG), considered to be putative metallopeptidases. Oma1 peptidase is part of the quality control system in the inner membrane of mitochondria, with its catalytic site facing the matrix space. It cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins. Oma1 can cleave the misfolded multi-pass membrane protein Oxa1, thus exerting a function similar to the ATP-dependent m-AAA protease for quality control of inner membrane proteins. It has been proposed that in the absence of m-AAA protease, proteolysis of Oxa1 is mediated by Oma1 in an ATP-independent manner. Homologs of Oma1 are present in higher eukaryotes, eubacteria and archaebacteria, suggesting that Oma1 is the founding member of a conserved family of membrane-embedded metallopeptidases, all containing the zinc metalloprotease motif (HEXXH). M48 peptidases proteolytically remove the C-terminal three residues of farnesylated proteins.
Statistics
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PSSM-Id: 320683
Aligned: 406 rows
Threshold Bit Score: 85.6943
Created: 29-Feb-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteputative active
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:3C37: Geobacter sulfurreducens PCA putative Zn-dependent peptidase (Q74d82); contact distance 4.0A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
3C37_A         45 YVDKVGKRLLSGarav--efdYVFKVVkddsvNAFAIp---gGRVYVHTGLLkaa-----------------dneTELAG 102  Geobacter sul...
ABR71007       72 YLKDALSQILPQtnly--nttVEMTLLnssqsNAFVIp---gNHLFIYSDIMemi-----------------tseDMLFG 129  Marinomonas s...
OAH06121       34 ALQELARPILQAanls--serVKILVVddlqlNAFVId---nHHIFLNAGMVlkt-----------------nsaSMLQS 91   Rhodobacterac...
EEE37641       43 GLRELAFPILRAagln--tnrVRVLVVndstfNAFVId---yNTIYINYGLIlsv-----------------etpEMLQA 100  Rhodobacterac...
WP_027272573   47 KIKSIIQRIFEKnsltntlcmPQLQLSgsdneNASIIttgkqPVLIITKGLLknv-----------------qseDELAG 109  Legionella sa...
EAU51285       33 TLRIITAPLLENtkin--kenFKVLVVndssmNAFVTs---gQYIFIHYGLItkl-----------------envEQLQS 90   Rhodobacteral...
EPG74065       74 SIDNAFARLSQNsgnp--pfpIVYKIVkdpsfNAFAMa---gGQFCIHSGALdsldqiisqreanaasnldfhreRYIAG 148  Leptospira fa...
CUB03951       73 YLREAVASIVPNtgly--dktIDLALLnstetNAFVIp---gNHLFIYSDILrli-----------------nneSTLMG 130  Marinomonas s...
WP_018704580   56 IFRKLLNAMETSr--------SKSYMVrvyknNVMNAfc-gpDAQVYIYSPIadl------------------pdDCIAG 108  Anaeromusa ac...
WP_015144543   93 SIAEGYACWRADpsf---nlnYHFWLIaqalrSDFDIm----PPTDIFGQLQyqts---------------qifrDMIAF 150  Pleurocapsa m...
Feature 1            #   #                                                              #         
3C37_A        103 VLAHEINHAVArHGTRQXTQeygyslvlslvlgdnpn-----------xlaqlagqlfgkagxxsYSREYENQADFLGVE 171  Geobacter sul...
ABR71007      130 LLGHEIAHLDLrHYERQTKHsgeelqktlvmlgagiaaalagagsdattalwlggianqaentltYSRNQEQEADRRGRE 209  Marinomonas s...
OAH06121       92 IIAHEAAHIANgHIARRAKTiktarsaagfgmalgiaagaaggnvalgtglaiglnssaernflaYNRSEESSADQSAMQ 171  Rhodobacterac...
EEE37641      101 VIAHEAAHIANgHLARRSENlraaqrnaqlgtllalataaag-ggraaagiaagtqasalrsflgHTRAEEASADRSAAS 179  Rhodobacterac...
WP_027272573  110 VIAHELGHLLLyKQHQETEH---------------------------------------------HNKIEETAADNLGVK 144  Legionella sa...
EAU51285       91 VIAHEIAHIIGgHYIKRMEDiesaqtvagigmalsaaaglaagdtnlviglaagtqsasrraflkNTRTQEASADQTGIK 170  Rhodobacteral...
EPG74065      149 VLSHELSHFYNkHVLNSVKKfyalkneea---------------------------gkaflentkFSQEQELDADQTGLF 201  Leptospira fa...
CUB03951      131 LLAHEVSHLELhHYQRSLENqkneqakalllvlagvaaatag-dgettsalwlggmanqvenmlsYSRAHEQEADRRGRE 209  Marinomonas s...
WP_018704580  109 VMAHELGHNEKkHWQNAYERvmlqqigiaglalkggvt---------glglqladtatkalffrgYGFEKEWEADNYGFD 179  Anaeromusa ac...
WP_015144543  151 VAAHELAHFIKhDLARKLVEasltgst--------------------------------pisamfFSRGLEIEADLLGLS 198  Pleurocapsa m...
Feature 1                                                               #            
3C37_A        172 TXYkagy---npngLTSFFQKLNaxdggt---------------qsnvaRFFSTHPLtsERIQRVQA 220  Geobacter sulfurreducens PCA
ABR71007      210 YLInagl---apegMTKLFQAFFkqalg-----------------rpklEYLSSHPSpnSRLSDSFS 256  Marinomonas sp. MWYL1
OAH06121      172 YMRragv---slqgMADVLEIFSgqesll---------------parqdTYLRSHPLsrERLRQARS 220  Rhodobacteraceae bacterium...
EEE37641      180 YLRwagi---sprgMVNLHRKFAgqells---------------eanqdPYMRSHPSsrERLRAAEA 228  Rhodobacteraceae bacterium...
WP_027272573  145 LLHqagy---dpdgIIYFLRRAGgdkahlitiedithadsldegahliqTVTDPHPSdkSRIRAMET 208  Legionella sainthelensi
EAU51285      171 LMAdani---npnaALEVLEIFKdqeflt---------------akrqdPYIQTHPLntQRISSINK 219  Rhodobacterales bacterium ...
EPG74065      202 LLDragy---ggeyMLVTLQALNeveqsykdslaas-kadktrtelvgsSYFSSHPSpnERLSRLNT 264  Leptospira fainei serovar ...
CUB03951      210 LMQlsgf---ptsgMNELLAGLFkqslg-----------------snriEFLSTHPLpqNRLSDSLT 256  Marinomonas sp. AN44
WP_018704580  180 LLIrtey---npmgLALFLHEVDkpeyqs---------------pnttaEFINPHPQtaKRIVNQTN 228  Anaeromusa acidaminophila
WP_015144543  199 LLVqagydprgallSLAFMDYLDkftg-------------------rqpHPLDPHPPasDRFTIVQQ 246  Pleurocapsa minor

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