3C37


Conserved Protein Domain Family
M48C_Oma1-like

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cd07324: M48C_Oma1-like 
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Oma1 peptidase-like, integral membrane metallopeptidase
This family contains peptidase M48 subfamily C (also known as Oma1 peptidase or mitochondrial metalloendopeptidase OMA1), including similar peptidases containing tetratricopeptide (TPR) repeats, as well as uncharacterized proteins such as E. coli bepA (formerly yfgC), ycaL and loiP (formerly yggG), considered to be putative metallopeptidases. Oma1 peptidase is part of the quality control system in the inner membrane of mitochondria, with its catalytic site facing the matrix space. It cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins. Oma1 can cleave the misfolded multi-pass membrane protein Oxa1, thus exerting a function similar to the ATP-dependent m-AAA protease for quality control of inner membrane proteins. It has been proposed that in the absence of m-AAA protease, proteolysis of Oxa1 is mediated by Oma1 in an ATP-independent manner. Homologs of Oma1 are present in higher eukaryotes, eubacteria and archaebacteria, suggesting that Oma1 is the founding member of a conserved family of membrane-embedded metallopeptidases, all containing the zinc metalloprotease motif (HEXXH). M48 peptidases proteolytically remove the C-terminal three residues of farnesylated proteins.
Statistics
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PSSM-Id: 320683
View PSSM: cd07324
Aligned: 406 rows
Threshold Bit Score: 85.6943
Threshold Setting Gi: 504957441
Created: 29-Feb-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteputative active
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:3C37: Geobacter sulfurreducens PCA putative Zn-dependent peptidase (Q74d82); contact distance 4.0A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                          
3C37_A          45 YVDKVGKRLLSGarav--efdYVFKVVkddsvNAFAIp---gGRVYVHTGLLkaa-----------------dneTELAG 102
gi 150837031    72 YLKDALSQILPQtnly--nttVEMTLLnssqsNAFVIp---gNHLFIYSDIMemi-----------------tseDMLFG 129
gi 1027539623   34 ALQELARPILQAanls--serVKILVVddlqlNAFVId---nHHIFLNAGMVlkt-----------------nsaSMLQS 91
gi 221534653    43 GLRELAFPILRAagln--tnrVRVLVVndstfNAFVId---yNTIYINYGLIlsv-----------------etpEMLQA 100
gi 653020669    47 KIKSIIQRIFEKnsltntlcmPQLQLSgsdneNASIIttgkqPVLIITKGLLknv-----------------qseDELAG 109
gi 114548399    33 TLRIITAPLLENtkin--kenFKVLVVndssmNAFVTs---gQYIFIHYGLItkl-----------------envEQLQS 90
gi 514180523    74 SIDNAFARLSQNsgnp--pfpIVYKIVkdpsfNAFAMa---gGQFCIHSGALdsldqiisqreanaasnldfhreRYIAG 148
gi 973989739    73 YLREAVASIVPNtgly--dktIDLALLnstetNAFVIp---gNHLFIYSDILrli-----------------nneSTLMG 130
gi 517534372    56 IFRKLLNAMETSr--------SKSYMVrvyknNVMNAfc-gpDAQVYIYSPIadl------------------pdDCIAG 108
gi 504957441    93 SIAEGYACWRADpsf---nlnYHFWLIaqalrSDFDIm----PPTDIFGQLQyqts---------------qifrDMIAF 150
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #   #                                                              #         
3C37_A         103 VLAHEINHAVArHGTRQXTQeygyslvlslvlgdnpn-----------xlaqlagqlfgkagxxsYSREYENQADFLGVE 171
gi 150837031   130 LLGHEIAHLDLrHYERQTKHsgeelqktlvmlgagiaaalagagsdattalwlggianqaentltYSRNQEQEADRRGRE 209
gi 1027539623   92 IIAHEAAHIANgHIARRAKTiktarsaagfgmalgiaagaaggnvalgtglaiglnssaernflaYNRSEESSADQSAMQ 171
gi 221534653   101 VIAHEAAHIANgHLARRSENlraaqrnaqlgtllalataaag-ggraaagiaagtqasalrsflgHTRAEEASADRSAAS 179
gi 653020669   110 VIAHELGHLLLyKQHQETEH---------------------------------------------HNKIEETAADNLGVK 144
gi 114548399    91 VIAHEIAHIIGgHYIKRMEDiesaqtvagigmalsaaaglaagdtnlviglaagtqsasrraflkNTRTQEASADQTGIK 170
gi 514180523   149 VLSHELSHFYNkHVLNSVKKfyalkneea---------------------------gkaflentkFSQEQELDADQTGLF 201
gi 973989739   131 LLAHEVSHLELhHYQRSLENqkneqakalllvlagvaaatag-dgettsalwlggmanqvenmlsYSRAHEQEADRRGRE 209
gi 517534372   109 VMAHELGHNEKkHWQNAYERvmlqqigiaglalkggvt---------glglqladtatkalffrgYGFEKEWEADNYGFD 179
gi 504957441   151 VAAHELAHFIKhDLARKLVEasltgst--------------------------------pisamfFSRGLEIEADLLGLS 198
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                                                #            
3C37_A         172 TXYkagy---npngLTSFFQKLNaxdggt---------------qsnvaRFFSTHPLtsERIQRVQA 220
gi 150837031   210 YLInagl---apegMTKLFQAFFkqalg-----------------rpklEYLSSHPSpnSRLSDSFS 256
gi 1027539623  172 YMRragv---slqgMADVLEIFSgqesll---------------parqdTYLRSHPLsrERLRQARS 220
gi 221534653   180 YLRwagi---sprgMVNLHRKFAgqells---------------eanqdPYMRSHPSsrERLRAAEA 228
gi 653020669   145 LLHqagy---dpdgIIYFLRRAGgdkahlitiedithadsldegahliqTVTDPHPSdkSRIRAMET 208
gi 114548399   171 LMAdani---npnaALEVLEIFKdqeflt---------------akrqdPYIQTHPLntQRISSINK 219
gi 514180523   202 LLDragy---ggeyMLVTLQALNeveqsykdslaas-kadktrtelvgsSYFSSHPSpnERLSRLNT 264
gi 973989739   210 LMQlsgf---ptsgMNELLAGLFkqslg-----------------snriEFLSTHPLpqNRLSDSLT 256
gi 517534372   180 LLIrtey---npmgLALFLHEVDkpeyqs---------------pnttaEFINPHPQtaKRIVNQTN 228
gi 504957441   199 LLVqagydprgallSLAFMDYLDkftg-------------------rqpHPLDPHPPasDRFTIVQQ 246

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