Conserved Protein Domain Family
M48_Ste24p_like

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cd07325: M48_Ste24p_like 
M48 Ste24 endopeptidase-like, integral membrane metallopeptidase
This family contains peptidase M48 family Ste24p-like proteins that are as yet uncharacterized, but probably function as intracellular, membrane-associated zinc metalloproteases; they all contain the HEXXH Zn-binding motif, which is critical for Ste24p activity. They likely remove the C-terminal three residues of farnesylated proteins proteolytically and are possibly associated with the endoplasmic reticulum and golgi. Some members also contain ankyrin domains which occur in very diverse families of proteins and mediate protein-protein interactions.
Statistics
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PSSM-Id: 320684
View PSSM: cd07325
Aligned: 128 rows
Threshold Bit Score: 110.007
Threshold Setting Gi: 775304261
Created: 3-Mar-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteputative active
Feature 1:Zn binding site [ion binding site]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 48428739   74 FGNMILLG-----PEQFPELHQMVVAGSQEIGLSEp-PKTFLYNSngvFNAFARRll-ggRYVFLTSALVEansdAQVRF 146
gi 493575462  47 LGHALKLT-----ESLLPELYQLYQNCLKIVGQHLq-GDLYVQQQs-dYNAGVYAvg-nrFDLVLSSGIVKdfqaAEIAF 118
gi 655904238 127 LEVSVRLT-----SESSPDIYKIGEKCRDILGFKRd-IELYVYEDe-kMRAFSYLlkdnnVHIFLSSGLLEklnhAELTN 199
gi 515812180  30 WINSVDATellicRELTPDLFLAFESVVLRLGANRknVRGYIYQSh-eLNAYSSFdd-kkCIIRVSSSLVRlldiKEFQF 107
gi 759685240  51 LSNAFKLT-----HPVAPRVLDALAACKEVLGYEGp-VDVFVNPEp-mIRAAAVHappdtPAIVLSSRLLEafqeAELRF 123
gi 502811251  41 LRHGVLIS-----KSVTPSLHDQLNSVCESLYIPRecVTAFVYNSp-eVQADCLIdspdtCVLRFTSGLINlmdeNEFKF 114
gi 568804438 139 LKSSLRLT-----PTLAPVLHEIGQHCIEILKLKAt-IEFFVYQSd-qFNASCYPpdddkLYIILSSGILErfekEELAF 211
gi 575425599  45 LATAVRLT-----RGMSPPLYGIVDECREVLSITMp-MEIYVYASa-qLNAMCIKpeegrLFLAFTSSLIEkfslPELKF 117
gi 783331897   7 LSTSARIT-----AALLPDLHRLYQECLGYVGGELk-GNLYVQQSs-eYNAFIYSag-dcFDIVVSSSIIKdfdtREIAF 78
gi 551334172  47 LATSVRLS-----KGMAPDVHRMADECIETLQMDIp-LELYVYPSp-qFNAMCFKpeegrLHVMFSSSLLEgfkdDELKF 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #   #                                         #                              
gi 48428739  147 VIGHELGHHAAg-HLNPWLNTlklpahi---------vpflgkaYSRSREYTCDNIGAYLSKDfeaSRSSLQMLGCGcrr 216
gi 493575462 119 VIGHELGHVLFe-HNQIPVQLilseeqqin-----ydlarillqWSRSAEISADRIGLLCSGSltsAANVFFKTSSGlsv 192
gi 655904238 200 VIGHELGHALFs-HHNYPTEYlmeigidyls----sfqrmklysWRRSAEISADRIGLLCCQNlkaAFSSFQKLYPDair 274
gi 515812180 108 VIGHELGHFLFq-HQLVDFQDsqs------------------lrLSRAQEISADRLGLLGCDSfepAIKAILKFSFGlds 168
gi 759685240 124 ILGHELGHLAFe-HFTLPLPAtaiawdeesgrcvspasalglyrWNRAAEASADRAGLLCAREleaSASVLLARVSGwts 202
gi 502811251 115 VAGHELGHFLLg-HGACSQYLsegts--------------edfmVRRARELSADRLGYLSIGNqeeSLQAIIKTASGlnn 179
gi 568804438 212 VIGHEIGHVLFe-HFKYPVKYildegrndla----pihamklyaWNRNAEISADRAGLLCCQDfeaAGRTFFKLSSGvtt 286
gi 575425599 118 VLGHELGHFVFqhHDIPIGYIlkgrvkpdp------nvvlklfaWSRYAEISADRAGAVCSRDldaVAGSMFKLASGlts 191
gi 783331897  79 VIGHELGHVIFg-HNEIPAGWflsqqtqmp-----helmhmissWSKACEISADRLGLLCCGNlrsAASAFFKLVSGlcl 152
gi 551334172 120 VIGHELGHHVYk-HHDIPIGYllkgeapvg-----prlalelfaWSRYAEISADRAGAHCAQNldaVARALFKLASGltg 193
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
Feature 1                                               #            
gi 48428739  217 lnqamsces---------fvaqeamvppvfGFLNEICRTHPRltRRVAAIKE 259
gi 493575462 193 dkeneiina---------lrnqyeeiaklaFSSHDYFNTHPLipIRFKSLEL 235
gi 655904238 275 asrsfnir------------displigdntSNEEYWYYTHPLipIRIKALDL 314
gi 515812180 169 tyinfdvg------------flvsrlnsidFDNYFLQSSHPFfsIRCRAILW 208
gi 759685240 203 gsvkselqaaarhvdallsdpsarerrgedEESLGGFRSHAFspWRVRALVA 254
gi 502811251 180 qflrfdvas----------fmsqtnmisnpSKGESKNSTHPSmlIRCRSLLW 221
gi 568804438 287 dslafqlneyi-----qqfvdlekvlndsdHDPSDWYTTHPFspLRIKALEL 333
gi 575425599 192 plvkasmddfls---qledmqvvndtpgrgAASQDWFSTHPFspLRLQALKY 240
gi 783331897 153 edsdavircl-------saqydeikaisqtQWLSDDLSTHPLipIRYKSLEL 197
gi 551334172 194 slvqfdlqdflk---qvnemqlvdaepgqgAPKQDWFSTHPFspMRVKALDL 242

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