Conserved Protein Domain Family
M48C_Oma1_like

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cd07331: M48C_Oma1_like 
Peptidase M48C, integral membrane endopeptidase
This subfamily contains peptidase M48C Oma1 (also called mitochondrial metalloendopeptidase OMA1) protease homologs that are mostly uncharacterized. Oma1 is part of the quality control system in the inner membrane of mitochondria, with its catalytic site facing the matrix space. It cleaves and thereby promotes the turnover of mistranslated or misfolded membrane proteins. Oma1 can cleave the misfolded multi-pass membrane protein Oxa1, thus exerting a function similar to the ATP-dependent m-AAA protease for quality control of inner membrane proteins; it cleaves a misfolded polytopic membrane protein at multiple sites. It has been proposed that in the absence of m-AAA protease, proteolysis of Oxa1 is mediated by Oma1 in an ATP-independent manner. Oma1 is part of highly conserved mitochondrial metallopeptidases, with homologs present in higher eukaryotes, eubacteria and archaebacteria, all containing the zinc binding motif (HEXXH). It forms a high molecular mass complex in the inner membrane, possibly a homo-hexamer.
Statistics
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PSSM-Id: 320690
View PSSM: cd07331
Aligned: 159 rows
Threshold Bit Score: 131.16
Threshold Setting Gi: 444791514
Created: 2-Mar-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteputative active
Feature 1:Zn binding site [ion binding site]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                           #   #        
gi 74751828  263 VKEVLCHLIECNKDVPGIsq-inWVIHVVDSPi-iNAFVLPnGQMFVFTGFLNSVT-DIHQLSFLLGHEIAHAVLGHAAE 339
gi 81783240   58 IHAIFNKMVPYANAENQTgqpfhWQMSVIKSKe-lNAWAMPgGKMAFYTGLVDTLQlTNDEIATVIGHEMAHALKEHGKK 136
gi 699058622  74 VYRITGRLIAQAIKMRPEtnnwdWSIKVIDDPktvNAWAMAgGKMAIYSGLPIQLKaTDDELAQVLGHEIAHALANHSAE 153
gi 480039576  65 INTVMQRLVPYANQMNQTgqpfqWQLAVLKSDt-vNAYVAPgGKVVFYTGIVNKLNlTDAEIAAVMGHEMTHALEEHSKS 143
gi 557030349  65 VKDITGRIIAQAIELYPDakewdWQIKVIDDPemvNAWAMAgGKMAVYSGLIEQLRpTDDELAQVLAHEIGHAVANHTAE 144
gi 577705134  69 VLKITNRLVEKAVLYKPDaqkwkWQVNVIESEe-vNAFCMAgGKMAVYTGLLEKVNpTDDELAQVMGHEIAHALANHTAE 147
gi 81784020   81 VQAVFRRMLPYADAANNTghkfdWKMTVFKNDe-lNAWAMPgGKMAFYTGIVDKLKlTDGEIAAIMGHEMTHALHEHGKN 159
gi 219679779  69 VARITGRVVTTAIEAFPHsadwkWSVAIIDDPetvNAWCMAgGRMAAYTGLFEKLKlTDDEFAQIMGHEIAHALANHTAE 148
gi 193076404  73 VVNIAKKITAQVQDIKPEtnqwtWELHVINTTt-iNAFCVGqGKMAIFEGMIKTLNlNDDEIAAIIGHEIAHALLEHGRE 151
gi 480038457  72 VNRVAKRLIAQVPHYRADaanwnWEVNTIRDNe-iNAFCLSgGKIGVLTGSITKINaTDDELAALIGHEIAHALRDHGRE 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                 #                      
gi 74751828  340 KAGMVhlldflgmifltmiwaicp-----rdslallcqwiqsklqeymFNRPYSRKLEAEADKIGLLLAAKACADIRASS 414
gi 81783240  137 KVNMGqftdvlaqvshialssa---------igsdgsamvvgltkdwaLDKPYSRSNETEADEVGLMLMAKSGFNPQAAP 207
gi 699058622 154 KMSVAmassigvvavgiaser------------kglaltgaalaaalaVQRPNSRTAESEADRIGIELAAKAGYDPRAAI 221
gi 480039576 144 KIGAEaltglalnigkayagds----------igqlgsaaldlgsqvgVGLPYSRNLESRADFGGLMLMAKAGYNPQAAI 213
gi 557030349 145 RMSVAlasqlgvlglglavdsd----------yrgyaltggalaatvaIGLPNSRTSEAEADQIGIELAARAGYNPYAAV 214
gi 577705134 148 KMSVDiltkvavatatvavatagggsqqqrnnnanaaqniailagaafVTLPNSRGAETEADKLGIEIAAQAGYNPAASI 227
gi 81784020  160 KVGQKiltnmaaqigtqiildkkp------dtnpelvglgmdilgmygITLPYSRSLEEEADEGGMMLMAQAGYHPAAAV 233
gi 219679779 149 RMSRAmatslgvvavgvssdn------------gglamtgaalaakyaLELPNSRTAESEADTIGMRLATEAGYDPEAAV 216
gi 193076404 152 KASRNlvsdlalgqiggn------------------aqilayfgtklgLTLPHSRSQESEADLLGLEIAAKAGFNPDAAI 213
gi 480038457 151 KVSKKlltglgvlaassagl-------------gdmvvsgtsllgdygVNLPGSRKLESEADLLGVDIMVRAGYNPQGAV 217
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
Feature 1                                #                 
gi 74751828  415 VFWQQMEfvdslhgqpkmPEWLSTHPSHgNRVEYLDRLIPQA 456
gi 81783240  208 RVWEKMQrassg-srgvlAALSSTHPNDaERQKNLLRLMPKA 248
gi 699058622 222 TLWQKMAqigg----kgpPEFFSTHSSPaNREKKLAEYVPEM 259
gi 480039576 214 TLWEKMNkldg---agagPSFLSTHPSNaQRINDMRKNLPAA 252
gi 557030349 215 TLWEKMAevgg----sspVEFLSTHPSPgNRQKTLQRLAPHY 252
gi 577705134 228 TLWEKMMeatg---dknkSDFLSTHPSSpKRIEALQALQEPM 266
gi 81784020  234 RVWEKMNqendq--ngfiYAITSTHPTNnARIENLKRLLPTV 273
gi 219679779 217 TLWQKMGdlse----erpPEFLSTHPAPeNRQAALDGMIPEM 254
gi 193076404 214 TLWKKVGdqqkg-qnnklSQMLSTHPMPqKRMEDLALAAPKF 254
gi 480038457 218 SFWNKVVaqek---qgtkIDFLSTHPTSeKRIVAIQEYINQN 256

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