Conserved Protein Domain Family
M48B_HtpX_like

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cd07339: M48B_HtpX_like 
Peptidase M48 subfamily B HtpX-like membrane-bound metallopeptidase
This HtpX family of peptidase M48 subfamily B includes uncharacterized HtpX homologs and consists of proteins smaller than Ste24p, with homology restricted to the C-terminal half of Ste24p. HtpX expression is controlled by the Cpx stress response system, which senses abnormal membrane proteins. HtpX participates in the proteolytic quality control of these misfolded proteins by undergoing self-degradation and collaborating with FtsH, a membrane-bound and ATP-dependent protease, to eliminate them. HtpX, a zinc metalloprotease with an active site motif HEXXH, has an FtsH-like topology, and is capable of introducing endoproteolytic cleavages into SecY (also an FtsH substrate). However, HtpX does not have an ATPase activity and will only act against cytoplasmic regions of a target membrane protein. Thus, HtpX and FtsH have overlapping and/or complementary functions, which are especially important at high temperature; in E. coli and Xylella fastidiosa, HtpX is heat-inducible, while in Streptococcus gordonii it is not.
Statistics
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PSSM-Id: 320698
View PSSM: cd07339
Aligned: 46 rows
Threshold Bit Score: 194.704
Threshold Setting Gi: 388529137
Created: 25-Feb-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteputative active
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 223689984  51 SYFLTPRVPAHLIMLASGARRVSpgslPQLHGIAGTLSQRAGLT-TLPRLYYHPSaRLNAFAAGtpedPAICVSRGLLSv 129
gi 550785586  50 TLYLSGRVPARLVLANAGAGVLHrhqaPQLYRVMDLLYRRAGLS-QPPWLFYVPTaDLNAFAVGdardGGIAVTEGLLHc 128
gi 737480768  57 WLPLQPGWVLRLHRAQALHYNQA----PQLYWLLEQLCQRAELAsIPRLYWLPSQePNAFTLGQgr-qTAIALSEGLLRr 131
gi 763368279  55 STRVSSQMIMRFHGGRPLHPQQA----PQLSRLLQQLAQRAGLP-ATPKLYYVPNnSLNAFATGskkdPAIAITHGLLSt 129
gi 655493803  59 QPLAGPELVLRLYRAQPIARSAA----PELHALVERLAARAGLPrVPRLYFVDTPiVNAFSVGShn-dAAIALTSGLLAr 133
gi 339412238  49 LIYLMVRLSRDAYFIPANARPLSrweaPEVYRLVDTLSERAGIP-QAPQLYLVPSpLMNALTTGpaerPVIVVTDTLLSs 127
gi 503714648  70 HRGPEMQNTPRDHFAIRTLEPADa---PELFAEIDRICWRAKLPqRPRICVLIGQrAMNAYAFGgpndAIVTFTEGLLCg 146
gi 738658478  55 LRLLPTHWTLQIYNARRLSYQEA----PELYRVTQILSQRAGLNrVPELYWIPSRmLNAFSVGDet-rSGVGLTHGLLNt 129
gi 544855766  52 VFSLHAKQSSKFLLKIHNGVLLKyedvPWLFGVVDFLSAKAGLEsSPELYILNTKvPNAFTTETke-gPILAISAGLIAr 130
gi 388529137  52 LPGLPAGLVLRAHRARPIPYAAL----PEIHDALAALAARAGIHaRPRLCWCPARqPNAFALDDag-vPVVVITDGLLRr 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #   #                                                                
gi 223689984 130 lnlDEIAGVMGHEISHISNnDMKVMGFAALFGLLTQFASlagql--lllfSLPLILLSDVEISLvalaLLIFAPALSTLL 207
gi 550785586 129 lslRQLAGVLAHEVSHLRHgDTRVMSMAATMTRLTVWGAflvql--alivMLPMVMAGELRLPWlellVVGLAPTASTLL 206
gi 737480768 132 lnsRQLQGVLAHELAHVRQgDWRLLAWADGISRLLRGLSllgql--glilALPFWLLGQVQISWggmlLLVLLPWLSTLL 209
gi 763368279 130 mdlRGLSGILAHEISHIRNnDLQLKSMVKLFSRYTRFFSlfgqi--llfiNLPLFFMGEATVSWmaiaLLLLAPTLVTLM 207
gi 655493803 134 ldlRQITGVLAHEVAHIAHgDIRVMSLADSLTRMTSVLSltgql--lllvNLPLLLVGAAVVNWlavgLLIFAPHIAMLV 211
gi 339412238 128 lppRELAGVLAHEIAHIRNgDLTLFRMVEIIRQFTEMVSqagwv--llvfFFPFLLFARQVQPLsfflFMVASPILSLLL 205
gi 503714648 147 mttKEVGAIFAHEIAHICNgDSATMSWAAQLQRAINDVAaa--------gLAPVHAFGAVKQQSslqwVLTRAPAIAELL 218
gi 738658478 130 lthRELVGVMAHEISHIAHnDTRLMALADIISRLNYLLAltacl--mtllLMPMALLGLVDLSLlalmLLVLTPWLSGLL 207
gi 544855766 131 mdkREIKGVIAHELSHIIHkDATYLKIVQGLYAFVAFLStlvhisiifflPFYLMGSFNLSTSFl--lAILIVPSILRLV 208
gi 388529137 127 ltpPELMAVLAHELAHIANgDLKIMRLADGLGRITGLMAwlgia--llalNLPLILLGAVTVPLaavlLLIAAPGLVGLM 204
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                #                                                      #            
gi 223689984 208 QFTLSRTREFDADLGSAFLTGNPlMLASALNKLEvyrqhglk-----rffrlapDQGLVWLNTHPStgERIRRLMN 278
gi 550785586 207 QLALSRNREFTADLEAAALTRDPeGLAEALAVLEaqkglwlt----tlfgrrqlPSWLRFLQTHPAteERVGRLMA 278
gi 737480768 210 QLALSRTREFSADMEAARLSGDPeGLAQALEALHwqpgwwqr-----llipakaEAGSAWLRTHPPtpERIKRLRA 280
gi 763368279 208 VQAFSRSREYDADLEAARLTGDPnALADALETLDyynkggwl----arfqsprgIKVPTILSSHPKikDRVKRLRE 279
gi 655493803 212 QLGLSRVREFDADLAAVALTDDPeGLASALMAIErvqrgwra-----wlfpgwgSPEPSWLRTHPAteERVRRLLE 282
gi 339412238 206 ALAIQRTREFQADLTAAELTGDPqGLAMALYRITsprydilgalfpfgrslrrlEREHSLFLSHPPteERIRRLLS 281
gi 503714648 219 MLALSRFREIEADAFALELTGDAkTLETALAKLEhhhralsg-----ipegyieDRLASYLRSHPVtsERIDHLRA 289
gi 738658478 208 QLKLSRTREFAADLQAAHLTGDPmGLASALSKIDmgerkgwq-----rilvgyqQTQPSLLRSHPAtkERIRALKQ 278
gi 544855766 209 ILALMRNREYAADLMAVNLTEDPeGLALALSKLNsmnhwvvg-----lmfpynfGRKNSLLDTHPLpkQRIQRLMA 279
gi 388529137 205 QLALSRTREFAADLEAARLTGDPaALARALLALErsgpwe--------aifrlrHQGPGLLRTHPAtaERVRRLAE 272

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