Conserved Protein Domain Family
M48B_Htpx_like

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cd07340: M48B_Htpx_like 
Peptidase M48 subfamily B HtpX-like membrane-bound metallopeptidase
This HtpX family of peptidase M48 subfamily B includes uncharacterized HtpX homologs and consists of proteins smaller than Ste24p, with homology restricted to the C-terminal half of Ste24p. HtpX expression is controlled by the Cpx stress response system, which senses abnormal membrane proteins. HtpX participates in the proteolytic quality control of these misfolded proteins by undergoing self-degradation and collaborating with FtsH, a membrane-bound and ATP-dependent protease, to eliminate them. HtpX, a zinc metalloprotease with an active site motif HEXXH, has an FtsH-like topology, and is capable of introducing endoproteolytic cleavages into SecY (also an FtsH substrate). However, HtpX does not have an ATPase activity and will only act against cytoplasmic regions of a target membrane protein. Thus, HtpX and FtsH have overlapping and/or complementary functions, which are especially important at high temperature; in E. coli and Xylella fastidiosa, HtpX is heat-inducible, while in Streptococcus gordonii it is not.
Statistics
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PSSM-Id: 320699
View PSSM: cd07340
Aligned: 75 rows
Threshold Bit Score: 243.173
Threshold Setting Gi: 564723604
Created: 11-Mar-2009
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteputative active
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 166224440   52 IYAGVMIFQSTEVVMAMNGAREvse----qeaPELYHIVQDMAMVAQIPMPRVYIVEDpsPNAFATGskPENAAVAATTG 127
gi 83853024    77 AIWFAIAWFSHQAIIDASTGARkvsr---tdaPELYNLLENLTISRGMPMPSLRIIETdaLNAYASGlsEKKAVITVTRG 153
gi 315603707   73 LWIVIAYFFHQKLIDAVTGGHAvtr----aeqPRLYNLLENLCISRGIPMPKLKIMDSaaLNAFASGlnPKQYAITVTSG 148
gi 347591707   80 IWFIIAWFFNTRMVAMLSHAKPvtr----aeePALYNLLENLCIARGLPMPHLNIIETdaLNAFASGvqRSDYTVTVTRG 155
gi 406931432   76 IWALISFTFYRQIIFSFSDARAitr----aenPEIYNIVENLCISRGLAVPNIGILEDdsLNAFAVGwnVKKSWIVFSRW 151
gi 668956966   70 LAAAAWVFIGFKVNVGLIGAVTgasgvtreqnPKLYRMLENLCISRGLTVPKLSIVESeaLNAFASGvnDKQFTVTVTTG 149
gi 261372281   88 VWFIIAYCANTAIIRHATHAKPver----kdnLRVYNIVENLCIAGGIEMPQINIIQDsgMNAFASGidIPSFTITLTTG 163
gi 746968571   83 IWFIIAWFSHQAMIDAATGARKvtr----eeqPELYNLLENLCISRGITMPALRIIETpqMNAYASGltEKQYSVTVTSG 158
gi 815129499   79 IWFAIAYFTNVAMIQRATGARPler----renPRVYNIVENLCMTCGMSMPQIHVVDDpqLNAFASGinDKSYTVTLTTG 154
gi 1024845836  79 LWLFVAFHAHQALVSGVVGARLlar----peaPGLHRLLEDLCISRGITVPALQIVDDsaLNAYATGlnPQQYAITVTTG 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        #   #                                                            
gi 166224440  128 ILQiMNREELEGVIGHEVSHIRNyDIRISTIAVALASAITMLsslagrmmwfgggr-----------rssndrdndsglg 196
gi 83853024   154 LMErLDRDELEAVLAHELSHVINrDVRLLVIAVIFVGIISFTveiaarsvfygsls-----------ragggrrgrsgna 222
gi 315603707  149 LVDrLDDAELEAVLAHELTHIKNgDVQMMVIAVIIAGVVGFFgelmfrlffqggvrigggwsgggssssssssgrkggga 228
gi 347591707  156 LLNtLQPDEVEGVLAHELTHIINhDVRLLMVCIIFTGMIGFVmqlvwssvrygly--------------mprsgnnrnng 221
gi 406931432  152 ILNkLNKSEIEAVAAHELTHIINkDGLLLVTIIVFIGAIAAIweiifrtglhmwgg------------kssdgkdsgqlk 219
gi 668956966  150 LIQtLTDDEIEAVLAHELTHIRNgDVRMMIIAVVIAGVISLIgeiifrsigrvr----------------vssddakkgs 213
gi 261372281  164 LIEkLDDRELSAVVGHELTHIKNrDTRLMVVCIVFVGIFATIqmvsmklmsaivrspq--------rssrrnrnsgradi 235
gi 746968571  159 LMQrLDRDELEAVLAHELTHIINrDVRLLVISVIFVGIFSFVaqigvramfhgava-----------rsgrsrrggggna 227
gi 815129499  155 IINrLNDEELKGVVAHELTHIRNkDTRLLVVSIIFVGIISTVmslvvrmmyqtmwfgg-------svrrskdergtglsi 227
gi 1024845836 155 LMAaLDAREMRAVLAHELTHIRNdDVRTMMLAVVIAGLYAFVaegmaradlmra---------------paqgdgkrtga 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        #                                                
gi 166224440  197 iILLIVSLIAIVLAPLAAtlv--qlAISRQREFLADASSVELTRNPqGMINALLKLDrsepmehhvddasa--------- 265
gi 83853024   223 gVILLVAGLIVALAYGLAivi--rfALSRSREYMADAGAVELTKNPdAMISALEKISghseikdapkevr---------- 290
gi 315603707  229 iVVVILAIVLILLAWLLSqvv--klALSRSREFLADAGSVELTKNPdAMISALRKIEnrgelpgatsavm---------- 296
gi 347591707  222 gTIIIALAILLILAIGYGaslltrfALSRRREYMADAGAVELTRNPdAMMRALQRISgrdhipavpddv----------- 290
gi 406931432  220 lILILVWLALLILWYLVLplv--qlAVSRKREYLADAGSVALTKDKaSMISALQNISqdstiesikkdsisalc------ 291
gi 668956966  214 gVAILLGVAIIAISSLLAvli--rlSLSRSREYLADAGAVELTKNPdAMISALLKIAgradidgvpsgvm---------- 281
gi 261372281  236 yILLILLLVFIWSSIGYVftwltrlAISRKREYVADAGGAELCGDPlALASALRKISkdpglmsvkrddiaqlyvihpde 315
gi 746968571  228 aVMMLIAVAIVALAWFLAiai--rfALSRKREFMADAGAVELTKNPdAMIGALEKISgnasmedapseir---------- 295
gi 815129499  228 lIILFVGVICCAIAYFFTlit--rfAISRKREYMADAGGAELCGNPlALADALRKISsdpgldqvkqedvaqlf------ 299
gi 1024845836 220 vPAMLLGAALIVLAWVLSqai--rfALSRSREYVADAGAVELTKDPdALISALLKISgrgdlvrapsgvm---------- 287
                         250       260       270
                  ....*....|....*....|....*....|...
Feature 1                              #           
gi 166224440  266 --alyisdpkkegglkKLFYTHPPISERVERLR 296
gi 83853024   291 ---qmfidnetqasfaGLFATHPPIEKRIEALV 320
gi 315603707  297 ----emcldnprsgfsDLFATHPSVESRVDALV 325
gi 347591707  291 ----almcienghafmGLFATHPSIDDRIRALS 319
gi 406931432  292 ienpfpratwfmnkfhEFFSTHPSVSNRIAILE 324
gi 668956966  282 ----dmcfendpddfaDLFSTHPSITKRVQALV 310
gi 261372281  316 efdnnmglkgwvakanIMFCTHPDTPERIQLLE 348
gi 746968571  296 ----emmienpksgfsGIFMTHPPIEKRIEALE 324
gi 815129499  300 ivhpdqmvsgimgfmnSLFATHPDTKKRIAILE 332
gi 1024845836 288 ----elcfdnprsgflDLLATHPPVEDRIGAIM 316

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